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[PMID]:29219994
[Ti] Título:Gene-drive technology needs thorough scrutiny.
[So] Source:Nature;552(7683):6, 2017 12 07.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Tecnologia de Impulso Genético/efeitos adversos
Tecnologia de Impulso Genético/legislação & jurisprudência
Edição de Genes/legislação & jurisprudência
Medição de Risco
Nações Unidas/legislação & jurisprudência
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Canadá
Congressos como Assunto
Correio Eletrônico
Cooperação Internacional
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1038/d41586-017-08214-4


  2 / 2351 MEDLINE  
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Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
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[PMID]:28455173
[Au] Autor:Dombkowski KJ; Cowan AE; Reeves SL; Foley MR; Dempsey AF
[Ad] Endereço:The Child Health Evaluation and Research (CHEAR) Center, Division of General Pediatrics, University of Michigan, 300 N Ingalls St, Ann Arbor, MI 48109, United States. Electronic address: kjd@med.umich.edu.
[Ti] Título:The impacts of email reminder/recall on adolescent influenza vaccination.
[So] Source:Vaccine;35(23):3089-3095, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We sought to: (1) explore the feasibility of using email for seasonal influenza vaccination reminders to parents of adolescents and (2) assess influenza vaccination rates among adolescents whose parents were randomized to either receive or not receive email reminders. METHODS: Email addresses were obtained for parents of patients 10-18years from 4 practices in Michigan. Addresses were randomized to either receive email reminders, or not. Reminder messages were sent during October 2012-March 2013 (Season 1) and October 2013-March 2014 (Season 2). Vaccination status was determined 60days following the last email reminder for each season using the statewide Michigan Care Improvement Registry (MCIR); per protocol bivariate and multivariate logistic regression analyses were conducted to evaluate reminder notification. RESULTS: After email cleaning, testing, and matching with MCIR, approximately half of email addresses (2348 of 5312 in Season 1; 3457 of 6549 in Season 2) were randomized. Bivariate analyses found that influenza vaccination within 60days after notification date was similar among those notified (34%) versus not notified (29%) in both Season 1 (p=0.06) and Season 2 (39% vs. 37%, p=0.20). However, multivariate models adjusted for season, site, and receipt of notification in two seasons found a higher likelihood of influenza vaccination among children that received notification (aOR=1.28, 95% CI=1.09, 1.51); in addition, differences in influenza vaccination were also observed between practice sites (range: p=0.15 to p<0.001). CONCLUSIONS: We found that practice-based email influenza vaccine reminders to parents of adolescents are feasible, but not without complications. Our study demonstrates that email reminders from practices can yield increases in influenza vaccination rates among adolescents. Practices should consider email as an option for influenza reminders and establish business practices for collecting and maintaining patient email addresses. This study is registered at www.ClinicalTrials.gov id #NCT01732315.
[Mh] Termos MeSH primário: Correio Eletrônico
Programas de Imunização/métodos
Vacinas contra Influenza
Influenza Humana/prevenção & controle
Sistema de Registros
Sistemas de Alerta/instrumentação
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Seres Humanos
Vacinas contra Influenza/administração & dosagem
Masculino
Michigan
Pais
Estações do Ano
Mensagem de Texto
Vacinação
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Influenza Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:28470786
[Au] Autor:Tavarez MM; Ayers B; Jeong JH; Coombs CM; Thompson A; Hickey RW
[Ad] Endereço:The Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
[Ti] Título:Practice Variation and Effects of E-mail-only Performance Feedback on Resource Use in the Emergency Department.
[So] Source:Acad Emerg Med;24(8):948-956, 2017 Aug.
[Is] ISSN:1553-2712
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Higher resource utilization in the management of pediatric patients with undifferentiated vomiting and/or diarrhea does not correlate consistently with improved outcomes or quality of care. Performance feedback has been shown to change physician practice behavior and may be a mechanism to minimize practice variation. We aimed to evaluate the effects of e-mail-only, provider-level performance feedback on the ordering and admission practice variation of pediatric emergency physicians for patients presenting with undifferentiated vomiting and/or diarrhea. METHODS: We conducted a prospective, quality improvement intervention and collected data over 3 consecutive fiscal years. The setting was a single, tertiary care pediatric emergency department. We collected admission and ordering practices data on 19 physicians during baseline, intervention, and postintervention periods. We provided physicians with quarterly e-mail-based performance reports during the intervention phase. We measured admission rate and created four categories for ordering practices: no orders, laboratory orders, pharmacy orders, and radiology orders. RESULTS: There was wide (two- to threefold) practice variation among physicians. Admission rates ranged from 15% to 30%, laboratory orders from 19% to 43%, pharmacy orders from 29% to 57%, and radiology orders from 11% to 30%. There was no statistically significant difference in the proportion of patients admitted or with radiology or pharmacy orders placed between preintervention, intervention, or postintervention periods (p = 0.58, p = 0.19, and p = 0.75, respectively). There was a significant but very small decrease in laboratory orders between the preintervention and postintervention periods. CONCLUSIONS: Performance feedback provided only via e-mail to pediatric emergency physicians on a quarterly basis does not seem to significantly impact management practices for patients with undifferentiated vomiting and/or diarrhea.
[Mh] Termos MeSH primário: Correio Eletrônico
Serviço Hospitalar de Emergência/estatística & dados numéricos
Retroalimentação
Recursos em Saúde/utilização
Hospitalização/estatística & dados numéricos
Padrões de Prática Médica/estatística & dados numéricos
[Mh] Termos MeSH secundário: Criança
Diarreia/terapia
Serviço Hospitalar de Emergência/economia
Feminino
Seres Humanos
Masculino
Padrões de Prática Médica/economia
Estudos Prospectivos
Melhoria de Qualidade
Vômito/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/acem.13211


  4 / 2351 MEDLINE  
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[PMID]:28880308
[Au] Autor:Cobey K
[Ad] Endereço:Ottawa Hospital Research Institute in Canada.
[Ti] Título:Illegitimate journals scam even senior scientists.
[So] Source:Nature;549(7670):7, 2017 09 06.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Vítimas de Crime
Fraude/prevenção & controle
Publicações Periódicas como Assunto/ética
Publicações Periódicas como Assunto/normas
Pesquisadores/educação
[Mh] Termos MeSH secundário: Consultores
Vítimas de Crime/economia
Publicação Duplicada como Assunto
Políticas Editoriais
Correio Eletrônico
Fraude/economia
Internet
Publicação de Acesso Aberto/economia
Publicação de Acesso Aberto/ética
Publicação de Acesso Aberto/normas
Publicações Periódicas como Assunto/economia
Pesquisadores/economia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1038/549007a


  5 / 2351 MEDLINE  
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[PMID]:28759606
[Au] Autor:Matos J; Petri CR; Mukamal KJ; Vanka A
[Ad] Endereço:Clinical Fellow, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
[Ti] Título:Spaced education in medical residents: An electronic intervention to improve competency and retention of medical knowledge.
[So] Source:PLoS One;12(7):e0181418, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Spaced education is a novel method that improves medical education through online repetition of core principles often paired with multiple-choice questions. This model is a proven teaching tool for medical students, but its effect on resident learning is less established. We hypothesized that repetition of key clinical concepts in a "Clinical Pearls" format would improve knowledge retention in medical residents. METHODS: This study investigated spaced education with particular emphasis on using a novel, email-based reinforcement program, and a randomized, self-matched design, in which residents were quizzed on medical knowledge that was either reinforced or not with electronically-administered spaced education. Both reinforced and non-reinforced knowledge was later tested with four quizzes. RESULTS: Overall, respondents incorrectly answered 395 of 1008 questions (0.39; 95% CI, 0.36-0.42). Incorrect response rates varied by quiz (range 0.34-0.49; p = 0.02), but not significantly by post-graduate year (PGY1 0.44, PGY2 0.33, PGY3 0.38; p = 0.08). Although there was no evidence of benefit among residents (RR = 1.01; 95% CI, 0.83-1.22; p = 0.95), we observed a significantly lower risk of incorrect responses to reinforced material among interns (RR = 0.83, 95% CI, 0.70-0.99, p = 0.04). CONCLUSIONS: Overall, repetition of Clinical Pearls did not statistically improve test scores amongst junior and senior residents. However, among interns, repetition of the Clinical Pearls was associated with significantly higher test scores, perhaps reflecting their greater attendance at didactic sessions and engagement with Clinical Pearls. Although the study was limited by a low response rate, we employed test and control questions within the same quiz, limiting the potential for selection bias. Further work is needed to determine the optimal spacing and content load of Clinical Pearls to maximize retention amongst medical residents. This particular protocol of spaced education, however, was unique and readily reproducible suggesting its potential efficacy for intern education within a large residency program.
[Mh] Termos MeSH primário: Competência Clínica
Educação de Pós-Graduação em Medicina/métodos
Internato e Residência
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Avaliação Educacional/métodos
Correio Eletrônico
Seres Humanos
Conhecimento
Aprendizagem
Médicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181418


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[PMID]:28720917
[Au] Autor:Al-Jumaili AA; Al-Rekabi MD; Alsawad OS; Allela OQB; Carnahan R; Saaed H; Naqishbandi A; Kadhim DJ; Sorofman B
[Ad] Endereço:University of Iowa College of Pharmacy, Iowa City, Iowa.
[Ti] Título:Exploring Electronic Communication Modes Between Iraqi Faculty and Students of Pharmacy Schools Using the Technology Acceptance Model.
[So] Source:Am J Pharm Educ;81(5):89, 2017 Jun.
[Is] ISSN:1553-6467
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To explore for the first time the extent to which Iraqi pharmacy students and faculty use Facebook and university email for academic communications, and to examine factors influencing utilization within the framework of the Technology Acceptance Model (TAM). An electronic survey was administered to convenience samples of students and faculty of six Iraqi public schools and colleges of pharmacy in 2015. Responses included 489 student and 128 faculty usable surveys. Both students and faculty use Facebook more than university email for academic communications. Less than a third of the faculty used university email. Students used Facebook for academic purposes twice as much as faculty. Absence of university email in Iraqi schools and colleges of pharmacy makes Facebook essential for faculty-student communications. The majority (71.1% to 82%) of respondents perceived that Facebook was easy to use. Three TAM variables (intention to use, attitude toward use and perceived usefulness) had significant positive associations with actual use of both Facebook messaging and university email.
[Mh] Termos MeSH primário: Correio Eletrônico/utilização
Docentes de Farmácia/estatística & dados numéricos
Mídias Sociais/utilização
Estudantes de Farmácia/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Atitude Frente aos Computadores
Estudos Transversais
Educação em Farmácia
Feminino
Seres Humanos
Iraque
Masculino
Meia-Idade
Faculdades de Farmácia/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.5688/ajpe81589


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[PMID]:28708847
[Au] Autor:Stalter RM; Tharaldson J; Owen DH; Okumu E; Moench T; Mack N; Tolley EE; MacQueen KM
[Ad] Endereço:Contraceptive Technology Innovation Department, FHI 360, Durham, North Carolina, United States of America.
[Ti] Título:Attitudes and perceptions towards novel objective measures of ARV-based vaginal ring use: Results from a global stakeholder survey.
[So] Source:PLoS One;12(7):e0180963, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Results of recent microbicide and pre-exposure prophylaxis clinical trials have shown adherence to be a significant challenge with new HIV prevention technologies. As the vaginal ring containing dapivirine moves into two open label follow-on studies (HOPE/MTN-025 and DREAM) and other antiretroviral-based and multi-purpose prevention technology ring products advance through the development pipeline, there is a need for more accurate and reliable measures of adherence to microbicide ring products. We previously conducted a comprehensive landscape analysis to identify new technologies that could be applied to adherence measurement of vaginal rings containing antiretrovirals. To explore attitudes and perceptions towards the approaches that we identified, we conducted a survey of stakeholders with experience and expertise in microbicide and HIV prevention clinical trials. From May to July 2015 an electronic survey was distributed via email to 894 stakeholders; a total of 206 eligible individuals responded to at least one question and were included in the data analysis. Survey respondents were presented with various objective measures and asked about their perceived acceptability to trial participants, feasibility of implementation by study staff, usefulness for measuring adherence and ethical concerns. Methods that require no additional input from the participant and require no modifications to the existing ring product (i.e., measurement of residual drug or excipient, or a vaginal analyte that enters the ring) were viewed as being more acceptable to trial participants and more feasible to implement in the field. Respondents saw value in using objective measures to provide real-time feedback on adherence. However, approaches that involve unannounced home visits for sample collection or spot checks of ring use, which could provide significant value to adherence feedback efforts, were met with skepticism. Additional research on the acceptability of these methods to potential trial participants and trial staff is recommended.
[Mh] Termos MeSH primário: Antirretrovirais/análise
Atitude
Dispositivos Anticoncepcionais Femininos
Percepção
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antirretrovirais/sangue
Antirretrovirais/uso terapêutico
Correio Eletrônico
Feminino
Infecções por HIV/prevenção & controle
Cabelo/química
Seres Humanos
Masculino
Pirimidinas/análise
Pirimidinas/sangue
Pirimidinas/uso terapêutico
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Retroviral Agents); 0 (Pyrimidines); TCN4MG2VXS (Dapivirine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180963


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[PMID]:28689638
[Au] Autor:Guien C; Fabre A; Lagarde A; Salgado D; Gensollen-Thiriez C; Zattara H; Beroud C; Olschwang S
[Ad] Endereço:Aix-Marseille université, Inserm, GMGF UMR_S 910, 27, boulevard Jean-Moulin, 13385 Marseille, France; RGDS, hôpital Clairval, 317, boulevard du Redon, 13009 Marseille, France.
[Ti] Título:[OISO, automatic treatment of patients management in oncogenetics].
[Ti] Título:OISO, traitement informatisé de la prise en charge en oncogénétique clinique..
[So] Source:Bull Cancer;104(7-8):602-607, 2017 Jul - Aug.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Oncogenetics is a long-term process, which requires a close relation between patients and medical teams, good familial links allowing lifetime follow-up. Numerous documents are exchanged in between the medical team, which has to frequently interact. We present here a new tool that has been conceived specifically for this management. METHODS: The tool has been developed according to a model-view-controler approach with the relational system PostgreSQL 9.3. The web site used PHP 5.3, HTML5 and CSS3 languages, completed with JavaScript and jQuery-AJAX functions and two additional modules, FPDF and PHPMailer. RESULTS: The tool allows multiple interactions, clinical data management, mailing and emailing, follow-up plannings. Requests are able to follow all patients and planning automatically, to send information to a large number of patients or physicians, and to report activity. DISCUSSION: The tool has been designed for oncogenetics and adapted to its different aspects. The CNIL delivered an authorization for use. Secured web access allows the management at a regional level. Its simple concept makes it evolutive according to the constant updates of genetic and clinical management of patients.
[Mh] Termos MeSH primário: Bases de Dados Factuais
Correio Eletrônico
Gestão da Informação em Saúde/métodos
Internet
Neoplasias/genética
Neoplasias/terapia
Relações Profissional-Paciente
Software
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE


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[PMID]:28642554
[Au] Autor:O'Brien S; Duane B
[Ad] Endereço:Dublin Dental University Hospital, Dublin, Eire.
[Ti] Título:Delivery of information to orthodontic patients using social media.
[So] Source:Evid Based Dent;18(2):59-60, 2017 06 23.
[Is] ISSN:1476-5446
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:DesignRandomised controlled trial in a hospital setting.InterventionBoth groups were given standard verbal and written information for patients receiving orthodontic treatment. In addition, patients in the intervention group received e-mails asking them to view a specifically designed YouTube unlisted video accessible through a web link in the e-mail. All patients were administered with a baseline questionnaire at bond-up which was repeated at six weeks.Outcome measureChange in question score from baseline.ResultsSixty-seven patients were randomised (control = 34; intervention = 34). Seven patients were lost to follow-up; four in the control and three in intervention group. In all the participants watched the video 90 times. Participants in the intervention group scored, on average, almost one point higher on the second questionnaire than did those in the control group (95% CI for the difference, 0.305-1.602; P = 0.005). Ethnicity had a statistically significant effect on improvement in knowledge, but sex did not.ConclusionsPresenting audiovisual information through the YouTube web site to orthodontic patients resulted in a significant improvement in patient knowledge. Supplementation of verbal and written patient information with audiovisual information via the internet is therefore worthy of consideration.
[Mh] Termos MeSH primário: Mídias Sociais
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Correio Eletrônico
Seres Humanos
Internet
Perda de Seguimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1038/sj.ebd.6401245


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[PMID]:28591223
[Au] Autor:Ban JW; Wallace E; Stevens R; Perera R
[Ad] Endereço:Evidence-Based Health Care Programme, Centre for Evidence-Based Medicine, University of Oxford, Oxford, United Kingdom.
[Ti] Título:Why do authors derive new cardiovascular clinical prediction rules in the presence of existing rules? A mixed methods study.
[So] Source:PLoS One;12(6):e0179102, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Researchers should examine existing evidence to determine the need for a new study. It is unknown whether developers evaluate existing evidence to justify new cardiovascular clinical prediction rules (CPRs). OBJECTIVE: We aimed to assess whether authors of cardiovascular CPRs cited existing CPRs, why some authors did not cite existing CPRs, and why they thought existing CPRs were insufficient. METHOD: Derivation studies of cardiovascular CPRs from the International Register of Clinical Prediction Rules for Primary Care were evaluated. We reviewed the introduction sections to determine whether existing CPRs were cited. Using thematic content analysis, the stated reasons for determining existing cardiovascular CPRs insufficient were explored. Study authors were surveyed via e-mail and post. We asked whether they were aware of any existing cardiovascular CPRs at the time of derivation, how they searched for existing CPRs, and whether they thought it was important to cite existing CPRs. RESULTS: Of 85 derivation studies included, 48 (56.5%) cited existing CPRs, 33 (38.8%) did not cite any CPR, and four (4.7%) declared there was none to cite. Content analysis identified five categories of existing CPRs insufficiency related to: (1) derivation (5 studies; 11.4% of 44), (2) construct (31 studies; 70.5%), (3) performance (10 studies; 22.7%), (4) transferability (13 studies; 29.5%), and (5) evidence (8 studies; 18.2%). Authors of 54 derivation studies (71.1% of 76 authors contacted) responded to the survey. Twenty-five authors (46.3%) reported they were aware of existing CPR at the time of derivation. Twenty-nine authors (53.7%) declared they conducted a systematic search to identify existing CPRs. Most authors (90.7%) indicated citing existing CPRs was important. CONCLUSION: Cardiovascular CPRs are often developed without citing existing CPRs although most authors agree it is important. Common justifications for new CPRs concerned construct, including choice of predictor variables or relevance of outcomes. Developers should clearly justify why new CPRs are needed with reference to existing CPRs to avoid unnecessary duplication.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Sistema Cardiovascular/fisiopatologia
Técnicas de Apoio para a Decisão
Serviços de Saúde
[Mh] Termos MeSH secundário: Doenças Cardiovasculares/diagnóstico
Doenças Cardiovasculares/fisiopatologia
Correio Eletrônico
Seres Humanos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179102



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