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[PMID]:28934326
[Au] Autor:Rodriguez Torres Y; Huang J; Mihlstin M; Juzych MS; Kromrei H; Hwang FS
[Ad] Endereço:Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan, United States of America.
[Ti] Título:The effect of electronic health record software design on resident documentation and compliance with evidence-based medicine.
[So] Source:PLoS One;12(9):e0185052, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to determine the role of electronic health record software in resident education by evaluating documentation of 30 elements extracted from the American Academy of Ophthalmology Dry Eye Syndrome Preferred Practice Pattern. The Kresge Eye Institute transitioned to using electronic health record software in June 2013. We evaluated the charts of 331 patients examined in the resident ophthalmology clinic between September 1, 2011, and March 31, 2014, for an initial evaluation for dry eye syndrome. We compared documentation rates for the 30 evidence-based elements between electronic health record chart note templates among the ophthalmology residents. Overall, significant changes in documentation occurred when transitioning to a new version of the electronic health record software with average compliance ranging from 67.4% to 73.6% (p < 0.0005). Electronic Health Record A had high compliance (>90%) in 13 elements while Electronic Health Record B had high compliance (>90%) in 11 elements. The presence of dialog boxes was responsible for significant changes in documentation of adnexa, puncta, proptosis, skin examination, contact lens wear, and smoking exposure. Significant differences in documentation were correlated with electronic health record template design rather than individual resident or residents' year in training. Our results show that electronic health record template design influences documentation across all resident years. Decreased documentation likely results from "mouse click fatigue" as residents had to access multiple dialog boxes to complete documentation. These findings highlight the importance of EHR template design to improve resident documentation and integration of evidence-based medicine into their clinical notes.
[Mh] Termos MeSH primário: Documentação
Registros Eletrônicos de Saúde
Medicina Baseada em Evidências
Internato e Residência
Médicos
Desenho de Programas de Computador
[Mh] Termos MeSH secundário: Documentação/métodos
Síndromes do Olho Seco/terapia
Medicina Baseada em Evidências/métodos
Feminino
Fidelidade a Diretrizes
Seres Humanos
Masculino
Meia-Idade
Oftalmologia/educação
Padrões de Prática Médica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185052


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[PMID]:28852741
[Au] Autor:Arnetzl G
[Ti] Título:Editorial: Come back when you've finished your homework!
[So] Source:Int J Comput Dent;20(3):223-225, 2017.
[Is] ISSN:1463-4201
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Desenho de Programas de Computador
Software/normas
[Mh] Termos MeSH secundário: Odontologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE


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[PMID]:28816851
[Au] Autor:Kane-Gill SL; Dasta JF; Buckley MS; Devabhakthuni S; Liu M; Cohen H; George EL; Pohlman AS; Agarwal S; Henneman EA; Bejian SM; Berenholtz SM; Pepin JL; Scanlon MC; Smith BS
[Ad] Endereço:1Department of Pharmacy and Therapeutics, Critical Care Medicine, Biomedical Informatics and Clinical Translational Science Institute, University of Pittsburgh, Pittsburgh, PA. 2Department of Pharmacy, UPMC, Pittsburgh, PA. 3Department of Pharmacy Practice and Science, The Ohio State University, College of Pharmacy, Columbus, OH. 4Department of Pharmacy, Banner University Medical Center Phoenix, Phoenix, AZ. 5Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD. 6Department of Pharmacy, Yale-New Haven Hospital, New Haven, CT. 7Department of Pharmacy Services, Touro College of Pharmacy, New York, NY. 8Kingsbrook Jewish Medical Center, Brooklyn, NY. 9UPMC-Presbyterian, Pittsburgh, PA. 10Department of Medicine, University of Chicago, Chicago, IL. 11Pediatric Critical Care, Department of Pediatrics, Inova Children's Hospital, Falls Church, VA. 12College of Nursing, University of Massachusetts Amherst, Amherst, MA. 13Inova Fairfax Hospital, Falls Church, VA. 14Departments of Anesthesia/CCM and Surgery, and Health Policy & Management, Johns Hopkins Schools of Medicine and Bloomberg School of Public Health, Baltimore, MD. 15Department of Pharmacy, Seton Medical Center Williamson, Round Rock, TX. 16Department of Pediatrics and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI. 17Children's Hospital of Wisconsin, Milwaukee, WI. 18Department of Pharmacy, UMass Memorial Medical Center, Worcester, MA.
[Ti] Título:Clinical Practice Guideline: Safe Medication Use in the ICU.
[So] Source:Crit Care Med;45(9):e877-e915, 2017 Sep.
[Is] ISSN:1530-0293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To provide ICU clinicians with evidence-based guidance on safe medication use practices for the critically ill. DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, CINAHL, Scopus, and ISI Web of Science for relevant material to December 2015. STUDY SELECTION: Based on three key components: 1) environment and patients, 2) the medication use process, and 3) the patient safety surveillance system. The committee collectively developed Population, Intervention, Comparator, Outcome questions and quality of evidence statements pertaining to medication errors and adverse drug events addressing the key components. A total of 34 Population, Intervention, Comparator, Outcome questions, five quality of evidence statements, and one commentary on disclosure was developed. DATA EXTRACTION: Subcommittee members were assigned selected Population, Intervention, Comparator, Outcome questions or quality of evidence statements. Subcommittee members completed their Grading of Recommendations Assessment, Development, and Evaluation of the question with his/her quality of evidence assessment and proposed strength of recommendation, then the draft was reviewed by the relevant subcommittee. The subcommittee collectively reviewed the evidence profiles for each question they developed. After the draft was discussed and approved by the entire committee, then the document was circulated among all members for voting on the quality of evidence and strength of recommendation. DATA SYNTHESIS: The committee followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation system to determine quality of evidence and strength of recommendations. CONCLUSIONS: This guideline evaluates the ICU environment as a risk for medication-related events and the environmental changes that are possible to improve safe medication use. Prevention strategies for medication-related events are reviewed by medication use process node (prescribing, distribution, administration, monitoring). Detailed considerations to an active surveillance system that includes reporting, identification, and evaluation are discussed. Also, highlighted is the need for future research for safe medication practices that is specific to critically ill patients.
[Mh] Termos MeSH primário: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle
Unidades de Terapia Intensiva/organização & administração
Erros de Medicação/prevenção & controle
Sistemas de Medicação no Hospital/organização & administração
[Mh] Termos MeSH secundário: Processamento Automatizado de Dados
Pesos e Medidas Corporais
Lista de Checagem/normas
Protocolos Clínicos/normas
Sistemas de Apoio a Decisões Clínicas/organização & administração
Revelação
Documentação/normas
Relação Dose-Resposta a Droga
Rotulagem de Medicamentos/métodos
Meio Ambiente
Prática Clínica Baseada em Evidências
Seres Humanos
Bombas de Infusão
Capacitação em Serviço
Unidades de Terapia Intensiva/normas
Unidades de Terapia Intensiva Pediátrica/organização & administração
Sistemas de Registro de Ordens Médicas/organização & administração
Reconciliação de Medicamentos/organização & administração
Sistemas de Medicação no Hospital/normas
Cultura Organizacional
Pacotes de Assistência ao Paciente/normas
Transferência da Responsabilidade pelo Paciente/normas
Participação do Paciente
Fatores de Risco
Desenho de Programas de Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/CCM.0000000000002533


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[PMID]:28662064
[Au] Autor:McMurry JA; Juty N; Blomberg N; Burdett T; Conlin T; Conte N; Courtot M; Deck J; Dumontier M; Fellows DK; Gonzalez-Beltran A; Gormanns P; Grethe J; Hastings J; Hériché JK; Hermjakob H; Ison JC; Jimenez RC; Jupp S; Kunze J; Laibe C; Le Novère N; Malone J; Martin MJ; McEntyre JR; Morris C; Muilu J; Müller W; Rocca-Serra P; Sansone SA; Sariyar M; Snoep JL; Soiland-Reyes S; Stanford NJ; Swainston N; Washington N; Williams AR; Wimalaratne SM; Winfree LM; Wolstencroft K; Goble C; Mungall CJ; Haendel MA; Parkinson H
[Ad] Endereço:Department of Medical Informatics and Epidemiology and OHSU Library, Oregon Health & Science University, Portland, Oregon, United States of America.
[Ti] Título:Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data.
[So] Source:PLoS Biol;15(6):e2001414, 2017 Jun.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar that make integration possible; identifiers are a core component of this integration infrastructure. Drawing on our experience and on work by other groups, we outline 10 lessons we have learned about the identifier qualities and best practices that facilitate large-scale data integration. Specifically, we propose actions that identifier practitioners (database providers) should take in the design, provision and reuse of identifiers. We also outline the important considerations for those referencing identifiers in various circumstances, including by authors and data generators. While the importance and relevance of each lesson will vary by context, there is a need for increased awareness about how to avoid and manage common identifier problems, especially those related to persistence and web-accessibility/resolvability. We focus strongly on web-based identifiers in the life sciences; however, the principles are broadly relevant to other disciplines.
[Mh] Termos MeSH primário: Disciplinas das Ciências Biológicas/métodos
Biologia Computacional/métodos
Mineração de Dados/métodos
Desenho de Programas de Computador
Software
[Mh] Termos MeSH secundário: Disciplinas das Ciências Biológicas/estatística & dados numéricos
Disciplinas das Ciências Biológicas/tendências
Biologia Computacional/tendências
Mineração de Dados/estatística & dados numéricos
Mineração de Dados/tendências
Bases de Dados Factuais/estatística & dados numéricos
Bases de Dados Factuais/tendências
Previsões
Seres Humanos
Internet
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001414


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[PMID]:28651515
[Au] Autor:Billot L; Venkatesh B; Myburgh J; Finfer S; Cohen J; Webb S; McArthur C; Joyce C; Bellomo R; Rhodes A; Perner A; Arabi Y; Rajbhandari D; Glass P; Thompson K; Correa M; Harward M
[Ad] Endereço:The George Institute for Global Health, Sydney, NSW, Australia. bmvenkat@bigpond.net.au.
[Ti] Título:Statistical analysis plan for the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial.
[So] Source:Crit Care Resusc;19(2):183-191, 2017 Jun.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial, a 3800-patient, multicentre, randomised controlled trial, will be the largest study to date of corticosteroid therapy in patients with septic shock. OBJECTIVE: To describe a statistical analysis plan (SAP) and make it public before completion of patient recruitment and data collection. The SAP will be adhered to for the final data analysis of this trial, to avoid analysis bias arising from knowledge of study findings. METHODS: The SAP was designed by the chief investigators and statisticians and approved by the ADRENAL management committee. All authors were blind to treatment allocation and to the unblinded data produced during two interim analyses conducted by the Data Safety and Monitoring Committee. The data shells were produced from a previously published protocol. Statistical analyses are described in broad detail. Trial outcomes were selected and categorised into primary, secondary and tertiary outcomes, and appropriate statistical comparisons between groups are planned and described in a way that is transparent, available to the public, verifiable and determined before completion of data collection. RESULTS: We developed a standard SAP for the ADRENAL trial, and have produced a trial profile outline and list of mock tables. We describe analyses of baseline characteristics, processes of care, measures of efficacy and outcomes. Six pre-specified subgroups were defined, and statistical comparisons between groups in these subgroups are described. CONCLUSION: We have developed an SAP for the ADRENAL trial. This plan accords with high-quality standards of internal validity to minimise analysis bias.
[Mh] Termos MeSH primário: Cuidados Críticos/métodos
Coleta de Dados/estatística & dados numéricos
Interpretação Estatística de Dados
Hidrocortisona/uso terapêutico
Unidades de Terapia Intensiva
Choque Séptico/tratamento farmacológico
[Mh] Termos MeSH secundário: Algoritmos
Austrália
Método Duplo-Cego
Infusões Intravenosas
Nova Zelândia
Avaliação de Processos e Resultados (Cuidados de Saúde)/estatística & dados numéricos
Seleção de Pacientes
Projetos de Pesquisa
Choque Séptico/mortalidade
Desenho de Programas de Computador
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28637963
[Au] Autor:Shinohara N; Tanaka R; Shiraishi J
[Ad] Endereço:Gifu University of Medical Science.
[Ti] Título:Welcome to Imaging Section for Coloring Your Research Life.
[So] Source:Nihon Hoshasen Gijutsu Gakkai Zasshi;73(6):486-489, 2017.
[Is] ISSN:0369-4305
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Pesquisa Biomédica
Sociedades Científicas
[Mh] Termos MeSH secundário: Desenho de Programas de Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.6009/jjrt.2017_JSRT_73.6.486


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[PMID]:28636581
[Au] Autor:Kuzman MR; Andlauer O; Burmeister K; Dvoracek B; Lencer R; Koelkebeck K; Nawka A; Riese F
[Ad] Endereço:Department of Psychiatry, Zagreb University Hospital Centre, Kispaticeva 12, 10000 Zagreb, Croatia, mrojnic@gmail.com.
[Ti] Título:The PsyLOG mobile application: development of a tool for the assessment and monitoring of side effects of psychotropic medication.
[So] Source:Psychiatr Danub;29(2):214-217, 2017 Jun.
[Is] ISSN:0353-5053
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Mobile health interventions are regarded as affordable and accessible tools that can enhance standard psychiatric care. As part of the mHealth Psycho-Educational Intervention Versus Antipsychotic-Induced Side Effects (mPIVAS) project (www.psylog.eu), we developed the mobile application "PsyLOG" based on mobile "smartphone" technology to monitor antipsychotic-induced side effects. The aim of this paper is to describe the rationale and development of the PsyLOG and its clinical use. The PsyLOG application runs on smartphones with Android operating system. The application is currently available in seven languages (Croatian, Czech, English, French, German, Japanese and Serbian). It consists of several categories: "My Drug Effects", "My Life Styles", "My Charts", "My Medication", "My Strategies", "My Supporters", "Settings" and "About". The main category "My Drug Effects" includes a list of 30 side effects with the possibility to add three additional side effects. Side effects are each accompanied by an appropriate description and the possibility to rate its severity on a visual analogue scale from 0-100%. The PsyLOG application is intended to enhance the link between patients and mental health professionals, serving as a tool that more objectively monitors side-effects over certain periods of time. To the best of our knowledge, no such applications have so far been developed for patients taking antipsychotic medication or for their therapists.
[Mh] Termos MeSH primário: Sistemas de Notificação de Reações Adversas a Medicamentos
Antipsicóticos/efeitos adversos
Aplicativos Móveis
Transtornos Psicóticos/tratamento farmacológico
Transtornos Psicóticos/psicologia
Autorrelato
[Mh] Termos MeSH secundário: Antipsicóticos/uso terapêutico
Croácia
Seres Humanos
Relações Médico-Paciente
Desenho de Programas de Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE


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[PMID]:28580908
[Au] Autor:Burnley T; Palmer CM; Winn M
[Ad] Endereço:Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, England.
[Ti] Título:Recent developments in the CCP-EM software suite.
[So] Source:Acta Crystallogr D Struct Biol;73(Pt 6):469-477, 2017 Jun 01.
[Is] ISSN:2059-7983
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As part of its remit to provide computational support to the cryo-EM community, the Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced a software framework which enables easy access to a range of programs and utilities. The resulting software suite incorporates contributions from different collaborators by encapsulating them in Python task wrappers, which are then made accessible via a user-friendly graphical user interface as well as a command-line interface suitable for scripting. The framework includes tools for project and data management. An overview of the design of the framework is given, together with a survey of the functionality at different levels. The current CCP-EM suite has particular strength in the building and refinement of atomic models into cryo-EM reconstructions, which is described in detail.
[Mh] Termos MeSH primário: Microscopia Crioeletrônica/métodos
Software
[Mh] Termos MeSH secundário: Desenho de Programas de Computador
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1107/S2059798317007859


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[PMID]:28579365
[Au] Autor:Wetzel HN; Cohen C; Norman AB; Webster RP
[Ad] Endereço:Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.
[Ti] Título:A novel Python program for implementation of quality control in the ELISA.
[So] Source:J Immunol Methods;448:80-84, 2017 Sep.
[Is] ISSN:1872-7905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The use of semi-quantitative assays such as the enzyme-linked immunosorbent assay (ELISA) requires stringent quality control of the data. However, such quality control is often lacking in academic settings due to unavailability of software and knowledge. Therefore, our aim was to develop methods to easily implement Levey-Jennings quality control methods. For this purpose, we created a program written in Python (a programming language with an open-source license) and tested it using a training set of ELISA standard curves quantifying the Fab fragment of an anti-cocaine monoclonal antibody in mouse blood. A colorimetric ELISA was developed using a goat anti-human anti-Fab capture method. Mouse blood samples spiked with the Fab fragment were tested against a standard curve of known concentrations of Fab fragment in buffer over a period of 133days stored at 4°C to assess stability of the Fab fragment and to generate a test dataset to assess the program. All standard curves were analyzed using our program to batch process the data and to generate Levey-Jennings control charts and statistics regarding the datasets. The program was able to identify values outside of two standard deviations, and this identification of outliers was consistent with the results of a two-way ANOVA. This program is freely available, which will help laboratories implement quality control methods, thus improving reproducibility within and between labs. We report here successful testing of the program with our training set and development of a method for quantification of the Fab fragment in mouse blood.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/sangue
Transtornos Relacionados ao Uso de Cocaína/diagnóstico
Cocaína/imunologia
Ensaio de Imunoadsorção Enzimática/normas
Fragmentos Fab das Imunoglobulinas/sangue
Controle de Qualidade
Desenho de Programas de Computador
Validação de Programas de Computador
Detecção do Abuso de Substâncias/normas
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Automação Laboratorial
Calibragem
Transtornos Relacionados ao Uso de Cocaína/sangue
Transtornos Relacionados ao Uso de Cocaína/imunologia
Camundongos
Valor Preditivo dos Testes
Padrões de Referência
Reprodutibilidade dos Testes
Detecção do Abuso de Substâncias/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Immunoglobulin Fab Fragments); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


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[PMID]:28548983
[Au] Autor:Staggers N; Elias BL
[Ad] Endereço:Nancy Staggers is the president of Summit Health Informatics and an adjunct professor, Biomedical Informatics and College of Nursing, at the University of Utah College in Salt Lake City, Utah. Beth L. Elias is a term associate professor, School of Nursing, at Virginia Commonwealth University in Richmond, Va.
[Ti] Título:Cross the nursing and HIT divide.
[So] Source:Nurs Manage;48(6):21-23, 2017 06.
[Is] ISSN:1538-8670
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Relações Interprofissionais
Enfermeiras e Enfermeiros/psicologia
Informática em Enfermagem/organização & administração
Desenho de Programas de Computador
[Mh] Termos MeSH secundário: Atitude Frente aos Computadores
Seres Humanos
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.1097/01.NUMA.0000516486.74049.90



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