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[PMID]: 28917503 [Au] Autor: Surette V; Ward S; Morin P; Vatanparast H; Bélanger M [Ti] Título: Food Reluctance of Preschool Children Attending Daycare Centers Is Associated with a Lower Body Mass Index. [So] Source: J Acad Nutr Diet;117(11):1749-1756, 2017 Nov. [Is] ISSN: 2212-2672 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Food reluctance can present as fussiness, picky eating, slowness in eating, and high satiety responsiveness. It can be associated with inadequate weight gain during early childhood. Although a majority of preschoolers attend daycare centers, associations between their eating behaviors at daycare and their body composition have not been studied. OBJECTIVE: Our aim was to develop an estimate of food reluctance and to assess the relationship between food reluctance at daycare and body mass index (BMI) and waist circumference of preschoolers. DESIGN: We conducted a cross-sectional secondary analyses. Food reluctance was estimated using weighted digital plate waste analysis. Intra-rater, inter-rater, and test-retest reliability and convergent validity of the food reluctance score were tested. The food reluctance score was then compared to preschool children's BMI and waist circumference. PARTICIPANTS/SETTING: Participants included 309 children aged 3 to 5 years in 24 daycare centers across the Canadian province of New Brunswick. MAIN OUTCOME MEASURES: Preschool children's waist circumference and age-adjusted BMI derived from objectively measured height and weight were analyzed. STATISTICAL ANALYSES PERFORMED: Intraclass correlations were used to determine the reliability of the new estimate. Spearman correlation was used to compare the estimate with parental report of food reluctance. Multivariate linear regressions were used to examine the relationship between food reluctance and waist circumference and age-adjusted BMI. RESULTS: The estimated food reluctance score demonstrated excellent inter- and intra-rater reliability (intraclass correlation>0.97; P<0.0001) and good test-retest reliability (intraclass correlation=0.72; P<0.0001). It also provided evidence of convergent validity through correlation with reluctance-related subscales of the Child Eating Behavior Questionnaire (ρ=.53, P<0.0001). Greater demonstration of food reluctance at the daycare center was associated with a lower age-adjusted BMI (adjusted ß -1.41; 95% CI -.15 to -2.67), but was not associated with children's waist circumference (adjusted ß -.60; 95% CI -2.06 to .86). CONCLUSIONS: Signs of food reluctance can be observed in daycare and relate to lower BMI among preschoolers. [Mh] Termos MeSH primário: Índice de Massa Corporal Creches Comportamento Alimentar/fisiologia [Mh] Termos MeSH secundário: Composição Corporal Canadá/epidemiologia Comportamento Infantil Pré-Escolar Estudos Transversais Feminino Alimentos Seres Humanos Masculino Desnutrição/epidemiologia Pais Reprodutibilidade dos Testes Saciação Inquéritos e Questionários Circunferência da Cintura [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171102 [Lr] Data última revisão: 171102 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170918 [St] Status: MEDLINE

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[PMID]: 28902291 [Au] Autor: André ED; Pereira RFA; Snyder RE; Machado TS; André LSP; Cardoso CAA; Aguiar-Alves F [Ad] Endereço: Universidade Federal Fluminense, Laboratóro Universitário Rodolfo Albino, Laboratório de Epidemiologia e Biotecnologia Molecular, Niterói, RJ, Brasil. [Ti] Título: Emergence of methicillin-resistant Staphylococcus aureus from clonal complex 398 with no livestock association in Brazil. [So] Source: Mem Inst Oswaldo Cruz;112(9):647-649, 2017 Sep. [Is] ISSN: 1678-8060 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: CC398 is a livestock-associated Staphylococcus aureus. However, it has also been isolated from humans with no previous contact with livestock. A surveillance of methicillin-resistant S. aureus colonisation among children attending public day care centres and hospitals in Niterói and Rio de Janeiro, Brazil, between 2011 and 2013, resulted in the isolation of six cases of CC398 from individuals with no previous exposure to livestock. These isolates showed a high frequency of the erm(C) gene (4/6, 66.7%) with induced resistance to clindamycin, and a relatively high frequency of SEs and lukS/lukF genes. These results suggest the emergence of a non-LA-CC398 in Brazil. [Mh] Termos MeSH primário: Staphylococcus aureus Resistente à Meticilina/genética Mucosa Nasal/microbiologia Infecções Estafilocócicas/microbiologia [Mh] Termos MeSH secundário: Brasil Criança Creches Genótipo Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170914 [St] Status: MEDLINE

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[PMID]: 28854281 [Au] Autor: Falenchuk O; Perlman M; McMullen E; Fletcher B; Shah PS [Ad] Endereço: Applied Psychology and Human Development, University of Toronto/OISE, Toronto, Ontario, Canada. [Ti] Título: Education of staff in preschool aged classrooms in child care centers and child outcomes: A meta-analysis and systematic review. [So] Source: PLoS One;12(8):e0183673, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Staff education is considered key to quality of early childhood education and care (ECEC) programs. However, findings about associations between staff education and children's outcomes have been inconsistent. We conducted a systematic review and meta-analysis of associations between ECEC staff education and child outcomes. Searches of Medline, PsycINFO, and ERIC, websites of large datasets and reference sections of all retrieved articles were conducted. Eligible studies provided a statistical link between staff education and child outcomes for preschool-aged children in ECEC programs. Titles, abstracts and paper reviews as well as all data extraction were conducted by two independent raters. Of the 823 studies reviewed for eligibility, 39 met our inclusion criteria. Research in this area is observational in nature and subject to the inherent biases of that research design. Results from our systematic review were hampered by heterogeneity in how staff education was defined, variability in whose education was measured and the child outcomes that were assessed. However, overall the qualitative summary indicates that associations between staff education and childhood outcomes are non-existent to very borderline positive. In our meta-analysis of more homogeneous studies we identified certain positive, albeit very weak, associations between staff education and children's language outcomes (specifically, vocabulary and letter word identification) and no significant association with a mathematics outcome (WJ Applied Problems). Thus, our findings suggest that within the range of education levels found in the existing literature, education is not a key driver of child outcomes. However, since we only explored levels of education that were reported in the literature, our findings cannot be used to argue for lowering education standards in ECEC settings. [Mh] Termos MeSH primário: Cuidado da Criança/recursos humanos Cuidado da Criança/normas Creches/normas Desenvolvimento Infantil Escolaridade [Mh] Termos MeSH secundário: Creches/estatística & dados numéricos Pré-Escolar Seres Humanos Aprendizagem Instituições Acadêmicas [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171023 [Lr] Data última revisão: 171023 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170831 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0183673

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[PMID]: 28774504 [Au] Autor: Larson N; Ayers Looby A; Frost N; Nanney MS; Story M [Ti] Título: What Can Be Learned from Existing Investigations of Weight-Related Practices and Policies with the Potential to Impact Disparities in US Child-Care Settings? A Narrative Review and Call for Surveillance and Evaluation Efforts. [So] Source: J Acad Nutr Diet;117(10):1554-1577, 2017 Oct. [Is] ISSN: 2212-2672 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Child-care settings and the combination of policies and regulations under which they operate may reduce or perpetuate disparities in weight-related health, depending on the environmental supports they provide for healthy eating and activity. The objectives of this review are to summarize research on state and local policies germane to weight-related health equity among young children in the United States and on how federal policies and regulations may provide supports for child-care providers serving families with the most limited resources. In addition, a third objective is to comprehensively review studies of whether there are differences in practices and policies within US child-care facilities according to the location or demographics of providers and children. The review found there is growing evidence addressing disparities in the social and physical child-care environments provided for young children, but scientific gaps are present in the current understanding of how resources should best be allocated and policies designed to promote health equity. Additional research is needed to address limitations of prior studies relating to the measurement of supports for weight-related health; complexities of categorizing socioeconomic position, ethnicity/race, and urban and rural areas; exclusion of legally nonlicensed care settings from most research; and the cross-sectional nature of most study designs. There is a particularly great need for the development of strong surveillance systems to allow for better monitoring and evaluation of state policies that may impact weight-related aspects of child-care environments, implementation at the program level, and needed implementation supports. [Mh] Termos MeSH primário: Cuidado da Criança/estatística & dados numéricos Creches/estatística & dados numéricos Política de Saúde Promoção da Saúde/métodos Disparidades nos Níveis de Saúde [Mh] Termos MeSH secundário: Peso Corporal Criança Pré-Escolar Feminino Seres Humanos Masculino Obesidade Pediátrica/prevenção & controle Fatores Socioeconômicos Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171005 [Lr] Data última revisão: 171005 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170805 [St] Status: MEDLINE

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[PMID]: 28674111 [Au] Autor: Cabana MD; Merenstein DJ [Ad] Endereço: Department of Pediatrics, michael.cabana@ucsf.edu. [Ti] Título: Probiotics in the Child Care Center: Context Matters. [So] Source: Pediatrics;140(2), 2017 08. [Is] ISSN: 1098-4275 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Cuidado da Criança Probióticos [Mh] Termos MeSH secundário: Criança Creches Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE; COMMENT [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170705 [St] Status: MEDLINE

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[PMID]: 28666535 [Au] Autor: Adamo KB; Wasenius NS; Grattan KP; Harvey ALJ; Naylor PJ; Barrowman NJ; Goldfield GS [Ad] Endereço: School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; Healthy Active Living and Obesity (HALO) Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada. Electronic address: kadamo@uottawa.ca. [Ti] Título: Effects of a Preschool Intervention on Physical Activity and Body Composition. [So] Source: J Pediatr;188:42-49.e2, 2017 Sep. [Is] ISSN: 1097-6833 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To investigate the effect of a preschool physical activity intervention program delivered in licensed childcare settings, with or without a parent-facilitated home component, on children's daily physical activity, sedentary time, and body composition. STUDY DESIGN: For this cluster randomized controlled trial, 18 childcare centers were randomly allocated in equal numbers to the typical curriculum comparison group, childcare intervention alone (CC), or childcare intervention with parental involvement. Accelerometers were used to asses physical activity and sedentary time, and body composition was measured by bioelectrical impedance. RESULTS: Linear mixed model regression analyses showed no differences between the CC, the childcare intervention with parental involvement, and the comparison groups in changes from baseline to 6 months in total physical activity (P for time × group interaction = .665) or moderate-to-vigorous physical activity (P for time × group interaction = .164) when adjusted for baseline physical activity levels. Furthermore, no group differences were found for changes in light physical activity, sedentary time, or anthropometric variables. CONCLUSIONS: An affordable and easily scalable preschool intervention program delivered in licensed childcare settings, with or without the addition of a parent-driven home physical activity promotion, seems to have no significant effect on physical activity, sedentary time, or body composition. TRIAL REGISTRATION: ISRCTN: ISRCTN94022291. [Mh] Termos MeSH primário: Composição Corporal/fisiologia Exercício/fisiologia Obesidade Pediátrica/fisiopatologia [Mh] Termos MeSH secundário: Acelerometria Cuidado da Criança Creches Pré-Escolar Impedância Elétrica Feminino Promoção da Saúde/métodos Seres Humanos Masculino Avaliação de Programas e Projetos de Saúde [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170915 [Lr] Data última revisão: 170915 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170702 [St] Status: MEDLINE

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[PMID]: 28572017 [Au] Autor: Longo-Silva G; Silveira JAC; Menezes RCE; Toloni MHA [Ad] Endereço: Universidade Federal de Alagoas (UFAL), Faculdade de Nutrição (FANUT), Programa de Pós-Graduação em Nutrição, Maceió, AL, Brazil. Electronic address: giovana_longo@yahoo.com.br. [Ti] Título: Age at introduction of ultra-processed food among preschool children attending day-care centers. [So] Source: J Pediatr (Rio J);93(5):508-516, 2017 Sep - Oct. [Is] ISSN: 1678-4782 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To identify the age of introduction of ultra-processed food and its associated factors among preschool children. METHODS: Cross-sectional study carried out from March to June 2014 with 359 preschool children aged 17 to 63 months attending day-care centers. Time until ultra-processed food introduction (outcome variable) was described by the Kaplan-Meier analysis, and the log-rank test was used to compare the survival functions of independent variables. Factors associated with ultra-processed food introduction were investigated using the multivariate Cox proportional hazards model. The results were shown as hazard ratios with their respective 95% confidence intervals. RESULTS: The median time until ultra-processed food introduction was six months. Between the 3rd and 6th months, there is a significant increase in the probability of introducing ultra-processed food in the children's diet; and while the probability in the 3rd month varies from 0.15 to 0.25, at six months the variation ranges from 0.6 to 1.0. The final Cox proportional hazards model showed that unplanned pregnancy (1.32 [1.05-1.65]), absence of prenatal care (2.50 [1.02-6.16]), and income >2 minimum wages (1, 50 [1.09-2.06]) were independent risk factors for the introduction of ultra-processed food. CONCLUSION: Up to the 6th month of life, approximately 75% of preschool children had received one or more ultra-processed food in their diet. In addition, it was observed that the poorest families, as well as unfavorable prenatal factors, were associated with early introduction of ultra-processed food. [Mh] Termos MeSH primário: Creches/estatística & dados numéricos Dieta Ingestão de Energia Manipulação de Alimentos [Mh] Termos MeSH secundário: Fatores Etários Pré-Escolar Estudos Transversais Fast Foods Feminino Seres Humanos Lactente Masculino Valor Nutritivo Fatores Socioeconômicos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170603 [St] Status: MEDLINE

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[PMID]: 28562271 [Au] Autor: Shope TR; Walker BH; Aird LD; Southward L; McCown JS; Martin JM [Ad] Endereço: Division of General Academic Pediatrics, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania; timothy.shope@chp.edu. [Ti] Título: Pandemic Influenza Preparedness Among Child Care Center Directors in 2008 and 2016. [So] Source: Pediatrics;139(6), 2017 Jun. [Is] ISSN: 1098-4275 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Children in child care centers represent an important population to consider in attempts to mitigate the spread of an influenza pandemic. This national survey, conducted in 2008 and 2016, assessed directors' reports of their child care centers' pandemic influenza preparation before and after the 2009 H1N1 novel influenza pandemic. METHODS: This was a telephone-based survey of child care center directors randomly selected from a national database of licensed US child care centers who were queried about their preparedness for pandemic influenza. We grouped conceptually related items in 6 domains into indexes: general infection control, communication, seasonal influenza control, use of health consultants, quality of child care, and perceived barriers. These indexes, along with other center and director characteristics, were used to predict pandemic influenza preparedness. RESULTS: Among 1500 and 518 child care center directors surveyed in 2008 and 2016, respectively, preparation for pandemic influenza was low and did not improve. Only 7% of directors had taken concrete actions to prepare their centers. Having served as a center director during the 2009 influenza pandemic did not influence preparedness. After adjusting for covariates, child care health consultation and years of director's experience were positively associated with pandemic influenza preparation, whereas experiencing perceived barriers such as lack of knowing what to do in the event of pandemic influenza, was negatively associated with pandemic influenza preparedness. CONCLUSIONS: Pandemic influenza preparedness of child care center's directors needs to improve. Child care health consultants are likely to be important collaborators in addressing this problem. [Mh] Termos MeSH primário: Creches/organização & administração Conhecimentos, Atitudes e Prática em Saúde Controle de Infecções/estatística & dados numéricos Influenza Humana/prevenção & controle Pandemias [Mh] Termos MeSH secundário: Pré-Escolar Seres Humanos Lactente Controle de Infecções/métodos Vírus da Influenza A Subtipo H1N1 Influenza Humana/epidemiologia Inquéritos e Questionários [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170907 [Lr] Data última revisão: 170907 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170601 [St] Status: MEDLINE

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[PMID]: 28490316 [Au] Autor: Schlinkmann KM; Bakuli A; Mikolajczyk R [Ad] Endereço: Department for Epidemiology, Helmholtz Centre for Infection Research, ESME - Epidemiological and Statistical Methods Research Group, Inhoffenstraße 7, 38124, Braunschweig, Germany. [Ti] Título: Incidence and comparison of retrospective and prospective data on respiratory and gastrointestinal infections in German households. [So] Source: BMC Infect Dis;17(1):336, 2017 May 11. [Is] ISSN: 1471-2334 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Acute respiratory infections (ARI) and acute gastrointestinal infections (AGI) are the most common childhood infections, and corresponding data can either be collected prospectively or retrospectively. The aim of this study was to estimate the incidence of respiratory and gastrointestinal episodes in German households with children attending day care and to compare results of prospective and retrospective data collection. METHODS: We conducted a 4 months prospective cohort study in the winter period 2014/2015 and recruited parents of children aged 0-6 years in 75 day care centers in Braunschweig, Lower Saxony, Germany. For all household members, we collected information on episodes of ARI and AGI. We applied prospective data collection in one study arm and retrospective data collection with a reporting period of 2 months in the other. Poisson regression was used to model monthly incidence rates for both study arms. RESULTS: In total, 100 households (including 404 persons) participated in the retrospective group and 77 households (282 persons) in the prospective group. Incidence estimates for ARI (retrospective group: 0.52 per person month, prospective group: 0.47) were higher than for AGI (retrospective group: 0.14, prospective group: 0.13). The adjusted incidence estimates were similar in both study arms for ARI (incidence rate ratio for retrospective versus prospective data collection: 1.11 [confidence interval (CI) 95% 0.99; 1.24], p = 0.42) as well as for AGI (1.10 [CI 95% 0.89; 1.37], p = 0.27). CONCLUSION: If there is no need to collect biomaterials or data on severity of the diseases, incidence of infections in the household setting over a short time period (2 months) can be assessed retrospectively. [Mh] Termos MeSH primário: Gastroenteropatias/epidemiologia Infecções Respiratórias/epidemiologia [Mh] Termos MeSH secundário: Doença Aguda/epidemiologia Adolescente Criança Creches/estatística & dados numéricos Pré-Escolar Estudos de Coortes Características da Família Feminino Alemanha/epidemiologia Seres Humanos Lactente Masculino Pais Estudos Prospectivos Estudos Retrospectivos Instituições Acadêmicas/estatística & dados numéricos Estações do Ano [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170814 [Lr] Data última revisão: 170814 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170512 [St] Status: MEDLINE [do] DOI: 10.1186/s12879-017-2434-5

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seleciona para imprimir Fotocópia Timenetsky, Jorge Texto completo SciELO Brasil

[PMID]: 28482183 [Au] Autor: Carvalho SP; Almeida JB; Andrade YMFS; Silva LSCD; Oliveira AC; Nascimento FS; Campos GB; Oliveira MV; Timenetsky J; Marques LM [Ad] Endereço: Universidade Estadual de Santa Cruz, Departamento de Microbiologia, Ilhéus, BA, Brazil; Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Núcleo de Tecnologia em Saúde, Vitória da Conquista, BA, Brazil. [Ti] Título: Community-acquired methicillin-resistant Staphylococcus aureus carrying SCCmec type IV and V isolated from healthy children attending public daycares in northeastern Brazil. [So] Source: Braz J Infect Dis;21(4):464-467, 2017 Jul - Aug. [Is] ISSN: 1678-4391 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) have increasingly been reported in healthy communities. This study aimed to assess the rate of S. aureus in general and MRSA in particular from nasal secretion of children in daycare centers in Vitória da Conquista, Brazil. The isolates were identified based on morphology, biochemical tests and by PCR. Detection of virulence genes, biofilm production, and susceptibility test by disk diffusion agar were performed. MRSA isolates were characterized by spa, SCCmec, and multilocus sequence typing (MLST). S. aureus were recovered from 70 (47.3%) of 148 children. Among the 11 MRSA strains (15.7%), two SCCmec types (IV and V) were detected. MLST identified four STs related to three clonal complexes (CC): 5, 45, and 398. Four spa types were found circulating in this setting. Resistance of S. aureus isolates to ampicillin, erythromycin, ciprofloxacin, clindamycin, and tetracycline was 80%, 32.8%, 7.1%, 7.1% and 4.3%, respectively. One isolate presented intermediate resistance to vancomycin detected by Etest methodology. All strains were biofilm producers. The virulence genes seb, sec, spa, and pvl were detected in some isolates. This study revealed a high rate of children carrying MRSA among healthy attendees in daycare centers in Vitória da Conquista, Brazil. [Mh] Termos MeSH primário: Creches Staphylococcus aureus Resistente à Meticilina/isolamento & purificação Nariz/microbiologia Infecções Estafilocócicas/microbiologia [Mh] Termos MeSH secundário: Antibacterianos/farmacologia Biofilmes/crescimento & desenvolvimento Criança Pré-Escolar Infecções Comunitárias Adquiridas/microbiologia Testes de Sensibilidade a Antimicrobianos por Disco-Difusão Feminino Genótipo Seres Humanos Lactente Masculino Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos Staphylococcus aureus Resistente à Meticilina/patogenicidade Fatores de Virulência [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Virulence Factors) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170825 [Lr] Data última revisão: 170825 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170509 [St] Status: MEDLINE

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