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[PMID]:28466016
[Au] Autor:Kucuk M; Oncel CR; Belgi Yildirim A; Canan F; Kuloglu MM
[Ad] Endereço:Akdeniz University Medical Faculty, Department of Cardiology, Antalya, Turkey.
[Ti] Título:Evaluation of Subclinical Left Ventricular Systolic Dysfunction in Chronic Asymptomatic Alcoholics by Speckle Tracking Echocardiography.
[So] Source:Biomed Res Int;2017:6582568, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:By using two-dimensional speckle tracking echocardiography, we aimed to investigate the structural and functional changes on myocardium in chronic asymptomatic alcoholics without any cardiovascular disease. Forty-one consecutive asymptomatic male alcoholics who were admitted to the outpatient alcoholism unit and 30 age matched healthy male volunteers selected as the control group were enrolled in the study. The study group were investigated by using standard two-dimensional echocardiography and speckle tracking echocardiography. The left ventricular (LV) global longitudinal strain and LV global circumferential strain were significantly lower in alcoholics when compared with control subjects. There was no difference in global radial strain between the two groups. To demonstrate the effect of total life time dose of ethanol (TLDE) on echocardiographic abnormalities, we assessed the correlation analysis. There was a nonsignificant weak correlation between global LV circumferential strain and TLDE ( = 0.27, = 0.083). Speckle tracking echocardiography derived left ventricular systolic function was impaired in chronic alcoholic patients when compared with healthy controls.
[Mh] Termos MeSH primário: Ecocardiografia
Etanol/toxicidade
Coração/diagnóstico por imagem
Disfunção Ventricular Esquerda/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Alcoólicos
Doenças Assintomáticas
Doenças Cardiovasculares/fisiopatologia
Voluntários Saudáveis
Coração/efeitos dos fármacos
Coração/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Sístole/efeitos dos fármacos
Disfunção Ventricular Esquerda/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1155/2017/6582568


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[PMID]:28460231
[Au] Autor:Claisse C; Cottencin O; Ott L; Berna G; Danel T; Nandrino JL
[Ad] Endereço:University of Lille, SCALab, UMR CNRS 9193, France. Electronic address: caroline.claisse@univ-lille3.fr.
[Ti] Título:Heart rate variability changes and emotion regulation abilities in short- and long-term abstinent alcoholic individuals.
[So] Source:Drug Alcohol Depend;175:237-245, 2017 06 01.
[Is] ISSN:1879-0046
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Difficulties in identifying and regulating emotion are recognized as major factors of relapse in alcohol use disorders (AUD). This study aimed to evaluate the differences of emotion regulation processes in AUD patients with short-term (STA, less than one month) and long-term abstinence (LTA, at least six months) by recording the high frequency of Heart Rate Variability (HF-HRV) in response to emotional and neutral stimuli. METHOD: Emotional induction constituted the presentation of highly emotional and neutral pictures (IAPS data base) presenting human interactions. HF-HRV was recorded before (at rest), during (pictures) and after emotional induction (recovery). RESULTS: The results showed higher phasic HF-HRV in the STA group in comparison to the LTA and C groups for negative, positive and neutral stimuli. In the LTA group, we observed a normalization of HRV, in response to emotional stimuli. However, for negative valence stimuli in the recovery period, LTA participants are no more different from STA group. A main positive correlation was observed for both patient groups between craving scores and increased HF-HRV during and after the emotion induction. CONCLUSION: The data support the hypothesis of emotion regulation impairment after STA but also show a partial improvement with prolonged abstinence. This impairment in patients may correspond to the maintenance of negative feedback that accentuates the difficulties in the emotional physiological process and limits the ability to engage in or maintain other processes. HF-HRV is a good indicator of emotion regulation processes related to the intensity of the craving even after long-term abstinence.
[Mh] Termos MeSH primário: Abstinência de Álcool/psicologia
Alcoólicos/psicologia
Alcoolismo/fisiopatologia
Emoções/fisiologia
Frequência Cardíaca/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alcoolismo/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28702879
[Au] Autor:Rana SVS; Verma Y; Singh GD
[Ad] Endereço:Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut, UP, 250004, India. sureshvs_rana@yahoo.com.
[Ti] Título:Assessment of genotoxicity amongst smokers, alcoholics, and tobacco chewers of North India using micronucleus assay and urinary 8-hydroxyl-2'-deoxyguanosine, as biomarkers.
[So] Source:Environ Monit Assess;189(8):391, 2017 Aug.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The main objective of the present study was to screen the genotoxicity caused by individual and combined habits of smoking, tobacco chewing, and alcohol consumption in human population of North India. Study recruited 67 male subjects aged 25 to 65 years. Buccal mucosal cells were subjected to micronucleus (MN) assay, and 8-hydroxyl-2-deoxyguanosine (8-OHdG) was estimated in their urine samples. Number and shape of the MN cells varied in the buccal epithelium of different groups. Maximum number of MN (0.47%) were found in tobacco chewers followed by smokers (0.45%) and alcoholics (0.44%) (P < 0.05). These results reciprocated the concentration of urinary 8-OHdG. Maximum value for 8-OHdG was also recorded in tobacco chewers (21.07 ± 5.51 mg/mg creatinine) followed by smokers (20.25 ± 3.96 mg/mg creatinine) and alcoholics (19.06 ± 3.41 mg/mg creatinine) (P < 0.05). Combined effects of these agents were found to be statistically different from individual effects. Carcinogenic compounds present in cigarette smoke, nitrosamines found in solid tobacco, and acetaldehyde, a metabolic product of alcohol, induce oxidative stress that manifests into genotoxicity. In conclusion, demographical differences occur in the genotoxicity caused by these three habits. MN assay and urinary 8-OHdG are simple, noninvasive, and reliable biomarkers of genotoxicity.
[Mh] Termos MeSH primário: Alcoólicos/estatística & dados numéricos
Dano ao DNA
Desoxiguanosina/análogos & derivados
Exposição Ambiental/estatística & dados numéricos
Poluição por Fumaça de Tabaco/estatística & dados numéricos
Tabaco sem Fumaça
Tabaco
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/urina
Desoxiguanosina/urina
Monitoramento Ambiental
Seres Humanos
Índia
Masculino
Testes para Micronúcleos
Meia-Idade
Nitrosaminas
Estresse Oxidativo
Fumar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Nitrosamines); 0 (Tobacco Smoke Pollution); 88847-89-6 (8-oxo-7-hydrodeoxyguanosine); G9481N71RO (Deoxyguanosine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6103-3


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[PMID]:28062228
[Au] Autor:Heuvelings CC; de Vries SG; Grobusch MP
[Ad] Endereço:Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address: c.c.heuvelings@amc.uva.nl.
[Ti] Título:Tackling TB in low-incidence countries: improving diagnosis and management in vulnerable populations.
[So] Source:Int J Infect Dis;56:77-80, 2017 Mar.
[Is] ISSN:1878-3511
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:In low tuberculosis incidence regions, tuberculosis is mainly concentrated among hard-to-reach populations like migrants, homeless people, drug or alcohol abusers, prisoners and people living with HIV. To be able to eliminate tuberculosis from these low incidence regions tuberculosis screening and treatment programs should focus on these hard-to-reach populations. Here we discuss the barriers and facilitators of health care-seeking, interventions improving tuberculosis screening uptake and interventions improving treatment adherence in these hard-to-reach populations.
[Mh] Termos MeSH primário: Acesso aos Serviços de Saúde/estatística & dados numéricos
Programas de Rastreamento
Tuberculose
Populações Vulneráveis
[Mh] Termos MeSH secundário: Alcoólicos/estatística & dados numéricos
Antituberculosos/uso terapêutico
Coinfecção/epidemiologia
Usuários de Drogas/estatística & dados numéricos
Europa (Continente)/epidemiologia
Infecções por HIV/tratamento farmacológico
Infecções por HIV/epidemiologia
Conhecimentos, Atitudes e Prática em Saúde
Necessidades e Demandas de Serviços de Saúde
Pessoas em Situação de Rua/estatística & dados numéricos
Seres Humanos
Incidência
Adesão à Medicação/estatística & dados numéricos
Prisioneiros/estatística & dados numéricos
Fatores de Risco
Migrantes/estatística & dados numéricos
Tuberculose/diagnóstico
Tuberculose/tratamento farmacológico
Tuberculose/epidemiologia
Populações Vulneráveis/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE


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[PMID]:27684550
[Au] Autor:Di Ciaula A; Grattagliano I; Portincasa P
[Ad] Endereço:Division of Internal Medicine, Hospital of Bisceglie, Italy.
[Ti] Título:Chronic alcoholics retain dyspeptic symptoms, pan-enteric dysmotility, and autonomic neuropathy before and after abstinence.
[So] Source:J Dig Dis;17(11):735-746, 2016 Nov.
[Is] ISSN:1751-2980
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence. METHODS: Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lactulose H -breath test), stool form score (indirect marker of colonic transit), and autonomic neuropathy (sweat spot test, R-R ratio) were assessed at baseline in 268 subjects (136 chronic alcoholics and 132 healthy controls). A subgroup of 39 patients was re-evaluated after 12 months of abstinence. RESULTS: Chronic alcoholics had increased dyspepsia, delayed gastric emptying and oro-cecal transit time but faster gallbladder emptying, with slightly accelerated colonic transit. Sympathetic, but not parasympathetic, autonomic dysfunction was found. Dyspeptic symptoms and functional alterations of gastric emptying and oro-cecal transit tests were still present after 12-month abstinence, whereas gallbladder motility, stool form score and sympathetic function improved. CONCLUSIONS: Chronic alcoholics exhibit combined and interdependent presence of dyspeptic symptoms, impaired motility at different levels of the gastrointestinal tract, with sympathetic dysfunction. Only a few of these abnormalities improve after one year of abstinence from alcohol.
[Mh] Termos MeSH primário: Abstinência de Álcool
Alcoolismo/fisiopatologia
Doenças do Sistema Nervoso Autônomo/fisiopatologia
Dispepsia/fisiopatologia
Gastroenteropatias/fisiopatologia
Motilidade Gastrointestinal/fisiologia
[Mh] Termos MeSH secundário: Adulto
Neuropatia Alcoólica/etiologia
Neuropatia Alcoólica/fisiopatologia
Alcoólicos
Alcoolismo/complicações
Doenças do Sistema Nervoso Autônomo/etiologia
Doença Crônica
Dispepsia/etiologia
Feminino
Gastroenteropatias/etiologia
Seres Humanos
Masculino
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.1111/1751-2980.12415


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[PMID]:27567586
[Au] Autor:Shirolkar A; Sharma B; Lata S; Dabur R
[Ad] Endereço:Department of Biochemistry, National Research Institute of Basic Ayurvedic Sciences (NRIBAS), Kothrud, Pune, 411038, Maharashtra, India.
[Ti] Título:Guduchi Sawras (Tinospora cordifolia): An Ayurvedic drug treatment modulates the impaired lipid metabolism in alcoholics through dopaminergic neurotransmission and anti-oxidant defense system.
[So] Source:Biomed Pharmacother;83:1265-1277, 2016 Oct.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Tinospora cordifolia (Guduchi Sawras) though has been clearly demonstrated in literature for its hypolipidemic and anti-alcoholism properties but its anti-hyperlipidemia mechanistic approach is still missing. Moreover, its direct implication with alcohol induced hyperlipidemia has also not been reported till date. In order to explore the answers of these questions, phytochemicals of Tinospora cordifolia water extract "Guduchi Sawras" (GS) was analyzed using HPLC-Q-TOF-MS. On the basis of relative peak volumes 110 compounds were selected and identified in GS. Besides that, protein targets of most abundant compounds present in GS were fetched from ChEMBL and protein interaction network (PIN) was constructed. GO enrichment analysis showed that GS targets various pathways including dopamine metabolism, cAMP-dependent signaling pathway, and glycolytic process. Biological processes obtained via PIN were correlated with hyperlipidemia markers and dopamine metabolism in moderate alcohol consumers (n=25) and healthy volunteers (n=27) of age 41±3.8years. Metabolic analysis demonstrated the increased serotonin (1.9-fold) and decreased dopamine (-2.3-fold) levels in alcoholics. Further data analysis revealed a significant increase in urinary BCAAs (>2.0-fold), pantothenic acid (1.8-fold), carnitines (>2-fold) levels, and decrease in PPARα activation markers levels i.e. nicotinamide-1-oxide (-1.7-fold), and N-methylnicotinamide (-1.6-fold) in alcoholics. Biochemical analysis showed the increased AST/ALT ratio (1.91), along with triglycerides (20%), and MDA (34%) and GSH (56%) levels in alcoholics. GS treatment significantly reverted the most of the discussed metabolites levels (p<0.05) and enzymes activities (p<0.05) in alcoholics. The data depict that moderate chronic alcohol consumption lead to hyperlipidemia and oxidative burden; whereas GS treatment ameliorates hyperlipidemia by decreasing oxidative stress, activating PPARα, CREB and SREBP-1 through stimulation of dopamine D1 receptors mediated signalling molecules i.e. cAMP and protein kinase A.
[Mh] Termos MeSH primário: Alcoolismo/metabolismo
Antioxidantes/farmacologia
Metabolismo dos Lipídeos/efeitos dos fármacos
Extratos Vegetais/farmacologia
Receptores de Dopamina D1/metabolismo
Tinospora
[Mh] Termos MeSH secundário: Adulto
Alcoólicos
Alcoolismo/tratamento farmacológico
Antioxidantes/isolamento & purificação
Antioxidantes/uso terapêutico
Estudos de Coortes
Dopamina/metabolismo
Neurônios Dopaminérgicos/efeitos dos fármacos
Neurônios Dopaminérgicos/metabolismo
Seres Humanos
Metabolismo dos Lipídeos/fisiologia
Masculino
Medicina Ayurvédica
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Receptores de Dopamina D1/agonistas
Transmissão Sináptica/efeitos dos fármacos
Transmissão Sináptica/fisiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Receptors, Dopamine D1); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160829
[St] Status:MEDLINE


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[PMID]:27230610
[Au] Autor:Park S; Schepp KG; Park D
[Ad] Endereço:a Inha University , Incheon , South Korea.
[Ti] Título:Living with appending a scarlet letter: The lifelong suffering of children of alcoholics in South Korea.
[So] Source:J Ethn Subst Abuse;15(4):367-385, 2016 Oct-Dec.
[Is] ISSN:1533-2659
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Children of alcoholics (COAs) are those who have grown up with parental alcoholism. The purpose of this study was to understand the lives of Korean COAs within a Korean cultural context, influenced by Confucianism. Prior literature has extensively reported about the adverse life experiences of COAs related to their alcohol dependent parents. Indeed, most of these studies assume the U.S.- or Western-centric perspective. However, in order to provide culture-specific care, health professionals who provide care for diverse ethnic families have to understand the cultural influences on the families which have an ill family member. Data were collected from 20 Korean adult children through semi-structured interviews. All interviews were audio-recorded and fully transcribed. Thematic analysis was used for the data analysis. The lives of Korean COAs were described with four themes, namely: "Losing family," "Life with holding a bomb," "My life ruined," and "Being bound." CONCLUSION: In conclusion, the findings of this study demonstrated how cultural components could shape individual's life experiences in a family having an alcohol dependent family member. This study would be helpful for health professionals to deeply understand the alcoholic family members within a specific cultural background as well as to build a cultural-specific care-plans for them.
[Mh] Termos MeSH primário: Adultos Sobreviventes de Eventos Adversos na Infância/psicologia
Alcoólicos/psicologia
Filho de Pais Incapacitados/psicologia
Confucionismo/psicologia
Relações Familiares/etnologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Pesquisa Qualitativa
Religião e Psicologia
República da Coreia/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE


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[PMID]:26912003
[Au] Autor:Donoghue K; Rose A; Coulton S; Milward J; Reed K; Drummond C; Little H
[Ad] Endereço:Addictions Department, National Addiction Centre, Institute of Psychiatry, King's College London, 4 Windsor Walk, London, SE5 8BB, UK. kim.donoghue@kcl.ac.uk.
[Ti] Título:Double-blind, 12 month follow-up, placebo-controlled trial of mifepristone on cognition in alcoholics: the MIFCOG trial protocol.
[So] Source:BMC Psychiatry;16:40, 2016 Feb 24.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Increased levels of cortisol during acute alcohol withdrawal have been linked to cognitive deficits and depression. Preclinical research found that the glucocorticoid Type II receptor antagonist, mifepristone, prevented some of the neurotoxic effects of withdrawal and memory loss. Clinical trials have shown mifepristone effective in the treatment of depression. This study aims to examine the extent to which the glucocorticoid Type II receptor antagonist, mifepristone, when given to alcohol dependent males during the acute phase of alcohol withdrawal, will protect against the subsequent memory loss and depressive symptoms during abstinence from alcohol. METHODS/DESIGN: The study is a Phase 4 therapeutic use, "Proof of Concept" trial. The trial is a double-blind randomised controlled clinical trial of mifepristone versus inactive placebo. The trial aims to recruit 120 participants referred for an inpatient alcohol detoxification from community alcohol teams, who meet the inclusion criteria; 1) Male, 2) Aged 18-60 inclusive, 3) alcohol dependent for 5 or more years. A screening appointment will take place prior to admission to inpatient alcohol treatment units to ensure that the individual is suitable for inclusion in the trial in accordance with the inclusion and exclusion criteria. On admission participants are randomised to receive 600 mg a day of mifepristone (200 mg morning, afternoon and evening) for 7 days and 400 mg for the subsequent 7 days (200 mg morning and evening) or the equivalent number of placebo tablets for 14 days. Participants will remain in the trial for 4 weeks (at least 2 weeks as an inpatient) and will be followed up at 3, 6 and 12 months post randomisation. Primary outcome measures are cognitive function at week 3 and 4 after cessation of drinking and symptoms of depression over the 4 weeks after cession of drinking, measured using the Cambridge Neuropsychological Test Automated battery and Beck Depression Inventory, respectively. Secondary outcome measures are severity of the acute phase of alcohol withdrawal, alcohol craving, symptoms of protracted withdrawal and maintenance of abstinence and levels of relapse drinking at follow-up. DISCUSSION: The current trial will provide evidence concerning the role of glucocorticoid Type II receptor activation in cognitive function and depression during acute alcohol withdrawal and the efficacy of treatment with mifepristone. ISRCTN: ISRCTN54001953, Registered 29th September 2011.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/tratamento farmacológico
Alcoólicos
Alcoolismo/tratamento farmacológico
Transtornos Cognitivos/tratamento farmacológico
Mifepristona/uso terapêutico
Síndrome de Abstinência a Substâncias/etiologia
[Mh] Termos MeSH secundário: Adulto
Alcoolismo/complicações
Transtornos Cognitivos/etiologia
Método Duplo-Cego
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Síndrome de Abstinência a Substâncias/prevenção & controle
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE IV; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
320T6RNW1F (Mifepristone)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160226
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-016-0757-1


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[PMID]:26577704
[Au] Autor:Altgassen M; Ariese L; Wester AJ; Kessels RP
[Ad] Endereço:Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
[Ti] Título:Salient cues improve prospective remembering in Korsakoff's syndrome.
[So] Source:Br J Clin Psychol;55(2):123-36, 2016 Jun.
[Is] ISSN:0144-6657
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Korsakoff's syndrome is characterized by deficits in episodic memory and executive functions. Both cognitive functions are needed to remember to execute delayed intentions (prospective memory, PM), an ability that is crucial for independent living in everyday life. So far, PM has only been targeted by one study in Korsakoff's syndrome. This study explored the effects of executive control demands on PM to shed further light on a possible interdependence of memory and executive functions in Korsakoff's syndrome, METHOD: Twenty-five individuals with Korsakoff's syndrome and 23 chronic alcoholics (without amnesia) performed a categorization task into which a PM task was embedded that put either high or low demands on executive control processes (using low vs. high salient cues). RESULTS: Overall, Korsakoff patients had fewer PM hits than alcoholic controls. Across groups, participants had fewer PM hits when cues were low salient as compared to high salient. Korsakoff patients performed better on PM when highly salient cues were presented than cues of low salience, while there were no differential effects for alcoholic controls. CONCLUSIONS: While overall Korsakoff patients' showed a global PM deficit, the extent of this deficit was moderated by the executive control demands of the task applied. This indicated further support for an interrelation of executive functions and memory performance in Korsakoff. PRACTITIONER POINTS: Positive clinical implications of the work Prospective memory (PM) performance in Korsakoff's syndrome is related to executive control load. Increasing cues' salience improves PM performance in Korsakoff's syndrome. Salient visual aids may be used in everyday life to improve Korsakoff individuals' planning and organization skills. Cautions or limitations of the study Results were obtained in a structured laboratory setting and need to be replicated in a more naturalistic setting to assess their transferability to everyday life. Given the relatively small sample size, individual predictors of PM performance should be determined in larger samples.
[Mh] Termos MeSH primário: Sinais (Psicologia)
Função Executiva
Síndrome de Korsakoff/psicologia
Memória Episódica
Rememoração Mental
[Mh] Termos MeSH secundário: Alcoólicos/psicologia
Feminino
Seres Humanos
Masculino
Transtornos da Memória/diagnóstico
Transtornos da Memória/psicologia
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151119
[St] Status:MEDLINE
[do] DOI:10.1111/bjc.12099


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[PMID]:26456730
[Au] Autor:Pandey AK; Kamarajan C; Manz N; Chorlian DB; Stimus A; Porjesz B
[Ad] Endereço:Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, 450 Clarkson Avenue, MSC #1203, Brooklyn, NY 11203, USA. Electronic address: akp@hbnl.downstate.edu.
[Ti] Título:Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing.
[So] Source:Prog Neuropsychopharmacol Biol Psychiatry;65:158-71, 2016 Feb 04.
[Is] ISSN:1878-4216
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Higher impulsivity observed in alcoholics is thought to be due to neurocognitive functional deficits involving impaired inhibition in several brain regions and/or neuronal circuits. Event-related oscillations (EROs) offer time-frequency measure of brain rhythms during perceptual and cognitive processing, which provide a detailed view of neuroelectric oscillatory responses to external/internal events. The present study examines evoked power (temporally locked to events) of oscillatory brain signals in alcoholics during an equal probability Go/NoGo task, assessing their functional relevance in execution and inhibition of a motor response. The current study hypothesized that increases in the power of slow frequency bands and their topographical distribution is associated with tasks that have increased cognitive demands, such as the execution and inhibition of a motor response. Therefore, it is hypothesized that alcoholics would show lower spectral power in their topographical densities compared to controls. The sample consisted of 20 right-handed abstinent alcoholic males and 20 age and gender-matched healthy controls. Evoked delta (1.0-3.5Hz; 200-600ms), theta (4.0-7.5Hz; 200-400ms), slow alpha (8.0-9.5Hz; 200-300ms), and fast alpha (10.0-12.5Hz; 100-200ms) ERO power were compared across group and task conditions. Compared to controls, alcoholics had higher impulsiveness scores on the Barrett Impulsiveness Scale (BIS-11) and made more errors on Go trials. Alcoholics showed significantly lower evoked delta, theta, and slow alpha power compared to controls for both Go and NoGo task conditions, and lower evoked fast alpha power compared to controls for only the NoGo condition. The results confirm previous findings and are suggestive of neurocognitive deficits while executing and suppressing a motor response. Based on findings in the alpha frequency ranges, it is further suggested that the inhibitory processing impairments in alcoholics may arise from inadequate early attentional processing with respect to the stimulus related aspects/semantic memory processes, which may be reflected in lower posterio-temporal evoked fast alpha power. It can thus be concluded that alcoholics show neurocognitive deficits in both execution and suppression of a motor response and inadequate early attentional processing with respect to the semantic memory/stimulus related aspects while suppressing a motor response.
[Mh] Termos MeSH primário: Alcoolismo/fisiopatologia
Ritmo alfa
Encéfalo/fisiopatologia
Ritmo Delta
Atividade Motora/fisiologia
Ritmo Teta
[Mh] Termos MeSH secundário: Adulto
Alcoólicos/psicologia
Alcoolismo/psicologia
Ritmo alfa/efeitos dos fármacos
Atenção/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Ritmo Delta/efeitos dos fármacos
Eletroencefalografia
Função Executiva/efeitos dos fármacos
Seres Humanos
Comportamento Impulsivo/efeitos dos fármacos
Inibição (Psicologia)
Análise dos Mínimos Quadrados
Masculino
Atividade Motora/efeitos dos fármacos
Testes Neuropsicológicos
Tempo de Reação
Ritmo Teta/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151013
[St] Status:MEDLINE



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