Base de dados : MEDLINE
Pesquisa : M01.686 [Categoria DeCS]
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[PMID]:29373595
[Au] Autor:Brussoni M; George MA; Jin A; Amram O; McCormick R; Lalonde CE
[Ad] Endereço:Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
[Ti] Título:Hospitalizations due to unintentional transport injuries among Aboriginal population of British Columbia, Canada: Incidence, changes over time and ecological analysis of risk markers.
[So] Source:PLoS One;13(1):e0191384, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Worldwide, Indigenous people have disproportionately higher rates of transport injuries. We examined disparities in injury-related hospitalizations resulting from transport incidents for three population groups in British Columbia (BC): total population, Aboriginal off-reserve, and Aboriginal on-reserve populations. We also examined sociodemographic, geographic and ethnic risk markers for disparities. METHODS: We identified Aboriginal people through BC's universal health care insurance plan insurance premium group and birth and death record notations. We calculated crude incidence rate and Standardized Relative Risk (SRR) of hospitalization for unintentional transport injury, standardized for age, gender and Health Service Delivery Area (HSDA), relative to the total population of BC. We tested hypothesized associations of geographic, socio-economic, and employment-related characteristics of Aboriginal communities with SRR of transport injury by multivariable linear regression. RESULTS: During the period 1991-2010, the SRR for the off-reserve Aboriginal population was 1.77 (95% CI: 1.71 to 1.83); and 2.00 (95% CI: 1.93 to 2.07) among those living on-reserve. Decline in crude rate and SRRs was observed over this period among both the Aboriginal and total populations of BC, but was proportionally greater among the Aboriginal population. The best-fitting multivariable risk marker model was an excellent fit (R2 = 0.912, p<0.001), predicted SRRs very close to observed values, and retained the following terms: urban residence, population per room, proportion of the population with a high school certificate, proportion of the population employed; and multiplicative interactions of Aboriginal ethnicity with population per room and proportion of the population employed. CONCLUSIONS: Disparities in risk of hospitalization due to unintentional transport injury have narrowed. Aboriginal ethnicity modifies the effects of socioeconomic risk factors. Continued improvement of socioeconomic conditions and implementation of culturally relevant injury prevention interventions are needed.
[Mh] Termos MeSH primário: Hospitalização/estatística & dados numéricos
Transferência de Pacientes
Grupos Populacionais/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Colúmbia Britânica
Criança
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Fatores de Risco
População Rural/estatística & dados numéricos
Classe Social
Fatores de Tempo
População Urbana/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191384


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[PMID]:29246102
[Au] Autor:Montano V; Jombart T
[Ad] Endereço:School of Biology, University of St Andrews, Bute Building, St Andrews, KY16 9TS, UK. mirainoshojo@gmail.com.
[Ti] Título:An Eigenvalue test for spatial principal component analysis.
[So] Source:BMC Bioinformatics;18(1):562, 2017 Dec 16.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The spatial Principal Component Analysis (sPCA, Jombart (Heredity 101:92-103, 2008) is designed to investigate non-random spatial distributions of genetic variation. Unfortunately, the associated tests used for assessing the existence of spatial patterns (global and local test; (Heredity 101:92-103, 2008) lack statistical power and may fail to reveal existing spatial patterns. Here, we present a non-parametric test for the significance of specific patterns recovered by sPCA. RESULTS: We compared the performance of this new test to the original global and local tests using datasets simulated under classical population genetic models. Results show that our test outperforms the original global and local tests, exhibiting improved statistical power while retaining similar, and reliable type I errors. Moreover, by allowing to test various sets of axes, it can be used to guide the selection of retained sPCA components. CONCLUSIONS: As such, our test represents a valuable complement to the original analysis, and should prove useful for the investigation of spatial genetic patterns.
[Mh] Termos MeSH primário: Biologia Computacional/métodos
Variação Genética/genética
Genética Populacional/métodos
Análise de Componente Principal
[Mh] Termos MeSH secundário: Algoritmos
DNA Mitocondrial/genética
Seres Humanos
Grupos Populacionais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1988-y


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[PMID]:29293632
[Au] Autor:Geter A; Sutton MY; Armon C; Durham MD; Palella FJ; Tedaldi E; Hart R; Buchacz K; HIV Outpatient Study Investigators
[Ad] Endereço:Epidemiology Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
[Ti] Título:Trends of racial and ethnic disparities in virologic suppression among women in the HIV Outpatient Study, USA, 2010-2015.
[So] Source:PLoS One;13(1):e0189973, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the United States, women accounted for 19% of new HIV diagnoses in 2015 and were less likely to reach virologic suppression when compared to men. We assessed trends and disparities in virologic suppression among HIV-positive women to inform HIV treatment strategies. Data were from a prospective cohort of the HIV Outpatient Study and collected at nine United States HIV clinics. We included women aged ≥18 years, with ≥1 visit, who were prescribed antiretroviral therapy, and had ≥1 viral load test performed between 2010 and 2015. We defined virologic suppression as viral load <50 copies/mL and calculated adjusted prevalence ratios (aPR) with 95% confidence intervals (CI) for virologic suppression by race/ethnicity and year of measure. Generalized estimating equations were used for multivariable analyses to assess factors associated with virologic suppression. Among 809 women (median age = 44 years), 482 (60%) were black, 177 (22%) white, 150 (19%) Hispanic/Latina. Virologic suppression was less prevalent among black women (73%) compared with Hispanic/Latina women (83%) and white women (91%). In multivariable analyses, not achieving virologic suppression was more likely among black women (aPR = 2.13; CI = 1.50-3.02) or Hispanic/Latina women (aPR = 1.66; CI = 1.08-2.56) compared with white women, and among women who attended public clinics (aPR = 1.42; CI = 1.07-1.87) compared with those who attended a private clinic. Between 2010 and 2015, virologic suppression among HIV-positive women increased from 68% to 83%, but racial/ethnic disparities persisted. Black and Hispanic/Latina women had significantly lower rates of virologic suppression than white women. Interventions targeting virologic suppression improvement among HIV-positive women of color, especially those who attend public clinics, are warranted.
[Mh] Termos MeSH primário: Grupos Étnicos
Infecções por HIV/etnologia
Infecções por HIV/virologia
Pacientes Ambulatoriais
Grupos Populacionais
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Meia-Idade
Estudos Prospectivos
Estados Unidos
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189973


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[PMID]:29364947
[Au] Autor:Graham AD; Lundgrin EL; Lin MC
[Ad] Endereço:Clinical Research Center, School of Optometry, University of California, Berkeley, California, United States of America.
[Ti] Título:The Berkeley Dry Eye Flow Chart: A fast, functional screening instrument for contact lens-induced dryness.
[So] Source:PLoS One;13(1):e0190752, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In this article, we introduce a novel flow chart-based screening tool for the categorization of contact lens-induced dryness (CLIDE) and its impact on daily visual activities: the Berkeley Dry Eye Flow Chart (DEFC). METHODS: One hundred thirty (130) experienced soft contact lens wearers discontinued lens wear for 24 hrs, passed a baseline screening and eye health examination, completed the Ocular Surface Disease Index (OSDI) then were dispensed fresh pairs of their habitual lenses. After 6 hrs of wear, subjects were administered a battery of symptom questionnaires, and underwent non-invasive tear breakup time (NITBUT) measurement, grading of distortion in reflected topographer mires, grading of lens surface wettability, and a fluorescein examination of the ocular surface. Subjects returned after at least 48 hrs and repeated all assessments after 6 hrs of wear of a second fresh pair of habitual lenses. RESULTS: The repeatability of the DEFC between visits was within 1%, and Limits of Agreement and Coefficient of Repeatability were comparable to those of the other CLIDE assessments. Higher DEFC score was significantly related to shorter pre-lens NITBUT, higher OSDI score, and higher Visual Analog Scale (VAS) ratings of average and end-of-day severity and frequency of dryness (all p < 0.001). For CLIDE as diagnosed based on DEFC score, the highest sensitivities and specificities were achieved by the OSDI and VAS ratings; pre-lens NITBUT exhibited good sensitivity but poor specificity. The optimum pre-lens NITBUT diagnostic threshold was found to be ≤ 2.0 sec for debilitating CLIDE, and the OSDI threshold was ≥ 11.4. CONCLUSIONS: The DEFC provides a means of quickly categorizing CLIDE patients based on severity and frequency of symptoms, and on the degree to which symptoms impact daily life. The DEFC has several potential advantages as a CLIDE screening and monitoring tool, has good repeatability, and is significantly related to commonly employed clinical assessments for CLIDE.
[Mh] Termos MeSH primário: Lentes de Contato Hidrofílicas/efeitos adversos
Xeroftalmia/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Grupos Populacionais
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Visão Ocular
Molhabilidade
Xeroftalmia/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190752


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[PMID]:28468619
[Au] Autor:Gorham G; Howard K; Togni S; Lawton P; Hughes J; Majoni SW; Brown S; Barnes S; Cass A
[Ad] Endereço:Menzies School of Health Research, PO Box 41096, Casuarina, NT, 0811, Australia. gillian.gorham@menzies.edu.au.
[Ti] Título:Economic and quality of care evaluation of dialysis service models in remote Australia: protocol for a mixed methods study.
[So] Source:BMC Health Serv Res;17(1):320, 2017 05 03.
[Is] ISSN:1472-6963
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Australia's Northern Territory (NT) has the country's highest incidence and prevalence of kidney disease. Indigenous people from remote areas suffer the heaviest disease burden. Concerns regarding cost and sustainability limit the provision of dialysis treatments in remote areas and most Indigenous people requiring dialysis relocate to urban areas. However, this dislocation of people from their family, community and support networks may prove more costly when the broader health, societal and economic consequences for the individual, family and whole of government are considered. METHODS: The Dialysis Models of Care Study is a large cross organisation mixed methods study. It includes a retrospective (2000-2014) longitudinal data linkage study of two NT cohorts: Renal Cohort 1- comprising approximately 2000 adults who received dialysis and Renal Cohort 2- comprising approximately 400 children of those adults. Linkage of administrative data sets from the Australian and New Zealand Dialysis and Transplant Registry, NT Departments of Health, Housing and Education by a specialist third party (SA/NT Datalink) will enable extraction of activity, financial and outcome data. Interviews with patients, clinicians and service providers, using a snowball technique, will canvass relevant issues and assist in determining the full costs and impacts of the five most used dialysis Models of Care. DISCUSSION: The study uses a mixed methods approach to investigate the quantitative and qualitative dimensions of the full costs and outcomes associated with the choice of particular dialysis models of care for any given patient. The study includes a large data linkage component that for the first time links health, housing and education data to fully analyse and evaluate the impact on patients, their families and the broader community, resulting from the relocation of people for treatment. The study will generate a large amount of activity, financial and qualitative data that will investigate health costs less directly related to dialysis treatment, costs to government such as housing and/or education and the health, social and economic outcomes experienced by patients. This approach fills an evidence gap critical to health service planners.
[Mh] Termos MeSH primário: Custos de Cuidados de Saúde
Serviços de Saúde do Indígena
Nefropatias/etnologia
Qualidade da Assistência à Saúde
Diálise Renal
[Mh] Termos MeSH secundário: Adulto
Criança
Serviços de Saúde do Indígena/economia
Serviços de Saúde do Indígena/normas
Seres Humanos
Armazenamento e Recuperação da Informação
Nefropatias/terapia
Northern Territory
Grupos Populacionais
Diálise Renal/economia
Projetos de Pesquisa
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12913-017-2273-5


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[PMID]:29261704
[Au] Autor:Vergara-Asenjo G; Mateo-Vega J; Alvarado A; Potvin C
[Ad] Endereço:Department of Biology, McGill University, Montreal, Quebec, Canada.
[Ti] Título:A participatory approach to elucidate the consequences of land invasions on REDD+ initiatives: A case study with Indigenous communities in Panama.
[So] Source:PLoS One;12(12):e0189463, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Land tenure and tenure security are among the most important factors determining the viability and success of Reducing Emissions from Deforestation and Forest Degradation (REDD+) initiatives. The premise of the present paper is that territorial conflicts lead to forest loss and compromise the successful implementation of REDD+. Within this context, the main objectives of this paper are to (i) document, relying on participatory methods, the extent to which land conflicts drive deforestation and (ii) reflect on the legal context of REDD+ examining if, from an Indigenous perspective, it offers tools to resolve such conflicts. We used the Upper Bayano Watershed in eastern Panama as a case study of complex land tenure dynamics, and their effects on forest conservation in the context of REDD+. Combining a range of participatory methods including participatory mapping and forest carbon stock assessment, we estimated the consequences of land invasions on forest carbon stocks. Our analysis shows that invasions of Indigenous territories amounted to 27.6% of the total deforestation for the period of 2001-2014. The situation is of paramount concern in the Embera territory of Majé where 95.4% of total deforestation was caused by colonist invaders. Using and validating the maps made freely available by the Global Forest Change initiative of the University of Maryland, we then developed a reference level for the watershed and carried out a back of the envelop estimation of likely REDD+ revenue, showing its potential to bring much needed income to Indigenous communities striving to protect their forest estate. Our analysis of current legislation in Panama highlights confusion and important legal voids and emphasizes the strong links between land tenure, carbon ownership, and territorial invasions. The options and shortcoming of implementing REDD+ in Indigenous territories is discussed in the conclusion taking our legal review into account.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais
Florestas
Grupos Populacionais
[Mh] Termos MeSH secundário: Poluição do Ar/análise
Dióxido de Carbono/análise
Conservação dos Recursos Naturais/legislação & jurisprudência
Geografia
Seres Humanos
Legislação como Assunto
Panamá
Territorialidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189463


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[PMID]:29210239
[Au] Autor:Raby GD; Donaldson MR; Nguyen VM; Taylor; Sopinka NM; Cook KV; Patterson DA; Robichaud D; Hinch SG; Cooke SJ
[Ti] Título:Bycatch mortality of endangered coho salmon: impacts, solutions, and aboriginal perspectives.
[So] Source:Ecol Appl;24(7):1803-19, 2014.
[Is] ISSN:1051-0761
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We used biotelemetry and human dimensions surveys to explore potential solutions to migration mortality of an endangered population of coho salmon caught as bycatch in an aboriginal beach seine fishery. From 2009 to 2011, 182 wild coho salmon caught as bycatch in the lower Fraser River (Canada) were radio-tagged and tracked as they attempted to complete their migrations to natal spawning areas over 300 km upstream. Failure to survive to reach terminal radio receiving stations averaged 39% over three years. This mortality estimate is low compared to those obtained from telemetry studies on other salmon fisheries in the Fraser River. However, this value is markedly higher than the mortality estimate currently used to manage the fishery's impact. It is also in contrast to the perceptions of the majority of aboriginal fishers, who did not think survival of coho salmon is affected by capture and release from their fishery. Increased probability of survival was associated with lower reflex impairment, which is consistent with previous findings. Reflex impairment was positively correlated with entanglement time, suggesting that greater efforts by the fishers to release bycatch from their nets quickly would minimize post-release mortality. Survey responses by aboriginal fishers also suggested that they are receptive to employing new bycatch handling methods if they are shown to increase post-release survival. However, attempts to facilitate revival of a subset of captured fish using cylindrical in-river recovery bags did not improve migration success. Fisheries managers could use the new information from this study to better quantify impacts and evaluate different harvest options. Since aboriginal fishers were receptive to using alternate handling methods, efforts to improve knowledge on minimizing reflex impairment through reductions in handling time could help increase bycatch survival. Such a direct integration of social science and applied ecology is a novel approach to understanding conservation issues that can better inform meaningful actions to promote species recovery.
[Mh] Termos MeSH primário: Migração Animal
Pesqueiros
Oncorhynchus kisutch/fisiologia
Grupos Populacionais
Rios
[Mh] Termos MeSH secundário: Animais
Canadá
Conservação dos Recursos Naturais/métodos
Espécies em Perigo de Extinção
Seres Humanos
Telemetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:27776499
[Au] Autor:Brodziak A; Rózyk-Myrta A; Wolinska A
[Ad] Endereço:Institute of Occupational Medicine and Environmental Health, Koscielna 13, 41-200, Sosnowiec, Poland. andrzejbrodziak@wp.pl.
[Ti] Título:Does the recent intensification of nationalistic and xenophobic attitudes in Eastern European countries adversely affect public mental health?
[So] Source:BMC Public Health;16(1):1115, 2016 10 24.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The authors postulate that the recent intensification of the nationalist and xenophobic attitude in Poland and other Eastern European countries is detrimental to public mental health. The xenophobic attitude is accompanied by a higher incidence of anxiety and depression, disputes due to the polarization of opinions, a sense of embarrassment and a sense of contradictions with so-called Christian values, unfavorable demographic predictions and reduced life satisfaction. DISCUSSION: The authors attempt to describe the sequence of adverse events that led to the intensification of xenophobia and characterize the current state of public mental health in European countries. They formulate and propose possible actions which could counteract the consequences of that transformation. SHORT CONCLUSION: The actions which may be undertaken to counteract the deterioration of public mental health can be based on the recommendations of so-called 'positive psychology' and 'positive psychiatry' as well as the principles of strengthening local social capital.
[Mh] Termos MeSH primário: Atitude
Saúde Mental
Saúde Pública
Xenofobia/psicologia
[Mh] Termos MeSH secundário: Ansiedade/etiologia
Demografia
Depressão/etiologia
Europa (Continente)
Europa Oriental
Seres Humanos
Incidência
Satisfação Pessoal
Polônia
Grupos Populacionais
Valores Sociais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28977000
[Au] Autor:Healy ME; Hill D; Berwick M; Edgar H; Gross J; Hunley K
[Ad] Endereço:Department of Anthropology, University of New Mexico, Albuquerque, NM, United States of America.
[Ti] Título:Social-group identity and population substructure in admixed populations in New Mexico and Latin America.
[So] Source:PLoS One;12(10):e0185503, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We examined the relationship between continental-level genetic ancestry and racial and ethnic identity in an admixed population in New Mexico with the goal of increasing our understanding of how racial and ethnic identity influence genetic substructure in admixed populations. Our sample consists of 98 New Mexicans who self-identified as Hispanic or Latino (NM-HL) and who further categorized themselves by race and ethnic subgroup membership. The genetic data consist of 270 newly-published autosomal microsatellites from the NM-HL sample and previously published data from 57 globally distributed populations, including 13 admixed samples from Central and South America. For these data, we 1) summarized the major axes of genetic variation using principal component analyses, 2) performed tests of Hardy Weinberg equilibrium, 3) compared empirical genetic ancestry distributions to those predicted under a model of admixture that lacked substructure, 4) tested the hypotheses that individuals in each sample had 100%, 0%, and the sample-mean percentage of African, European, and Native American ancestry. We found that most NM-HL identify themselves and their parents as belonging to one of two groups, conforming to a region-specific narrative that distinguishes recent immigrants from Mexico from individuals whose families have resided in New Mexico for generations and who emphasize their Spanish heritage. The "Spanish" group had significantly lower Native American ancestry and higher European ancestry than the "Mexican" group. Positive FIS values, PCA plots, and heterogeneous ancestry distributions suggest that most Central and South America admixed samples also contain substructure, and that this substructure may be related to variation in social identity. Genetic substructure appears to be common in admixed populations in the Americas and may confound attempts to identify disease-causing genes and to understand the social causes of variation in health outcomes and social inequality.
[Mh] Termos MeSH primário: Grupos Étnicos/genética
Grupos Populacionais/genética
Identificação Social
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
América Latina
Masculino
Repetições de Microssatélites/genética
New Mexico
Análise de Componente Principal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185503


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[PMID]:28886193
[Au] Autor:Storme M; Semionov A; Assayag D; Lefson M; Kitty D; Dannenbaum D; Torrie J; Lejeune P; Robinson E; Ahmad Khan F
[Ad] Endereço:Division of Respiratory Medicine, McGill University, Montreal, Quebec, Canada.
[Ti] Título:Estimating the incidence of interstitial lung diseases in the Cree of Eeyou Istchee, northern Québec.
[So] Source:PLoS One;12(9):e0184548, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Little is known about the epidemiology of interstitial lung disease (ILD) amongst Canada's Indigenous populations. Clinicians working in Eeyou Istchee (the Cree territory of the James Bay region of Québec, population 17, 956) suspected that ILD was more common in this area. We sought to identify all prevalent and incident cases of ILD in Eeyou Istchee between 2006 and 2013, to describe characteristics of affected patients, distribution of subtypes, and estimate disease incidence. METHODS: Potential ILD cases amongst Eeyou Istchee residents were identified by searching hospitalization databases and lists of patients on long term home oxygen in the region's nine communities, and surveying physicians and nurses. Clinical, radiological and pathological data were reviewed. Potential cases were classified as 'Definite ILD' if an open lung biopsy demonstrated ILD or, in the absence of histopathologic confirmation, if their thoracic CT imaging was deemed consistent with ILD by a panel of two respirologists and a chest radiologist. Potential cases for whom CT images could not be retrieved for our review were not eligible for classification as Definite ILD, unless they had undergone open lung biopsy. The Definite ILD group was further categorized by subtype of ILD. For usual interstitial pneumonia and non-specific interstitial pneumonitis patterns, we assumed cases were idiopathic in the absence of documentation of connective tissue disease or occupational exposures in the medical chart. For Definite ILD and the most common subtype, we calculated the average annual incidence rates, age-standardized to the province of Quebec, for 2006 to 2013, using a gamma distribution to calculate 95% confidence intervals. RESULTS: Of 167 potential cases, 52 were categorized as Definite ILD: 14 on the basis of histopathology and 38 on the basis of CT imaging alone. Six patients had a prior history of connective tissue disease. Information on occupation was recorded in the charts of 18/52 (35%) cases, and missing in the remainder. We found the most common subtype was idiopathic pulmonary fibrosis (27/52, 52%), followed by idiopathic non-specific interstitial pneumonia (13/52, 25%), and secondary usual interstitial pneumonia associated with connective tissue diseases (5/52, 10%). The age-standardized annual incidence between 2006-2013 was 80 per 100,000 person-years observed (PYO) for ILD, and 46 per 100,000 PYO for idiopathic pulmonary fibrosis. INTERPRETATION: The incidence of ILD and of idiopathic pulmonary fibrosis in Eeyou Istchee may be higher than rates reported in other populations; however, cautious interpretation is required due to the lack of histopathological confirmation in the majority of cases, and our reliance on chart review to exclude secondary causes. A prospective study of incident cases with standardized assessments to establish the types of ILD and to assess for potential causes could overcome some of the limitations of the present analysis. Studies evaluating ILD incidence and subtype distribution in other Indigenous populations would also be of interest.
[Mh] Termos MeSH primário: Doenças Pulmonares Intersticiais/epidemiologia
Grupos Populacionais/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biópsia
Feminino
Seres Humanos
Incidência
Doenças Pulmonares Intersticiais/diagnóstico
Doenças Pulmonares Intersticiais/mortalidade
Masculino
Meia-Idade
Vigilância da População
Quebeque
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184548



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