Base de dados : MEDLINE
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[PMID]:27771183
[Au] Autor:Clendinen C; Zhang Y; Warburton RN; Light DW
[Ad] Endereço:Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: csclendi@gmail.com.
[Ti] Título:Manufacturing costs of HPV vaccines for developing countries.
[So] Source:Vaccine;34(48):5984-5989, 2016 11 21.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nearly all of the 500,000 new cases of cervical cancer and 270,000 deaths occur in middle or lower income countries. Yet the two most prevalent HPV vaccines are unaffordable to most. Even prices to Gavi, the Vaccine Alliance, are unaffordable to graduating countries, once they lose Gavi subsidies. Merck and Glaxosmithkline (GSK) claim their prices to Gavi equal their manufacturing costs; but these costs remain undisclosed. We undertook this investigation to estimate those costs. METHODS: Searches in published and commercial literature for information about the manufacturing of these vaccines. Interviews with experts in vaccine manufacturing. FINDINGS: This detailed sensitivity analysis, based on the best available evidence, finds that after a first set of batches for affluent markets, manufacturing costs of Gardasil for developing countries range between $0.48 and $0.59 a dose, a fraction of its alleged costs of $4.50. Because volume of Cervarix is low, its per unit costs are much higher, though at comparable volumes, its costs would be similar. INTERPRETATION: Given the recovery of fixed and annual costs from sales in affluent markets, Merck's break-even price to Gavi could be $0.50-$0.60, not $4.50. These savings could support Gavi programs to strengthen delivery and increase coverage. Outside Gavi, prices to lower- and middle-income countries, with profit, could also be lowered and made available to millions more adolescents at risk. These estimates and their policy implications deserve further discussion.
[Mh] Termos MeSH primário: Países em Desenvolvimento
Vacina Quadrivalente Recombinante contra HPV tipos 6, 11, 16, 18/economia
Vacinas contra Papillomavirus/economia
[Mh] Termos MeSH secundário: Adolescente
Custos e Análise de Custo
Feminino
Seres Humanos
Instalações Industriais e de Manufatura/economia
Neoplasias do Colo do Útero/prevenção & controle
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18); 0 (Papillomavirus Vaccines); 0 (human papillomavirus vaccine, L1 type 16, 18)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28889025
[Au] Autor:Fernández-Navarro P; García-Pérez J; Ramis R; Boldo E; López-Abente G
[Ad] Endereço:Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública - CIBERESP), Spain. Electronic
[Ti] Título:Industrial pollution and cancer in Spain: An important public health issue.
[So] Source:Environ Res;159:555-563, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cancer can be caused by exposure to air pollution released by industrial facilities. The European Pollutant Release and Transfer Register (E-PRTR) has made it possible to study exposure to industrial pollution. This study seeks to describe the industrial emissions in the vicinity of Spanish towns and their temporal changes, and review our experience studying industrial pollution and cancer. Data on industrial pollutant sources (2007-2010) were obtained from the E-PRTR registries. Population exposure was estimated by the distance from towns to industrial facilities. We calculated the amount of carcinogens emitted into the air in the proximity (<5km) of towns and show them in municipal maps. We summarized the most relevant results and conclusions reported by ecological E-PRTR-based on studies of cancer mortality and industrial pollution in Spain and the limitations and result interpretations of these types of studies. There are high amounts of carcinogen emissions in the proximity of towns in the southwest, east and north of the country and the total amount of emitted carcinogens is considerable (e.g. 20Mt of arsenic, 63Mt of chromium and 9Mt of cadmium). Although the emissions of some carcinogens in the proximity of certain towns were reduced during the study period, emissions of benzene, dioxins+furans and polychlorinated biphenyls rose. Moreover, the average population of towns lying within a 5km radius from emission sources of carcinogens included in the International Agency for Research on Cancer list of carcinogens was 9 million persons. On the other hand, the results of the reviewed studies suggest that those Spanish regions exposed to the pollution released by certain types of industrial facilities have around 17% cancer excess mortality when compared with those unexposed. Moreover, excess mortality is focused on digestive and respiratory tract cancers, leukemias, prostate, breast and ovarian cancers. Despite their limitations, ecological studies are a useful tool in environmental epidemiology, not only for proposing etiological hypotheses about the risk of living close to industrial pollutant sources, but also for providing data to account for situations of higher mortality in specific areas. Nevertheless, the reduction of emissions should be a goal, with special relevance given to establishing limits for known carcinogens and other toxic substances in the environs of population centers, as well as industry-specific emission limits.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Carcinógenos/toxicidade
Exposição Ambiental
Poluentes Ambientais/toxicidade
Neoplasias/mortalidade
[Mh] Termos MeSH secundário: Monitoramento Ambiental
Seres Humanos
Instalações Industriais e de Manufatura
Neoplasias/induzido quimicamente
Saúde Pública
Espanha/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Carcinogens); 0 (Environmental Pollutants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


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[PMID]:28801015
[Au] Autor:David NA; Penumarti A; Burks AW; Slater JE
[Ad] Endereço:Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
[Ti] Título:Food allergen extracts to diagnose food-induced allergic diseases: How they are made.
[So] Source:Ann Allergy Asthma Immunol;119(2):101-107, 2017 Aug.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To review the manufacturing procedures of food allergen extracts and applicable regulatory requirements from government agencies, potential approaches to standardization, and clinical application of these products. The effects of thermal processing on allergenicity of common food allergens are also considered. DATA SOURCES: A broad literature review was conducted on the natural history of food allergy, the manufacture of allergen extracts, and the allergenicity of heated food. Regulations, guidance documents, and pharmacopoeias related to food allergen extracts from the United States and Europe were also reviewed. STUDY SELECTIONS: Authoritative and peer-reviewed research articles relevant to the topic were chosen for review. Selected regulations and guidance documents are current and relevant to food allergen extracts. RESULTS: Preparation of a food allergen extract may require careful selection and identification of source materials, grinding, defatting, extraction, clarification, sterilization, and product testing. Although extractions for all products licensed in the United States are performed using raw source materials, many foods are not consumed in their raw form. Heating foods may change their allergenicity, and doing so before extraction may change their allergenicity and the composition of the final product. CONCLUSION: The manufacture of food allergen extracts requires many considerations to achieve the maximal quality of the final product. Allergen extracts for a select number of foods may be inconsistent between manufacturers or unreliable in a clinical setting, indicating a potential area for future improvement.
[Mh] Termos MeSH primário: Alérgenos/metabolismo
Alérgenos/uso terapêutico
Dessensibilização Imunológica/métodos
Hipersensibilidade Alimentar/diagnóstico
Hipersensibilidade Alimentar/terapia
[Mh] Termos MeSH secundário: Alérgenos/imunologia
Reações Cruzadas/imunologia
Hipersensibilidade Alimentar/imunologia
Temperatura Alta
Seres Humanos
Instalações Industriais e de Manufatura/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


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[PMID]:28596144
[Au] Autor:Hu G; Wang T; Liu J; Chen Z; Zhong L; Yu S; Zhao Z; Zhai M; Jia G
[Ad] Endereço:Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
[Ti] Título:Serum protein expression profiling and bioinformatics analysis in workers occupationally exposed to chromium (VI).
[So] Source:Toxicol Lett;277:76-83, 2017 Aug 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cr(VI) is widely-recognized as occupational and environmental contaminant, but the precise underlying mechanisms of Cr(VI) induced carcinogenic toxicity remain to be elucidated. Among kinds of toxic mechanisms, alteration of protein profiling usually elaborate a key mechanism of Cr(VI) induced toxicity and carcinogenesis. Large-scale proteins changes can reflect the onset or progression of carcinogenic toxicity, and potential serum protein biomarkers of Cr(VI) exposure. To gain an insight into the serum proteins expression profiling in chromate workers and find potential novel serum proteins biomarkers of Cr(VI) exposure, 107 male participants from a chromate production plant were recruited into the study. Questionnaire was applied to collect personal information and occupational history. Chromium concentration in blood (CrB) was measured to evaluate the participants' internal exposure. Serum proteins profiling and bioinformatics analysis were performed to explore differentially expressed proteins, proteins-chemical interaction network, critical proteins nodes related to the signaling pathways among 16 controls and 25 exposure workers in the first stage. ELISA tests were applied to verify the critical interested proteins nodes in the remaining 41 exposure workers and 25 controls. The results showed that the CrB levels in the control group were significantly lower than that in the exposure group (P<0.05). 44 significantly differentially expressed serum proteins formed 16 significant signaling pathways and a complex proteins-chemical interaction network, which associated with the immune system and extracellular matrix organization. C reactive protein (CRP), sonic hedgehog protein (SHH) and calcium located at critical nodes in proteins-chemical interaction network. There was a significant negative correlation between serum CRP level and CrB (P<0.05), and a significant positive correlation between SHH concentrations and CrB (P<0.05), which indicated that CRP and SHH might be as the potential novel biomarkers of Cr(VI) exposure. Also, the current study preliminarily paved the way to further functional studies to understand the underlying mechanisms and novel serum biomarkers of Cr(VI) exposure.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/análise
Cromo/efeitos adversos
Biologia Computacional
Instalações Industriais e de Manufatura
Exposição Ocupacional/efeitos adversos
Saúde do Trabalhador
Proteômica/métodos
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Proteína C-Reativa/análise
Estudos de Casos e Controles
Cromo/sangue
Monitoramento Ambiental/métodos
Ensaio de Imunoadsorção Enzimática
Proteínas Hedgehog/sangue
Seres Humanos
Masculino
Mapas de Interação de Proteínas
Medição de Risco
Transdução de Sinais
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Proteins); 0 (Hedgehog Proteins); 0 (SHH protein, human); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


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[PMID]:28476140
[Au] Autor:Hsieh NH; Chung SH; Chen SC; Chen WY; Cheng YH; Lin YJ; You SH; Liao CM
[Ad] Endereço:Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77845, USA.
[Ti] Título:Anemia risk in relation to lead exposure in lead-related manufacturing.
[So] Source:BMC Public Health;17(1):389, 2017 May 05.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lead-exposed workers may suffer adverse health effects under the currently regulated blood lead (BPb) levels. However, a probabilistic assessment about lead exposure-associated anemia risk is lacking. The goal of this study was to examine the association between lead exposure and anemia risk among factory workers in Taiwan. METHODS: We first collated BPb and indicators of hematopoietic function data via health examination records that included 533 male and 218 female lead-exposed workers between 2012 and 2014. We used benchmark dose (BMD) modeling to estimate the critical effect doses for detection of abnormal indicators. A risk-based probabilistic model was used to characterize the potential hazard of lead poisoning for job-specific workers by hazard index (HI). We applied Bayesian decision analysis to determine whether BMD could be implicated as a suitable BPb standard. RESULTS: Our results indicated that HI for total lead-exposed workers was 0.78 (95% confidence interval: 0.50-1.26) with risk occurrence probability of 11.1%. The abnormal risk of anemia indicators for male and female workers could be reduced, respectively, by 67-77% and 86-95% by adopting the suggested BPb standards of 25 and 15 µg/dL. CONCLUSIONS: We conclude that cumulative exposure to lead in the workplace was significantly associated with anemia risk. This study suggests that current BPb standard needs to be better understood for the application of lead-exposed population protection in different scenarios to provide a novel standard for health management. Low-level lead exposure risk is an occupational and public health problem that should be paid more attention.
[Mh] Termos MeSH primário: Anemia/sangue
Anemia/epidemiologia
Chumbo/sangue
Instalações Industriais e de Manufatura
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Teorema de Bayes
Feminino
Seres Humanos
Masculino
Meia-Idade
Risco
Taiwan/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2P299V784P (Lead)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4315-7


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[PMID]:28472563
[Au] Autor:Mahajan R; Solanki J; Kurdekar RS; Gupta S; Modh A; Yadav O
[Ad] Endereço:Department of Public Health Dentistry, Vyas Dental College and Hospital, Jodhpur, Rajasthan, India.
[Ti] Título:Educating the handicraft factory workers about tobacco cessation and to assess its effectiveness by motivational interviewing: An Intervention study.
[So] Source:J Exp Ther Oncol;12(1):43-49, 2017 May.
[Is] ISSN:1359-4117
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Tobacco use is considered to be global pandemic. The study was done to assess the effectiveness of smoking cessation intervention among workers by motivational interviewing among handicraft factories, Jodhpur, Rajasthan. METHODOLOGY: An interventional study was carried out among 400 handicraft factory workers on the basis of inclusion and exclusion criterion. Twenty one handicraft factories were taken into consideration. Training, Standardization and Calibration of Examiners was carried out in the public health department. The structured pre-tested proforma and Fagerstrom questionnaire was used to record the data. Four sessions of intervention were given to workers. Follow ups were carried out after 1 month, 3month and 6month. Paired t-test was used to compare Fagerstrom/smoking analysis mean scores among study and control groups before and after intervention. RESULTS: showed that in study group, a percentage change of +1.2%, seen in high dependence category and -1.5 in very high dependence and after 6 months the change was+14.2%, 18.7%, -19.2% in Very low dependence, Low dependence, Medium dependence, -11.8% was seen in high dependence category and -1.8 in very high dependence. When comparison was done among Fagerstrom/smoking analysis mean scores among study subjects before and after intervention. It was found that there was a significant difference between the mean scores of Fagerstrom/smoking analysis between baseline - 3 months, 3 months to 6 months and 6 months to 9 months among study group as compared to control group. CONCLUSION: Tobacco addiction produces neurological and behavioural change, optima; approach involving behavioural change and pharmacotherapy are needed.
[Mh] Termos MeSH primário: Fumar/psicologia
Abandono do Uso de Tabaco/psicologia
Tabagismo/psicologia
Tabagismo/terapia
[Mh] Termos MeSH secundário: Calibragem
Educação/métodos
Promoção da Saúde/métodos
Seres Humanos
Índia
Instalações Industriais e de Manufatura
Entrevista Motivacional/métodos
Padrões de Referência
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:28320979
[Au] Autor:Shankar K; Fung V; Seneviratne M; O'Donnell GE
[Ad] Endereço:Chemical Analysis Branch, SafeWork NSW - TestSafe Australia.
[Ti] Título:Exposure to 4,4'-methylene bis (2-chloroaniline) (MbOCA) in New South Wales, Australia.
[So] Source:J Occup Health;59(3):296-303, 2017 May 25.
[Is] ISSN:1348-9585
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study was conducted to determine the level of exposure of 4,4'-methylene bis (2-chloroaniline) (MbOCA) in New South Wales (NSW), Australia. METHODS: An integrated occupational hygiene and biological monitoring program were used to assess the workers' exposure to MbOCA via inhalation, ingestion and dermal contact. This was conducted by personal air monitoring, static air monitoring and surface contamination monitoring of the work environment and biological monitoring of the workers' exposure to MbOCA at nine workplaces in NSW. RESULTS: The air monitoring results for MbOCA gave a geometric mean (GM) of 0.06 µg/m and a geometric standard deviation (GSD) of 2.70 and a 95% confidence interval of 0.29 µg/m . The surface contamination in the main work area showed the highest contamination with a GM of 74 ng/cm and a GSD of 17 and a 95% confidence interval of 7,751 ng/cm . Biological monitoring showed a GM of 0.89 µmol/mol cr and a GSD of 11.9 and a 95% confidence interval of 52 µmol/mol cr. This indicated that 13% of the workers were over the SafeWork NSW Biological Occupational Exposure Limit of 15 µmol/mol cr. CONCLUSIONS: Workers' exposure through inhalation was minimal; however, evidence from biological monitoring of MbOCA suggested that the main contributing factor to exposure was skin absorption. This was attributed to poor housekeeping and inadequate personal protection. Improvements in these areas were recommended, and it was also recommended to improve the awareness of the workers to the adverse effects to their health of exposure to this carcinogen.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise
Poluição do Ar em Ambientes Fechados/análise
Compostos de Anilina/análise
Exposição Ocupacional/análise
[Mh] Termos MeSH secundário: Ingestão de Alimentos
Monitoramento Ambiental/métodos
Seres Humanos
Exposição por Inalação/análise
Instalações Industriais e de Manufatura
New South Wales
Absorção Cutânea
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Aniline Compounds); G14I494T2F (2-chloroaniline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1539/joh.16-0254-BR


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[PMID]:28185157
[Au] Autor:de Blas M; Navazo M; Alonso L; Gangoiti G; García JA; de Cámara ES; Valdenebro V; García-Ruiz E; García-Borreguero N
[Ad] Endereço:Faculty of Engineering-Bilbao, University of the Basque Country UPV/EHU, Alameda de Urquijo s/n, 48013, Bilbao, Spain. maite.deblas@ehu.eus.
[Ti] Título:Continuous measurement of atmospheric reduced sulphur compounds as key tracers between odour complaints and source apportionment.
[So] Source:Environ Monit Assess;189(3):102, 2017 Mar.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Odour complaints are frequent nowadays, particularly nearby industrial facilities emitting odorous compounds. Among all compounds susceptible of causing odour annoyance, reduced sulphur compounds (RSC) were studied, due to their unpleasant odour and low odour threshold. RSC ambient air mixing ratios, meteorological conditions and population complaints were analysed in an area of complex topography in order to identify their potential sources. Mixing ratios of three compounds, dimethyl sulphide (DMS), carbon disulphide (CDS) and dimethyl disulphide (DMDS), were continuously monitored using an online gas chromatograph coupled with a mass spectrometer detector (GC-MSD), which was placed in a mobile air quality monitoring unit. Measurement campaigns were performed during 2012 and 2013 for periods of 7-25 days in an urban area (four campaigns, N = 1368) and an urban area surrounded by industrial activities (three campaigns, N = 564). During such campaigns, RSC mixing ratios were frequently above their odour thresholds, which did not always involve citizen complaints. Average RSC ambient air mixing ratios tended to be lower in the urban area (DMS 0.06-0.33, CDS 0.05-0.10, DMDS 0.07-0.30 µg m ) than in the industry surrounded one (DMS 0.30-2.39, 0.05-0.18, DMDS 0.09-0.62 µg m ). The DMS/DMDS mixing ratio was frequently above 1, being a paper mill one of the main sources of RSC in the area. DMS/DMDS ratios below 1 were also recorded, suggesting a waste treatment plant as the RSC source or older air masses coming from the paper mill.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Poluição do Ar/análise
Dissulfeto de Carbono/análise
Dissulfetos/análise
Monitoramento Ambiental
Odorantes/análise
Sulfetos/análise
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Instalações Industriais e de Manufatura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Disulfides); 0 (Sulfides); 3P8D642K5E (dimethyl disulfide); QS3J7O7L3U (dimethyl sulfide); S54S8B99E8 (Carbon Disulfide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5800-2


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[PMID]:28128776
[Au] Autor:de Almeida LB; Vieira ER; Zaia JE; de Oliveira Santos BM; Lourenço AR; Quemelo PR
[Ad] Endereço:Department of Health Promotion, University of Franca, Franca, São Paulo, Brazil.
[Ti] Título:Musculoskeletal disorders and stress among footwear industry workers.
[So] Source:Work;56(1):67-73, 2017.
[Is] ISSN:1875-9270
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Manufacturing footwear requires intense manual labor and high repetitions with low variability in function that may lead to musculoskeletal disorders (MSD) symptoms and psychological stress. OBJECTIVE: To evaluate a potential association between musculoskeletal disorders (MSD) and perceived stress among footwear industry workers. METHODS: The Nordic General Questionnaire (NGQ) and the Perceived Stress Scale (PSS-10) were completed by 357 footwear industry workers. The association between MSD and perceived stress was evaluated using the Chi-Square test and Odds Ratios along with their 95% Confidence Interval (95% CI) were calculated. RESULTS: The twelve-month prevalence of MSD symptoms among the respondents was 66% (n = 236) and the symptoms were significantly associated with perceived stress (p = 0.002, OR: 10, 95% CI: 1.7 to 60.6). The seven-day prevalence of MSD symptoms was 33% and the symptoms were also significantly associated with perceived stress (p = 0.001, OR: 2.7, 95% CI:0.8 to 9.3). The association between perceived stress and MSD symptoms indicates a strong association between MSD symptoms and perceived stress levels. CONCLUSION: Considering that these problems are important determinants of worker's health, a combined approach to reduce both stress and MSD symptoms is necessary for prevention and health promotion in the footwear industry.
[Mh] Termos MeSH primário: Instalações Industriais e de Manufatura/recursos humanos
Doenças Musculoesqueléticas/psicologia
Percepção
Estresse Psicológico/psicologia
[Mh] Termos MeSH secundário: Adulto
Brasil
Feminino
Seres Humanos
Masculino
Instalações Industriais e de Manufatura/estatística & dados numéricos
Doenças Musculoesqueléticas/etiologia
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/estatística & dados numéricos
Prevalência
Psicometria/instrumentação
Sapatos/estatística & dados numéricos
Estresse Psicológico/etiologia
Local de Trabalho/psicologia
Local de Trabalho/normas
Local de Trabalho/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.3233/WOR-162463


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[PMID]:28121270
[Au] Autor:Lipka K; Falandysz J
[Ad] Endereço:a Laboratory of Environmental Chemistry & Ecotoxicology , Gdansk University , Gdansk , Poland.
[Ti] Título:Accumulation of metallic elements by Amanita muscaria from rural lowland and industrial upland regions.
[So] Source:J Environ Sci Health B;52(3):184-190, 2017 Mar 04.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was carried out on the accumulation and occurrence of Ag, Al, Ba, Ca, Cd, Co, Cu, Fe, Hg, K, Mg, Mn, Na, Rb, Sr and Zn in the mushroom Amanita muscaria and forest topsoil from two lowland sites in the Tuchola Pinewoods in the north-central region and an upland site in the Swietokrzyskie Mountains in the south-central region of Poland. Topsoil from the upland location showed Ag, Al, Ba, Ca, Cd, Co, Cu, Fe, Hg, Na and Zn at significantly higher concentration levels (pseudo-total fraction and often also the labile or extractable fraction) than at both lowland locations, where topsoil was richer in Mg, and similar in Rb. Amanita muscaria from the upland region differed from individuals collected in the lowland sites by higher concentration levels of Cd, Cu, Hg and Mn in caps. This could be related to higher concentration levels of the metallic elements in topsoil in the upland region. On other side, A. muscaria from the upland site was poorer in Co and Fe in caps, and in Ca, Co, Fe and Sr in stipes. In spite of the differences in content of the geogenic metallic elements in topsoil between the lowland and upland locations, A. muscaria from both regions was able to regulate uptake and accumulation of Ag, Al, Ba, Ca, K, Mg, Na, Rb and Zn, which were at similar concentration levels in caps but not necessarily in stipes.
[Mh] Termos MeSH primário: Amanita/química
Monitoramento Ambiental/métodos
Metais/análise
[Mh] Termos MeSH secundário: Altitude
Geografia
Instalações Industriais e de Manufatura
Polônia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2017.1261547



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