Base de dados : MEDLINE
Pesquisa : L01.453.245.390 [Categoria DeCS]
Referências encontradas : 538 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 54 ir para página                         

  1 / 538 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26693218
[Au] Autor:Hecht A; Busch-Heidger B; Gertzen H; Pfister H; Ruhfus B; Sanden PH; Schmidt GB
[Ad] Endereço:Global Quality Medicine, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
[Ti] Título:Quality expectations and tolerance limits of trial master files (TMF) - Developing a risk-based approach for quality assessments of TMFs.
[So] Source:Ger Med Sci;13:Doc23, 2015.
[Is] ISSN:1612-3174
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This article addresses the question of when a trial master file (TMF) can be considered sufficiently accurate and complete: What attributes does the TMF need to have so that a clinical trial can be adequately reconstructed from documented data and procedures? Clinical trial sponsors face significant challenges in assembling the TMF, especially when dealing with large, international, multicenter studies; despite all newly introduced archiving techniques it is becoming more and more difficult to ensure that the TMF is complete. This is directly reflected in the number of inspection findings reported and published by the EMA in 2014. Based on quality risk management principles in clinical trials the authors defined the quality expectations for the different document types in a TMF and furthermore defined tolerance limits for missing documents. This publication provides guidance on what type of documents and processes are most important, and in consequence, indicates on which documents and processes trial team staff should focus in order to achieve a high-quality TMF. The members of this working group belong to the CQAG Group (Clinical Quality Assurance Germany) and are QA (quality assurance) experts (auditors or compliance functions) with long-term experience in the practical handling of TMFs.
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto/métodos
Curadoria de Dados
Arquivamento
Registros como Assunto/normas
Gestão de Riscos/organização & administração
[Mh] Termos MeSH secundário: Acurácia dos Dados
Arquivamento/métodos
Arquivamento/normas
Guias como Assunto
Seres Humanos
Melhoria de Qualidade/organização & administração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE
[do] DOI:10.3205/000227


  2 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Biffi, Joäo Carlos Gabrielli
Texto completo SciELO Brasil
[PMID]:25466326
[Au] Autor:Oliveira MA; Venâncio JF; Raposo LH; Barbosa Júnior N; Biffi JC
[Ad] Endereço:Department of Endodontics, School of Dentistry, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
[Ti] Título:Morphometric evaluation and planning of anticurvature filing in roots of maxillary and mandibular molars.
[So] Source:Braz Oral Res;29:1-9, 2015.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study aimed to guide the planning of anticurvature filing using pre-determined anatomical points on teeth to establish directions for proper implementation of the technique. Two hundred digital periapical radiographs of human molar teeth were selected and divided into two groups (n = 100): MX (maxillary) and MD (mandibular) molars. Mesiobuccal roots were considered for the MX group and mesial roots for the MD group. Pre-determined anatomical points required for planning the anticurvature filing on the root canal path were located, and the distances between these points obtained. The anticurvature filing was simulated in two different protocols for each group, and the region of dentin removal and the remaining dentin thickness were measured in the safety and danger zones of the root canals. Statistical analysis was carried out at a significance level of 5%. The distances between the anatomical points and the thickness of remaining dentin showed significant differences when the two groups were compared (p < 0.001). No significant differences were found between the two experimental groups regarding the area of dentin removal at the root region, but differences were detected in comparison with dentin removal at the crown (p < 0.001). In terms of wear produced after simulation of both anticurvature filing protocols, significant differences were verified for all regions, except for the dentin remaining at the danger zone. The radiographic location of anatomical points allows for planning and implementation of controlled and efficient anticurvature filing and can be performed in the same manner for maxillary and mandibular molars.
[Mh] Termos MeSH primário: Arquivamento
Dente Molar/anatomia & histologia
Dente Molar/diagnóstico por imagem
Preparo de Canal Radicular/métodos
Raiz Dentária/anatomia & histologia
Raiz Dentária/diagnóstico por imagem
[Mh] Termos MeSH secundário: Análise de Variância
Pontos de Referência Anatômicos/diagnóstico por imagem
Dentina/anatomia & histologia
Dentina/diagnóstico por imagem
Seres Humanos
Odontometria/métodos
Radiografia
Valores de Referência
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1504
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:141204
[St] Status:MEDLINE


  3 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25326077
[Au] Autor:Norman P
[Ad] Endereço:Norman Consulting , 18 Pink Lane, Burnham, Bucks, SL1 8JW , UK peter.norman2@btinternet.com.
[Ti] Título:Evaluation of WO2014075392 and WO2014075393, Merck's first PI3Kδ inhibitor filings.
[So] Source:Expert Opin Ther Pat;24(11):1277-82, 2014 Nov.
[Is] ISSN:1744-7674
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: There is considerable interest in the development of selective PI3Kδ inhibitors for the treatment of inflammatory diseases and haematological cancers. Merck has no previous filings in this field but licensed Exelixis' programme, including its lead compound XL-499, in December 2011. AREAS COVERED: Both applications claim novel 9-alkyl-6,8-disubstituted purine derivatives as selective δ inhibitors for the treatment of asthma, obstructive airways disease, arthritis and cancer. The two applications differ in the range of exemplified substituents, the first focusing on 8-heteroaryl substituted purines, the second on 8-aminopurine derivatives. Many of the exemplified compounds have IC50 values < 10 nM against PI3Kδ with a number having sub-nanomolar potency. EXPERT OPINION: The compounds appear to be XL-499 derivatives, some of which are more potent than XL-499. The compounds claimed by Merck are some of the most potent PI3Kδ inhibitors yet described but it is unclear whether a development compound has been identified.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Classe I de Fosfatidilinositol 3-Quinases/antagonistas & inibidores
Inibidores de Proteínas Quinases/uso terapêutico
Purinas/uso terapêutico
Quinazolinonas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antirreumáticos/farmacologia
Arquivamento
Seres Humanos
Patentes como Assunto
Inibidores de Proteínas Quinases/química
Inibidores de Proteínas Quinases/farmacologia
Purinas/química
Purinas/farmacologia
Quinazolinonas/química
Quinazolinonas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antirheumatic Agents); 0 (Protein Kinase Inhibitors); 0 (Purines); 0 (Quinazolinones); EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (PIK3CD protein, human)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141018
[Lr] Data última revisão:
141018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141019
[St] Status:MEDLINE
[do] DOI:10.1517/13543776.2014.969710


  4 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:23771325
[Au] Autor:Toge R; Morishita J; Sasaki Y; Doi K
[Ad] Endereço:Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. risa.toge@gmail.com
[Ti] Título:Computerized image-searching method for finding correct patients for misfiled chest radiographs in a PACS server by use of biological fingerprints.
[So] Source:Radiol Phys Technol;6(2):437-43, 2013 Jul.
[Is] ISSN:1865-0341
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We have developed an automated image-searching method based on biological fingerprints for identifying correct patients in misfiled chest radiographs in a picture archiving and communication system (PACS) server. We used five biological fingerprints including distinctive anatomic structures in a misfiled chest radiograph of an unknown patient to find another image of the same patient stored with correct patient information in a PACS server. The correlation values were determined for the corresponding biological fingerprints in all images in the image server. The correlation indices as a measure of the overall similarity of the two images were determined from the summation of five correlation values and the combination of correlation values with the weighting factors. Finally, the correct patient was identified automatically by the image with the highest correlation index. By use of the summation of five correlation values as the correlation index, 78.0% (156/200) of the 200 patients for misfiled images were correctly identified in the database. When we applied the weighting factors for each biological fingerprint to determine the correlation index, the performance in identifying the correct patient was improved to 87.5% (175/200). An additional 5.0% (10/200) of images were included in the Top 10 ranking of the correlation index in the database. These cases could be identified manually by radiology personnel. We conclude that the automated image-searching method based on biological fingerprints with weighting factors would be useful for identification of the correct patient in the case of misfiled chest radiographs in a PACS server.
[Mh] Termos MeSH primário: Processamento Automatizado de Dados
Sistemas de Gerenciamento de Base de Dados
Sistemas de Identificação de Pacientes/métodos
Reconhecimento Automatizado de Padrão
Interpretação de Imagem Radiográfica Assistida por Computador/métodos
Radiografia Torácica
Sistemas de Informação em Radiologia
[Mh] Termos MeSH secundário: Algoritmos
Feminino
Arquivamento
Controle de Formulários e Registros
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1402
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130618
[St] Status:MEDLINE
[do] DOI:10.1007/s12194-013-0221-6


  5 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:23547285
[Au] Autor:Marx V
[Ti] Título:The author file: John Yates III.
[So] Source:Nat Methods;10(1):3, 2013 Jan.
[Is] ISSN:1548-7105
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Arquivamento
Espectrometria de Massas/métodos
Proteoma/análise
Proteômica/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Retratos como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteome)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130403
[St] Status:MEDLINE


  6 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:23329437
[Au] Autor:Bessoth F
[Ad] Endereço:Patent Attorneys Ter Meer Steinmeister & Partner, Munich, Germany. bessoth@termeer.de
[Ti] Título:Practical aspects of the preparation and filing of patent applications.
[So] Source:Methods Mol Biol;949:85-102, 2013.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This chapter is intended to give a brief introduction into the most important patent basics. More importantly, it provides some practical advice to scientists on various considerations when contemplating and preparing the filing of a patent application, irrespective of whether this is assisted by a patent professional or not.
[Mh] Termos MeSH primário: Arquivamento/métodos
Patentes como Assunto
[Mh] Termos MeSH secundário: Invenções
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1306
[Cu] Atualização por classe:130118
[Lr] Data última revisão:
130118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130119
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-62703-134-9_6


  7 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
[PMID]:23661826
[Au] Autor:Teviu EA; Aikins M; Abdulai TI; Sackey S; Boni P; Afari E; Wurapa F
[Ad] Endereço:Municipal Hospital, Goaso, P. O. Box 27, Goaso, Ghana.
[Ti] Título:Improving medical records filing in a municipal hospital in Ghana.
[So] Source:Ghana Med J;46(3):136-41, 2012 Sep.
[Is] ISSN:0016-9560
[Cp] País de publicação:Ghana
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Medical records are kept in the interest of both the patient and clinician. Proper filing of patient's medical records ensures easy retrieval and contributes to decreased patient waiting time at the hospital and continuity of care. This paper reports on an intervention study to address the issue of misfiling and multiple patient folders in a health facility. DESIGN: Intervention study. SETTING: Municipal Hospital, Goaso, Asunafo North District, Brong Ahafo Region, Ghana. METHODS: Methods employed for data collection were records review, direct observation and tracking of folders. Interventions instituted were staff durbars, advocacy and communication, consultations, in-service trainings, procurement and monitoring. Factors contributing to issuance of multiple folders and misfiling were determined. Proportion of multiple folders was estimated. RESULTS: Results revealed direct and indirect factors contributing to issuance of multiple patient folders and misfiling. Interventions and monitoring reduce acquisition of numerous medical folders per patient and misfiling. After the intervention, there was significant reduction in the use of multiple folders (i.e., overall 97% reduction) and a high usage of single patient medical folders (i.e., 99%). CONCLUSION: In conclusion, a defined medical records filing system with adequate training, logistics and regular monitoring and supervision minimises issuance of multiple folders and misfiling.
[Mh] Termos MeSH primário: Arquivamento/normas
Registros Médicos
[Mh] Termos MeSH secundário: Continuidade da Assistência ao Paciente
Gana
Gestão da Informação em Saúde/educação
Hospitais Municipais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1312
[Cu] Atualização por classe:150426
[Lr] Data última revisão:
150426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130511
[St] Status:MEDLINE


  8 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:23166996
[Au] Autor:Matlin B
[Ad] Endereço:EZ and Paperless. financialscience@yahoo.com
[Ti] Título:Your virtual filing cabinet.
[So] Source:Todays FDA;24(6):28, 31, 2012 Sep-Oct.
[Is] ISSN:1048-5317
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Sistemas de Computação
Arquivamento
Software
[Mh] Termos MeSH secundário: Auditoria Odontológica
Florida
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1212
[Cu] Atualização por classe:121121
[Lr] Data última revisão:
121121
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:121122
[St] Status:MEDLINE


  9 / 538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22752950
[Au] Autor:Spidlen J; Breuer K; Brinkman R
[Ad] Endereço:BC Cancer Agency, Terry Fox Laboratory, Vancouver, British Columbia, Canada.
[Ti] Título:Preparing a Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) compliant manuscript using the International Society for Advancement of Cytometry (ISAC) FCS file repository (FlowRepository.org).
[So] Source:Curr Protoc Cytom;Chapter 10:Unit 10.18, 2012 Jul.
[Is] ISSN:1934-9300
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:FlowRepository.org is a Web-based flow cytometry data repository provided by the International Society for Advancement of Cytometry (ISAC). It supports storage, annotation, analysis, and sharing of flow cytometry datasets. A fundamental tenet of scientific research is that published results should be open to independent validation and refutation. With FlowRepository, researchers can annotate their datasets in compliance with the Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) standard, thus greatly facilitating third-party interpretation of their data. In this unit, we will mainly focus on the deposition, sharing, and annotation of flow cytometry data.
[Mh] Termos MeSH primário: Bases de Dados Factuais
Arquivamento
Citometria de Fluxo/métodos
Fidelidade a Diretrizes
Internacionalidade
Internet
Sociedades Científicas
[Mh] Termos MeSH secundário: Armazenamento e Recuperação da Informação
Manuscritos como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1211
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120704
[St] Status:MEDLINE
[do] DOI:10.1002/0471142956.cy1018s61


  10 / 538 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:22571073
[Au] Autor:Deneyer M; Hachimi-Idrissi S; Michel L; Nyssen M; De Moor G; Vandenplas Y
[Ad] Endereço:Department of Paediatrics, Universitair Kinderziekenhuis Brussel. michel.deneyer@telenet.be
[Ti] Título:Electronic medical file exchange between on-duty care providers and the attending paediatrician: a Belgian paediatric pilot project.
[So] Source:Acta Chir Belg;112(2):116-20, 2012 Mar-Apr.
[Is] ISSN:0001-5458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The authors propose the introduction of a pilot project: "paediatric core file exchange in emergencies" (PCF-EXEM) which enables the exchange of medical data between the attending paediatrician (AP), holder of the medical record, and on-duty medical units (i.e. general practitioners, paediatricians, surgeons, emergency physicians,...). This project is based on two pillars: a protected server (PCF-server) containing paediatric core files (PCF), with important clinical data that should be available for the physician in order to quickly get a clear insight into the relevant clinical medical history of the child, and secondly, the possibility to provide feedback to the attending physician about the findings recorded during the on-call duty. The permanent availability of health data on the PCF-server and the possibility to provide feedback represent together the PCF-EXEM-project. This project meets the demand of the care providers to have relevant medical information permanently available in order to guarantee high quality care in emergency situations. The frail balance between the right to informative privacy and professional confidentiality on the one hand and the right to quality health care on the other hand has been taken into account. The technical and practical feasibility of this project is described. The objectives and vision of the PCF-EXEM project are conform to Belgian legislation concerning the processing of medical data and are in line with the still under consideration European projects which are focusing on interoperability and the development of a common access control to databanks containing health data for care providers. PCF-EXEM could therefore be a model for other EU countries as well.
[Mh] Termos MeSH primário: Registros Eletrônicos de Saúde
Arquivamento
Pediatria
Atenção Primária à Saúde
Qualidade da Assistência à Saúde
[Mh] Termos MeSH secundário: Bélgica
Criança
Confidencialidade
Serviço Hospitalar de Emergência
Estudos de Viabilidade
Retroalimentação Psicológica
Seres Humanos
Projetos Piloto
Privacidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1206
[Cu] Atualização por classe:120510
[Lr] Data última revisão:
120510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120511
[St] Status:MEDLINE



página 1 de 54 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde