Base de dados : MEDLINE
Pesquisa : J01.937.285.850 [Categoria DeCS]
Referências encontradas : 11334 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1134 ir para página                         

  1 / 11334 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29419273
[Au] Autor:Hinkelbein J; Komorowski M; Grau S
[Ad] Endereço:University Hospital of Cologne, Cologne, Germany
[Ti] Título:Effects of Spaceflight on Astronaut Brain Structure.
[So] Source:N Engl J Med;378(6):582, 2018 02 08.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Astronautas
Voo Espacial
[Mh] Termos MeSH secundário: Medicina Aeroespacial
Encéfalo
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1716067


  2 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29419272
[Au] Autor:Wilson MH; Hargens AR; Imray CH
[Ad] Endereço:Imperial College London, London, United Kingdom m.wilson@imperial.ac.uk
[Ti] Título:Effects of Spaceflight on Astronaut Brain Structure.
[So] Source:N Engl J Med;378(6):581, 2018 02 08.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Astronautas
Voo Espacial
[Mh] Termos MeSH secundário: Medicina Aeroespacial
Encéfalo
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1716067


  3 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29414278
[Au] Autor:Roberts; Antonucci
[Ad] Endereço:Medical University of South Carolina, Charleston, SC robertdr@musc.edu
[Ti] Título:Effects of Spaceflight on Astronaut Brain Structure.
[So] Source:N Engl J Med;378(6):582-583, 2018 02 08.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Astronautas
Voo Espacial
[Mh] Termos MeSH secundário: Medicina Aeroespacial
Encéfalo
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1716067


  4 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28471415
[Au] Autor:Albi E; Krüger M; Hemmersbach R; Lazzarini A; Cataldi S; Codini M; Beccari T; Ambesi-Impiombato FS; Curcio F
[Ad] Endereço:Department of Pharmaceutical Science, University of Perugia, San Costanzo, via Romana, 06121 Perugia, Italy. elisabetta.albi@unipg.it.
[Ti] Título:Impact of Gravity on Thyroid Cells.
[So] Source:Int J Mol Sci;18(5), 2017 May 04.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Physical and mental health requires a correct functioning of the thyroid gland, which controls cardiovascular, musculoskeletal, nervous, and immune systems, and affects behavior and cognitive functions. Microgravity, as occurs during space missions, induces morphological and functional changes within the thyroid gland. Here, we review relevant experiments exposing cell cultures (normal and cancer thyroid cells) to simulated and real microgravity, as well as wild-type and transgenic mice to hypergravity and spaceflight conditions. Well-known mechanisms of damage are presented and new ones, such as changes of gene expression for extracellular matrix and cytoskeleton proteins, thyrocyte phenotype, sensitivity of thyrocytes to thyrotropin due to thyrotropin receptor modification, parafollicular cells and calcitonin production, sphingomyelin metabolism, and the expression and movement of cancer molecules from thyrocytes to colloids are highlighted. The identification of new mechanisms of thyroid injury is essential for the development of countermeasures, both on the ground and in space, against thyroid cancer. We also address the question whether normal and cancer cells show a different sensitivity concerning changes of environmental conditions.
[Mh] Termos MeSH primário: Glândula Tireoide/citologia
Neoplasias da Glândula Tireoide/etiologia
Ausência de Peso/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Voo Espacial
Glândula Tireoide/patologia
Glândula Tireoide/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  5 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29206364
[Au] Autor:Antonsen E; Garbino A; Davis Reed R; Kehnhardt K
[Ti] Título:Above the Atmosphere: Unique medical challenges for commercial space flight tourism.
[So] Source:JEMS;41(12):35-9, 2016 12.
[Is] ISSN:0197-2510
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Medicina Aeroespacial/educação
Serviços Médicos de Emergência/organização & administração
Medicina de Emergência/educação
Voo Espacial
Viagem
[Mh] Termos MeSH secundário: Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  6 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29244852
[Au] Autor:Ott E; Kawaguchi Y; Kölbl D; Chaturvedi P; Nakagawa K; Yamagishi A; Weckwerth W; Milojevic T
[Ad] Endereço:Department of Biophysical Chemistry, University of Vienna, Vienna, Austria.
[Ti] Título:Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission.
[So] Source:PLoS One;12(12):e0189381, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The multiple extremes resistant bacterium Deinococcus radiodurans is able to withstand harsh conditions of simulated outer space environment. The Tanpopo orbital mission performs a long-term space exposure of D. radiodurans aiming to investigate the possibility of interplanetary transfer of life. The revealing of molecular machinery responsible for survivability of D. radiodurans in the outer space environment can improve our understanding of underlying stress response mechanisms. In this paper, we have evaluated the molecular response of D. radiodurans after the exposure to space-related conditions of UVC irradiation and vacuum. Notably, scanning electron microscopy investigations showed that neither morphology nor cellular integrity of irradiated cells was affected, while integrated proteomic and metabolomic analysis revealed numerous molecular alterations in metabolic and stress response pathways. Several molecular key mechanisms of D. radiodurans, including the tricarboxylic acid cycle, the DNA damage response systems, ROS scavenging systems and transcriptional regulators responded in order to cope with the stressful situation caused by UVC irradiation under vacuum conditions. These results reveal the effectiveness of the integrative proteometabolomic approach as a tool in molecular analysis of microbial stress response caused by space-related factors.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Deinococcus/efeitos da radiação
Proteoma/metabolismo
[Mh] Termos MeSH secundário: Ciclo do Ácido Cítrico
Deinococcus/metabolismo
Deinococcus/ultraestrutura
Viabilidade Microbiana
Voo Espacial
Raios Ultravioleta
Vácuo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Proteome)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189381


  7 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27776994
[Au] Autor:Kokhan VS; Matveeva MI; Bazyan AS; Kudrin VS; Mukhametov A; Shtemberg AS
[Ad] Endereço:Laboratory of Extreme Physiology, Institute of Medico-Biological Problems RAS, Moscow, Russia. Electronic address: viktor_kohan@hotmail.com.
[Ti] Título:Combined effects of antiorthostatic suspension and ionizing radiation on the behaviour and neurotransmitters changes in different brain structures of rats.
[So] Source:Behav Brain Res;320:473-483, 2017 03 01.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Space flight factors (SFF) significantly affect the operating activity of astronauts during deep space missions. In contrast to an orbital flight, leaving the Earth's magnetic field is fraught with the dangers of exposure to ionizing radiation and more specifically, the high-energy nuclei component of galactic cosmic rays. Microgravity, just another critical non-radiation factor, significantly affects the normal functioning of the CNS. Some morphological structures of the brain, such as the prefrontal cortex and the hippocampus, that are rich in monoaminergic and acetylcholinergic neurones, are the most sensitive to the effects of ionizing radiation and non-radiation spaceflight factors (SFF). In this work we have studied the combined effects of microgravity (in antiorthostatic suspension model, AS) and irradiation (γ-ray and protons in spread-out Bragg peak) on the behaviour, cognitive abilities, and metabolism of monoamines and acetylcholine in the key structures of the rat's brain. Irradiation (as independently as combined with AS) resulted in the decrease of thigmotaxis in rats. Learning problems, caused by the malfunctioning of the working memory but not the spatial memory, were observed in response to AS as well as to the SFF in combination. Analysis of monoamines metabolism showed that the serotoninergic system was the most affected by the SFF. Concentration of acetylcholine in the hippocampus significantly increased in the groups of irradiated rats, and in the groups which were exposed to the SFF in combination, compared to the rats exposed only to AS.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos da radiação
Encéfalo/metabolismo
Encéfalo/efeitos da radiação
Gravitação
Neurotransmissores/metabolismo
Radiação Ionizante
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva/fisiologia
Aprendizagem da Esquiva/efeitos da radiação
Comportamento Animal/fisiologia
Comportamento Exploratório/efeitos da radiação
Masculino
Aprendizagem em Labirinto/fisiologia
Aprendizagem em Labirinto/efeitos da radiação
Ratos
Ratos Wistar
Voo Espacial
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Neurotransmitter Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  8 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29186131
[Au] Autor:Rudobeck E; Bellone JA; Szücs A; Bonnick K; Mehrotra-Carter S; Badaut J; Nelson GA; Hartman RE; Vlkolinský R
[Ad] Endereço:Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, United States of America.
[Ti] Título:Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's disease - Implications for space travel.
[So] Source:PLoS One;12(11):e0186168, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Space radiation represents a significant health risk for astronauts. Ground-based animal studies indicate that space radiation affects neuronal functions such as excitability, synaptic transmission, and plasticity, and it may accelerate the onset of Alzheimer's disease (AD). Although protons represent the main constituent in the space radiation spectrum, their effects on AD-related pathology have not been tested. We irradiated 3 month-old APP/PSEN1 transgenic (TG) and wild type (WT) mice with protons (150 MeV; 0.1-1.0 Gy; whole body) and evaluated functional and biochemical hallmarks of AD. We performed behavioral tests in the water maze (WM) before irradiation and in the WM and Barnes maze at 3 and 6 months post-irradiation to evaluate spatial learning and memory. We also performed electrophysiological recordings in vitro in hippocampal slices prepared 6 and 9 months post-irradiation to evaluate excitatory synaptic transmission and plasticity. Next, we evaluated amyloid ß (Aß) deposition in the contralateral hippocampus and adjacent cortex using immunohistochemistry. In cortical homogenates, we analyzed the levels of the presynaptic marker synaptophysin by Western blotting and measured pro-inflammatory cytokine levels (TNFα, IL-1ß, IL-6, CXCL10 and CCL2) by bead-based multiplex assay. TG mice performed significantly worse than WT mice in the WM. Irradiation of TG mice did not affect their behavioral performance, but reduced the amplitudes of population spikes and inhibited paired-pulse facilitation in CA1 neurons. These electrophysiological alterations in the TG mice were qualitatively different from those observed in WT mice, in which irradiation increased excitability and synaptic efficacy. Irradiation increased Aß deposition in the cortex of TG mice without affecting cytokine levels and increased synaptophysin expression in WT mice (but not in the TG mice). Although irradiation with protons increased Aß deposition, the complex functional and biochemical results indicate that irradiation effects are not synergistic to AD pathology.
[Mh] Termos MeSH primário: Doença de Alzheimer/patologia
Modelos Animais de Doenças
Prótons
Voo Espacial
[Mh] Termos MeSH secundário: Doença de Alzheimer/metabolismo
Peptídeos beta-Amiloides/metabolismo
Animais
Comportamento Animal/efeitos da radiação
Biomarcadores/metabolismo
Córtex Cerebral/metabolismo
Córtex Cerebral/efeitos da radiação
Citocinas/metabolismo
Relação Dose-Resposta à Radiação
Masculino
Camundongos
Camundongos Transgênicos
Sinaptofisina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Biomarkers); 0 (Cytokines); 0 (Protons); 0 (Synaptophysin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186168


  9 / 11334 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29167331
[Au] Autor:Zhang LF; Hargens AR
[Ad] Endereço:Department of Aerospace Physiology, Fourth Military Medical University, Xi'an, China; and Department of Orthopaedic Surgery, University of California, San Diego, California.
[Ti] Título:Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and Countermeasures.
[So] Source:Physiol Rev;98(1):59-87, 2018 Jan 01.
[Is] ISSN:1522-1210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained major risk for future long-duration spaceflight. NASA recently redefined this syndrome as Spaceflight-Associated Neuro-ocular Syndrome (SANS). Evidence thus reviewed supports that chronic, mildly elevated intracranial pressure (ICP) in space (as opposed to more variable ICP with posture and activity on Earth) is largely accounted for by loss of hydrostatic pressures and altered hemodynamics in the intracranial circulation and the cerebrospinal fluid system. In space, an elevated pressure gradient across the lamina cribrosa, caused by a chronic but mildly elevated ICP, likely elicits adaptations of multiple structures and fluid systems in the eye which manifest themselves as the VIIP syndrome. A chronic mismatch between ICP and intraocular pressure (IOP) in space may acclimate the optic nerve head, lamina cribrosa, and optic nerve subarachnoid space to a condition that is maladaptive to Earth, all contributing to the pathogenesis of space VIIP syndrome. Relevant findings help to evaluate whether artificial gravity is an appropriate countermeasure to prevent this seemingly adverse effect of long-duration spaceflight.
[Mh] Termos MeSH primário: Hipertensão Intracraniana/fisiopatologia
Pressão Intracraniana/fisiologia
Pressão Intraocular/fisiologia
Postura/fisiologia
Voo Espacial
Transtornos da Visão/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Hipertensão Intracraniana/etiologia
Hipertensão Intracraniana/patologia
Transtornos da Visão/etiologia
Transtornos da Visão/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171124
[St] Status:MEDLINE
[do] DOI:10.1152/physrev.00017.2016


  10 / 11334 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29091569
[Au] Autor:Roberts DR; Albrecht MH; Collins HR; Asemani D; Chatterjee AR; Spampinato MV; Zhu X; Chimowitz MI; Antonucci MU
[Ad] Endereço:From the Department of Radiology and Radiological Science, Division of Neuroradiology (D.R.R., M.H.A., H.R.C., D.A., A.R.C., M.V.S., M.U.A.), and the Department of Neurology (M.I.C.), Medical University of South Carolina, Charleston; the Department of Diagnostic and Interventional Radiology, Univers
[Ti] Título:Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI.
[So] Source:N Engl J Med;377(18):1746-1753, 2017 11 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is limited information regarding the effects of spaceflight on the anatomical configuration of the brain and on cerebrospinal fluid (CSF) spaces. METHODS: We used magnetic resonance imaging (MRI) to compare images of 18 astronauts' brains before and after missions of long duration, involving stays on the International Space Station, and of 16 astronauts' brains before and after missions of short duration, involving participation in the Space Shuttle Program. Images were interpreted by readers who were unaware of the flight duration. We also generated paired preflight and postflight MRI cine clips derived from high-resolution, three-dimensional imaging of 12 astronauts after long-duration flights and from 6 astronauts after short-duration flights in order to assess the extent of narrowing of CSF spaces and the displacement of brain structures. We also compared preflight ventricular volumes with postflight ventricular volumes by means of an automated analysis of T -weighted MRIs. The main prespecified analyses focused on the change in the volume of the central sulcus, the change in the volume of CSF spaces at the vertex, and vertical displacement of the brain. RESULTS: Narrowing of the central sulcus occurred in 17 of 18 astronauts after long-duration flights (mean flight time, 164.8 days) and in 3 of 16 astronauts after short-duration flights (mean flight time, 13.6 days) (P<0.001). Cine clips from a subgroup of astronauts showed an upward shift of the brain after all long-duration flights (12 astronauts) but not after short-duration flights (6 astronauts) and narrowing of CSF spaces at the vertex after all long-duration flights (12 astronauts) and in 1 of 6 astronauts after short-duration flights. Three astronauts in the long-duration group had optic-disk edema, and all 3 had narrowing of the central sulcus. A cine clip was available for 1 of these 3 astronauts, and the cine clip showed upward shift of the brain. CONCLUSIONS: Narrowing of the central sulcus, upward shift of the brain, and narrowing of CSF spaces at the vertex occurred frequently and predominantly in astronauts after long-duration flights. Further investigation, including repeated postflight imaging conducted after some time on Earth, is required to determine the duration and clinical significance of these changes. (Funded by the National Aeronautics and Space Administration.).
[Mh] Termos MeSH primário: Astronautas
Encéfalo/anatomia & histologia
Encéfalo/diagnóstico por imagem
Ventrículos Cerebrais/anatomia & histologia
Imagem por Ressonância Magnética
Voo Espacial
Ausência de Peso/efeitos adversos
[Mh] Termos MeSH secundário: Ventrículos Cerebrais/diagnóstico por imagem
Cérebro/anatomia & histologia
Cérebro/diagnóstico por imagem
Seres Humanos
Pressão Intracraniana
Meia-Idade
Fatores de Tempo
Transtornos da Visão/etiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171102
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1705129



página 1 de 1134 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde