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[PMID]:29283338
[Au] Autor:Devi AR; Sengupta M; Choudhury Y
[Ad] Endereço:Department of Biotechnology, Assam University, Silchar-788011, India.
[Ti] Título:Aqueous Extract of Smokeless Tobacco (gutkha) Deregulates Tumor Suppressor and DNA Repair Response in a Murine Model of Smokeless Tobacco Use.
[So] Source:J Environ Pathol Toxicol Oncol;36(3):245-267, 2017.
[Is] ISSN:2162-6537
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effect of smokeless tobacco (gutkha) was investigated by treating male and female Swiss Albino mice with an aqueous extract of smokeless tobacco (AEST). AEST was administered at a dose of 25 mg kg-1 body weight per day for different time periods (6, 12, 16, and 24 weeks), and control animals were provided only drinking water without AEST for the same period. Control and AEST-treated mice were observed for different oxidative stress parameters, nitric oxide (NO) release, and myeloperoxidase (MPO) release, and they were evaluated for alterations in tumor suppressor and DNA repair responses in the liver and spleen. Both male and female mice treated with AEST showed significant increase in lipid peroxidation, protein carbonylation, and NO and MPO release in the liver and spleen compared to age- and gender-matched controls. The significant decline in tumor suppressor p53 protein levels, likely mediated by concomitantly upregulated levels of Mdm2, was observed. We also observed a significant decline in the levels of DNA repair proteins Brca2 and Ape-1 compared to the respective controls. Thus, AEST induces oxidative stress, inflammation, and significantly lowers tumor suppressor and DNA repair responses. These factors may work in conjunction to increase the risk for certain diseases, including cancer.
[Mh] Termos MeSH primário: Reparo do DNA/efeitos dos fármacos
Extratos Vegetais/farmacologia
Proteínas Proto-Oncogênicas c-mdm2/análise
Tabaco sem Fumaça
Proteína Supressora de Tumor p53/análise
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Masculino
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Peroxidase/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Tumor Suppressor Protein p53); EC 1.11.1.7 (Peroxidase); EC 2.3.2.27 (Mdm2 protein, mouse); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1615/JEnvironPatholToxicolOncol.2017021847


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[PMID]:29072129
[Au] Autor:Kumar M; Srivastava S; Singh SA; Das AK; Das GC; Dhar B; Ghosh SK; Mondal R
[Ad] Endereço:1 Molecular Medicine Laboratory, Department of Biotechnology, Assam University, Silchar, India.
[Ti] Título:Cell-free mitochondrial DNA copy number variation in head and neck squamous cell carcinoma: A study of non-invasive biomarker from Northeast India.
[So] Source:Tumour Biol;39(10):1010428317736643, 2017 Oct.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Head and neck squamous cell carcinoma is the most commonly diagnosed cancer worldwide. The lifestyle, food habits, and customary practices manifest the Northeast Indian population toward higher susceptibility to develop head and neck squamous cell carcinoma. Here, we have investigated the association of smoke and smokeless tobacco, and alcohol with copy number variation of cell-free mitochondrial DNA and cell-free nuclear DNA in cases and controls. Cell-free DNA from plasma was isolated from 50 head and neck squamous cell carcinoma cases and 50 controls with informed written consent using QIAamp Circulating Nucleic Acid Kit. Real-time polymerase chain reaction was done for copy number variation in cell-free mitochondrial DNA and cell-free nuclear DNA. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic application between the two study groups using clinicopathological parameters. The levels of cell-free nuclear DNA and cell-free mitochondrial DNA of cases in association with smoke and smokeless tobacco, alcohol with smoking (p < 0.05) were significantly higher (p < 0.01 and p < 0.001, respectively) than controls. Using receiver operating characteristic curve analysis between head and neck squamous cell carcinoma cases and controls, we distinguished cell-free mitochondrial DNA (cutoff: 19.84 raw Ct; sensitivity: 84%; specificity: 100%; p < 0.001) and cell-free nuclear DNA (cutoff: 463,282 genomic equivalent/mL; sensitivity: 53%; specificity: 87%; p < 0.001). The copy number variation in cases (cell-free nuclear DNA: 5451.66 genomic equivalent/mL and cell-free mitochondrial DNA: 29,103,476.15 genomic equivalent/mL) and controls (cell-free nuclear DNA: 1650.9 genomic equivalent/mL and cell-free mitochondrial DNA: 9,189,312.54 genomic equivalent/mL), respectively. Our result indicates that the cell-free mitochondrial DNA content is highly associated with smoke and smokeless tobacco, betel quid chewing, and alcohol which shows greater promises, holding the key characteristics of diagnostic biomarkers, that is, minimal invasiveness, high specificity, and sensitivity.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Carcinoma de Células Escamosas/genética
DNA Mitocondrial/genética
Predisposição Genética para Doença
Neoplasias de Cabeça e Pescoço/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Consumo de Bebidas Alcoólicas/efeitos adversos
Biomarcadores Tumorais/sangue
Carcinoma de Células Escamosas/sangue
Carcinoma de Células Escamosas/patologia
Variações do Número de Cópias de DNA
DNA Mitocondrial/sangue
Feminino
Estudos de Associação Genética
Neoplasias de Cabeça e Pescoço/sangue
Neoplasias de Cabeça e Pescoço/patologia
Seres Humanos
Índia
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
Fumar/efeitos adversos
Tabaco sem Fumaça/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (DNA, Mitochondrial)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317736643


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[PMID]:28817323
[Au] Autor:Roberts ME; Doogan NJ; Stanton CA; Quisenberry AJ; Villanti AC; Gaalema DE; Keith DR; Kurti AN; Lopez AA; Redner R; Cepeda-Benito A; Higgins ST
[Ad] Endereço:Megan E. Roberts, Nathan J. Doogan, and Amanda J. Quisenberry are with the Center of Excellence in Regulatory Tobacco Science, Ohio State University, Columbus. Cassandra A. Stanton is with Westat, Center for Evaluation and Coordination of Training and Research in Tobacco Regulatory Science, Rockvill
[Ti] Título:Rural Versus Urban Use of Traditional and Emerging Tobacco Products in the United States, 2013-2014.
[So] Source:Am J Public Health;107(10):1554-1559, 2017 Oct.
[Is] ISSN:1541-0048
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To examine urban-rural differences in US prevalences of traditional and emerging tobacco product use as well as dual or polytobacco use of these products. METHODS: Our data were derived from wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study. We estimated weighted prevalences of adult tobacco use across urban-rural geographies and examined prevalences classified by gender, poverty level, and region of the country. RESULTS: Nationally, cigarette use and smokeless tobacco use, as well as dual or polytobacco use of traditional products, were more prevalent in rural than in urban areas. Conversely, cigarillo and hookah use and dual or polytobacco use of emerging products were higher in urban areas. There was no significant urban-rural difference in use of e-cigarettes. Gender, poverty, and region of the country did not seem to be driving most urban-rural differences, although differences related to cigarillo use and dual or polytobacco use of emerging products became nonsignificant after control for covariates. CONCLUSIONS: Our findings highlight important urban-rural differences in tobacco use. Whether the changing tobacco product landscape will contribute to a continuation of rural health disparities remains to be seen.
[Mh] Termos MeSH primário: População Rural/estatística & dados numéricos
Produtos do Tabaco/estatística & dados numéricos
Uso de Tabaco/epidemiologia
População Urbana/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Sistemas Eletrônicos de Liberação de Nicotina/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Meia-Idade
Distribuição Espacial da População
Fatores de Risco
Fatores Sexuais
Fatores Socioeconômicos
Produtos do Tabaco/classificação
Tabaco sem Fumaça/estatística & dados numéricos
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.2105/AJPH.2017.303967


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[PMID]:28727534
[Au] Autor:Cheng YC; Rostron BL; Day HR; Stanton CA; Hull LC; Persoskie A; Travers MJ; Taylor K; Conway KP; Ambrose BK; Borek N
[Ad] Endereço:Yu-Ching Cheng, Brian L. Rostron, Hannah R. Day, Lynn C. Hull, Alexander Persoskie, Bridget K. Ambrose, and Nicolette Borek are with the Office of Science, Center for Tobacco Products, US Food and Drug Administration, Silver Spring, MD. Cassandra A. Stanton and Kristie Taylor are with Westat Inc, Ro
[Ti] Título:Patterns of Use of Smokeless Tobacco in US Adults, 2013-2014.
[So] Source:Am J Public Health;107(9):1508-1514, 2017 Sep.
[Is] ISSN:1541-0048
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To examine patterns of smokeless tobacco (SLT) use, by type, in wave 1 (2013-2014) of the Population Assessment of Tobacco and Health Study in the United States. METHODS: We analyzed data from 32 320 adults (aged ≥ 18 years) to assess the use of pouched snus and other SLT products (loose snus, moist snuff, dip, spit, and chewing tobacco). RESULTS: Overall, SLT use was most common among men, younger adults, non-Hispanic Whites, and nonurban respondents. Pouched snus users were more likely to report nondaily and polytobacco use than users of other SLT products. Respondents who used SLT some days were more likely to be current established cigarette smokers than those who used SLT every day (57.9% vs 20.2%). Furthermore, current established smokers who used SLT some days were more likely to smoke every day and had a higher median number of cigarettes smoked per day than smokers who used SLT every day. CONCLUSIONS: Polytobacco use, especially cigarette smoking, is common among SLT users. Pouched snus users are more likely to report nondaily snus use and polytobacco use than users of other SLT products.
[Mh] Termos MeSH primário: Produtos do Tabaco/estatística & dados numéricos
Uso de Tabaco/tendências
Tabaco sem Fumaça/utilização
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Fumar
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.2105/AJPH.2017.303921


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[PMID]:28704507
[Au] Autor:Björkman F; Edin F; Mattsson CM; Larsen F; Ekblom B
[Ad] Endereço:Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
[Ti] Título:Regular moist snuff dipping does not affect endurance exercise performance.
[So] Source:PLoS One;12(7):e0181228, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Physiological and medical effects of snuff have previously been obtained either in cross-sectional studies or after snuff administration to non-tobacco users. The effects of snuff cessation after several years of daily use are unknown. 24 participants with >2 years of daily snuff-use were tested before and after >6 weeks snuff cessation (SCG). A control group (CO) of 11 snuff users kept their normal habits. Resting heart rate (HR) and blood pressure (BP) were significantly lower in SCG after snuff cessation, and body mass was increased by 1.4 ± 1.7 kg. Total cholesterol increased from 4.12 ± 0.54 (95% CI 3.89-4.35) to 4.46 ± 0.70 (95% CI 4.16-4.75) mM L-1 in SCG, due to increased LDL, and this change was significantly different from CO. Resting values of HDL, C-reactive protein, and free fatty acids (FFA) remained unchanged in both groups. In SCG group, both HR and BP were reduced during a four-stage incremental cycling test (from 50 to 80% of VO2max) and a prolonged cycling test (60 min at 50% of VO2max). Oxygen uptake (VO2), respiratory exchange ratio, blood lactate (bLa) and blood glucose (bGlu) concentration, and rate of perceived exertion (RPE) were unchanged. In CO group, all measurements were unchanged. During the prolonged cycling test, FFA was reduced, but with no significant difference between groups. During the maximal treadmill running test peak values of VO2, pulmonary ventilation (VE), time to exhaustion and bLa were unchanged in both groups. In conclusion, endurance exercise performance (VO2max and maximal endurance time) does not seem to be affected by prolonged snuff use, while effects on cardiovascular risk factors are contradictory. HR and BP during rest and submaximal exercise are reduced after cessation of regular use of snuff. Evidently, the long-time adrenergic stress on circulation is reversible.
[Mh] Termos MeSH primário: Resistência Física
Tabaco sem Fumaça
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Estudos Transversais
Teste de Esforço
Seres Humanos
Masculino
Esforço Físico/fisiologia
Troca Gasosa Pulmonar
Corrida
Fatores de Tempo
Abandono do Uso de Tabaco
Tabaco sem Fumaça/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181228


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[PMID]:28702879
[Au] Autor:Rana SVS; Verma Y; Singh GD
[Ad] Endereço:Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut, UP, 250004, India. sureshvs_rana@yahoo.com.
[Ti] Título:Assessment of genotoxicity amongst smokers, alcoholics, and tobacco chewers of North India using micronucleus assay and urinary 8-hydroxyl-2'-deoxyguanosine, as biomarkers.
[So] Source:Environ Monit Assess;189(8):391, 2017 Aug.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The main objective of the present study was to screen the genotoxicity caused by individual and combined habits of smoking, tobacco chewing, and alcohol consumption in human population of North India. Study recruited 67 male subjects aged 25 to 65 years. Buccal mucosal cells were subjected to micronucleus (MN) assay, and 8-hydroxyl-2-deoxyguanosine (8-OHdG) was estimated in their urine samples. Number and shape of the MN cells varied in the buccal epithelium of different groups. Maximum number of MN (0.47%) were found in tobacco chewers followed by smokers (0.45%) and alcoholics (0.44%) (P < 0.05). These results reciprocated the concentration of urinary 8-OHdG. Maximum value for 8-OHdG was also recorded in tobacco chewers (21.07 ± 5.51 mg/mg creatinine) followed by smokers (20.25 ± 3.96 mg/mg creatinine) and alcoholics (19.06 ± 3.41 mg/mg creatinine) (P < 0.05). Combined effects of these agents were found to be statistically different from individual effects. Carcinogenic compounds present in cigarette smoke, nitrosamines found in solid tobacco, and acetaldehyde, a metabolic product of alcohol, induce oxidative stress that manifests into genotoxicity. In conclusion, demographical differences occur in the genotoxicity caused by these three habits. MN assay and urinary 8-OHdG are simple, noninvasive, and reliable biomarkers of genotoxicity.
[Mh] Termos MeSH primário: Alcoólicos/estatística & dados numéricos
Dano ao DNA
Desoxiguanosina/análogos & derivados
Exposição Ambiental/estatística & dados numéricos
Poluição por Fumaça de Tabaco/estatística & dados numéricos
Tabaco sem Fumaça
Tabaco
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/urina
Desoxiguanosina/urina
Monitoramento Ambiental
Seres Humanos
Índia
Masculino
Testes para Micronúcleos
Meia-Idade
Nitrosaminas
Estresse Oxidativo
Fumar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Nitrosamines); 0 (Tobacco Smoke Pollution); 88847-89-6 (8-oxo-7-hydrodeoxyguanosine); G9481N71RO (Deoxyguanosine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6103-3


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[PMID]:28692704
[Au] Autor:Khan Z; Dreger S; Shah SMH; Pohlabeln H; Khan S; Ullah Z; Rehman B; Zeeb H
[Ad] Endereço:Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
[Ti] Título:Oral cancer via the bargain bin: The risk of oral cancer associated with a smokeless tobacco product (Naswar).
[So] Source:PLoS One;12(7):e0180445, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the wake of smokeless tobacco (SLT) being advocated as a mean of tobacco harm reduction, it is pertinent to establish individual health risks associated with each SLT product. This case-control study was aimed at assessing the risk of oral cancer associated with a smokeless tobacco product (Naswar). The study was conducted from September 2014 till May 2015 in Khyber Pakhtunkhwa, Pakistan. Exposure and covariate information was collected through a structured questionnaire. Conditional logistic regression was used to calculate odds ratios (OR) along with their 95% confidence intervals (CI). 84 oral cancer cases (62% males) and 174 age- and sex-matched controls were recruited. Ever users of Naswar had more than a 20-fold higher risk of oral cancer compared to never-users (OR 21.2, 95% CI 8.4-53.8). Females had a higher risk of oral cancer with the use of Naswar (OR 29.0, 95% CI 5.4-153.9) as compared to males (OR 21.0, 95% CI 6.1-72.1). Based on this result, 68% (men) and 38% (women) of the oral cancer burden in Pakistan is attributable to Naswar. The risk estimates observed in this study are comparable to risk estimates reported by previous studies on other forms of SLT use and the risk of oral cancer in Pakistan. The exposure-response relationship also supports a strong role of Naswar in the etiology of oral cancer in Pakistan. Although still requiring further validation through independent studies, these findings may be used for smokeless tobacco control in countries where Naswar use is common.
[Mh] Termos MeSH primário: Neoplasias Bucais/epidemiologia
Tabaco sem Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Seres Humanos
Estilo de Vida
Modelos Logísticos
Masculino
Meia-Idade
Paquistão/epidemiologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180445


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[PMID]:28642795
[Au] Autor:Ladusingh L; Dhillon P; Narzary PK
[Ad] Endereço:Department of Mathematical Demography and Statistics, International Institute for Population Sciences, Mumbai, India.
[Ti] Título:Why Do the Youths in Northeast India Use Tobacco?
[So] Source:J Environ Public Health;2017:1391253, 2017.
[Is] ISSN:1687-9813
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study is an assessment of the influence of parent's tobacco use on prospective tobacco use trajectories among young offspring. The study is based on unit level data from District Level Household and Facility Survey-4 (2012-2013) comprising 27,706 youths in 15-24 years' age group from northeastern states of India and used multilevel regression to identify the potential risk factors of tobacco consumption. The likelihood of using tobacco was found to be 3.4 and 1.14 times more, respectively, for the youths coresiding with mothers who use tobacco and fathers who use tobacco, in comparison to youths staying with parents not taking tobacco. The significant effect of peers on tobacco consumption among youths was also observed. School-going youths had significantly lower risk of tobacco use. The estimated likelihood of a young person from a household to use any tobacco, use smokeless tobacco, and smoke was found to be 28, 12, and 17 percent, respectively. There is an urgent need to extend National Tobacco Control Programme (NTCP) to the community level involving civil societies and young and adult generations for spreading awareness about the health hazards of tobacco use, providing support and facilitating quitting tobacco use.
[Mh] Termos MeSH primário: Fumar/tendências
Uso de Tabaco/tendências
Tabaco sem Fumaça
[Mh] Termos MeSH secundário: Adolescente
Características da Família
Feminino
Seres Humanos
Índia
Masculino
Pais
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1155/2017/1391253


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[PMID]:28642557
[Au] Autor:Seenan P; Conway D
[Ad] Endereço:Glasgow Dental Hospital and School, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK.
[Ti] Título:Smokeless tobacco - a substantial risk for oral potentially malignant disorders in South Asia.
[So] Source:Evid Based Dent;18(2):54-55, 2017 06 23.
[Is] ISSN:1476-5446
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Data sourcesMedline, the Science Citation Index (SCI) via Web of Science, Scopus, CINAHL, Global Index Medicus, Google Scholar and SLT-related reports of the International Agency for Research on Cancer and the National Cancer Institute of the United States.Study selectionObservational studies on the use of SLT and the risk of developing OPMDs in South Asian Populations.Data extraction and synthesisDuplicate selection of studies was undertaken with two reviewers undertaking data abstraction and quality assessment independently. Risk and odds ratios were extracted or calculated for studies where possible. Meta odds ratios (mOR) were calculated using a random effects analysis.ResultsFifteen papers reporting 18 studies were included. The majority (12) were from India. All the studies were case-control designs. MOR for any OPMD with the use of any SLT product was 15.5 (95% CI; 9.9-24.2). Risk was higher in women; mOR = 22.2 (95% CI, 9.1-54.1) than men; mOR = 8.7 (95% CI, 2.1-34.8). Betel quid with tobacco carried the highest risk for OPMD, mOR = 16.1 (95% CI, 7.8-33.5).ConclusionsThe findings of our study point towards a strong association between some forms of OPMDs and SLT use in South Asia. The risk estimates are high, irrespective of controlling for confounders such as smoking and alcohol or stratification by sex, country or source of controls. There is also an exposure-response relationship between OPMDs and SLT use.
[Mh] Termos MeSH primário: Neoplasias Bucais
Tabaco sem Fumaça
[Mh] Termos MeSH secundário: Ásia
Feminino
Seres Humanos
Índia
Masculino
Fumar
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1038/sj.ebd.6401242


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[PMID]:28486772
[Au] Autor:Araghi M; Rosaria Galanti M; Lundberg M; Lager A; Engström G; Alfredsson L; Knutsson A; Norberg M; Sund M; Wennberg P; Trolle Lagerros Y; Bellocco R; Pedersen NL; Östergren PO; Magnusson C
[Ad] Endereço:Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
[Ti] Título:Use of moist oral snuff (snus) and pancreatic cancer: Pooled analysis of nine prospective observational studies.
[So] Source:Int J Cancer;141(4):687-693, 2017 Aug 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.
[Mh] Termos MeSH primário: Neoplasias Pancreáticas/epidemiologia
Tabaco sem Fumaça/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Seres Humanos
Masculino
Meia-Idade
Estudos Observacionais como Assunto
Modelos de Riscos Proporcionais
Estudos Prospectivos
Medição de Risco
Suécia/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30773



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