Base de dados : MEDLINE
Pesquisa : J01.637.767.844 [Categoria DeCS]
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[PMID]:29381718
[Au] Autor:Sasaki M; Chubachi S; Kameyama N; Sato M; Haraguchi M; Miyazaki M; Takahashi S; Nakano T; Kuroda Y; Betsuyaku T; Matsuo K
[Ad] Endereço:Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan.
[Ti] Título:Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema.
[So] Source:PLoS One;13(1):e0191611, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health remain largely unknown. We report bone deterioration in a mouse model of emphysema induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure for 4-weeks decreased bone turnover and increased bone volume in mice. However, prolonged exposure for 20- and 40-weeks reversed the effects from suppression to promotion of bone resorption. This long-term CS exposure increased osteoclast number and impaired bone growth, while it increased bone volume. Strikingly, long-term CS exposure deteriorated bone quality of the lumbar vertebrae as illustrated by disorientation of collagen fibers and the biological apatite c-axis. This animal model may provide a better understanding of the mechanisms underlying the deterioration of bone quality in pulmonary emphysema caused by smoking.
[Mh] Termos MeSH primário: Osso e Ossos/metabolismo
Modelos Animais de Doenças
Enfisema/metabolismo
Fumaça
Produtos do Tabaco
[Mh] Termos MeSH secundário: Animais
Remodelação Óssea
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191611


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[PMID]:28452697
[Au] Autor:Johnson Shen M; Banerjee SC; Greene K; Carpenter A; Ostroff JS
[Ad] Endereço:Weill Cornell Medical College, Department of Medicine, Division of Geriatrics and Palliative Medicine, New York, NY, USA.
[Ti] Título:A Content Analysis of Unique Selling Propositions of Tobacco Print Ads.
[So] Source:Am J Health Behav;41(2):194-203, 2017 Mar 01.
[Is] ISSN:1945-7359
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We describe the unique selling propositions (USPs) (propositions used to convince customers to use a particular brand/product by focusing on the unique benefit) of print tobacco ads. METHODS: A qualitative content analysis was conducted of print tobacco ads (N = 171) selected from August 2012 to August 2013 for cigarettes, moist snuff, e-cigarettes, cigars, and snus to determine the content and themes of USPs for tobacco ads. RESULTS: Cigarette ad USP themes focused on portraying the product as attractive; moist snuff ads focused on portraying product as masculine; cigar ads focused on selling a "high end product;" and new and emerging tobacco products (e-cigarette, snus) focused on directly comparing these products to cigarettes. CONCLUSIONS: Whereas traditional tobacco product ads used USPs focused on themes of enjoyment and pleasure (eg, attractive for cigarettes, "high end product" for cigars), new and emerging tobacco product ads offered the unique benefit (USP) of their product being a better and "safer" alternative to traditional tobacco products. Snuff's USPs focused nearly exclusively on the masculinity of their products. Our results provide targets for potential tobacco regulatory actions that could be implemented to reduce demand for tobacco products by reducing their perceived unique benefits.
[Mh] Termos MeSH primário: Publicidade como Assunto/estatística & dados numéricos
Produtos do Tabaco/estatística & dados numéricos
[Mh] Termos MeSH secundário: Seres Humanos
Pesquisa Qualitativa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.5993/AJHB.41.2.11


  3 / 2188 MEDLINE  
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[PMID]:29329351
[Au] Autor:Miyazaki Y; Tabuchi T
[Ad] Endereço:School of Medicine, Osaka University, Suita, Osaka, Japan.
[Ti] Título:Educational gradients in the use of electronic cigarettes and heat-not-burn tobacco products in Japan.
[So] Source:PLoS One;13(1):e0191008, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: In addition to electronic cigarettes (e-cigarettes), tobacco companies have recently begun to sell heat-not-burn tobacco products, Ploom and iQOS in Japan. Previous research has reported an inverse association between combustible cigarette smoking and educational attainment, but little is known about the association for e-cigarettes, especially heat-not-burn tobacco products. Our objective was to analyze the relationship between educational attainment and e-cigarette and heat-not-burn tobacco use. SETTING: An internet survey (randomly sampled research agency panelists) in Japan. PARTICIPANTS: A total of 7338 respondents aged 18-69 years in 2015 (3632 men and 3706women). PRIMARY MEASURES: Adjusted odds ratios (ORs) of educational attainment for current smoking (combustible cigarettes), e-cigarette ever-use, and heat-not-burn ever-use were calculated by multivariable logistic regression models using covariates including socio-demographic factors. Stratified analyses according to smoking status (combustible cigarettes) were additionally performed for e-cigarette ever-use and heat-not-burn tobacco product ever-use. RESULTS: Associations between educational attainment and e-cigarette ever-use or heat-not-burn tobacco ever-use are not straightforward, although these associations are not statistically significant except for one cell. For example, using "graduate school" education as a reference category, adjusted ORs for "high school" were 1.44 (95% confidence interval [CI]: 0.85-2.44) for e-cigarettes ever-use and 0.75 (95% CI:0.19-2.97) for heat-not-burn tobacco product ever-use. Among current smokers, compared with "graduate school" (reference), those with lower educational attainment showed 0.6 to 0.7 ORs for e-cigarette ever-use: e.g.,"4-year university"(OR = 0.54, 95% CI:0.24-1.24) and "high school" (OR = 0.69, 95% CI: 0.30-1.60). Among former smokers, lower education indicated higher ORs for both e-cigarettes and heat-not-burn tobacco ever-use. CONCLUSIONS: This study provides baseline information on educational gradients of e-cigarette and heat-not-burn tobacco products, ever-use. As heat-not-burn tobacco products are increasing their market share in Japan, continuous monitoring of these products will be necessary.
[Mh] Termos MeSH primário: Sistemas Eletrônicos de Liberação de Nicotina
Educação em Saúde
Produtos do Tabaco
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Temperatura Alta
Seres Humanos
Internet
Japão
Masculino
Meia-Idade
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191008


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[PMID]:28468623
[Au] Autor:Murray LA; Dunmore R; Camelo A; Da Silva CA; Gustavsson MJ; Habiel DM; Hackett TL; Hogaboam CM; Sleeman MA; Knight DA
[Ad] Endereço:Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, United Kingdom. murrayl@medimmune.com.
[Ti] Título:Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium.
[So] Source:Respir Res;18(1):82, 2017 May 03.
[Is] ISSN:1465-993X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associated with epithelial damage and fragility, airway remodelling and sub-epithelial fibrosis. The aim of this study was to assess the acute effects of cigarette smoke on epithelial cell phenotype and pro-fibrotic responses in vitro and in vivo. RESULTS: Apoptosis was significantly greater in unstimulated cells from COPD patients compared to control, but proliferation and CXCL8 release were not different. Cigarette smoke dose-dependently induced apoptosis, proliferation and CXCL8 release with normal epithelial cells being more responsive than COPD patient derived cells. Cigarette smoke did not induce epithelial-mesenchymal transition. In vivo, cigarette smoke exposure promoted epithelial apoptosis and proliferation. Moreover, mimicking a virus-induced exacerbation by exposing to mice to poly I:C, exaggerated the inflammatory responses, whereas expression of remodelling genes was similar in both. CONCLUSIONS: Collectively, these data indicate that cigarette smoke promotes epithelial cell activation and hyperplasia, but a secondary stimulus is required for the remodelling phenotype associated with COPD.
[Mh] Termos MeSH primário: Transição Epitelial-Mesenquimal/efeitos dos fármacos
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Fibrose Pulmonar/induzido quimicamente
Mucosa Respiratória/efeitos dos fármacos
Mucosa Respiratória/fisiopatologia
Fumaça/efeitos adversos
Produtos do Tabaco/envenenamento
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Doença Pulmonar Obstrutiva Crônica/induzido quimicamente
Doença Pulmonar Obstrutiva Crônica/patologia
Fibrose Pulmonar/patologia
Fibrose Pulmonar/fisiopatologia
Mucosa Respiratória/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12931-017-0565-2


  5 / 2188 MEDLINE  
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[PMID]:29251976
[Au] Autor:Arger CA; Heil SH; Sigmon SC; Tidey JW; Stitzer ML; Gaalema DE; Durand HJ; Bunn JY; Ruggieri EK; Higgins ST
[Ad] Endereço:Vermont Center on Tobacco Regulatory Science, Department of Psychiatry, University of Vermont.
[Ti] Título:Preliminary validity of the modified Cigarette Evaluation Questionnaire in predicting the reinforcing effects of cigarettes that vary in nicotine content.
[So] Source:Exp Clin Psychopharmacol;25(6):473-478, 2017 12.
[Is] ISSN:1936-2293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Validity studies evaluating self-report measures in relation to behavioral preference of cigarettes varying in nicotine content are needed. The current study examined the relationship between ratings on the modified Cigarette Evaluation Questionnaire (mCEQ) and the relative reinforcing effects of Spectrum research cigarettes (15.8, 5.2, 2.4, 0.4 mg per gram of tobacco). Data for this secondary analysis were obtained from a double-blind study (Higgins et al., 2017) evaluating the subjective and reinforcing effects of Spectrum cigarettes under acute smoking abstinence. Current smokers (N = 26) were recruited from three vulnerable smoking populations (economically disadvantaged women of reproductive age, opioid-maintained individuals, individuals with affective disorders). In Phase 1 (five sessions), the mCEQ (Satisfaction, Psychological Reward, Enjoyment of Respiratory Tract Sensations, Craving Reduction, Aversion subscales) was administered following ad lib smoking of Spectrum cigarettes and subscale differences scores were calculated by subtracting ratings of the 15.8 mg/g cigarette from ratings of the reduced nicotine content cigarettes. In Phase 2 (six sessions), participants completed six 2-dose concurrent choice tests. The relationship between mCEQ subscale difference scores from Phase 1 and nicotine dose choice from Phase 2 was examined using mixed-model repeated-measures analyses of variance. Higher Satisfaction and lower Aversion subscale difference scores were associated with choosing the 15.8 mg/g cigarette more than the 5.2, 2.4, and 0.4 mg/g cigarettes. Scores on the other mCEQ subscales were not associated with nicotine choice. These results provide support for validity of the mCEQ Satisfaction and Aversion subscales predicting the relative reinforcing effects and abuse liability of varying nicotine content cigarettes. (PsycINFO Database Record
[Mh] Termos MeSH primário: Nicotina/administração & dosagem
Agonistas Nicotínicos/administração & dosagem
Abandono do Hábito de Fumar
Fumar/psicologia
Inquéritos e Questionários
Produtos do Tabaco/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Relação Dose-Resposta a Droga
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Avaliação de Resultados (Cuidados de Saúde)
Satisfação Pessoal
Valor Preditivo dos Testes
Reforço (Psicologia)
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Nicotinic Agonists); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1037/pha0000145


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[PMID]:29389916
[Au] Autor:Perks SN; Armour B; Agaku IT
[Ti] Título:Cigarette Brand Preference and Pro-Tobacco Advertising Among Middle and High School Students - United States, 2012-2016.
[So] Source:MMWR Morb Mortal Wkly Rep;67(4):119-124, 2018 Feb 02.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nearly all adult smokers first try cigarettes before age 18 years (1), and adolescents can show symptoms of nicotine dependence within days to weeks of the onset of occasional cigarette smoking (2). Having a usual cigarette brand among adolescent smokers could reflect exposure and receptivity to pro-tobacco advertising and tobacco product appeal (1). To identify usual cigarette brands smoked among U.S. middle and high school students who were current (past 30-day) cigarette smokers, CDC analyzed data from the 2012-2016 National Youth Tobacco Survey (NYTS). Marlboro, Newport, and Camel were the most commonly reported brands smoked during 2012-2016; in 2016, these three were the brands usually smoked for 73.1% and 78.7% of current cigarette smokers in middle and high school, respectively. These three brands also were the three most commonly identified as having a "favorite cigarette ad" in 2012. Efforts to reduce youth exposure to pro-tobacco advertising could help reduce youth smoking (1,3).
[Mh] Termos MeSH primário: Publicidade como Assunto/estatística & dados numéricos
Comportamento do Consumidor/estatística & dados numéricos
Fumar/psicologia
Estudantes/psicologia
Produtos do Tabaco/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Instituições Acadêmicas
Fumar/epidemiologia
Estudantes/estatística & dados numéricos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6704a3


  7 / 2188 MEDLINE  
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[PMID]:29370150
[Au] Autor:Odani S; Armour BS; Graffunder CM; Willis G; Hartman AM; Agaku IT
[Ti] Título:State-Specific Prevalence of Tobacco Product Use Among Adults - United States, 2014-2015.
[So] Source:MMWR Morb Mortal Wkly Rep;67(3):97-102, 2018 Jan 26.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite recent declines in cigarette smoking prevalence, the tobacco product landscape has shifted to include emerging tobacco products* (1,2). Previous research has documented adult use of smokeless tobacco and cigarettes by state (3); however, state-specific data on other tobacco products are limited. To assess tobacco product use in the 50 U.S. states and the District of Columbia (DC), CDC and the National Cancer Institute analyzed self-reported use of six tobacco product types: cigarettes, cigars, regular pipes, water pipes, electronic cigarettes (e-cigarettes), and smokeless tobacco products among adults aged ≥18 years using data from the 2014-2015 Tobacco Use Supplement to the Current Population Survey (TUS-CPS). Prevalence of ever-use of any tobacco product ranged from 27.0% (Utah) to 55.4% (Wyoming). Current (every day or some days) use of any tobacco product ranged from 10.2% (California) to 27.7% (Wyoming). Cigarettes were the most common currently used tobacco product in all states and DC. Among current cigarette smokers, the proportion who currently used one or more other tobacco products ranged from 11.5% (Delaware) to 32.3% (Oregon). Differences in tobacco product use across states underscore the importance of implementing proven population-level strategies to reduce tobacco use and expanding these strategies to cover all forms of tobacco marketed in the United States. Such strategies could include comprehensive smoke-free policies, tobacco product price increases, anti-tobacco mass media campaigns, and barrier-free access to clinical smoking cessation resources (1,4).
[Mh] Termos MeSH primário: Produtos do Tabaco/utilização
Tabagismo/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Inquéritos Epidemiológicos
Seres Humanos
Prevalência
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6703a3


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[PMID]:29361661
[Au] Autor:White RS; Thomson Reuters Accelus.
[Ti] Título:Pharmaceuticals and Medical Devices: FDA Oversight.
[So] Source:Issue Brief Health Policy Track Serv;2017:1-43, 2017 Dec 26.
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aprovação de Drogas/organização & administração
Legislação de Medicamentos
United States Food and Drug Administration
[Mh] Termos MeSH secundário: Sistemas de Notificação de Reações Adversas a Medicamentos
Contaminação de Medicamentos
Rotulagem de Medicamentos
Drogas em Investigação
Farmacoeconomia
Sistemas Eletrônicos de Liberação de Nicotina
Terapia Genética
Regulamentação Governamental
Seres Humanos
Disponibilidade de Medicamentos Via Internet
Medicamentos sob Prescrição/efeitos adversos
Medicamentos sob Prescrição/economia
Medicamentos sob Prescrição/uso terapêutico
Regeneração
Produtos do Tabaco/legislação & jurisprudência
Estados Unidos
United States Food and Drug Administration/legislação & jurisprudência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Investigational); 0 (Prescription Drugs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE


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[PMID]:27776582
[Au] Autor:Latif E; Nair M
[Ad] Endereço:Department of Tobacco Control, International Union Against Tuberculosis and Lung Disease, Edinburgh, UK.
[Ti] Título:E-cigarettes: a need to broaden the debate.
[So] Source:Int J Tuberc Lung Dis;20(11):1430-1435, 2016 Nov.
[Is] ISSN:1815-7920
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The unregulated market for e-cigarettes continues to grow, with debates on their efficacy and impact on global public health. E-cigarettes, or electronic nicotine delivery systems (ENDs), are marketed as a 'safe' alternative to tobacco products and a tool for 'harm reduction'. Some public health experts are calling it a 'game changer' and favour the 'harm reduction' strategy, while others dispute this claim. In our opinion, the debate needs to be broadened to encompass other related concerns and effects on non-users and affected stakeholders. As with tobacco control, a holistic approach is needed to build a raft of policies that effectively address the issue from all angles and look beyond the direct health implications of e-cigarette use to explore the social, economic, political and environmental aspects of this debate, putting 'harm reduction' in context.
[Mh] Termos MeSH primário: Sistemas Eletrônicos de Liberação de Nicotina
Regulamentação Governamental
Saúde Pública
[Mh] Termos MeSH secundário: Redução do Dano
Seres Humanos
Abandono do Hábito de Fumar/legislação & jurisprudência
Produtos do Tabaco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  10 / 2188 MEDLINE  
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[PMID]:29240751
[Au] Autor:Chambers J
[Ad] Endereço:Manager, Tobacco Control Team, Ministry of Health, Wellington.
[Ti] Título:New Zealand's legal action against IQOS postponed, consultation with Big Tobacco follows: a response from the Ministry of Health.
[So] Source:N Z Med J;130(1467):101, 2017 12 15.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Mh] Termos MeSH primário: Produtos do Tabaco
Tabaco
[Mh] Termos MeSH secundário: Seres Humanos
Nova Zelândia
Encaminhamento e Consulta
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE



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