[PMID]: | 29352322 |
[Au] Autor: | Mohr C; Friedrich A; Wojnar D; Kenar E; Polatkan AC; Codrea MC; Czemmel S; Kohlbacher O; Nahnsen S |
[Ad] Endereço: | Applied Bioinformatics, Center for Bioinformatics Tübingen, University of Tübingen, Sand 14, 72076 Tübingen, Germany. |
[Ti] Título: | qPortal: A platform for data-driven biomedical research. |
[So] Source: | PLoS One;13(1):e0191603, 2018. |
[Is] ISSN: | 1932-6203 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Modern biomedical research aims at drawing biological conclusions from large, highly complex biological datasets. It has become common practice to make extensive use of high-throughput technologies that produce big amounts of heterogeneous data. In addition to the ever-improving accuracy, methods are getting faster and cheaper, resulting in a steadily increasing need for scalable data management and easily accessible means of analysis. We present qPortal, a platform providing users with an intuitive way to manage and analyze quantitative biological data. The backend leverages a variety of concepts and technologies, such as relational databases, data stores, data models and means of data transfer, as well as front-end solutions to give users access to data management and easy-to-use analysis options. Users are empowered to conduct their experiments from the experimental design to the visualization of their results through the platform. Here, we illustrate the feature-rich portal by simulating a biomedical study based on publically available data. We demonstrate the software's strength in supporting the entire project life cycle. The software supports the project design and registration, empowers users to do all-digital project management and finally provides means to perform analysis. We compare our approach to Galaxy, one of the most widely used scientific workflow and analysis platforms in computational biology. Application of both systems to a small case study shows the differences between a data-driven approach (qPortal) and a workflow-driven approach (Galaxy). qPortal, a one-stop-shop solution for biomedical projects offers up-to-date analysis pipelines, quality control workflows, and visualization tools. Through intensive user interactions, appropriate data models have been developed. These models build the foundation of our biological data management system and provide possibilities to annotate data, query metadata for statistics and future re-analysis on high-performance computing systems via coupling of workflow management systems. Integration of project and data management as well as workflow resources in one place present clear advantages over existing solutions. |
[Mh] Termos MeSH primário: |
Pesquisa Biomédica Metodologias Computacionais Software
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[Mh] Termos MeSH secundário: |
Pesquisa Biomédica/estatística & dados numéricos Biologia Computacional/métodos Biologia Computacional/estatística & dados numéricos Sistemas de Gerenciamento de Base de Dados/estatística & dados numéricos Bases de Dados Factuais/estatística & dados numéricos Bases de Dados Genéticas/estatística & dados numéricos Sequenciamento de Nucleotídeos em Larga Escala/estatística & dados numéricos Seres Humanos Internet Interface Usuário-Computador Fluxo de Trabalho
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Em] Mês de entrada: | 1802 |
[Cu] Atualização por classe: | 180226 |
[Lr] Data última revisão:
| 180226 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 180121 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1371/journal.pone.0191603 |
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