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Pesquisa : L01.178.847.698.500 [Categoria DeCS]
Referências encontradas : 233 [refinar]
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[PMID]:25273408
[Au] Autor:Sun K; Ye J; Zhao Y
[Ad] Endereço:Division of Materials Science, Nanyang Technological University, Singapore 639798.
[Ti] Título:Path induced coherent energy transfer in light-harvesting complexes in purple bacteria.
[So] Source:J Chem Phys;141(12):124103, 2014 Sep 28.
[Is] ISSN:1089-7690
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Features of path dependent energy transfer in a dual-ring light-harvesting (LH2) complexes (B850) system have been examined in detail systematically. The Frenkel-Dirac time dependent variational method with the Davydov D1 Ansatz is employed with detailed evolution of polaron dynamics in real space readily obtained. It is found that the phase of the transmission amplitude through the LH2 complexes plays an important role in constructing the coherent excitonic energy transfer. It is also found that the symmetry breaking caused by the dimerization of bacteriochlorophylls and coherence or correlation between two rings will be conducive in enhancing the exciton transfer efficiency.
[Mh] Termos MeSH primário: Transferência de Energia
Complexos de Proteínas Captadores de Luz/química
Modems
Proteobactérias/química
[Mh] Termos MeSH secundário: Algoritmos
Teoria da Informação
Teoria Quântica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Light-Harvesting Protein Complexes)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141002
[Lr] Data última revisão:
141002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141003
[St] Status:MEDLINE
[do] DOI:10.1063/1.4895791


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[PMID]:24706947
[Au] Autor:Penny CJ; Kilpatrick BS; Han JM; Sneyd J; Patel S
[Ad] Endereço:Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
[Ti] Título:A computational model of lysosome-ER Ca2+ microdomains.
[So] Source:J Cell Sci;127(Pt 13):2934-43, 2014 Jul 01.
[Is] ISSN:1477-9137
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acidic organelles form an important intracellular Ca(2+) pool that can drive global Ca(2+) signals through coupling with endoplasmic reticulum (ER) Ca(2+) stores. Recently identified lysosome-ER membrane contact sites might allow formation of Ca(2+) microdomains, although their size renders observation of Ca(2+) dynamics impractical. Here, we generated a computational model of lysosome-ER coupling that incorporated a previous model of the inositol trisphosphate (IP3) receptor as the ER Ca(2+) 'amplifier' and lysosomal leaks as the Ca(2+) 'trigger'. The model qualitatively described global Ca(2+) responses to the lysosomotropic agent GPN, which caused a controlled but substantial depletion of small solutes from the lysosome. Adapting this model to physiological lysosomal leaks induced by the Ca(2+) mobilising messenger NAADP demonstrated that lysosome-ER microdomains are capable of driving global Ca(2+) oscillations. Interestingly, our simulations suggest that the microdomain [Ca(2+)] need not be higher than that in the cytosol for responses to occur, thus matching the relatively high affinity of IP3 receptors for Ca(2+). The relative distribution and overall density of the lysosomal leaks dictated whether microdomains triggered or modulated global signals. Our data provide a computational framework for probing lysosome-ER Ca(2+) dynamics.
[Mh] Termos MeSH primário: Canais de Cálcio/metabolismo
Sinalização do Cálcio/fisiologia
Cálcio/metabolismo
Retículo Endoplasmático/metabolismo
Lisossomos/metabolismo
NADP/análogos & derivados
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Microdomínios da Membrana/metabolismo
Modems
NADP/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Calcium Channels); 53-59-8 (NADP); 5502-96-5 (NAADP); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140408
[St] Status:MEDLINE
[do] DOI:10.1242/jcs.149047


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[PMID]:24480448
[Au] Autor:Shoeva OY; Khlestkina EK; Berges H; Salina EA
[Ad] Endereço:Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. Electronic address: olesya_ter@bionet.nsc.ru.
[Ti] Título:The homoeologous genes encoding chalcone-flavanone isomerase in Triticum aestivum L.: structural characterization and expression in different parts of wheat plant.
[So] Source:Gene;538(2):334-41, 2014 Apr 01.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chalcone-flavanone isomerase (CHI; EC 5.5.1.6.) participates in the early step of flavonoid biosynthesis, related to plant adaptive and protective responses to environmental stress. The bread wheat genomic sequences encoding CHI were isolated, sequenced and mapped to the terminal segment of the long arms of chromosomes 5A, 5B and 5D. The loss of the final Chi intron and junction of the two last exons was found in the wheat A, B and D genomes compared to the Chi sequences of most other plant species. Each of the three diploid genomes of hexaploid wheat encodes functional CHI; however, transcription of the three homoeologous genes is not always co-regulated. In particular, the three genes demonstrated different response to salinity in roots: Chi-D1 was up-regulated, Chi-A1 responds medially, whereas Chi-B1 was not activated at all. The observed variation in transcriptional activity between the Chi homoeologs is in a good agreement with structural diversification of their promoter sequences. In addition, the correlation between Chi transcription and anthocyanin pigmentation in different parts of wheat plant has been studied. The regulatory genes controlling anthocyanin pigmentation of culm and pericarp modulated transcription of the Chi genes. However, in other organs, there was no strong relation between tissue pigmentation and the transcription of the Chi genes, suggesting complex regulation of the Chi expression in most parts of wheat plant.
[Mh] Termos MeSH primário: Genes de Plantas
Liases Intramoleculares/genética
Proteínas de Plantas/genética
Triticum/enzimologia
Triticum/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sequência de Bases
Cromossomos de Plantas/genética
Clonagem Molecular
DNA de Plantas/genética
Evolução Molecular
Éxons
Expressão Gênica
Liases Intramoleculares/química
Íntrons
Modems
Dados de Sequência Molecular
Filogenia
Proteínas de Plantas/química
Poliploidia
Regiões Promotoras Genéticas
Conformação Proteica
Homologia de Sequência de Aminoácidos
Homologia de Sequência do Ácido Nucleico
Especificidade da Espécie
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Plant Proteins); EC 5.5.- (Intramolecular Lyases); EC 5.5.1.6 (chalcone isomerase)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140219
[Lr] Data última revisão:
140219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140201
[St] Status:MEDLINE


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[PMID]:23759394
[Au] Autor:Agboola S; Havasy R; Myint-U K; Kvedar J; Jethwani K
[Ad] Endereço:Partners Center for Connected Health, 25 New Chardon St., Boston, MA 02114, USA. Sagboola@partners.org
[Ti] Título:The impact of using mobile-enabled devices on patient engagement in remote monitoring programs.
[So] Source:J Diabetes Sci Technol;7(3):623-9, 2013 May 01.
[Is] ISSN:1932-2968
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Different types of data transmission technologies are used in remote monitoring (RM) programs. This study reports on a retrospective analysis of how participants engage, based on the type of data transfer technology used in a blood pressure (BP) RM program, and its potential impact on RM program design and outcomes. METHODS: Thirty patients, aged 23-84 years (62 ± 14 years), who had completed at least 2 months in the program and were not participating in any other clinical trial were identified from the Remote Monitoring Data Repository. Half of these patients used wireless-based data transfer devices [wireless-based device (WBD)] while the other half used telephone modem-based data transfer devices [modem-based device (MBD)]. Participants were matched by practice and age. Engagement indices, which include frequency of BP measurements, frequency of data uploads, time to first BP measurement, and time to first data upload, were compared in both groups using the Wilcoxon-Mann-Whitney two-sample rank-sum test. Help desk call data were analyzed by Chi square test. RESULTS: The frequency of BP measurements and data uploads was significantly higher in the WBD group versus the MBD group [median = 0.66 versus 0.2 measurements/day (p = .01) and 0.46 versus 0.01 uploads/day (p < .001), respectively]. Time to first upload was significantly lower in the WBD group (median = 4 versus 7 days; p = .02), but time to first BP measurement did not differ between the two groups (median = 2 versus 1 day; p = .98). CONCLUSION: Wireless transmission ensures instantaneous transmission of readings, providing clinicians timely data to intervene on. Our findings suggest that mobile-enabled wireless technologies can positively impact patient engagement, outcomes, and operational workflow in RM programs.
[Mh] Termos MeSH primário: Telefone Celular
Disseminação de Informação/métodos
Modems/instrumentação
Monitorização Fisiológica/instrumentação
Consulta Remota/instrumentação
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Pressão Sanguínea
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1401
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130614
[St] Status:MEDLINE


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[PMID]:23662160
[Au] Autor:Kruger KM; Tikekar NM; Heiner AD; Baer TE; Lannutti JJ; Callaghan JJ; Brown TD
[Ad] Endereço:Orthopaedic Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242-1100, USA.
[Ti] Título:Encoding scratch and scrape features for wear modeling of total joint replacements.
[So] Source:Comput Math Methods Med;2013:624267, 2013.
[Is] ISSN:1748-6718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Damage to hard bearing surfaces of total joint replacement components typically includes both thin discrete scratches and broader areas of more diffuse scraping. Traditional surface metrology parameters such as average roughness (R a) or peak asperity height (R p) are not well suited to quantifying those counterface damage features in a manner allowing their incorporation into models predictive of polyethylene wear. A diffused lighting technique, which had been previously developed to visualize these microscopic damage features on a global implant level, also allows damaged regions to be automatically segmented. These global-level segmentations in turn provide a basis for performing high-resolution optical profilometry (OP) areal scans, to quantify the microscopic-level damage features. Algorithms are here reported by means of which those imaged damage features can be encoded for input into finite element (FE) wear simulations. A series of retrieved clinically failed implant femoral heads analyzed in this manner exhibited a wide range of numbers and severity of damage features. Illustrative results from corresponding polyethylene wear computations are also presented.
[Mh] Termos MeSH primário: Análise de Falha de Equipamento/estatística & dados numéricos
Prótese Articular
Falha de Prótese
[Mh] Termos MeSH secundário: Algoritmos
Biologia Computacional
Simulação por Computador
Análise de Elementos Finitos
Prótese de Quadril
Seres Humanos
Prótese do Joelho
Modems
Fenômenos Ópticos
Fotografia
Polietileno
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
9002-88-4 (Polyethylene)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130511
[St] Status:MEDLINE
[do] DOI:10.1155/2013/624267


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[PMID]:21753831
[Au] Autor:Rowlett P
[Ti] Título:The unplanned impact of mathematics.
[So] Source:Nature;475(7355):166-9, 2011 Jul 13.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Matemática
[Mh] Termos MeSH secundário: Astronomia
DNA/química
Jogo de Azar
História do Século XVI
História do Século XVII
História do Século XVIII
História do Século XIX
História do Século XX
História do Século XXI
Matemática/história
Matemática/métodos
Matemática/tendências
Modelos Teóricos
Modems/instrumentação
Energia Nuclear
Pandemias
Probabilidade
Teoria Quântica
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
9007-49-2 (DNA)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110715
[St] Status:MEDLINE
[do] DOI:10.1038/475166a


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[PMID]:21545151
[Au] Autor:Gong Y; Radachowsky SE; Wolf M; Nielsen ME; Girguis PR; Reimers CE
[Ad] Endereço:College of Oceanic & Atmospheric Sciences, Hatfield Marine Science Center, Oregon State University, Newport, Oregon 97365, USA.
[Ti] Título:Benthic microbial fuel cell as direct power source for an acoustic modem and seawater oxygen/temperature sensor system.
[So] Source:Environ Sci Technol;45(11):5047-53, 2011 Jun 01.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Supported by the natural potential difference between anoxic sediment and oxic seawater, benthic microbial fuel cells (BMFCs) promise to be ideal power sources for certain low-power marine sensors and communication devices. In this study a chambered BMFC with a 0.25 m(2) footprint was used to power an acoustic modem interfaced with an oceanographic sensor that measures dissolved oxygen and temperature. The experiment was conducted in Yaquina Bay, Oregon over 50 days. Several improvements were made in the BMFC design and power management system based on lessons learned from earlier prototypes. The energy was harvested by a dynamic gain charge pump circuit that maintains a desired point on the BMFC's power curve and stores the energy in a 200 F supercapacitor. The system also used an ultralow power microcontroller and quartz clock to read the oxygen/temperature sensor hourly, store data with a time stamp, and perform daily polarizations. Data records were transmitted to the surface by the acoustic modem every 1-5 days after receiving an acoustic prompt from a surface hydrophone. After jump-starting energy production with supplemental macroalgae placed in the BMFC's anode chamber, the average power density of the BMFC adjusted to 44 mW/m(2) of seafloor area which is better than past demonstrations at this site. The highest power density was 158 mW/m(2), and the useful energy produced and stored was ≥ 1.7 times the energy required to operate the system.
[Mh] Termos MeSH primário: Fontes de Energia Bioelétrica
[Mh] Termos MeSH secundário: Eletrodos
Modems
Oxigênio/análise
Água do Mar/análise
Alga Marinha
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110507
[St] Status:MEDLINE
[do] DOI:10.1021/es104383q


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[PMID]:20575734
[Au] Autor:Pappas G
[Ad] Endereço:Intel Corporation-Digital Health, Beaverton, Oregon 97006, USA. george.s.pappas@intel.com
[Ti] Título:Planning for Internet connectivity in remote patient monitoring.
[So] Source:Telemed J E Health;16(5):639-41, 2010 Jun.
[Is] ISSN:1556-3669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is important for healthcare organizations to understand the requirements and challenges of logistics when deploying remote patient monitoring (RPM) technologies in patient homes. Although most organizations prepare thoroughly for the clinical and work flow aspect of RPM solutions, they neglect to consider the logistical resources necessary to successfully manage a broad deployment. The term "logistics" in this context refers to the processes and infrastructure required to enable the use of RPM technologies in the patient's home. This article has been generated from the findings and observations of several studies where logistical objectives were included in the protocol in addition to the conventional metrics of clinical outcome, satisfaction, and economic measures. These studies implemented several high-speed Internet connectivity models with the use of wired broadband, 3G wireless, or a combination. The organizations that utilized 3G to provide Internet connectivity experienced significantly fewer logistical issues and patient frustration. It was also observed that regardless of the model, each of the clinical partners in these studies were not adequately prepared to manage Internet connectivity. Because of this, all experienced some level of difficulty installing and supporting RPM devices in the home.
[Mh] Termos MeSH primário: Implementação de Plano de Saúde/organização & administração
Serviços de Assistência Domiciliar/organização & administração
Internet/organização & administração
Monitorização Ambulatorial/métodos
Consulta Remota/organização & administração
[Mh] Termos MeSH secundário: Necessidades e Demandas de Serviços de Saúde
Seres Humanos
Internet/instrumentação
Modems
Monitorização Ambulatorial/instrumentação
Fibras Ópticas
Oregon
Técnicas de Planejamento
Desenvolvimento de Programas
Consulta Remota/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1011
[Cu] Atualização por classe:100625
[Lr] Data última revisão:
100625
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100626
[St] Status:MEDLINE
[do] DOI:10.1089/tmj.2009.0137


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[PMID]:19948707
[Au] Autor:Kwak MJ; Kim JM; Shin IH; Shin SD; Song KJ; Suh GJ; Kim HC
[Ad] Endereço:Department of Biomedical Engineering, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110-744, Korea.
[Ti] Título:Real-time medical control using a wireless audio-video transmission device in a pre-hospital emergency service in Korea.
[So] Source:J Telemed Telecare;15(8):404-8, 2009.
[Is] ISSN:1758-1109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We developed a hands-free portable device which can provide two-way, real-time audio and video communication between hospital doctors and emergency medical technicians (EMTs) providing pre-hospital care. The device was based on an ultra mobile PC with a camera, a microphone/earphone set and a WIBRO modem for wireless Internet connection at an average data transmission rate of 1 Mbit/s. Feasibility tests were conducted in 55 real emergency situations over a period of three months at five different Rescue Centres in Seoul. Successful communication between an EMT and a doctor was achieved in 46 cases (84%). The device showed acceptable performance in terms of audio/video transmission time delays and maximum transmitted video frame rates, both outdoors, inside a building and in a moving vehicle at 70 km/h. Eight control centre staff and 11 EMTs who used the device completed a questionnaire. Despite acceptable basic performance, the device was found to be limited in terms of the contribution it made to the medical control of EMTs. However, improvements in device performance should produce higher quality pre-hospital emergency medical care in the future.
[Mh] Termos MeSH primário: Serviços Médicos de Emergência/métodos
Inquéritos e Questionários
Telemedicina/instrumentação
Telemetria/instrumentação
[Mh] Termos MeSH secundário: Adulto
Atitude do Pessoal de Saúde
Serviços Médicos de Emergência/organização & administração
Auxiliares de Emergência
Desenho de Equipamento
Estudos de Viabilidade
Seres Humanos
Internet/normas
Coreia (Geográfico)
Masculino
Modems
Consulta Remota/instrumentação
Consulta Remota/métodos
Consulta Remota/normas
Telemedicina/métodos
Telemedicina/normas
Telemetria/métodos
Telemetria/normas
Transporte de Pacientes/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1004
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091202
[St] Status:MEDLINE
[do] DOI:10.1258/jtt.2009.090504


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[PMID]:19341129
[Au] Autor:Egi SM
[Ad] Endereço:Galatasaray University, MTF Computer Engineering Department, Ortakoy, 34357, Istanbul, Turkiye.
[Ti] Título:Design of an acoustic telemetry system for rebreathers.
[So] Source:Undersea Hyperb Med;36(1):65-71, 2009 Jan-Feb.
[Is] ISSN:1066-2936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the abundance of telemetric applications for ecology, behavior and physiology of marine life, few efforts were reported about the use of acoustic telemetry for SCUBA divers. The objective of this study is to design and test an acoustic telemetry system for monitoring breathing gases of a Dräger Dolphin semi-closed circuit rebreather as well as the depth of the diver. The system is designed around a PC based surface unit and a microcontroller based diver carried module that digitizes the output of CO2 and O2 sensors located in the inhalation side of the canister. One pair of acoustic modems establishes the data link between the microcontroller and the topside PC. The graphical user interface is written in C# and enables the recording of the diving session as well. The system is calibrated in a hyperbaric chamber and tested successfully with four dives in three different environments using 100% O2 and Nitrox (47.9% O2 - 52.1% N2) up to 15 m depth and a distance of 40 m between acoustic modems. The telemetry data cannot be used only for recording physiological data but also provides an important operational safety tool to monitor the rebreather user. The future designs will include actuators for controlling the diluent and oxygen flow to closed circuit mix gas rebreathers.
[Mh] Termos MeSH primário: Dióxido de Carbono/análise
Periféricos de Computador
Mergulho
Oxigênio/análise
Software
Telemetria/instrumentação
[Mh] Termos MeSH secundário: Calibragem
Desenho de Equipamento
Estudos de Viabilidade
Seres Humanos
Modems
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:0904
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:090404
[St] Status:MEDLINE



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