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[PMID]:28748341
[Au] Autor:David M; Borde T; Brenne S; Ramsauer B; Henrich W; Breckenkamp J; Razum O
[Ad] Endereço:Department of Gynecology, Charité University Medicine Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. matthias.david@charite.de.
[Ti] Título:Obstetric and perinatal outcomes among immigrant and non-immigrant women in Berlin, Germany.
[So] Source:Arch Gynecol Obstet;296(4):745-762, 2017 Oct.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Germany, regular immigrants and their descendants have legal and financial access to health care equal to the general citizenry. Nonetheless, some of their health outcomes are comparatively unfavorable, and that is only partially explained by their lower socioeconomic status (SES). The aim of this study was to assess whether this disparity exists also for obstetric and perinatal outcomes. METHODS: We compared obstetric and perinatal outcomes between immigrant women (first or second generation) and non-immigrant women, delivering at three maternity hospitals in Berlin, Germany, 2011-2012. Multivariable logistic regression analysis was used to assess immigrant status and other possible risk factors for the baby being delivered preterm, small for gestational age (SGA), or transferred to neonatal care. RESULTS: The final database retained 6702 women, of whom 53.1% were first- or second-generation immigrants. First-generation Turkish immigrant women had significantly lower odds of preterm birth (OR 0.37, P < 0.001), SGA (OR 0.60, P = 0.0079), and transfer of the newborn to neonatal care (OR 0.61, P = 0.0034). Second-generation immigrant women had significantly lower odds of preterm birth (OR 0.67, P = 0.0049) or transfer of the newborn to neonatal care (OR 0.76, P = 0.0312). Moreover, women with education below university level, age 35+, or smokers had higher odds for poor outcomes. CONCLUSIONS: This study provides strong evidence that health disparities for obstetric and perinatal health outcomes do not exist in immigrants relative to native Germans, but exist instead in women without post-secondary-level education compared to women with such education, regardless of ethnicity or migration history.
[Mh] Termos MeSH primário: Emigrantes e Imigrantes/estatística & dados numéricos
Resultado da Gravidez/etnologia
Nascimento Prematuro/etnologia
[Mh] Termos MeSH secundário: Adulto
Berlim
Escolaridade
Feminino
Alemanha/epidemiologia
Seres Humanos
Recém-Nascido
Recém-Nascido Pequeno para a Idade Gestacional
Gravidez
Fatores de Risco
Turquia/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-017-4450-5


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[PMID]:29443470
[Au] Autor:Agbemenu K
[Ti] Título:Acculturation and Health Behaviors of African Immigrants Living in the United States: An Integrative Review.
[So] Source:ABNF J;27(3):67-73, 2016 Summer.
[Is] ISSN:1046-7041
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This research was conducted to identify the acculturation and health behaviors in the African Immigrant population, which is presently living in the United States. Ten studies met the criteria and included health behaviors of status, access to health care, psychiatric services, prostate cancer, morbidity and mortality, HIV knowledge and beliefs, perceptions of suicide, smoking, and obesity. Acculturation was measured using the most common social constructs that influenced the health behaviors of nativity, English (language proficiency), age at immigration, education and socioeconomic status, religion, age at immigration, and length of stay in the U.S. More research is needed to assist in prioritizing the health conditions that need intervention in serving this particular population.
[Mh] Termos MeSH primário: Aculturação
Afroamericanos/psicologia
Atitude Frente à Saúde
Emigrantes e Imigrantes/psicologia
Comportamentos Relacionados com a Saúde/etnologia
Suicídio/etnologia
Suicídio/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Gana
Seres Humanos
Masculino
Meia-Idade
Fatores Socioeconômicos
Estados Unidos/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE


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[PMID]:27771960
[Au] Autor:Tenkorang EY
[Ad] Endereço:a Department of Sociology , Memorial University of Newfoundland , St. John's , Canada.
[Ti] Título:Early onset of type 2 diabetes among visible minority and immigrant populations in Canada.
[So] Source:Ethn Health;22(3):266-284, 2017 Jun.
[Is] ISSN:1465-3419
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Type 2 diabetes is a chronic condition that affects nearly over three million Canadians, including immigrants. The timing of the first onset of diabetes has been linked to several other severe diseases. Yet, there is a dearth of empirical studies that examine the timing of the first onset of diabetes among Canadians, in general, and among immigrants and ethnic minority populations within Canada, in particular. DESIGN: Applying event history techniques to the 2013 Canadian Community and Health Survey, we address this research void by examining factors that contribute to the first onset of diabetes among immigrant and visible minority populations in Canada (N = 8905). Given the gendered patterns in the epidemiology of diseases and the differences in risk factors for men and women, gender-specific models were estimated. RESULTS: Results showed that South Asian, Black and Filipino women developed diabetes earlier, compared to women from the UK. Similarly, South Asian, Chinese, Filipino, Black, South East Asian and Arab men developed diabetes earlier than men from the UK. A significant and important finding of this analysis was that the risks of developing diabetes vanished completely for Black and Filipino women, after accounting for lifestyle factors. For South Asian women, however, there was significant attenuation in their risks after accounting for lifestyle factors. The findings were strikingly different for immigrant men. Specifically, their risks of developing diabetes increased after accounting for lifestyle factors. CONCLUSIONS: These results suggest the development of gender-specific and lifestyle interventions, targeted at specific immigrant groups with increased risks of developing diabetes earlier in the life course.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/etnologia
Emigrantes e Imigrantes/estatística & dados numéricos
Estilo de Vida
Grupos Minoritários/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Grupo com Ancestrais do Continente Africano/etnologia
Idade de Início
Idoso
Árabes/estatística & dados numéricos
Ásia Sudeste/etnologia
Canadá
Criança
China/etnologia
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Estilo de Vida/etnologia
Masculino
Meia-Idade
Filipinas/etnologia
Fatores de Risco
Fatores Sexuais
Reino Unido/etnologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1080/13557858.2016.1244623


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[PMID]:29223213
[Au] Autor:Cesario SK
[Ti] Título:Immigration Basics for Nurses.
[So] Source:Nurs Womens Health;21(6):499-505, 2017 Dec.
[Is] ISSN:1751-486X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The United States is known as a nation of immigrants and a land of promise that welcomes the needy, poor, and oppressed. Immigrants represent some of the most vulnerable in society. It is vital that nurses and other health care providers possess knowledge of social, economic, and political factors related to health care for immigrant populations. This article provides definitions of the various immigrant populations, addresses health needs within this group, and offers suggestions for nursing practice and advocacy.
[Mh] Termos MeSH primário: Emigrantes e Imigrantes/classificação
Emigrantes e Imigrantes/legislação & jurisprudência
Jurisprudência
[Mh] Termos MeSH secundário: Diversidade Cultural
Emigrantes e Imigrantes/estatística & dados numéricos
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


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[PMID]:29360333
[Au] Autor:Mortenson LC; Thomson Reuters Accelus.
[Ti] Título:Affordable Care Act Expansion.
[So] Source:Issue Brief Health Policy Track Serv;2017:1-40, 2017 Dec 26.
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Reforma dos Serviços de Saúde/legislação & jurisprudência
Medicaid/organização & administração
Patient Protection and Affordable Care Act/legislação & jurisprudência
[Mh] Termos MeSH secundário: Pessoas com Deficiência
Definição da Elegibilidade
Emigrantes e Imigrantes
Emprego
Governo Federal
Seres Humanos
Renda
Cobertura do Seguro
Prisioneiros
Governo Estadual
Detecção do Abuso de Substâncias
Estados Unidos
Veteranos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE


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Texto completo SciELO Saúde Pública
[PMID]:28453150
[Au] Autor:Restrepo-Pineda JE
[Ad] Endereço:Corporación Universitaria Minuto de Dios (UNIMINUTO), Antioquia, Colombia, jair.restrepo@uniminuto.edu.
[Ti] Título:[Comparative analysis of the perceptions of HIV/AIDS by gay and bisexual Colombian men with and without migratory experience].
[Ti] Título:Análisis comparativo de las percepciones sobre el VIH/SIDA de varones homosexuales y bisexuales colombianos, con experiencia migratoria o sin la misma..
[So] Source:Rev Salud Publica (Bogota);18(1):13-25, 2016 Feb.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:spa
[Ab] Resumo:Objective To compare the perceptions about HIV/AIDS of homosexual and bisexual Colombian males who live in the Colombian "Eje Cafetero" (Coffee Zone) and of those who migrated to Spain, in order to investigate whether those perceptions have an influence on the social vulnerability of the groups involved, which is determined by aspects such as inequalities that may emerge from ignorance about cultural and sexual diversity of the people who are undergoing a migratory process. Methods This research has a transnational character and was carried out by way of in-depth interviews of adult males living in the autonomous communities of Madrid, Valencia, Cataluña and Andalucía in Spain, and in the departments of Caldas, Quindío, Risaralda and Valle del Cauca in Colombia between 2011 and 2013. In total, 87 interviews were performed in both countries. Conclusion The relationship between migration and sexuality must be contemplated from a comprehensive viewpoint that enriches understanding both of the society of origin as well as of the welcoming country through a consideration of social and cultural aspects. Any health promotion and prevention program expecting to have an influence on social aspects must take into account people's particularities in order to avoid generalizations and their exploitation, recognizing them and making them visible as individuals with full rights who express opinions, speak and participatevisible as whole right individuals, who express opinions, speak and participate.
[Mh] Termos MeSH primário: Bissexualidade/fisiologia
Emigrantes e Imigrantes/psicologia
Infecções por HIV/psicologia
Homossexualidade Masculina/psicologia
Percepção
[Mh] Termos MeSH secundário: Síndrome de Imunodeficiência Adquirida/psicologia
Colômbia/etnologia
Seres Humanos
Masculino
Pesquisa Qualitativa
Espanha
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29320536
[Au] Autor:Broberg G; Wang J; Östberg AL; Adolfsson A; Nemes S; Sparén P; Strander B
[Ad] Endereço:Department of Obstetrics and Gynaecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
[Ti] Título:Socio-economic and demographic determinants affecting participation in the Swedish cervical screening program: A population-based case-control study.
[So] Source:PLoS One;13(1):e0190171, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cervical screening programs are highly protective for cervical cancer, but only for women attending screening procedure. OBJECTIVE: Identify socio-economic and demographic determinants for non-attendance in cervical screening. METHODS: Design: Population-based case-control study. Setting: Sweden. Population: Source population was all women eligible for screening. Based on complete screening records, two groups of women aged 30-60 were compared. The case group, non-attending women, (N = 314,302) had no smear registered for 6-8 years. The control group (N = 266,706) attended within 90 days of invitation. Main outcome measures: Risk of non-attendance by 9 groups of socioeconomic and demographic variables. Analysis: Unadjusted odds ratios (OR) and OR after adjustment for all variables in logistic regression models were calculated. RESULTS: Women with low disposable family income (adjOR 2.06; 95% confidence interval (CI) 2.01-2.11), with low education (adjOR 1.77; CI 1.73-1.81) and not cohabiting (adjOR 1.47; CI 1.45-1.50) were more likely to not attend cervical screening. Other important factors for non-attendance were being outside the labour force and receiving welfare benefits. Swedish counties are responsible for running screening programs; adjusted OR for non-participation in counties ranged from OR 4.21 (CI 4.06-4.35) to OR 0.54 (CI 0.52-0.57), compared to the reference county. Being born outside Sweden was a risk factor for non-attendance in the unadjusted analysis but this disappeared in certain large groups after adjustment for socioeconomic factors. CONCLUSION: County of residence and socio-economic factors were strongly associated with lower attendance in cervical screening, while being born in another country was of less importance. This indicates considerable potential for improvement of cervical screening attendance in several areas if best practice of routines is adopted.
[Mh] Termos MeSH primário: Detecção Precoce de Câncer/psicologia
Aceitação pelo Paciente de Cuidados de Saúde
Fatores Socioeconômicos
Neoplasias do Colo do Útero/prevenção & controle
Esfregaço Vaginal/psicologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Demografia
Escolaridade
Emigrantes e Imigrantes
Emprego
Feminino
Seres Humanos
Renda
Programas de Rastreamento
Meia-Idade
Razão de Chances
Fatores de Risco
Suécia/epidemiologia
Neoplasias do Colo do Útero/diagnóstico
Neoplasias do Colo do Útero/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190171


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[PMID]:29253429
[Au] Autor:Asadi L; Heffernan C; Menzies D; Long R
[Ad] Endereço:Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. Electronic address: lasadi@ualberta.ca.
[Ti] Título:Effectiveness of Canada's tuberculosis surveillance strategy in identifying immigrants at risk of developing and transmitting tuberculosis: a population-based retrospective cohort study.
[So] Source:Lancet Public Health;2(10):e450-e457, 2017 Oct.
[Is] ISSN:2468-2667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Canada, tuberculosis disproportionately affects the foreign-born population. The national tuberculosis medical surveillance programme aims to prevent these cases. Individuals referred for further in-country surveillance (referrals) have a history of active tuberculosis or have features of old, healed tuberculosis on chest radiograph; those not referred (non-referrals) do not undergo surveillance. We aimed to examine the risk of transmission arising from referrals versus non-referrals. METHODS: We did this population-based retrospective cohort study of foreign-born migrants (aged 15-64 years) to Alberta, Canada, between Jan 1, 2002, and Dec 31, 2013. We obtained information about year of arrival and country of citizenship from Immigration, Refugees and Citizenship Canada, and data for tuberculosis cases and their contacts from the Alberta Tuberculosis Registry. The outcome of interest was culture-positive pulmonary tuberculosis. We compared the incidence of pulmonary tuberculosis and the odds of transmission among referrals versus non-referrals. By use of conventional and molecular epidemiological techniques, we defined transmission as either a secondary case or a tuberculin skin-test (TST) conversion among close contacts. We used multivariate logistic regression to determine the independent association between referral for tuberculosis surveillance and transmission. FINDINGS: Between 2002 and 2013, there were 223 225 foreign-born migrants to Alberta, of whom 5500 (2%) were referrals and 217 657 (98%) were non-referrals. 3805 (69%) referrals and 115 226 (53%) non-referrals were from countries with a tuberculosis incidence of more than 150 per 100 000 populations, or sub-Saharan Africa. 234 foreign-born individuals were diagnosed with culture-positive pulmonary tuberculosis between Jan 1, 2004, and Dec 31, 2013. The incidence of culture-positive pulmonary disease was nine times higher in referrals (n=50) than all non-referrals (n=184; incidence rate ratio 9·1, 95% CI 6·7-12·5) and five times higher in referrals than non-referrals from high-risk countries (n=167; 5·0, 3·6-6·8). 71 total transmission events arose from the individuals with culture-positive pulmonary tuberculosis-three (4%) from referrals and 68 (96%) from non-referrals. No secondary cases were attributable to a referral source case, whereas 18 secondary cases were attributable to 11 different non-referral source cases. Three TST conversions were attributable to three different referral source cases compared with 50 conversions from 31 different non-referral source cases. That is, three (6%) referrals transmitted tuberculosis compared with 42 (22%) non-referrals (adjusted odds ratio of 0·19, 95% CI 0·054-0·66; p=0·009). INTERPRETATION: Despite a much higher incidence of pulmonary tuberculosis in referrals than non-referrals, referrals were 80% less likely to transmit tuberculosis. Rather than a focus on referrals, Canada could consider screening and treatment of latent tuberculosis in all migrants from high-risk countries-a group that accounted for 100% of secondary cases. FUNDING: Canadian Institutes of Health Research.
[Mh] Termos MeSH primário: Emigrantes e Imigrantes/estatística & dados numéricos
Vigilância da População/métodos
Encaminhamento e Consulta/estatística & dados numéricos
Tuberculose/epidemiologia
Tuberculose/transmissão
[Mh] Termos MeSH secundário: Adolescente
Adulto
Canadá/epidemiologia
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Avaliação de Programas e Projetos de Saúde
Estudos Retrospectivos
Medição de Risco
Tuberculose Pulmonar/epidemiologia
Tuberculose Pulmonar/transmissão
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29329117
[Au] Autor:Hu Sophia H; Fu Mei R; Liu S; Lin YK; Chang WY
[Ad] Endereço:Sophia H. Hu is an assistant professor and Wen-Yin Chang is a professor in the School of Nursing at Taipei Medical University, Taipei, Taiwan. Mei R. Fu is an associate professor in the Rory Meyers College of Nursing at New York University (NYU), New York City. Shan Liu is an associate professor in the College of Nursing and Public Health at Adelphi University, Garden City, NY. Yen-Kuang Lin is an associate research fellow in the Biostatistics Center at Taipei Medical University. This research was supported by grants from NYU's Muriel and Virginia Pless Center for Nursing Research, the Association of Chinese American Physicians, and the National Institute of Minority Health and Health Disparities (NIMHD project No. P60 MD000538-03). Contact author: Sophia H. Hu, sophiahu123@gmail.com. The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.
[Ti] Título:CE: Original Research: Physical Activity Among Chinese American Immigrants with Prediabetes or Type 2 Diabetes.
[So] Source:Am J Nurs;118(2):24-32, 2018 Feb.
[Is] ISSN:1538-7488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:: Background: Although the benefits of aerobic exercise and strength training for patients with type 2 diabetes have been studied extensively, research on physical activity among Chinese American immigrants diagnosed with prediabetes or type 2 diabetes has been limited. PURPOSE: We sought to learn more about this population's knowledge of physical activity, the types and intensity levels performed, and the barriers to such activity. DESIGN AND METHODS: A concurrent mixed-methods design was used. The short version of the International Physical Activity Questionnaire-Chinese was used to quantitatively measure participants' levels of exercise intensity. Semistructured face-to-face interviews were conducted to obtain qualitative information regarding participants' knowledge about physical activity, the types performed, and the barriers to such activity. RESULTS: A total of 100 Chinese American immigrants were recruited for the study from January to July 2012 in New York City. On average, participants had lived with a diagnosis of prediabetes or type 2 diabetes for 3.3 years and had lived in the United States for 21.5 years. Energy expenditure was measured in metabolic equivalent of task (MET) units; intensity was measured in cumulative MET-minutes per week. The mean total intensity score was 2,744 MET-minutes per week. This was achieved mainly through walking. The mean intensity score for walking was 1,454 MET-minutes per week; the mean duration was 79 minutes per day. Vigorous physical activity was least common. The mean intensity score for vigorous physical activity was 399 MET-minutes per week, and the mean duration was 17 minutes per week. Regarding types of physical activity, the most common were housekeeping, walking up stairs, and taking walking or stretching breaks every hour during the workday. Based on the interviews, three themes emerged regarding barriers to moderate or vigorous physical activity: insufficient education about physical activity, health concerns about physical activity, and work-related barriers to physical activity. CONCLUSIONS: The majority of Chinese American immigrants with prediabetes or type 2 diabetes do not engage in sufficient physical activity, performing at a rate significantly below that of the general U.S. POPULATION: Increases in the intensity and duration of physical activity should be promoted as part of diabetes management for Chinese American immigrants.
[Mh] Termos MeSH primário: Americanos Asiáticos
Diabetes Mellitus Tipo 2/epidemiologia
Exercício
Comportamentos Relacionados com a Saúde
Conhecimentos, Atitudes e Prática em Saúde
Estado Pré-Diabético/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Emigrantes e Imigrantes
Metabolismo Energético
Feminino
Seres Humanos
Masculino
Meia-Idade
Cidade de Nova Iorque/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1097/01.NAJ.0000530221.87469.86


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[PMID]:29237405
[Au] Autor:Lee J; Xiao YY; Sun YY; Balderacchi J; Clark B; Desani J; Kumar V; Saverimuthu A; Win KT; Huang Y; Xu Y
[Ad] Endereço:Division of Hematology and Oncology, Department of Internal Medicine, Maimonides Medical Center, 6300 8th Avenue, Brooklyn, NY, 11220, USA.
[Ti] Título:Prevalence and characteristics of hereditary non-polyposis colorectal cancer (HNPCC) syndrome in immigrant Asian colorectal cancer patients.
[So] Source:BMC Cancer;17(1):843, 2017 12 13.
[Is] ISSN:1471-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM. A non-hereditary, acquired process of hypermethylation of the MLH1 promoter can also lead to silencing of MLH1 protein expression. Diagnosis of HNPCC in patients with colorectal and other related cancers is important in the clinical treatment and surveillance of related cancers. The prevalence and clinical characteristics of HNPCC in Asian colorectal cancer patients has been reported in small studies and unique features have been suggested. METHODS: We retrospectively reviewed the clinical characteristics of Asian patients who were diagnosed of colon cancer between 1/2002 and 6/2015, and performed IHC for four MMR protein expressions on tumor specimens as a screening test for HNPCC, followed by confirmatory tests of genomic sequencing and hypermethylation analysis. RESULTS: One hundred forty-three patients were identified. Thirty-one patients were diagnosed younger than 50 years old, while 112 patients were diagnosed older than 50 years old. Six cases of HNPCC were found with a prevalence of 4.19%. The prevalence in the group of patients diagnosed younger than 50 years old is 16.1%, and that in patients diagnosed older than 50 years old is 0.89%. All patients with HNPCC had family histories of colon or gastric cancer. Tumor locations in the HNPCC patients were predominantly in the descending or sigmoid colon (67%). Half of the HNPCC patients had MSH6 mutations. Hypermethylation of the MLH1 gene was only present in 2.80% of the patients. CONCLUSION: The prevalence of HNPCC is high in patients younger than 50 years old and extremely low in those older than 50 years old. These results may be useful in the future development of guidelines for HNPCC laboratory screening among Asian patients. The pathological and clinical features of HNPCC in this group of Asian immigrant patients are more similar to those reported on Asian patients in their home countries than to Caucasian patients in Western countries, and will warrant further large-scale evaluation.
[Mh] Termos MeSH primário: Americanos Asiáticos/estatística & dados numéricos
Neoplasias Colorretais Hereditárias sem Polipose/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Colorretais Hereditárias sem Polipose/genética
Proteínas de Ligação a DNA/genética
Emigrantes e Imigrantes
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Prevalência
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (G-T mismatch-binding protein)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1186/s12885-017-3799-y



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