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[PMID]:29192310
[Au] Autor:Maslove DM
[Ad] Endereço:Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.
[Ti] Título:Medical Preprints-A Debate Worth Having.
[So] Source:JAMA;319(5):443-444, 2018 Feb 06.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Revisão da Pesquisa por Pares
Editoração
[Mh] Termos MeSH secundário: Sistemas On-Line
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.17566


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[PMID]:27776073
[Au] Autor:American College of Obstetricians and Gynecologists' Committee on Adolescent Health Care
[Ti] Título:Committee Opinion No. 678: Comprehensive Sexuality Education.
[So] Source:Obstet Gynecol;128(5):e227-e230, 2016 11.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Current sexuality education programs vary widely in the accuracy of content, emphasis, and effectiveness. Data have shown that not all programs are equally effective for all ages, races and ethnicities, socioeconomic groups, and geographic areas. Studies have demonstrated that comprehensive sexuality education programs reduce the rates of sexual activity, sexual risk behaviors (eg, number of partners and unprotected intercourse), sexually transmitted infections, and adolescent pregnancy. One key component of an effective program is encouraging community-centered efforts. In addition to counseling and service provision to individual adolescent patients, obstetrician-gynecologists can serve parents and communities by supporting and assisting sexuality education. Because of their knowledge, experience, and awareness of a community's unique challenges, obstetrician-gynecologists can be an important resource for sexuality education programs.
[Mh] Termos MeSH primário: Educação Sexual/métodos
[Mh] Termos MeSH secundário: Adolescente
Ginecologia
Seres Humanos
Disseminação de Informação
Obstetrícia
Sistemas On-Line
Papel do Médico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29205914
[Au] Autor:Wlodawer A
[Ad] Endereço:Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD, USA.
[Ti] Título:Online tools for enhancing presentation, understanding, and retention of 3D structural data.
[So] Source:FEBS J;284(23):3974-3976, 2017 Dec.
[Is] ISSN:1742-4658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dr Alexander Wlodawer, an Editor for The FEBS Journal, provides an overview of three useful resources for structural biologists: Protopedia, Molstack and the Integrated Resource for Reproducibility in Macromolecular Crystallography (IRRMC).
[Mh] Termos MeSH primário: Biologia Computacional/métodos
Internet
Sistemas On-Line
Conformação Proteica
[Mh] Termos MeSH secundário: Cristalografia
Seres Humanos
Modelos Moleculares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1111/febs.14316


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[PMID]:28743395
[Au] Autor:Munoz G; Labadie P; Geneste E; Pardon P; Tartu S; Chastel O; Budzinski H
[Ad] Endereço:University of Bordeaux, EPOC, UMR 5805, LPTC Research Group, Talence F-33400, France.
[Ti] Título:Biomonitoring of fluoroalkylated substances in Antarctica seabird plasma: Development and validation of a fast and rugged method using on-line concentration liquid chromatography tandem mass spectrometry.
[So] Source:J Chromatogr A;1513:107-117, 2017 Sep 01.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report on a fast, accurate and rugged analytical procedure to determine a wide span of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in seabird plasma. The 26 investigated compounds included perfluoroalkyl carboxylates (C -C PFCAs), perfluoroalkyl sulfonates (C , C , C , C , C PFSAs), perfluorooctane sulfonamide (FOSA) and N-alkyl derivatives (MeFOSA, EtFOSA), N-alkyl perfluorooctane sulfonamido acetic acids (MeFOSAA, EtFOSAA), fluorotelomer sulfonates (4:2 FTSA, 6:2 FTSA, 8:2 FTSA), polyfluoroalkyl phosphate diesters (diPAPs) and perfluorooctane sulfonamide phosphate diester (diSAmPAP). The method described herein requires a reduced sample amount (25µL) and involves rapid and simple sample preparation (protein precipitation with acetonitrile but without acidification) prior to analysis by on-line solid phase extraction (Oasis HLB sorbent) coupled to high performance liquid chromatography negative electrospray ionization tandem mass spectrometry. The optimization was conducted using experimental designs to account for potential interactions between variables. Out of the 26 target analytes, 23 compounds showed excellent accuracy (±25% of the expected values). Intermediate precision and matrix effects remained acceptable for most analytes thanks to efficient internal standardization. A human serum standard reference material (NIST SRM 1957) was included in the validation scheme to evaluate method trueness, which proved satisfactory (│Z-scores│<2 for most compounds). Notwithstanding the small initial sample intake, limits of detection as low as 0.003-0.1ngg plasma were obtained. This allowed the determination of 11 target PFASs in Antarctic seabird plasma samples. ΣPFASs in Antarctic seabird plasma ranged from 0.37 to 19ngg , with a predominance of PFOS (>54% of ΣPFASs on average). The reduced plasma amount required implies that the present method could also be applied to the analysis of PFASs in the plasma of smaller biological models.
[Mh] Termos MeSH primário: Alcanossulfonatos/sangue
Charadriiformes/sangue
Monitoramento Ambiental/métodos
Sistemas On-Line
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Alcanossulfonatos/análise
Animais
Regiões Antárticas
Calibragem
Cromatografia Líquida de Alta Pressão/métodos
Fluorcarbonetos/sangue
Limite de Detecção
Oceanos e Mares
Extração em Fase Sólida
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Alkanesulfonates); 0 (Fluorocarbons); 6P60ZBK0QL (perfluorooctane)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:28902857
[Au] Autor:Lim SH; Mburu G; Bourne A; Pang J; Wickersham JA; Wei CKT; Yee IA; Wang B; Cassolato M; Azwa I
[Ad] Endereço:Center of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Willingness to use pre-exposure prophylaxis for HIV prevention among men who have sex with men in Malaysia: Findings from an online survey.
[So] Source:PLoS One;12(9):e0182838, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We examined willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM) in Malaysia. METHODS: An online survey of 990 MSM was conducted between March and April 2016. Eligibility criteria included being biological male, Malaysian citizen, 18 years of age or above, identifying as MSM, and being HIV negative or unknown status. Participants' demographics, sexual and drug use behaviors, attitudes towards PrEP, and preferences regarding future access to PrEP were collected. Bivariate analysis and logistic regression were performed to determine factors associated with willingness to use PrEP. RESULTS: Fewer than half of participants (44%) knew about PrEP before completing the survey. Overall, 39% of the sample were willing to take PrEP. Multivariate logistic regression indicated that Malay men (AOR: 1.73, 95% CI:1.12, 2.70), having 2 or more male anal sex partners in the past 6 months (AOR: 1.98, 95% CI: 1.29, 3.05), previous knowledge of PrEP (AOR: 1.40, 95%CI: 1.06, 1.86), lack of confidence in practising safer sex (AOR: 1.36, 95% CI: 1.02, 1.81), and having ever paid for sex with a male partner (AOR: 1.39, 95% CI: 1.01, 1.91) were independently associated with greater willingness to use PrEP, while men who identified as heterosexual were less willing to use PrEP (AOR, 0.36, 95% CI: 0.13, 0.97). Majority of participants preferred to access PrEP at affordable cost below 100 Malaysian Ringgit (USD25) per month from community based organisations followed by private or government hospitals. CONCLUSIONS: Overall, MSM in Malaysia reported a relatively low level of willingness to use PrEP, although willingness was higher among those previously aware of PrEP. There is a need to provide PrEP at affordable cost, increase demand and awareness of PrEP, and to provide access to this preventative medication via diverse, integrated and tailored sexual health services.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Infecções por HIV/prevenção & controle
Homossexualidade Masculina/estatística & dados numéricos
Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos
Profilaxia Pré-Exposição/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
HIV-1
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Malásia/epidemiologia
Masculino
Meia-Idade
Motivação
Sistemas On-Line
Parceiros Sexuais
Inquéritos e Questionários
Volição
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182838


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[PMID]:28902854
[Au] Autor:Wijayaratna KP; Dixit VV; Denant-Boemont L; Waller ST
[Ad] Endereço:Research Centre for Integrated Transport Innovation (rCITI), School of Civil and Environmental Engineering, University of New South Wales, Sydney, Australia.
[Ti] Título:An experimental study of the Online Information Paradox: Does en-route information improve road network performance?
[So] Source:PLoS One;12(9):e0184191, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigates the empirical presence of a theoretical transportation paradox, defined as the "Online Information Paradox" (OIP). The paradox suggests that, for certain road networks, the provision of online information deteriorate travel conditions for all users of that network relative to the situation where no online information is provided to users. The analytical presence of the paradox was derived for a specific network structure by using two equilibrium models, the first being the Expected User Equilibrium (EUE) solution (no information scenario) and the other being the User Equilibrium with Recourse (UER) solution (with information scenario). An incentivised computerised route choice game was designed using the concepts of experimental economics and administered in a controlled laboratory environment to investigate the physical presence of the paradox. Aggregate statistics of path flows and Total System Travel Costs (TSTC) were used to compare the experimental results with the theoretical findings. A total of 12 groups of 12 participants completed the experiment and the OIP and the occurrence of the OIP being significant was observed in 11 of the 12 cases. Though information increased travel costs for users on average, it reduced the volatility of travel costs experienced in the no information scenario indicating that information can achieve a more reliable system. Further replications of similar experiments and more importantly field based identification of the phenomena will force transport professionals to be aware of the emergence of the paradox. In addition, studies such as this emphasise the need for the adoption of adaptive traffic assignment techniques to appropriately model the acquisition of information on a road network.
[Mh] Termos MeSH primário: Comportamento de Escolha/fisiologia
Instrução por Computador
Disseminação de Informação/métodos
Sistemas On-Line
Transportes
[Mh] Termos MeSH secundário: Simulação por Computador
Seres Humanos
Serviços de Informação/normas
Mapas como Assunto
Modelos Teóricos
Transportes/métodos
Transportes/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184191


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[PMID]:28878809
[Au] Autor:Wazir U; Mokbel K; Carmichael A; Mokbel K
[Ad] Endereço:The London Breast Institute, Princess Grace Hospital, 45 Nottingham Place, London, W1U 5NY UK.
[Ti] Título:Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer?
[So] Source:Cell Mol Biol Lett;22:20, 2017.
[Is] ISSN:1689-1392
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clinicians use clinical and pathological parameters, such as tumour size, grade and nodal status, to make decisions on adjuvant treatments for breast cancer. However, therapeutic decisions based on these features tend to vary due to their subjectivity. Computational and mathematical algorithms were developed using clinical outcome data from breast cancer registries, such as Adjuvant! Online and NHS PREDICT. More recently, assessments of molecular profiles have been applied in the development of better prognostic tools. METHODS: Based on the available literature on online registry-based tools and genomic assays, we evaluated whether these online tools could be valid and accurate alternatives to genomic and molecular profiling of the individual breast tumour in aiding therapeutic decisions, particularly in patients with early ER-positive breast cancer. RESULTS AND CONCLUSIONS: Early breast cancer is currently considered a systemic disease and a complex ecosystem with behaviour determined by the complex genetic and molecular signatures of the tumour cells, mammary stem cells, microenvironment and host immune system. We anticipate that molecular profiling will continue to evolve, expanding beyond the primary tumour to include the tumour microenvironment, cancer stem cells and host immune system. This should further refine therapeutic decisions and optimise clinical outcome. This article was specially invited by the editors and represents work by leading researchers.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico
Perfilação da Expressão Gênica/métodos
Software
[Mh] Termos MeSH secundário: Neoplasias da Mama/genética
Feminino
Genômica/métodos
Seres Humanos
Sistemas On-Line
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1186/s11658-017-0049-x


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[PMID]:28704382
[Au] Autor:Liu JG; Liu XL; Guo Q; Han JT
[Ad] Endereço:Data Science and Cloud Service Research Centre, Shanghai University of Finance and Economics, Shanghai 200433, PR China.
[Ti] Título:Identifying the perceptive users for online social systems.
[So] Source:PLoS One;12(7):e0178118, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this paper, the perceptive user, who could identify the high-quality objects in their initial lifespan, is presented. By tracking the ratings given to the rewarded objects, we present a method to identify the user perceptibility, which is defined as the capability that a user can identify these objects at their early lifespan. Moreover, we investigate the behavior patterns of the perceptive users from three dimensions: User activity, correlation characteristics of user rating series and user reputation. The experimental results for the empirical networks indicate that high perceptibility users show significantly different behavior patterns with the others: Having larger degree, stronger correlation of rating series and higher reputation. Furthermore, in view of the hysteresis in finding the rewarded objects, we present a general framework for identifying the high perceptibility users based on user behavior patterns. The experimental results show that this work is helpful for deeply understanding the collective behavior patterns for online users.
[Mh] Termos MeSH primário: Relações Interpessoais
Modelos Psicológicos
[Mh] Termos MeSH secundário: Seres Humanos
Internet
Modelos Estatísticos
Sistemas On-Line
Mídias Sociais
Apoio Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178118


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[PMID]:28679576
[Au] Autor:Anderson LC; Krichbaum KE
[Ad] Endereço:Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota; and ander350@umn.edu.
[Ti] Título:Best practices for learning physiology: combining classroom and online methods.
[So] Source:Adv Physiol Educ;41(3):383-389, 2017 Sep 01.
[Is] ISSN:1522-1229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Physiology is a requisite course for many professional allied health programs and is a foundational science for learning pathophysiology, health assessment, and pharmacology. Given the demand for online learning in the health sciences, it is important to evaluate the efficacy of online and in-class teaching methods, especially as they are combined to form hybrid courses. The purpose of this study was to compare two hybrid physiology sections in which one section was offered mostly in-class (85% in-class), and the other section was offered mostly online (85% online). The two sections in 2 yr ( and ) were compared in terms of knowledge of physiology measured in exam scores and pretest-posttest improvement, and in measures of student satisfaction with teaching. In , there were some differences on individual exam scores between the two sections, but no significant differences in mean exam scores or in pretest-posttest improvements. However, in terms of student satisfaction, the mostly in-class students in rated the instructor significantly higher than did the mostly online students. Comparisons between in-class and online students in the cohort yielded data that showed that mean exam scores were not statistically different, but pre-post changes were significantly greater in the mostly online section; student satisfaction among mostly online students also improved significantly. Education researchers must investigate effective combinations of in-class and online methods for student learning outcomes, while maintaining the flexibility and convenience that online methods provide.
[Mh] Termos MeSH primário: Aprendizagem/fisiologia
Fisiologia/educação
Fisiologia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Sistemas On-Line
Satisfação Pessoal
Estudantes/psicologia
Estudantes/estatística & dados numéricos
Ensino/normas
Ensino/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1152/advan.00099.2016


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[PMID]:28662046
[Au] Autor:Almquist M; von Allmen RS; Carradice D; Oosterling SJ; McFarlane K; Wijnhoven B
[Ad] Endereço:Dept of Surgery, Skåne University Hospital, Lund, Sweden; Institution of Clinical Sciences, Lund University, Lund, Sweden.
[Ti] Título:A prospective study on an innovative online forum for peer reviewing of surgical science.
[So] Source:PLoS One;12(6):e0179031, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Peer review is important to the scientific process. However, the present system has been criticised and accused of bias, lack of transparency, failure to detect significant breakthrough and error. At the British Journal of Surgery (BJS), after surveying authors' and reviewers' opinions on peer review, we piloted an open online forum with the aim of improving the peer review process. METHODS: In December 2014, a web-based survey assessing attitudes towards open online review was sent to reviewers with a BJS account in Scholar One. From April to June 2015, authors were invited to allow their manuscripts to undergo online peer review in addition to the standard peer review process. The quality of each review was evaluated by editors and editorial assistants using a validated instrument based on a Likert scale. RESULTS: The survey was sent to 6635 reviewers. In all, 1454 (21.9%) responded. Support for online peer review was strong, with only 10% stating that they would not subject their manuscripts to online peer review. The most prevalent concern was about intellectual property, being highlighted in 118 of 284 comments (41.5%). Out of 265 eligible manuscripts, 110 were included in the online peer review trial. Around 7000 potential reviewers were invited to review each manuscript. In all, 44 of 110 manuscripts (40%) received 100 reviews from 59 reviewers, alongside 115 conventional reviews. The quality of the open forum reviews was lower than for conventional reviews (2.13 (± 0.75) versus 2.84 (± 0.71), P<0.001). CONCLUSION: Open online peer review is feasible in this setting, but it attracts few reviews, of lower quality than conventional peer reviews.
[Mh] Termos MeSH primário: Sistemas On-Line
Revisão dos Cuidados de Saúde por Pares
Procedimentos Cirúrgicos Operatórios
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179031



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