Base de dados : MEDLINE
Pesquisa : L01.906 [Categoria DeCS]
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[PMID]:29351559
[Au] Autor:Hameed Z; Saleem S; Mirza J; Mustafa MS; Qamar-Ul-Islam
[Ad] Endereço:Department of Electrical Engineering, Institute of Space Technology, Islamabad, Pakistan.
[Ti] Título:Characterisation of ictal and interictal states of epilepsy: A system dynamic approach of principal dynamic modes analysis.
[So] Source:PLoS One;13(1):e0191392, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epilepsy is a brain disorder characterised by the recurrent and unpredictable interruptions of normal brain function, called epileptic seizures. The present study attempts to derive new diagnostic indices which may delineate between ictal and interictal states of epilepsy. To achieve this, the nonlinear modeling approach of global principal dynamic modes (PDMs) is adopted to examine the functional connectivity of the temporal and frontal lobes with the occipital brain segment using an ensemble of paediatric EEGs having the presence of epileptic seizure. The distinct spectral characteristics of global PDMs are found to be in line with the neural rhythms of brain dynamics. Moreover, we find that the linear trends of associated nonlinear functions (ANFs) associated with the 2nd and 4th global PDMs (representing delta, theta and alpha bands) of Fp1-F3 may differentiate between ictal and interictal states of epilepsy. These findings suggest that global PDMs and their associated ANFs may offer potential utility as diagnostic neural measures for ictal and interictal states of epilepsy.
[Mh] Termos MeSH primário: Epilepsia/diagnóstico
Epilepsia/fisiopatologia
[Mh] Termos MeSH secundário: Criança
Eletroencefalografia/estatística & dados numéricos
Lobo Frontal/fisiopatologia
Seres Humanos
Modelos Neurológicos
Dinâmica não Linear
Convulsões/diagnóstico
Convulsões/fisiopatologia
Análise de Sistemas
Lobo Temporal/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191392


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[PMID]:29351300
[Au] Autor:Holm S; Hilty LM; Lemm R; Thees O
[Ad] Endereço:Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Birmensdorf, Switzerland.
[Ti] Título:Empirical validation of an agent-based model of wood markets in Switzerland.
[So] Source:PLoS One;13(1):e0190605, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present an agent-based model of wood markets and show our efforts to validate this model using empirical data from different sources, including interviews, workshops, experiments, and official statistics. Own surveys closed gaps where data was not available. Our approach to model validation used a variety of techniques, including the replication of historical production amounts, prices, and survey results, as well as a historical case study of a large sawmill entering the market and becoming insolvent only a few years later. Validating the model using this case provided additional insights, showing how the model can be used to simulate scenarios of resource availability and resource allocation. We conclude that the outcome of the rigorous validation qualifies the model to simulate scenarios concerning resource availability and allocation in our study region.
[Mh] Termos MeSH primário: Comércio
Análise de Sistemas
Madeira
[Mh] Termos MeSH secundário: Modelos Teóricos
Suíça
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190605


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[PMID]:29391114
[Au] Autor:Russell TA; Angarita SAK; Showen A; Agopian V; Busuttil RW; Kaldas FM
[Ad] Endereço:Division of General Surgery, University of California Los Angeles, Los Angeles, California, USA.
[Ti] Título:Optimizing the Management of Abnormal Liver Function Tests after Orthotopic Liver Transplant: A Systems-Based Analysis of Health Care Utilization.
[So] Source:Am Surg;83(10):1152-1156, 2017 Oct 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Elevated liver function tests (eLFTs) are a major cause of unplanned readmissions (UR) after orthotopic liver transplantation. Diagnostic workup for eLFTs requires multiple invasive and noninvasive procedures, often done in the inpatient setting to expedite diagnosis, yet consequently resulting in increased costs. In this study, we evaluated eLFT readmissions at a single institution with respect to resource utilization. From 3/2013 to 12/2015, 388 patients underwent orthotopic liver transplantation, resulting in 463 UR totaling 5833 bed days; 87 (18.8%) UR and 929 (15.9%) bed days were for eLFTs. During eLFT-UR all patients underwent repeat laboratory testing, 75 (86.2%) liver ultrasound, 66 (75.8%) liver biopsy, and 17 (19.5%) endoscopic retrograde cholangiopancreatography. Discharge diagnoses were acute cellular rejection (40.2%), transaminitis not otherwise specified (17.2%), biliary complications (16.1%), recurrent hepatitis (11.5%), vascular complications (5.8%), viral hepatitis (5.8%), and steatohepatitis (3.5%). The greatest bed-day utilization was secondary to acute cellular rejection (60.8%) and biliary complications (13.7%). More than 35 per cent of eLFT-UR were due to transaminitis not otherwise specified, steatohepatitis, recurrent or viral hepatitis, none of which necessitate inpatient treatment. In addition, >25 per cent of eLFT-UR bed days were attributed to diagnostic workup. Identifying patients who can undergo expedited outpatient workup and require only outpatient management will result in significantly decreased readmissions, bed days, and hospital costs.
[Mh] Termos MeSH primário: Insuficiência Hepática/diagnóstico
Insuficiência Hepática/etiologia
Transplante de Fígado
Uso Excessivo de Produtos e Serviços de Saúde/estatística & dados numéricos
Readmissão do Paciente/estatística & dados numéricos
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: California
Seguimentos
Rejeição de Enxerto/diagnóstico
Rejeição de Enxerto/terapia
Insuficiência Hepática/terapia
Seres Humanos
Testes de Função Hepática
Complicações Pós-Operatórias/terapia
Análise de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29262277
[Au] Autor:Greene JA; Loscalzo J
[Ad] Endereço:From the Departments of Medicine and the History of Medicine and the Center for Medical Humanities and Social Medicine, Johns Hopkins University School of Medicine, Baltimore (J.A.G.); and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (J.L.).
[Ti] Título:Putting the Patient Back Together - Social Medicine, Network Medicine, and the Limits of Reductionism.
[So] Source:N Engl J Med;377(25):2493-2499, 2017 12 21.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doença/história
Filosofia Médica/história
Medicina Social/história
[Mh] Termos MeSH secundário: História do Século XVIII
História do Século XIX
História do Século XX
Seres Humanos
Modelos Biológicos
Determinantes Sociais da Saúde/história
Análise de Sistemas
Tuberculose/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMms1706744


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[PMID]:28742338
[Au] Autor:Zodrow KR; Li Q; Buono RM; Chen W; Daigger G; Dueñas-Osorio L; Elimelech M; Huang X; Jiang G; Kim JH; Logan BE; Sedlak DL; Westerhoff P; Alvarez PJJ
[Ad] Endereço:Department of Civil and Environmental Engineering, Rice University , Houston, Texas 77005, United States.
[Ti] Título:Advanced Materials, Technologies, and Complex Systems Analyses: Emerging Opportunities to Enhance Urban Water Security.
[So] Source:Environ Sci Technol;51(18):10274-10281, 2017 Sep 19.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Innovation in urban water systems is required to address the increasing demand for clean water due to population growth and aggravated water stress caused by water pollution, aging infrastructure, and climate change. Advances in materials science, modular water treatment technologies, and complex systems analyses, coupled with the drive to minimize the energy and environmental footprints of cities, provide new opportunities to ensure a resilient and safe water supply. We present a vision for enhancing efficiency and resiliency of urban water systems and discuss approaches and research needs for overcoming associated implementation challenges.
[Mh] Termos MeSH primário: Mudança Climática
Análise de Sistemas
Abastecimento de Água
[Mh] Termos MeSH secundário: Cidades
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b01679


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[PMID]:28747196
[Au] Autor:Doherty T; Besada D; Goga A; Daviaud E; Rohde S; Raphaely N
[Ad] Endereço:Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa. Tanya.doherty@mrc.ac.za.
[Ti] Título:"If donors woke up tomorrow and said we can't fund you, what would we do?" A health system dynamics analysis of implementation of PMTCT option B+ in Uganda.
[So] Source:Global Health;13(1):51, 2017 Jul 26.
[Is] ISSN:1744-8603
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In October 2012 Uganda extended its prevention of mother to child HIV transmission (PMTCT) policy to Option B+, providing lifelong antiretroviral treatment for HIV positive pregnant and breastfeeding women. The rapid changes and adoptions of new PMTCT policies have not been accompanied by health systems research to explore health system preparedness to implement such programmes. The implementation of Option B+ provides many lessons which can inform the shift to 'Universal Test and Treat', a policy which many sub-Saharan African countries are preparing to adopt, despite fragile health systems. METHODS: This qualitative study of PMTCT Option B+ implementation in Uganda three years following the policy adoption, uses the health system dynamics framework to explore the impacts of this programme on ten elements of the health system. Qualitative data were gathered through rapid appraisal during in-country field work. Key informant interviews and focus group discussions (FGDs) were undertaken with the Ministry of Health, implementing partners, multilateral agencies, district management teams, facility-based health workers and community cadres. A total of 82 individual interviews and 16 focus group discussions were completed. We conducted a simple manifest analysis, using the ten elements of a health system for grouping data into categories and themes. RESULTS: Of the ten elements in the health system dynamics framework, context and resources (finances, infrastructure & supplies, and human resources) were the most influential in the implementation of Option B+ in Uganda. Support from international actors and implementing partners attempted to strengthen resources at district level, but had unintended consequences of creating dependence and uncertainty regarding sustainability. CONCLUSIONS: The health system dynamics framework offers a novel approach to analysis of the effects of implementation of a new policy on critical elements of the health system. Its emphasis on relationships between system elements, population and context is helpful in unpacking impacts of and reactions to pressures on the system, which adds value beyond some previous frameworks.
[Mh] Termos MeSH primário: Infecções por HIV/prevenção & controle
Política de Saúde
Transmissão Vertical de Doença Infecciosa/prevenção & controle
[Mh] Termos MeSH secundário: África do Norte
Feminino
Administração Financeira
Infecções por HIV/tratamento farmacológico
Infecções por HIV/transmissão
Seres Humanos
Gravidez
Análise de Sistemas
Uganda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12992-017-0272-2


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[PMID]:29073653
[Au] Autor:Robb G; Stolarek I; Wells S; Bohm G
[Ad] Endereço:Senior Advisor, Health Quality & Safety Commission, Wellington.
[Ti] Título:The state of quality improvement and patient safety teaching in health professional education in New Zealand.
[So] Source:N Z Med J;130(1464):13-24, 2017 Oct 27.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:AIM: To investigate how quality and patient safety domains are being taught in the pre-registration curricula of health profession education programmes in New Zealand. METHODS: All tertiary institutions providing training for medicine, nursing, midwifery, dentistry, pharmacy, physiotherapy, dietetics and 11 other allied health professions in New Zealand were contacted and a person with relevant curriculum knowledge was invited to participate. Interviews were conducted using a semi-structured interview guide to explore nine quality and safety domains; improvement science, patient safety, quality and safety culture, evidence-based practice, patient-centred care, teamwork and communication, leadership for change, systems thinking and use of information technology (IT). Transcribed data were extracted and categorised by discipline and domain. Two researchers independently identified and categorised themes within each domain, using a general inductive approach. RESULTS: Forty-nine institutions were contacted and 43 (88%) people were interviewed. The inclusion and extent of quality and safety teaching was variable. Evidence-based practice, patient-centred care and teamwork and communication were the strongest domains and well embedded in programmes, while leadership, systems thinking and the role of IT were less explicitly included. Except for two institutions, improvement science was absent from pre-registration curricula. Patient safety teaching was focused mainly around incident reporting, and to a lesser extent learning from adverse events. Although a 'no blame' culture was articulated as important, the theme of individual accountability was still apparent. While participants agreed that all domains were important, the main barriers to incorporating improvement science and patient safety concepts into existing programmes included an 'already stretched curriculum' and having faculty with limited expertise in these areas. CONCLUSIONS: Although the building blocks for improving the quality and safety of healthcare are present, this national study of multiple health professional pre-registration education programmes has identified teaching gaps in patient safety and improvement science methods and tools. Failure to address these gaps will compromise the ability of new graduates to successfully implement and sustain improvements.
[Mh] Termos MeSH primário: Currículo
Pessoal de Saúde/educação
Segurança do Paciente/normas
Melhoria de Qualidade
[Mh] Termos MeSH secundário: Comunicação
Prática Clínica Baseada em Evidências/normas
Seres Humanos
Liderança
Informática Médica
Nova Zelândia
Cultura Organizacional
Equipe de Assistência ao Paciente/normas
Assistência Centrada no Paciente/normas
Pesquisa Qualitativa
Análise de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE


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[PMID]:29040294
[Au] Autor:Riaz F; Niazi MA
[Ad] Endereço:Dept. Of Computing-Iqra University, Islamabad, Pakistan.
[Ti] Título:Towards social autonomous vehicles: Efficient collision avoidance scheme using Richardson's arms race model.
[So] Source:PLoS One;12(10):e0186103, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper presents the concept of a social autonomous agent to conceptualize such Autonomous Vehicles (AVs), which interacts with other AVs using social manners similar to human behavior. The presented AVs also have the capability of predicting intentions, i.e. mentalizing and copying the actions of each other, i.e. mirroring. Exploratory Agent Based Modeling (EABM) level of the Cognitive Agent Based Computing (CABC) framework has been utilized to design the proposed social agent. Furthermore, to emulate the functionality of mentalizing and mirroring modules of proposed social agent, a tailored mathematical model of the Richardson's arms race model has also been presented. The performance of the proposed social agent has been validated at two levels-firstly it has been simulated using NetLogo, a standard agent-based modeling tool and also, at a practical level using a prototype AV. The simulation results have confirmed that the proposed social agent-based collision avoidance strategy is 78.52% more efficient than Random walk based collision avoidance strategy in congested flock-like topologies. Whereas practical results have confirmed that the proposed scheme can avoid rear end and lateral collisions with the efficiency of 99.876% as compared with the IEEE 802.11n-based existing state of the art mirroring neuron-based collision avoidance scheme.
[Mh] Termos MeSH primário: Acidentes de Trânsito/prevenção & controle
Condução de Veículo/psicologia
Automóveis
Aprendizado de Máquina
Modelos Psicológicos
Robótica/instrumentação
[Mh] Termos MeSH secundário: Simulação por Computador
Seres Humanos
Comportamento Imitativo
Intenção
Robótica/métodos
Análise de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186103


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[PMID]:29031440
[Au] Autor:Özkal CB; Frontistis Z; Antonopoulou M; Konstantinou I; Mantzavinos D; Meriç S
[Ad] Endereço:Environmental Engineering, Namik Kemal University, Faculty of Engineering, Tekirdag, Turkey. Electronic address: cbozkal@nku.edu.tr.
[Ti] Título:Removal of antibiotics in a parallel-plate thin-film-photocatalytic reactor: Process modeling and evolution of transformation by-products and toxicity.
[So] Source:J Environ Sci (China);60:114-122, 2017 Oct.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Photocatalytic degradation of sulfamethoxazole (SMX) antibiotic has been studied under recycling batch and homogeneous flow conditions in a thin-film coated immobilized system namely parallel-plate (PPL) reactor. Experimentally designed, statistically evaluated with a factorial design (FD) approach with intent to provide a mathematical model takes into account the parameters influencing process performance. Initial antibiotic concentration, UV energy level, irradiated surface area, water matrix (ultrapure and secondary treated wastewater) and time, were defined as model parameters. A full of 2 experimental design was consisted of 32 random experiments. PPL reactor test experiments were carried out in order to set boundary levels for hydraulic, volumetric and defined defined process parameters. TTIP based thin-film with polyethylene glycol+TiO additives were fabricated according to pre-described methodology. Antibiotic degradation was monitored by High Performance Liquid Chromatography analysis while the degradation products were specified by LC-TOF-MS analysis. Acute toxicity of untreated and treated SMX solutions was tested by standard Daphnia magna method. Based on the obtained mathematical model, the response of the immobilized PC system is described with a polynomial equation. The statistically significant positive effects are initial SMX concentration, process time and the combined effect of both, while combined effect of water matrix and irradiated surface area displays an adverse effect on the rate of antibiotic degradation by photocatalytic oxidation. Process efficiency and the validity of the acquired mathematical model was also verified for levofloxacin and cefaclor antibiotics. Immobilized PC degradation in PPL reactor configuration was found capable of providing reduced effluent toxicity by simultaneous degradation of SMX parent compound and TBPs.
[Mh] Termos MeSH primário: Antibacterianos/química
Modelos Químicos
Processos Fotoquímicos
Eliminação de Resíduos Líquidos/métodos
Águas Residuais/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Antibacterianos/toxicidade
Análise de Sistemas
Testes de Toxicidade
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Waste Water); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE


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[PMID]:29020024
[Au] Autor:Sun R; Mendez D
[Ad] Endereço:Department of Health Management and Policy, University of Michigan, Ann Arbor, MI, United States of America.
[Ti] Título:An application of the Continuous Opinions and Discrete Actions (CODA) model to adolescent smoking initiation.
[So] Source:PLoS One;12(10):e0186163, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the impact of peers' opinions on the smoking initiation process among adolescents. We applied the Continuous Opinions and Discrete Actions (CODA) model to study how social interactions change adolescents' opinions and behaviors about smoking. Through agent-based modeling (ABM), we simulated a population of 2500 adolescents and compared smoking prevalence to data from 9 cohorts of adolescents in the National Survey on Drug Use and Health (NSDUH) from year 2001 till 2014. Our model adjusts well for NSDUH data according to pseudo R2 values, which are at least 96%. Optimal parameter values indicate that adolescents exhibit imitator characteristics with regard to smoking opinions. The imitator characteristics suggests that teenagers tend to update their opinions consistently according to what others do, and these opinions later translate into smoking behaviors. As a result, peer influence from social networks plays a big role in the smoking initiation process and should be an important driver in policy formulation.
[Mh] Termos MeSH primário: Fumar
Análise de Sistemas
[Mh] Termos MeSH secundário: Adolescente
Estudos de Coortes
Simulação por Computador
Seres Humanos
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186163



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