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[PMID]: | 28499012 |
[Au] Autor: | Latimer CS; Keene CD; Flanagan ME; Hemmy LS; Lim KO; White LR; Montine KS; Montine TJ |
[Ad] Endereço: | From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli |
[Ti] Título: | Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies. |
[So] Source: | J Neuropathol Exp Neurol;76(6):458-466, 2017 Jun 01. | [Is] ISSN: | 1554-6578 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | Two population-based studies key to advancing knowledge of brain aging are the Honolulu-Asia Aging Study (HAAS) and the Nun Study. Harmonization of their neuropathologic data allows cross comparison, with findings common to both studies likely generalizable, while distinct observations may point to aging brain changes that are dependent on sex, ethnicity, environment, or lifestyle factors. Here, we expanded the neuropathologic evaluation of these 2 studies using revised NIA-Alzheimer's Association guidelines and compared directly the neuropathologic features of resistance and apparent cognitive resilience. There were significant differences in prevalence of Alzheimer disease neuropathologic change, small vessel vascular brain injury, and Lewy body disease between these 2 studies, suggesting that sex, ethnicity, and lifestyle factors may significantly influence resistance to developing brain injury with age. In contrast, hippocampal sclerosis prevalence was very similar, but skewed to poorer cognitive performance, suggesting that hippocampal sclerosis could act sequentially with other diseases to impair cognitive function. Strikingly, despite these observed differences, the proportion of individuals resistant to all 4 diseases of brain or displaying apparent cognitive resilience was virtually identical between HAAS and Nun Study participants. Future in vivo validation of these results awaits comprehensive biomarkers of these 4 brain diseases. |
[Mh] Termos MeSH primário: |
Envelhecimento/fisiologia Envelhecimento/psicologia Doença de Alzheimer/patologia Doença de Alzheimer/psicologia Cognição Freiras Resiliência Psicológica
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[Mh] Termos MeSH secundário: |
Idoso Idoso de 80 Anos ou mais Biomarcadores Doenças de Pequenos Vasos Cerebrais/patologia Estudos de Coortes Efeitos Psicossociais da Doença Grupos Étnicos Feminino Hawaii Hipocampo/patologia Seres Humanos Doença por Corpos de Lewy/patologia Estilo de Vida Masculino Caracteres Sexuais
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Biomarkers) |
[Em] Mês de entrada: | 1707 |
[Cu] Atualização por classe: | 171005 |
[Lr] Data última revisão:
| 171005 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170513 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1093/jnen/nlx030 |
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