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[PMID]:29305450
[Au] Autor:Kono K; Tomita T; Futai K; Yamazaki T; Tanaka S; Yoshikawa H; Sugamoto K
[Ad] Endereço:Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan and Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
[Ti] Título: three-dimensional kinematics of normal knees during different high-flexion activities.
[So] Source:Bone Joint J;100-B(1):50-55, 2018 Jan.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: In Asia and the Middle-East, people often flex their knees deeply in order to perform activities of daily living. The purpose of this study was to investigate the 3D kinematics of normal knees during high-flexion activities. Our hypothesis was that the femorotibial rotation, varus-valgus angle, translations, and kinematic pathway of normal knees during high-flexion activities, varied according to activity. MATERIALS AND METHODS: We investigated the kinematics of eight normal knees in four male volunteers (mean age 41.8 years; 37 to 53) using 2D and 3D registration technique, and modelled the knees with a computer aided design program. Each subject squatted, kneeled, and sat cross-legged. We evaluated the femoral rotation and varus-valgus angle relative to the tibia and anteroposterior translation of the medial and lateral side, using the transepicodylar axis as our femoral reference relative to the perpendicular projection on to the tibial plateau. This method evaluates the femur medially from what has elsewhere been described as the extension facet centre, and differs from the method classically applied. RESULTS: During squatting and kneeling, the knees displayed femoral external rotation. When sitting cross-legged, femurs displayed internal rotation from 10° to 100°. From 100°, femoral external rotation was observed. No significant difference in varus-valgus angle was seen between squatting and kneeling, whereas a varus position was observed from 140° when sitting cross-legged. The measure kinematic pathway using our methodology found during squatting a medial pivoting pattern from 0° to 40° and bicondylar rollback from 40° to 150°. During kneeling, a medial pivot pattern was evident. When sitting cross-legged, a lateral pivot pattern was seen from 0° to 100°, and a medial pivot pattern beyond 100°. CONCLUSION: The kinematics of normal knees during high flexion are variable according to activity. Nevertheless, our study was limited to a small number of male patients using a different technique to report the kinematics than previous publications. Accordingly, caution should be observed in generalizing our findings. Cite this article: 2018;100-B:50-5.
[Mh] Termos MeSH primário: Fenômenos Biomecânicos/fisiologia
Articulação do Joelho/fisiologia
[Mh] Termos MeSH secundário: Atividades Cotidianas
Adulto
Simulação por Computador
Projeto Auxiliado por Computador
Fluoroscopia
Seres Humanos
Imagem Tridimensional/métodos
Articulação do Joelho/diagnóstico por imagem
Masculino
Meia-Idade
Modelos Anatômicos
Amplitude de Movimento Articular/fisiologia
Rotação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180311
[Lr] Data última revisão:
180311
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B1.BJJ-2017-0553.R2


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[PMID]:29295698
[Au] Autor:Usha T; Shanmugarajan D; Goyal AK; Kumar CS; Middha SK
[Ad] Endereço:Department of Biochemistry, Bangalore University, Bengaluru, Karnataka, India.
[Ti] Título:Recent Updates on Computer-aided Drug Discovery: Time for a Paradigm Shift.
[So] Source:Curr Top Med Chem;17(30):3296-3307, 2017.
[Is] ISSN:1873-4294
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Computer-Aided Drug Designing (CADD) has gained a wide popularity among biologists and chemists as a part of interdisciplinary drug discovery approach. It plays a vital role in the discovery, design and analysis of drugs in pharmaceutical industry. It is extensively used to reduce cost, time and speed up the early stage development of biologically new active molecules. In the current review we presented a brief review of CADD, merits and demerits, DNA, protein and enzyme as targets, types of CADD: Structure Based Drug Designing (SBDD), Ligand Based Drug Designing (LBDD), Pharmacophore based drug designing (PBDD) and Fragment Based Drug Designing (FBDD), theory behind the types of CADD and their applications. The review also focuses on the in-silico pharmokinetic, pharmacodynamic and toxicity filters or predictions that play a major role in identifying the drug like molecules. Currently in pharmaceutical sciences computational tools and software are exhibiting imperative role in the different stages of drug discovery hence the review throws light on various commercial and freeware available for each step of CADD.
[Mh] Termos MeSH primário: Projeto Auxiliado por Computador
Descoberta de Drogas/métodos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Preparações Farmacêuticas/metabolismo
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.2174/1568026618666180101163651


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[PMID]:29267670
[Au] Autor:Bellan MC; Cunha PFJSD; Tavares JG; Spohr AM; Mota EG
[Ad] Endereço:Pontifícia Universidade Católica da Universidade Federal do Rio Grande do Sul - PUC-RS, School of Dentistry, Graduate Program, Porto Alegre, RS, Brazil.
[Ti] Título:Microtensile bond strength of CAD/CAM materials to dentin under different adhesive strategies.
[So] Source:Braz Oral Res;31:e109, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the microtensile bond strength (µTBS) of novel computer-aided design/computer-aided manufacturing (CAD/CAM) restorative materials to dentin using different adhesive strategies. Thirty-two crowns were milled using CAD/CAM materials (Vita Mark II as control, Vita Suprinity, Vita Enamic and Lava Ultimate) and luted to dentin using different resin cements (RelyX ARC, RelyX Unicem 2 and RelyX Ultimate). The specimens were stored in 100% relative humidity at 37°C for 24 h and sectioned. The samples (n = 16) with cross-sectional areas of approximately 0.90 mm2, were submitted to a µTBS test in a universal testing machine with a crosshead speed of 0.5 mm/min. The samples were analyzed with SEM to determinate the failure mode. According to 2-way ANOVA and Tukey's test (α=0.05), the interaction effect (material x luting strategy) was significant (p=0.001). Regardless of the luting strategy, a higher µTBS was obtained with Lava Ultimate and Vita Enamic, which were significantly different from Vita Mark II and Vita Suprinity (p<0.05). For Vita Mark II, Vita Suprinity, Vita Enamic, and Lava Ultimate, the µTBS obtained with RelyX Unicem 2 was not significantly different from that obtained with RelyX ARC or RelyX Ultimate. All groups obtained at least three types of failure. The adhesive strategy with self-adhesive resin cement was comparable to conventional resin cement with total-etch or self-etch adhesive techniques in the bond of novel CAD/CAM materials to dentin.
[Mh] Termos MeSH primário: Cerâmica/química
Projeto Auxiliado por Computador
Colagem Dentária/métodos
Dentina/efeitos dos fármacos
Cimentos de Resina/química
[Mh] Termos MeSH secundário: Análise de Variância
Falha de Restauração Dentária
Dentina/química
Seres Humanos
Teste de Materiais
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Propriedades de Superfície/efeitos dos fármacos
Resistência à Tração
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resin Cements)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29364328
[Au] Autor:Azar B; Eckert S; Kunkela J; Ingr T; Mounajjed R
[Ad] Endereço:Institute of Dentistry and Oral Sciences, Palacky University, Olomouc, Czech Republic.
[Ti] Título:The marginal fit of lithium disilicate crowns: Press vs. CAD/CAM.
[So] Source:Braz Oral Res;32:e001, 2018.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study aimed to compare the vertical marginal gap of teeth restored with lithium disilicate crowns fabricated using CAD/CAM or by pressed ceramic approach. Twenty mandibular third molar teeth were collected after surgical extractions and prepared to receive full veneer crowns. Teeth were optically scanned and lithium disilicate blocks were used to fabricate crowns using CAD/CAM technique. Polyvinyl siloxane impressions of the prepared teeth were made and monolithic pressed lithium disilicate crowns were fabricated. The marginal gap was measured using optical microscope at 200× magnification (Keyence VHX-5000, Japan). Statistical analysis was performed using Wilcoxon test. The lithium disilicate pressed crowns had significantly smaller (p = 0.006) marginal gaps (38 ± 12 µm) than the lithium disilicate CAD/CAM crowns (45 ± 12 µm). This research indicates that lithium disilicate crowns fabricated with the press technique have measurably smaller marginal gaps compared with those fabricated with CAD/CAM technique within in vitro environments. The marginal gaps achieved by the crowns across all groups were within a clinically acceptable range.
[Mh] Termos MeSH primário: Projeto Auxiliado por Computador
Coroas/normas
Técnica de Moldagem Odontológica
Adaptação Marginal Dentária/normas
Porcelana Dentária/química
[Mh] Termos MeSH secundário: Materiais para Moldagem Odontológica
Planejamento de Prótese Dentária
Seres Humanos
Teste de Materiais
Padrões de Referência
Valores de Referência
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Impression Materials); 0 (lithia disilicate); 12001-21-7 (Dental Porcelain)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:29182214
[Au] Autor:Davda K; Osnes C; Dillon S; Wu J; Hyde P; Keeling A
[Ad] Endereço:Leeds School of Dentistry.
[Ti] Título:An Investigation into the Trueness and Precision of Copy Denture Templates Produced by Rapid Prototyping and Conventional Means.
[So] Source:Eur J Prosthodont Restor Dent;25(4):186-192, 2017 Dec 01.
[Is] ISSN:0965-7452
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the trueness and precision of copy denture templates produced using traditional methods and 3D printing. MATERIAL AND METHODS: Six copies of a denture were made using: 1. Conventional technique with silicone putty in an impression tray (CT). 2. Conventional technique with no impression tray (CNT). 3. 3D scanning and printing (3D). Scan trueness and precision was investigated by scanning a denture six times and comparing five scans to the sixth. Then the scans of the six CT, CNT and 3D dentures were compared by aligning, in turn, the copies of each denture to the scanned original. Outcome measures were the mean surface-to-surface distance, standard deviation of that distance and the maximum distance. Student's unpaired t-tests with Bonferroni correction were used to analyse the results. RESULTS: The repeated scans of the original denture showed a scan trueness of 0.013mm (SD 0.002) and precision of 0.013mm (SD 0.002). Trueness: CT templates, 0.168mm (0.047), CNT templates 0.195mm (0.034) and 3D 0.103mm (0.021). Precision: CT templates 0.158mm (0.037), CNT 0.233mm (0.073), 3D 0.090mm (0.017). For each outcome measure the 3D templates demonstrated an improvement which was statistically significant (p⟨0.05). CONCLUSIONS: 3D printed copy denture templates reproduced the original with greater trueness and precision than conventional techniques.
[Mh] Termos MeSH primário: Técnica de Moldagem Odontológica
Prótese Total
Impressão Tridimensional
[Mh] Termos MeSH secundário: Projeto Auxiliado por Computador
Seres Humanos
Imagem Tridimensional
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1922/EJPRD_01716Davda07


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[PMID]:29292415
[Au] Autor:Saratti CM; Del Curto F; Rocca GT; Krejci I
[Ti] Título:Vertical dimension augmentation with a full digital approach: a multiple chairside sessions case report.
[So] Source:Int J Comput Dent;20(4):423-438, 2017.
[Is] ISSN:1463-4201
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The last few decades have seen an upward trend of the pathologies of abrasion, erosion, and abfraction. These pathologies, especially in combination, can provoke a significant loss of tooth substance. Nowadays, modern digital chairside technologies and new restorative materials allow clinicians to restore the lost tooth structure with a minimally invasive and fully digital approach. This article describes a step-by-step procedure of a full-mouth rehabilitation performed with a total digital chairside approach in several appointments.
[Mh] Termos MeSH primário: Restauração Dentária Permanente
Facetas Dentárias
Estética Dentária
Dimensão Vertical
[Mh] Termos MeSH secundário: Projeto Auxiliado por Computador
Seres Humanos
Masculino
Meia-Idade
Abrasão Dentária/reabilitação
Erosão Dentária/reabilitação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


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[PMID]:29242347
[Au] Autor:Hosseinzadeh P; Bhardwaj G; Mulligan VK; Shortridge MD; Craven TW; Pardo-Avila F; Rettie SA; Kim DE; Silva DA; Ibrahim YM; Webb IK; Cort JR; Adkins JN; Varani G; Baker D
[Ad] Endereço:Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
[Ti] Título:Comprehensive computational design of ordered peptide macrocycles.
[So] Source:Science;358(6369):1461-1466, 2017 12 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent therapeutics identified to date, but there is currently no way to systematically search the structural space spanned by such compounds. Natural proteins do not provide a useful guide: Peptide macrocycles lack regular secondary structures and hydrophobic cores, and can contain local structures not accessible with l-amino acids. Here, we enumerate the stable structures that can be adopted by macrocyclic peptides composed of l- and d-amino acids by near-exhaustive backbone sampling followed by sequence design and energy landscape calculations. We identify more than 200 designs predicted to fold into single stable structures, many times more than the number of currently available unbound peptide macrocycle structures. Nuclear magnetic resonance structures of 9 of 12 designed 7- to 10-residue macrocycles, and three 11- to 14-residue bicyclic designs, are close to the computational models. Our results provide a nearly complete coverage of the rich space of structures possible for short peptide macrocycles and vastly increase the available starting scaffolds for both rational drug design and library selection methods.
[Mh] Termos MeSH primário: Simulação por Computador
Projeto Auxiliado por Computador
Modelos Químicos
Peptídeos/química
Estabilidade Proteica
[Mh] Termos MeSH secundário: Desenho de Drogas
Ressonância Magnética Nuclear Biomolecular
Dobramento de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Peptides)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1126/science.aap7577


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[PMID]:29185607
[Au] Autor:Griffin JD
[Ti] Título:CAD/CAM Restorations: Achieving Excellence and Simplicity.
[So] Source:Dent Today;35(11):96,98, 100, 2016 Nov.
[Is] ISSN:8750-2186
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Projeto Auxiliado por Computador
Planejamento de Prótese Dentária
Restauração Dentária Permanente
[Mh] Termos MeSH secundário: Restauração Dentária Permanente/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:29185329
[Au] Autor:Adams D
[Ti] Título:Spotlight on Technology.
[So] Source:Dent Today;35(11):6, 2016 Nov.
[Is] ISSN:8750-2186
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Projeto Auxiliado por Computador
Planejamento de Prótese Dentária/métodos
Tecnologia Odontológica
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:29185317
[Au] Autor:Kaye
[Ti] Título:Restorative Digital Dentistry, Part 1: The Journey to New Paradigms.
[So] Source:Dent Today;35(10):22, 24, 26-7, 2016 Oct.
[Is] ISSN:8750-2186
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Projeto Auxiliado por Computador
Restauração Dentária Permanente/métodos
[Mh] Termos MeSH secundário: Planejamento de Prótese Dentária
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE



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