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[PMID]: 29297078 [Au] Autor: Knip M; Åkerblom HK; Al Taji E; Becker D; Bruining J; Castano L; Danne T; de Beaufort C; Dosch HM; Dupre J; Fraser WD; Howard N; Ilonen J; Konrad D; Kordonouri O; Krischer JP; Lawson ML; Ludvigsson J; Madacsy L; Mahon JL; Ormisson A; Palmer JP; Pozzilli P; Savilahti E; Serrano-Rios M; Songini M; Taback S; Vaarala O; White NH; Virtanen SM; Wasikowa R; Writing Group for the TRIGR Study Group [Ad] Endereço: University of Helsinki, Helsinki, Finland. [Ti] Título: Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial. [So] Source: JAMA;319(1):38-48, 2018 01 02. [Is] ISSN: 1538-3598 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Importance: Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed formulas. Objective: To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children. Design, Setting, and Participants: An international double-blind randomized clinical trial of 2159 infants with human leukocyte antigen-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to January 2007 in 78 study centers in 15 countries; 1081 were randomized to be weaned to the extensively hydrolyzed casein formula and 1078 to a conventional formula. The follow-up of the participants ended on February 28, 2017. Interventions: The participants received either a casein hydrolysate or a conventional adapted cow's milk formula supplemented with 20% of the casein hydrolysate. The minimum duration of study formula exposure was 60 days by 6 to 8 months of age. Main Outcomes and Measures: Primary outcome was type 1 diabetes diagnosed according to World Health Organization criteria. Secondary outcomes included age at diabetes diagnosis and safety (adverse events). Results: Among 2159 newborn infants (1021 female [47.3%]) who were randomized, 1744 (80.8%) completed the trial. The participants were observed for a median of 11.5 years (quartile [Q] 1-Q3, 10.2-12.8). The absolute risk of type 1 diabetes was 8.4% among those randomized to the casein hydrolysate (n = 91) vs 7.6% among those randomized to the conventional formula (n = 82) (difference, 0.8% [95% CI, -1.6% to 3.2%]). The hazard ratio for type 1 diabetes adjusted for human leukocyte antigen risk group, duration of breastfeeding, duration of study formula consumption, sex, and region while treating study center as a random effect was 1.1 (95% CI, 0.8 to 1.5; P = .46). The median age at diagnosis of type 1 diabetes was similar in the 2 groups (6.0 years [Q1-Q3, 3.1-8.9] vs 5.8 years [Q1-Q3, 2.6-9.1]; difference, 0.2 years [95% CI, -0.9 to 1.2]). Upper respiratory infections were the most common adverse event reported (frequency, 0.48 events/year in the hydrolysate group and 0.50 events/year in the control group). Conclusions and Relevance: Among infants at risk for type 1 diabetes, weaning to a hydrolyzed formula compared with a conventional formula did not reduce the cumulative incidence of type 1 diabetes after median follow-up for 11.5 years. These findings do not support a need to revise the dietary recommendations for infants at risk for type 1 diabetes. Trial Registration: clinicaltrials.gov Identifier: NCT00179777. [Mh] Termos MeSH primário: Caseínas Diabetes Mellitus Tipo 1/prevenção & controle Fórmulas Infantis [Mh] Termos MeSH secundário: Criança Diabetes Mellitus Tipo 1/epidemiologia Intervalo Livre de Doença Método Duplo-Cego Feminino Seguimentos Seres Humanos Fenômenos Fisiológicos da Nutrição do Lactente Recém-Nascido Masculino Política Nutricional Risco [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Caseins); 65072-00-6 (casein hydrolysate) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180311 [Lr] Data última revisão: 180311 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180104 [Cl] Clinical Trial: ClinicalTrial [St] Status: MEDLINE [do] DOI: 10.1001/jama.2017.19826

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[PMID]: 29297068 [Au] Autor: Xu G; Strathearn L; Liu B; Bao W [Ad] Endereço: Department of Epidemiology, University of Iowa College of Public Health, Iowa City. [Ti] Título: Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016. [So] Source: JAMA;319(1):81-82, 2018 01 02. [Is] ISSN: 1538-3598 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Transtorno do Espectro Autista/epidemiologia [Mh] Termos MeSH secundário: Adolescente Criança Pré-Escolar Feminino Inquéritos Epidemiológicos Seres Humanos Masculino Prevalência Estados Unidos/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180311 [Lr] Data última revisão: 180311 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180104 [St] Status: MEDLINE [do] DOI: 10.1001/jama.2017.17812

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[PMID]: 29173737 [Au] Autor: Peris TS; Rozenman MS; Sugar CA; McCracken JT; Piacentini J [Ad] Endereço: UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles. Electronic address: tperis@mednet.ucla.edu. [Ti] Título: Targeted Family Intervention for Complex Cases of Pediatric Obsessive-Compulsive Disorder: A Randomized Controlled Trial. [So] Source: J Am Acad Child Adolesc Psychiatry;56(12):1034-1042.e1, 2017 Dec. [Is] ISSN: 1527-5418 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Although evidence-based treatments for pediatric obsessive-compulsive disorder (OCD) exist, many youth fail to respond, and interventions tailored to the needs of specific subsets of patients are lacking. This study examines the efficacy of a family intervention module designed for cases of OCD complicated by poor family functioning. METHOD: Participants were 62 youngsters aged 8 to 17 years (mean age = 12.71 years; 57% male; 65% white) with a primary diagnosis of OCD and at least 2 indicators of poor family functioning. They were randomized to receive 12 sessions of individual child cognitive-behavioral therapy (CBT) plus weekly parent psychoeducation and session review (standard treatment [ST]) or the same 12 child sessions plus 6 sessions of family therapy aimed at improving OCD-related emotion regulation and problem solving (positive family interaction therapy [PFIT]). Blinded raters evaluated outcomes and tracked responders to 3-month follow-up. RESULTS: Compared to ST, PFIT demonstrated better overall response rates on the Clinician Global Impression-Improvement scale (CGI-I; 68% versus 40%, p = .03, φ = 0.28) and rates of remission (58% PFIT versus 27% ST, p = .01, φ = 0.32). PFIT also produced significantly greater reductions in functional impairment, symptom accommodation, and family conflict, and improvements in family cohesion. As expected, these shifts in family functioning constitute an important treatment mechanism, with changes in accommodation mediating treatment response. CONCLUSION: PFIT is efficacious for reducing OCD symptom severity and impairment and for improving family functioning. Findings are discussed in terms of personalized medicine and mechanisms of change in pediatric OCD treatment. Clinical trial registration information-Family Focused Treatment of Pediatric Obsessive Compulsive Disorder; http://clinicaltrials.gov/; NCT01409642. [Mh] Termos MeSH primário: Terapia Cognitiva/métodos Terapia Familiar/métodos Transtorno Obsessivo-Compulsivo/terapia Pais/educação [Mh] Termos MeSH secundário: Adolescente Criança Terapia Combinada Relações Familiares Feminino Seguimentos Seres Humanos Masculino Transtorno Obsessivo-Compulsivo/diagnóstico Escalas de Graduação Psiquiátrica Método Simples-Cego Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180311 [Lr] Data última revisão: 180311 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [Cl] Clinical Trial: ClinicalTrial [St] Status: MEDLINE

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[PMID]: 27770708 [Au] Autor: Glorennec P; Lucas JP; Mercat AC; Roudot AC; Le Bot B [Ad] Endereço: EHESP, School of Public Health, Sorbonne Paris Cité, - Avenue du Professeur Léon-Bernard, CS 74312, 35043 Rennes cedex, France; Irset Inserm, UMR 1085-Institut de Recherche sur la Santé, l'Environnement et le Travail, Rennes, France. Electronic address: Philippe.glorennec@ehesp.fr. [Ti] Título: Environmental and dietary exposure of young children to inorganic trace elements. [So] Source: Environ Int;97:28-36, 2016 12. [Is] ISSN: 1873-6750 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Children are exposed to toxic metals and metalloids via their diet and environment. Our objective was to assess the aggregate chronic exposure of children aged 3-6years, living in France, to As, Cd, Cr, Cu, Mn, Pb, Sb, Sr, and V present in diet, tap water, air, soil and floor dust in the years 2007-2009. Dietary data came from the French Total Diet Study, while concentrations in residential tap water, soil and indoor floor dust came from the 'Plomb-Habitat' nationwide representative survey on children's lead exposure at home. Indoor air concentrations were assumed to be equal to outdoor air concentrations, which were retrieved from regulatory measurements networks. Human exposure factors were retrieved from literature. Data were combined with Monte Carlo simulations. Median exposures were 1.7, 0.3, 10.2, 34.1, 60.3, 0.7, 0.1, 44.3, 1.5 and 95th percentiles were 4.4, 0.5, 15.8, 61.3, 98.3, 2.5, 0.1, 111.1, 2.9µg/kgbw/d for As, Cd, Cr, Cu, Mn, Pb, Sb, Sr, and V respectively. Dietary exposures dominate aggregate exposures, with the notable exception of Pb - for which soils and indoor floor dust ingestion contribute most at the 95th percentile. The strengths of this study are that it aggregates exposures that are often estimated separately, and uses a large amount of representative data. This assessment is limited to main diet and residential exposure, and does not take into account the relative bioavailability of compounds. These results could be used to help target prevention strategies. [Mh] Termos MeSH primário: Poluentes Ambientais/toxicidade Oligoelementos/toxicidade [Mh] Termos MeSH secundário: Poluição do Ar em Ambientes Fechados/efeitos adversos Criança Pré-Escolar Exposição Dietética/efeitos adversos Poeira/análise Exposição Ambiental/efeitos adversos Monitoramento Ambiental/métodos Feminino França Intoxicação por Metais Pesados Seres Humanos Masculino Poluentes do Solo/análise Poluentes do Solo/toxicidade Poluentes Químicos da Água/análise Poluentes Químicos da Água/toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Dust); 0 (Environmental Pollutants); 0 (Soil Pollutants); 0 (Trace Elements); 0 (Water Pollutants, Chemical) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 180311 [Lr] Data última revisão: 180311 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161023 [St] Status: MEDLINE

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[PMID]: 29505530 [Au] Autor: Shao H; Liu P; Zhang H; Chen C; Lin X [Ad] Endereço: Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University. [Ti] Título: Noncystoscopic removal of retained ureteral stents in children: A retrospective study from a single-center. [So] Source: Medicine (Baltimore);97(1):e9540, 2018 Jan. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Cystoscopic technique is the current common method of retrieving double J ureteral stent in most pediatric urological centers. In this study, we evaluated the feasibility and efficacy of a novel noncystoscopic method to remove retained ureteral stents in pediatric patients.We reviewed all medical records from a total of 102 patients who were treated in our hospital between January 2013 and December 2016 to remove the double J ureteral stent retained into the ureter. The pediatric patients were divided into 2 groups based on different surgical options: cystoscopic group and noncystoscopic group. The surgery time (including time for instrument preparation), operation time, expenses, postoperative urination discomfort, and hospitalization were compared between the 2 groups.The noncystoscopic group took significantly less time for surgery and operation than the cystoscopic group (surgery time:7.40 ±â€Š3.75 vs 18.42 ±â€Š2.77 min, P <.05; operation time: 3.54 ±â€Š2.03 vs 4.48 ±â€Š2.04 min, P <.05). The mean spending for patients in the noncystoscopic group were less than that in the cystoscopic group ($736.70 ±â€Š105.96 vs $618.23 ±â€Š110.31, P <.05). There were less children with postoperative urination discomforts in the noncystoscopic group than that in the cystoscopic group (8 vs 20 cases, χ = 4.241, P <.05). The mean hospitalization of the noncystoscopic group was shorter than that of the cystoscopic group (3.20 ±â€Š1.25 vs 4.13 ±â€Š1.63 d, P <.05). The differences in all comparison projects were significant.The noncystoscopic procedure is a safe and viable technique that may be used successfully in pediatric urology. This novel procedure which is much safer and more affordable provides an alternative solution to remove retained ureteral stents in child patients. [Mh] Termos MeSH primário: Remoção de Dispositivo/métodos Stents Ureter [Mh] Termos MeSH secundário: Adolescente Criança Pré-Escolar Cistoscopia/utilização Remoção de Dispositivo/estatística & dados numéricos Feminino Seres Humanos Lactente Masculino Estudos Retrospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180306 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009540

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[PMID]: 29505509 [Au] Autor: Xu L; Zhu Y; Yu J; Deng M; Zhu X [Ad] Endereço: Department of Children's Critical Care Medicine, Xin-Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. [Ti] Título: Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review. [So] Source: Medicine (Baltimore);97(1):e9112, 2018 Jan. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. SJS in children is not common but potentially serious disease. But the epidemiology of SJS in China is not well defined. PATIENT CONCERNS: A 6-year-old boy was initially diagnosed as pneumonia admitted to hospital after admission, and the body appears red rash with blisters, skin damage, lip debaucjed, repeated high fever, and rapid progression. DIAGNOSES: SJS often results from an allergy reaction response to a range of drugs. It is a clinical diagnosis suggested by fever and malaise followed by an extensive painful, nonblanching, macular rash that commonly progresses to blistering or sloughing, and mucositis. INTERVENTIONS: The boy was treated with continuous renal replacement therapy, anti-infection therapy, high-dose glucocorticoid treatment, and symptomatic treatment. OUTCOMES: The patient was recovered after 33 days of treatment. LESSONS: The current treatment is mainly symptomatic treatment, and for the patient, it is important to make skin care related well, included early out blisters at effusion, reducing skin ulceration of the mucosa area, keeping skin clean, removing mucosa secretion and blood clots, doing eye care related, preventing the complications, ensuring adequate intake of nutrition and warm and so on. [Mh] Termos MeSH primário: Antibacterianos/efeitos adversos Azitromicina/efeitos adversos Higiene da Pele/enfermagem Síndrome de Stevens-Johnson/enfermagem [Mh] Termos MeSH secundário: Criança Seres Humanos Masculino Pneumonia/tratamento farmacológico Síndrome de Stevens-Johnson/etiologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 83905-01-5 (Azithromycin) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180306 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009112

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[PMID]: 29505508 [Au] Autor: Li W; Cheng X; Guo L; Li H; Sun C; Cui X; Zhang Q; Song G [Ad] Endereço: Department of ICU, Affiliated Children's Hospital of Capital Institute of Pediatrics. [Ti] Título: Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children. [So] Source: Medicine (Baltimore);97(1):e9060, 2018 Jan. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We assessed the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and community-acquired pneumonia (CAP) among Chinese children.This observational study examined children aged 3 days to 14 years (n = 1582) from the Capital Institute of Pediatrics in 2009 to 2011. There were 797 children in the CAP group and 785 controls. The CAP group was divided into 2 groups: a pneumonia group and pneumonia-induced sepsis group. The serum 25(OH)D level was estimated using micro whole blood chemiluminescence.The average serum 25(OH)D level in all samples was 25.32 ±â€Š14.07 ng/mL, with the CAP group showing a lower value than the control group (P < .001). There were also significant differences between the pneumonia group and pneumonia-induced sepsis group (P < .001). In the pneumonia-induced sepsis group, significant differences in serum 25(OH)D levels were observed in children who received mechanical ventilation or presenting with multiple organ dysfunction (P < .01).All serum 25(OH)D levels in the pneumonia group and pneumonia-induced sepsis group were below normal levels, particularly in the sepsis group. A lower serum 25(OH)D level was associated with more serious symptoms in CAP children. Children with low serum 25(OH)D levels may be at higher risk of receiving mechanical ventilation and presenting with multiple organ dysfunction. These findings suggest that vitamin D supplements are beneficial for the treatment and prevention of CAP. [Mh] Termos MeSH primário: Pneumonia/sangue Deficiência de Vitamina D/complicações Vitamina D/análogos & derivados [Mh] Termos MeSH secundário: Adolescente Estudos de Casos e Controles Criança Pré-Escolar Infecções Comunitárias Adquiridas/sangue Infecções Comunitárias Adquiridas/etiologia Feminino Seres Humanos Lactente Recém-Nascido Masculino Estado Nutricional Pneumonia/etiologia Curva ROC Estações do Ano Sepse/sangue Sepse/etiologia Vitamina D/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180306 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009060

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[PMID]: 29499664 [Au] Autor: Kim WJ; Kim MM [Ad] Endereço: Department of Ophthalmology, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu, 42415, South Korea. [Ti] Título: The fast exodrift after the first surgical treatment of exotropia and its correlation with surgical outcome of second surgery. [So] Source: BMC Ophthalmol;18(1):67, 2018 Mar 02. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: To compare the rate of exodrift after a second surgery for recurrent exotropia, in patients grouped to fast versus slow exodrift after their first surgery. To determine whether there is a correlation with surgical outcome, and to evaluate the factors associated with fast exodrift. METHODS: Patients with recurrent intermittent exotropia, who underwent contralateral lateral rectus recession and medial rectus resection as the second surgery and were followed up for 24 months postoperatively between January 1991 and January 2013, were reviewed retrospectively. The patients were divided into two groups according to the rate of exodrift after the first surgery: Group F, patients exhibiting fast exodrift after the first surgery (> 10 prism diopters [PD] before postoperative month 6); and Group S, patients exhibiting slow exodrift after the first surgery (≤10 PD before postoperative month 6). The difference in the clinical course over the 24 months after the second surgery between the two groups and factors associated with fast exodrift were analyzed. RESULTS: In total, 106 patients with recurrent exotropia were enrolled in this study. Of these, 68 (64.2%) and 38 (35.8%) patients were included in group F and S, respectively. Group F showed more exodrift compared with groups S over the 24-month postoperative period; however, there was no significant difference in the clinical course between the two groups during that time (p = 0.54, repeated-measure ANOVA). In logistic analysis, immediate postoperative deviation after the first surgery was associated with fast exodrift (p <  0.001). CONCLUSION: Although patients with recurrent exotropia had shown fast exodrift after the first surgery, no significant difference in the surgical outcome was observed after the second surgery according to the rate of exodrift after the first surgery. [Mh] Termos MeSH primário: Exotropia/cirurgia Músculos Oculomotores/cirurgia [Mh] Termos MeSH secundário: Adolescente Adulto Criança Pré-Escolar Exotropia/diagnóstico Exotropia/fisiopatologia Movimentos Oculares/fisiologia Feminino Seguimentos Seres Humanos Masculino Músculos Oculomotores/fisiopatologia Procedimentos Cirúrgicos Oftalmológicos Prognóstico Recidiva Reoperação Estudos Retrospectivos Visão Binocular/fisiologia Acuidade Visual Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180304 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0722-5

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[PMID]: 29447181 [Au] Autor: Chen KYH; Messina N; Germano S; Bonnici R; Freyne B; Cheung M; Goldsmith G; Kollmann TR; Levin M; Burgner D; Curtis N [Ad] Endereço: Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Vic, Australia. [Ti] Título: Innate immune responses following Kawasaki disease and toxic shock syndrome. [So] Source: PLoS One;13(2):e0191830, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The pathogenesis of Kawasaki disease (KD) remains unknown and there is accumulating evidence for the importance of the innate immune system in initiating and mediating the host inflammatory response. We compared innate immune responses in KD and toxic shock syndrome (TSS) participants more than two years after their acute illness with control participants to investigate differences in their immune phenotype. Toxic shock syndrome shares many clinical features with KD; by including both disease groups we endeavoured to explore changes in innate immune responses following acute inflammatory illnesses more broadly. We measured the in vitro production of interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-1ß, IL-6, IL-1 receptor antagonist (IL-1ra), and IL-10 following whole blood stimulation with toll-like receptor and inflammasome ligands in 52 KD, 20 TSS, and 53 control participants in a case-control study. Analyses were adjusted for age, sex, and unstimulated cytokine concentrations. Compared to controls, KD participants have reduced IL-1ra production in response to stimulation with double stranded RNA (geometric mean ratio (GMR) 0.37, 95% CI 0.15, 0.89, p = 0.03) and increased IL-6 production in response to incubation with Lyovec™ (GMR 5.48, 95% CI 1.77, 16.98, p = 0.004). Compared to controls, TSS participants have increased IFN-γ production in response to peptidoglycan (GMR 4.07, 95% CI 1.82, 9.11, p = 0.001), increased IL-1ß production to lipopolysaccharide (GMR 1.64, 95% CI 1.13, 2.38, p = 0.01) and peptidoglycan (GMR 1.61, 95% CI 1.11, 2.33, p = 0.01), and increased IL-6 production to peptidoglycan (GMR 1.45, 95% CI 1.10, 1.92, p = 0.01). Years following the acute illness, individuals with previous KD or TSS exhibit a pro-inflammatory innate immune phenotype suggesting a possible underlying immunological susceptibility or innate immune memory. [Mh] Termos MeSH primário: Imunidade Inata Síndrome de Linfonodos Mucocutâneos/imunologia Choque Séptico/imunologia [Mh] Termos MeSH secundário: Adolescente Adulto Estudos de Casos e Controles Criança Feminino Seres Humanos Inflamassomos/metabolismo Masculino Receptores Toll-Like/metabolismo Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Inflammasomes); 0 (Toll-Like Receptors) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180216 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191830

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[PMID]: 29447169 [Au] Autor: Eom H; Park Y; Kim J; Yang JS; Kang H; Kim K; Chun BC; Park O; Hong JI [Ad] Endereço: Division of Vaccine-Preventable Diseases Control and National Immunization Program, Korea Center for Disease Control and Prevention, Cheongju-si, Chungcheongbuk-do, Republic of Korea. [Ti] Título: Occurrence of measles in a country with elimination status: Amplifying measles infection in hospitalized children due to imported virus. [So] Source: PLoS One;13(2):e0188957, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The Republic of Korea declared measles elimination in 2006. However, a measles outbreak occurred in 2013. This study aimed to identify the epidemiological characteristics of the sources of infection and the pattern of measles transmission in 2013 in South Korea. We utilized surveillance data, epidemiological data, immunization registry data, and genetic information. We describe the epidemiological characteristics of all measles case patients (sex, age distribution, vaccination status, sources of infection) as well as details of the outbreak (the pattern of transmission, duration, mean age of patients, and generation time). In 2013, a total of 107 measles cases were notified. Most patients were infants (43.0%) and unvaccinated individuals (60.7%). We identified 4 imported and 103 import-related cases. A total of 105 cases were related to four outbreaks that occurred in Gyeongnam, northern Gyeonggi, southern Gyeonggi, and Seoul. The predominant circulating genotype was B3 type, which was identified in the Gyeongnam, northern Gyeonggi, and southern Gyeonggi outbreaks. The B3 type had not been in circulation in South Korea in the previous 3 years; virologic evidence suggests that these outbreaks were import-related. Most measles cases in South Korea have been associated with imported measles virus. Although Korea has maintained a high level of herd immunity, clustering of susceptible people can cause such measles outbreaks. [Mh] Termos MeSH primário: Sarampo/epidemiologia [Mh] Termos MeSH secundário: Adolescente Adulto Criança Pré-Escolar Surtos de Doenças Feminino Hospitalização Seres Humanos Lactente Masculino República da Coreia/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180216 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0188957

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