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[PMID]:29210185
[Au] Autor:Camlin CS; Charlebois ED; Geng E; Semitala F; Wallenta J; Getahun M; Kampiire L; Bukusi EA; Sang N; Kwarisiima D; Clark TD; Petersen ML; Kamya MR; Havlir DV
[Ad] Endereço:University of California, San Francisco, CA, USA.
[Ti] Título:Redemption of the "spoiled identity:" the role of HIV-positive individuals in HIV care cascade interventions.
[So] Source:J Int AIDS Soc;20(4), 2017 Dec.
[Is] ISSN:1758-2652
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The concept of "therapeutic citizenship" has drawn attention to ways in which public testimony, the "story-telling in the public sphere" undertaken by people living with HIV (PLHIV), has shaped the global response to the epidemic. This paper presents qualitative findings from two large studies in eastern Africa that reveal how the advent of population-based HIV testing campaigns and efforts to accelerate antiretroviral "treatment for all" has precipitated a rapidly expanding therapeutic citizenship "project," or social movement. The title of this paper refers to Goffman's original conceptualization of stigma as a social process through which a person's identity is rendered "spoiled." METHODS: Data were derived from qualitative studies embedded within two clinical trials, Sustainable East African Research in Community Health (SEARCH) (NCT# 01864603) in Kenya and Uganda, and START-ART (NCT# 01810289) in Uganda, which aimed to offer insights into the pathways through which outcomes across the HIV care continuum can be achieved by interventions deployed in the studies, any unanticipated consequences, and factors that influenced implementation. Qualitative in-depth semi-structured interviews were conducted among cohorts of adults in 2014 through 2015; across both studies and time periods, 217 interviews were conducted with 166 individuals. Theoretically informed, team-based analytic approaches were used for the analyses. RESULTS: Narratives from PLHIV, who have not always been conceptualized as actors but rather usually as targets of HIV interventions, revealed strongly emergent themes related to these individuals' use of HIV biomedical resources and discourses to fashion a new, empowered subjecthood. Experiencing the benefits of antiretroviral therapy (ART) emboldens many individuals to transform their "spoiled" identities to attain new, valorized identities as "advocates for ART" in their communities. We propose that the personal revelation of what some refer to as the "gospel of ARVs," the telling of personal stories about HIV in the public sphere and actions to accompany other PLHIV on their journey into care, is driven by its power to redeem the "spoiled identity:" it permits PLHIV to overcome self-stigma and regain full personhood within their communities. CONCLUSIONS: PLHIV are playing an unanticipated but vital role in the successful implementation of HIV care cascade interventions.
[Mh] Termos MeSH primário: Infecções por HIV/terapia
Papel do Doente
Estigma Social
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Africano
Continuidade da Assistência ao Paciente
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/psicologia
Seres Humanos
Quênia
Masculino
Meia-Idade
Quartos de Pacientes
Pesquisa Qualitativa
Identificação Social
Uganda
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1002/jia2.25023


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[PMID]:29351564
[Au] Autor:Naran NH; Haagensen M; Crowther NJ
[Ad] Endereço:Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
[Ti] Título:Steatosis in South African women: How much and why?
[So] Source:PLoS One;13(1):e0191388, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Globally, steatosis is the commonest type of liver pathology and is closely associated with obesity and the metabolic syndrome. Obesity is common in urban African females but no data is available on hepatic fat content in this population group when compared to other ethnic groups. The aim of this study was therefore to compare hepatic fat content in woman from different ethnic groups in South Africa and to characterise the principle determinants of liver fat. MATERIALS AND METHODS: A convenience sample of 106 (48 Indian, 29 African and 29 Caucasian) female volunteers aged 20-60 years and having no history of cardiometabolic disorders were recruited. Hepatic fat was determined from CT scans using the liver-spleen attenuation ratio (LAR), which decreases with increasing levels of hepatic fat. Anthropometric and cardiometabolic parameters were measured with insulin resistance determined using the HOMA index and dysglycaemia defined as fasting glucose ≥5.60 mmol/L. RESULTS: The African subjects had significantly lower hepatic fat content (LAR as median [interquartile range]: 1.35 [1.28, 1.41]) than the Indian (1.22 [1.10, 1.35]; p<0.005) and Caucasian (1.27 [1.16, 1.33]; p<0.05) females even though they had significantly higher BMIs than both groups (p<0.0005 and p<0.05, respectively). Linear regression showed that: subcutaneous abdominal fat was a significant (unstandardised ß = 0.007; p = 0.03) negative, whilst insulin resistance (ß = -0.97; p = 0.01) and dysglycaemia (ß = -3.58; p = 0.01) were significant positive determinants of liver fat; higher hepatic fat levels in subjects with the metabolic syndrome were explained by insulin resistance and dysglycaemia. DISCUSSION: African ethnicity is associated with low liver fat content. Subcutaneous abdominal fat protects against steatosis, possibly by acting as a triglyceride reservoir. Insulin resistance and dysglycaemia lead to greater hepatic fat deposition and explain higher liver fat levels in subjects with the metabolic syndrome. These observations must be further investigated in longitudinal surveys.
[Mh] Termos MeSH primário: Fígado Gorduroso/patologia
[Mh] Termos MeSH secundário: Tecido Adiposo/diagnóstico por imagem
Tecido Adiposo/patologia
Adulto
Grupo com Ancestrais do Continente Africano
Antropometria
Índice de Massa Corporal
Estudos Transversais
Grupo com Ancestrais do Continente Europeu
Fígado Gorduroso/diagnóstico por imagem
Fígado Gorduroso/metabolismo
Feminino
Seres Humanos
Resistência à Insulina
Modelos Lineares
Fígado/diagnóstico por imagem
Fígado/patologia
Síndrome Metabólica/diagnóstico por imagem
Síndrome Metabólica/metabolismo
Síndrome Metabólica/patologia
Meia-Idade
África do Sul
Gordura Subcutânea Abdominal/diagnóstico por imagem
Gordura Subcutânea Abdominal/patologia
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191388


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[PMID]:29179827
[Au] Autor:Oruche UM; Robb SL; Aalsma M; Pescosolido B; Brown-Podgorski B; Draucker CB
[Ad] Endereço:School of Nursing, Indiana University-Purdue University Indianapolis, United States. Electronic address: uoruche@iu.edu.
[Ti] Título:Developing a Multiple Caregiver Group for Caregivers of Adolescents With Disruptive Behaviors.
[So] Source:Arch Psychiatr Nurs;31(6):596-601, 2017 12.
[Is] ISSN:1532-8228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article describes the development of a 6-week multiple caregiver group intervention for primary caregivers of adolescents diagnosed with Oppositional Defiant Disorder or Conduct Disorder in low-income African American families. The intervention is aimed at increasing the primary caregivers' self-efficacy in managing interactions within the family and especially with child serving educational, mental health, juvenile justice, and child welfare systems. Development of the intervention involved seven iterative activities performed in a collaborative effort between an interdisciplinary academic team, community engagement specialists, members of the targeted population, and clinical partners from a large public mental health system. The intervention development process described in this article can provide guidance for teams that aim to develop new mental health interventions that target specific outcomes in populations with unique needs.
[Mh] Termos MeSH primário: Cuidadores/educação
Cuidadores/psicologia
Comportamento Problema/psicologia
Autoeficácia
[Mh] Termos MeSH secundário: Adolescente
Grupo com Ancestrais do Continente Africano
Transtorno da Conduta/terapia
Feminino
Seres Humanos
Transtornos Mentais/psicologia
Pais/psicologia
Pobreza
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29406035
[Au] Autor:Jha LK; Hewlett AT
[Ad] Endereço:Section of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 98200 Nebraska Medical Center, Omaha, NE68198-2000.
[Ti] Título:Genetic Predisposition and Effect of Race in Achalasia.
[So] Source:Am J Med Sci;355(2):101, 2018 Feb.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano
Acalasia Esofágica/genética
Predisposição Genética para Doença
Caracteres Sexuais
[Mh] Termos MeSH secundário: Canadá/epidemiologia
Acalasia Esofágica/epidemiologia
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29181932
[Au] Autor:Aambø A; Klemsdal TO
[Ti] Título:Cardiovascular disease and diabetes in patients with African or Asian background.
[Ti] Título:Kardiovaskulær sykdom og diabetes ved afrikansk eller asiatisk bakgrunn..
[So] Source:Tidsskr Nor Laegeforen;137(22), 2017 11 28.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:eng; nor
[Ab] Resumo:BACKGROUND: Population groups of different ancestry appear to have varying prevalence of diabetes, different risks of developing cardiovascular disease and different responses to certain drugs that are used for these conditions. We wished to review the literature in this field. MATERIAL AND METHOD: We have performed searches in several databases for systematic review articles published from the year 2000 onwards, and supplemented these with articles from reference lists, our own literature archives and a pyramid search in the Norwegian Electronic Health Library database. Altogether 37 articles were included. RESULTS: With regard to diagnosed diabetes, the prevalence of coronary heart disease and stroke varies among groups of South Asian, East Asian, African and European ancestry. In patients of South Asian ancestry, the risk of coronary heart disease appears to be twice that of Europeans, and the disease occurs 5­10 years earlier. The prevalence of stroke is especially high in persons of African ancestry. Risk factors such as dyslipidemia and hypertension are distributed differently among these groups. The therapeutic response to drugs such as beta blockers, ACE inhibitors and various statins differs; for example, statin doses in Asians may often be halved in relation to those used for Caucasians, and ACE inhibitors are not recommended as monotherapy for hypertension in persons of African ancestry. These differences are partly attributable to variations in genetic disposition. INTERPRETATION: The findings are clinically significant ­ better insight in this field enables optimal tailoring of treatment for each patient, with more rapid achievement of goals and reduced risk of adverse effects. The recommendations given in this article are consistent with and complement the Directorate of Health's revised guidelines for the treatment of diabetes.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano/genética
Anti-Hipertensivos/farmacologia
Grupo com Ancestrais do Continente Asiático/genética
Doenças Cardiovasculares/etnologia
Diabetes Mellitus/etnologia
Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia
[Mh] Termos MeSH secundário: Anti-Hipertensivos/administração & dosagem
Doenças Cardiovasculares/tratamento farmacológico
Doenças Cardiovasculares/epidemiologia
Diabetes Mellitus/tratamento farmacológico
Diabetes Mellitus/epidemiologia
Grupo com Ancestrais do Continente Europeu/genética
Seres Humanos
Inibidores de Hidroximetilglutaril-CoA Redutases/administração & dosagem
Farmacogenética
Acidente Vascular Cerebral/tratamento farmacológico
Acidente Vascular Cerebral/epidemiologia
Acidente Vascular Cerebral/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.16.0680


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[PMID]:27771960
[Au] Autor:Tenkorang EY
[Ad] Endereço:a Department of Sociology , Memorial University of Newfoundland , St. John's , Canada.
[Ti] Título:Early onset of type 2 diabetes among visible minority and immigrant populations in Canada.
[So] Source:Ethn Health;22(3):266-284, 2017 Jun.
[Is] ISSN:1465-3419
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Type 2 diabetes is a chronic condition that affects nearly over three million Canadians, including immigrants. The timing of the first onset of diabetes has been linked to several other severe diseases. Yet, there is a dearth of empirical studies that examine the timing of the first onset of diabetes among Canadians, in general, and among immigrants and ethnic minority populations within Canada, in particular. DESIGN: Applying event history techniques to the 2013 Canadian Community and Health Survey, we address this research void by examining factors that contribute to the first onset of diabetes among immigrant and visible minority populations in Canada (N = 8905). Given the gendered patterns in the epidemiology of diseases and the differences in risk factors for men and women, gender-specific models were estimated. RESULTS: Results showed that South Asian, Black and Filipino women developed diabetes earlier, compared to women from the UK. Similarly, South Asian, Chinese, Filipino, Black, South East Asian and Arab men developed diabetes earlier than men from the UK. A significant and important finding of this analysis was that the risks of developing diabetes vanished completely for Black and Filipino women, after accounting for lifestyle factors. For South Asian women, however, there was significant attenuation in their risks after accounting for lifestyle factors. The findings were strikingly different for immigrant men. Specifically, their risks of developing diabetes increased after accounting for lifestyle factors. CONCLUSIONS: These results suggest the development of gender-specific and lifestyle interventions, targeted at specific immigrant groups with increased risks of developing diabetes earlier in the life course.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/etnologia
Emigrantes e Imigrantes/estatística & dados numéricos
Estilo de Vida
Grupos Minoritários/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Grupo com Ancestrais do Continente Africano/etnologia
Idade de Início
Idoso
Árabes/estatística & dados numéricos
Ásia Sudeste/etnologia
Canadá
Criança
China/etnologia
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Estilo de Vida/etnologia
Masculino
Meia-Idade
Filipinas/etnologia
Fatores de Risco
Fatores Sexuais
Reino Unido/etnologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1080/13557858.2016.1244623


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[PMID]:27771304
[Au] Autor:Lopes MB; Silva LF; Lopes GB; Penalva MA; Matos CM; Robinson BM; Lopes AA
[Ad] Endereço:Unit of Clinical Epidemiology and Evidence Based Medicine, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, Brazil.
[Ti] Título:Additional Contribution of the Malnutrition-Inflammation Score to Predict Mortality and Patient-Reported Outcomes as Compared With Its Components in a Cohort of African Descent Hemodialysis Patients.
[So] Source:J Ren Nutr;27(1):45-52, 2017 01.
[Is] ISSN:1532-8503
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The malnutrition-inflammation score (MIS) combines ten components to assess nutritional status. Higher MIS has been associated with higher mortality and poorer health-related quality of life (HRQOL) in maintenance hemodialysis (MHD) patients. It is interesting to investigate associations of each component with mortality and patient-reported outcomes (PROs), that is, HRQOL and depression symptoms, and if MIS associations are generalizable for diverse populations. This study assessed associations of MIS and its components with mortality and PROs in an African descent MHD population. DESIGN: Prospective cohort for mortality and cross-sectional design for PROs using data of the Prospective Study of the Prognosis of Chronic Hemodialysis Patients (PROHEMO). SUBJECTS: A total of 632 MHD patients (92% black or mixed race) treated in Salvador, Brazil. PREDICTORS: MIS (range: 0-30, higher worse) and each of its ten components (range: 0-4, higher worse). MAIN OUTCOME MEASURES: Mortality, HRQOL using the KDQOL-SF, and depression symptoms using the 20-item Center for Epidemiological Studies Depression Scale. STATISTICAL ANALYSIS: Linear regression for comparing scores and Cox regression for mortality. RESULTS: After extensive adjustments, MIS ≥6 was associated with 52% higher mortality (hazard ratio = 1.52; 95% confidence interval = 1.13-2.05), higher depression symptoms, and poorer HRQOL, including physical, mental, and kidney disease-targeted HRQOL measures. Weight change, comorbidity, muscle wasting, and albumin were the MIS components indicating associations between poor nutrition and higher mortality. By contrast, gastrointestinal symptoms and functional capacity were the MIS components denoting detrimental associations of poorer nutritional status with PROs. LIMITATION: Causal conclusions are not possible. CONCLUSIONS: The PROHEMO results indicate that MIS components associated with mortality are not the same associated with PROs. However, the MIS showed consistent associations with mortality and PROs. These results in a population that were not the target of previous investigations, add support for using tools combining nutritional components, such as MIS, to predict outcomes in MHD populations.
[Mh] Termos MeSH primário: Inflamação/diagnóstico
Inflamação/etnologia
Desnutrição/diagnóstico
Desnutrição/etnologia
Diálise Renal/mortalidade
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Africano
Idoso
Brasil/epidemiologia
Comorbidade
Estudos Transversais
Depressão/diagnóstico
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estado Nutricional
Medidas de Resultados Relatados pelo Paciente
Prognóstico
Estudos Prospectivos
Qualidade de Vida
Diálise Renal/efeitos adversos
Reprodutibilidade dos Testes
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28453118
[Au] Autor:Barreto-Zorza YM; Velasquez-Gutierrez VF
[Ad] Endereço:Facultad de Medicina. Universidad Nacional de Colombia. Bogotá. ymbarretoz@unal.edu.co.
[Ti] Título:[Community center for human development: program for African-Colombian families based on the participatory action research approach].
[Ti] Título:Centro de Desarrollo Humano Comunitario: programa para familias afrocolombianas desde la investigación acción participativa..
[So] Source:Rev Salud Publica (Bogota);18(5):768-781, 2016 Sep-Oct.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:spa
[Ab] Resumo:Objective: To describe the process of construction of a program of Primary Health Care (PHC) for African-Colombian families in Guapi, Cauca. Methodology : Participatory action research (PAR). Results: The PHC program is a collective construction between the IAP Group and the Commission for Support and Follow-up (CAS), carried out in four phases: 1. Field preparation; 2. Approximation to the universe of the African-Colombian families of Guapi; 3. Building the program "Center for Human Development: with strength, joy and love we go 'pa'lante' families"; and 4. Evaluation and socialization of results. Discussion: The collective construction of the program was conducted from the perspective of PHC, PAR and the cultural context, where the experts are the community, health professionals and institutions who have the ability to examine, reflect and participate in the transformation of reality based on their everyday life and view of the world. The starting point involves planning, developing and evaluating actions in healthy environments, relating not only to the physical space, but also to the work with families and community, taking into account needs, perceptions, beliefs, and actions towards health. The "Human Development Center Community" program allows a process of community participation towards achieving healthy environments to improve the health of the African-Colombian population, through the active participation of families, community, institutions and health professionals who, based on reality and knowledge exchange, generate actions directed to health of the large families of Guapi.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano
Participação da Comunidade
Promoção da Saúde/organização & administração
Desenvolvimento Humano
Atenção Primária à Saúde/organização & administração
Desenvolvimento de Programas
[Mh] Termos MeSH secundário: Colômbia
Promoção da Saúde/métodos
Pesquisa sobre Serviços de Saúde
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29293537
[Au] Autor:Gorlova OY; Li Y; Gorlov I; Ying J; Chen WV; Assassi S; Reveille JD; Arnett FC; Zhou X; Bossini-Castillo L; Lopez-Isac E; Acosta-Herrera M; Gregersen PK; Lee AT; Steen VD; Fessler BJ; Khanna D; Schiopu E; Silver RM; Molitor JA; Furst DE; Kafaja S; Simms RW; Lafyatis RA; Carreira P; Simeon CP; Castellvi I; Beltran E; Ortego N; Amos CI; Martin J; Mayes MD
[Ad] Endereço:Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States of America.
[Ti] Título:Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.
[So] Source:PLoS One;13(1):e0189498, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previously reported for systemic sclerosis (SSc, scleroderma). The objective of this study was to analyze genetic susceptibility loci in SSc at the gene level and to determine if the detected associations were shared in African-American and White populations, using data from ImmunoChip and GWAS genotyping studies. The White sample included 1833 cases and 3466 controls (956 cases and 2741 controls from the US and 877 cases and 725 controls from Spain) and the African American sample, 291 cases and 260 controls. In both Whites and African Americans, we performed a gene-level analysis that integrates association statistics in a gene possibly harboring multiple SNPs with weak effect on disease risk, using Versatile Gene-based Association Study (VEGAS) software. The SNP-level analysis was performed using PLINK v.1.07. We identified 4 novel candidate genes (STAT1, FCGR2C, NIPSNAP3B, and SCT) significantly associated and 4 genes (SERBP1, PINX1, TMEM175 and EXOC2) suggestively associated with SSc in the gene level analysis in White patients. As an exploratory analysis we compared the results on Whites with those from African Americans. Of previously established susceptibility genes identified in Whites, only TNFAIP3 was significant at the nominal level (p = 6.13x10-3) in African Americans in the gene-level analysis of the ImmunoChip data. Among the top suggestive novel genes identified in Whites based on the ImmunoChip data, FCGR2C and PINX1 were only nominally significant in African Americans (p = 0.016 and p = 0.028, respectively), while among the top novel genes identified in the gene-level analysis in African Americans, UNC5C (p = 5.57x10-4) and CLEC16A (p = 0.0463) were also nominally significant in Whites. We also present the gene-level analysis of SSc clinical and autoantibody phenotypes among Whites. Our findings need to be validated by independent studies, particularly due to the limited sample size of African Americans.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano/genética
Grupo com Ancestrais do Continente Europeu/genética
Estudo de Associação Genômica Ampla
Escleroderma Sistêmico/genética
[Mh] Termos MeSH secundário: Seres Humanos
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189498


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[PMID]:28453106
[Au] Autor:Campo-Arias A; Herazo E; Oviedo HC
[Ad] Endereço:Universidad del Magdalena, Santa Marta, Colombia, acampoa@unimagdalena.edu.co.
[Ti] Título:[Psychometric assessment of a brief Modern Racism Scale].
[Ti] Título:Valoración psicométrica de la Escala Breve para Racismo Moderno..
[So] Source:Rev Salud Publica (Bogota);18(3):437-446, 2016 Jun.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:spa
[Ab] Resumo:Objective To find the internal consistency of the Modern Racism Scale (MRS) among medical students in Bucaramanga, Colombia. Methods A total of 352 medical students, mean age=20.0 years (SD=1.9) reported their attitudes towards Afro-Colombians; 59.4 % were women. Students completed the 10-item version of MRS. Cronbach alpha and McDonald omega were calculated. Exploratory factor analyses were done to propose a brief version of the MRS. Results The 10-item version showed a Cronbach alpha of 0.48 and a McDonald omega of 0.15. The short version, the Brief Modern Racism Scale (BMRS) (items 1, 4, 5, 7 and 8) presented a Cronbach alpha of 0.64 and McDonald omega of 0.65. The BMRS showed one salient factor responsible of 41.6 % of the total variance. Conclusions A Spanish-language short version of the MRS shows better psychometric performance than the original version. Further study is needed to corroborate these findings or make adjustments for Colombian cultural regions.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano
Atitude
Racismo/psicologia
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adulto
Colômbia
Feminino
Seres Humanos
Linguagem
Masculino
Psicometria
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE



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