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[PMID]:29494572
[Au] Autor:Leavitt RA; Ertl A; Sheats K; Petrosky E; Ivey-Stephenson A; Fowler KA
[Ti] Título:Suicides Among American Indian/Alaska Natives - National Violent Death Reporting System, 18 States, 2003-2014.
[So] Source:MMWR Morb Mortal Wkly Rep;67(8):237-242, 2018 Mar 02.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Suicide disproportionately affects American Indians/Alaska Natives (AI/AN). The suicide rate among AI/AN has been increasing since 2003 (1), and in 2015, AI/AN suicide rates in the 18 states participating in the National Violent Death Reporting System (NVDRS) were 21.5 per 100,000, more than 3.5 times higher than those among racial/ethnic groups with the lowest rates.* To study completed suicides across all ages of AI/AN, NVDRS data collected from 2003 to 2014 were analyzed by comparing differences in suicide characteristics and circumstances between AI/AN and white decedents. Group differences were assessed using chi-squared tests and logistic regression. Across multiple demographics, incident characteristics, and circumstances, AI/AN decedents were significantly different from white decedents. More than one third (35.7%) of AI/AN decedents were aged 10-24 years (versus 11.1% of whites). Compared with whites, AI/AN decedents had 6.6 times the odds of living in a nonmetropolitan area, 2.1 times the odds of a positive alcohol toxicology result, and 2.4 times the odds of a suicide of a friend or family member affecting their death. Suicide prevention efforts should incorporate evidence-based, culturally relevant strategies at individual, interpersonal, and community levels (2) and need to account for the heterogeneity among AI/AN communities (3,4).
[Mh] Termos MeSH primário: Nativos do Alasca/estatística & dados numéricos
Índios Norte-Americanos/estatística & dados numéricos
Suicídio/etnologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Bases de Dados Factuais
Feminino
Seres Humanos
Masculino
Meia-Idade
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180302
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6708a1


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[PMID]:29267265
[Au] Autor:Odani S; Armour BS; Graffunder CM; Garrett BE; Agaku IT
[Ad] Endereço:Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, CDC.
[Ti] Título:Prevalence and Disparities in Tobacco Product Use Among American Indians/Alaska Natives - United States, 2010-2015.
[So] Source:MMWR Morb Mortal Wkly Rep;66(50):1374-1378, 2017 Dec 22.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An overarching goal of Healthy People 2020 is to achieve health equity, eliminate disparities, and improve health among all groups.* Although significant progress has been made in reducing overall commercial tobacco product use, disparities persist, with American Indians or Alaska Natives (AI/ANs) having one of the highest prevalences of cigarette smoking among all racial/ethnic groups (1,2). Variations in cigarette smoking among AI/ANs have been documented by sex and geographic location (3), but not by other sociodemographic characteristics. Furthermore, few data exist on use of tobacco products other than cigarettes among AI/ANs (4). CDC analyzed self-reported current (past 30-day) use of five tobacco product types among AI/AN adults from the 2010-2015 National Survey on Drug Use and Health (NSDUH); results were compared with six other racial/ethnic groups (Hispanic; non-Hispanic white [white]; non-Hispanic black [black]; non-Hispanic Native Hawaiian or other Pacific Islander [NHOPI]; non-Hispanic Asian [Asian]; and non-Hispanic multirace [multirace]). Prevalence of current tobacco product use was significantly higher among AI/ANs than among non-AI/ANs combined for any tobacco product, cigarettes, roll-your-own tobacco, pipes, and smokeless tobacco. Among AI/ANs, prevalence of current use of any tobacco product was higher among males, persons aged 18-25 years, those with less than a high school diploma, those with annual family income <$20,000, those who lived below the federal poverty level, and those who were never married. Addressing the social determinants of health and providing evidence-based, population-level, and culturally appropriate tobacco control interventions could help reduce tobacco product use and eliminate disparities in tobacco product use among AI/ANs (1).
[Mh] Termos MeSH primário: Nativos do Alasca/estatística & dados numéricos
Disparidades nos Níveis de Saúde
Índios Norte-Americanos/estatística & dados numéricos
Produtos do Tabaco/utilização
Tabagismo/etnologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Meia-Idade
Prevalência
Fatores de Risco
Fatores Socioeconômicos
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6650a2


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[PMID]:28746264
[Au] Autor:Singleton R; Seeman S; Grinnell M; Bulkow L; Kokesh J; Emmett S; Holve S; McCollum J; Hennessy T
[Ti] Título:Trends in Otitis Media and Myringotomy With Tube Placement Among American Indian and Alaska Native Children and the US General Population of Children After Introduction of the 13-valent Pneumococcal Conjugate Vaccine.
[So] Source:Pediatr Infect Dis J;37(1):e6-e12, 2018 Jan.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: American Indian/Alaska Native (AI/AN) children have experienced higher otitis media (OM) outpatient visit rates than other US children. To understand recent trends, we evaluated AI/AN OM rates before and after 13-valent pneumococcal conjugate vaccine introduction. METHODS: We analyzed outpatient visits listing OM as a diagnosis among AI/AN children <5 years of age from the Indian Health Service National Patient Information Reporting System for 2010-2013. OM outpatient visits for the general US child population <5 years of age were analyzed using the National Ambulatory Medical Care and National Hospital Ambulatory Care Surveys for 2010-2011. RESULTS: The 2010-2011 OM-associated outpatient visit rate for AI/AN children (63.5 per 100/year) was similar to 2010-2011 rate for same-age children in the general US population (62.8) and decreased from the 2003 to 2005 AI/AN rate (91.4). Further decline in AI/AN OM visit rates was seen for 2010-2011 to 2012-2013 (P < 0.0001). The AI/AN infant OM visit rate (130.5) was 1.6-fold higher than the US infant population. For 2010-2011, the highest AI/AN OM visit rate for <5 year olds was from Alaska (135.0). CONCLUSIONS: AI/AN <5-year-old OM visits declined by one third from 2003-2005 to 2010-2011 to a rate similar to the US general population <5 years. However, the AI/AN infant OM rate remained higher than the US infant population. The highest AI/AN <5-year-old OM rate occurred in Alaska.
[Mh] Termos MeSH primário: Nativos do Alasca/estatística & dados numéricos
Índios Norte-Americanos/estatística & dados numéricos
Ventilação da Orelha Média
Otite Média
Vacinas Pneumocócicas
Vacinação/estatística & dados numéricos
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Ventilação da Orelha Média/estatística & dados numéricos
Ventilação da Orelha Média/tendências
Otite Média/epidemiologia
Otite Média/cirurgia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (13-valent pneumococcal vaccine); 0 (Pneumococcal Vaccines)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001704


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[PMID]:29187399
[Au] Autor:Emerson MA; Banegas MP; Chawla N; Achacoso N; Alexeeff SE; Adams AS; Habel LA
[Ad] Endereço:Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland. memerso@live.unc.edu.
[Ti] Título:Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives.
[So] Source:Cancer Res;77(23):6770-6776, 2017 Dec 01.
[Is] ISSN:1538-7445
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cancer is the second leading cause of death among American Indians and Alaskan Natives (AIAN), although cancer survival information in this population is limited, particularly among urban AIAN. In this retrospective cohort study, we compared all-cause and prostate, breast, lung, and colorectal cancer-specific mortality among AIAN ( = 582) and non-Hispanic white (NHW; = 82,696) enrollees of Kaiser Permanente Northern California (KPNC) diagnosed with primary invasive breast, prostate, lung, or colorectal cancer from 1997 to 2015. Tumor registry and other electronic health records provided information on sociodemographic, comorbidity, tumor, clinical, and treatment characteristics. Cox regression models were used to estimate adjusted survival curves and hazard ratios (HR) with 95% confidence intervals (CI). AIAN had a significantly higher comorbidity burden compared with NHW ( < 0.05). When adjusting for patient, disease characteristics, and Charlson comorbidity scores, all-cause mortality and cancer-specific mortality were significantly higher for AIAN than NHW patients with breast cancer (HR, 1.47; 95% CI, 1.13-1.92) or with prostate cancer (HR, 1.87; 95% CI, 1.14-3.06) but not for AIAN patients with lung and colorectal cancer. Despite approximately equal access to preventive services and cancer care in this setting, we found higher mortality for AIAN than NHW with some cancers, and a greater proportion of AIAN cancer patients with multiple comorbid conditions. This study provides severely needed information on the cancer experience of the 71% of AIANs who live in urban areas and access cancer care outside of the Indian Health Services, from which the vast majority of AIAN cancer information comes. .
[Mh] Termos MeSH primário: Nativos do Alasca/estatística & dados numéricos
Neoplasias da Mama/mortalidade
Neoplasias Colorretais/mortalidade
Índios Norte-Americanos/estatística & dados numéricos
Neoplasias Pulmonares/mortalidade
Neoplasias da Próstata/mortalidade
[Mh] Termos MeSH secundário: Idoso
Neoplasias da Mama/epidemiologia
Neoplasias da Mama/terapia
Neoplasias Colorretais/epidemiologia
Neoplasias Colorretais/terapia
Comorbidade
Feminino
Seres Humanos
Neoplasias Pulmonares/epidemiologia
Neoplasias Pulmonares/terapia
Masculino
Meia-Idade
Avaliação de Resultados (Cuidados de Saúde)
Modelos de Riscos Proporcionais
Neoplasias da Próstata/epidemiologia
Neoplasias da Próstata/terapia
Estudos Retrospectivos
Taxa de Sobrevida
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1158/0008-5472.CAN-17-0429


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[PMID]:28891237
[Au] Autor:Dall'Era M; Cisternas MG; Snipes K; Herrinton LJ; Gordon C; Helmick CG
[Ad] Endereço:University of California, San Francisco.
[Ti] Título:The Incidence and Prevalence of Systemic Lupus Erythematosus in San Francisco County, California: The California Lupus Surveillance Project.
[So] Source:Arthritis Rheumatol;69(10):1996-2005, 2017 Oct.
[Is] ISSN:2326-5205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Estimates of the incidence and prevalence of systemic lupus erythematosus (SLE) in the US have varied widely. The purpose of this study was to conduct the California Lupus Surveillance Project (CLSP) to determine credible estimates of SLE incidence and prevalence, with a special focus on Hispanics and Asians. METHODS: The CLSP, which is funded by the Centers for Disease Control and Prevention, is a population-based registry of individuals with SLE residing in San Francisco County, CA, from January 1, 2007 through December 31, 2009. Data sources included hospitals, rheumatologists, nephrologists, commercial laboratories, and a state hospital discharge database. We abstracted medical records to ascertain SLE cases, which we defined as patients who met ≥4 of the 11 American College of Rheumatology classification criteria for SLE. We estimated crude and age-standardized incidence and prevalence, which were stratified by sex and race/ethnicity. RESULTS: The overall age-standardized annual incidence rate was 4.6 per 100,000 person-years. The average annual period prevalence was 84.8 per 100,000 persons. The age-standardized incidence rate in women and men was 8.6 and 0.7 per 100,000 person-years, respectively. This rate was highest among black women (30.5), followed by Hispanic women (8.9), Asian women (7.2), and white women (5.3). The age-standardized prevalence in women per 100,000 persons was 458.1 in blacks, 177.9 in Hispanics, 149.7 in Asians, and 109.8 in whites. Capture-recapture modeling estimated 33 additional incident cases and 147 additional prevalent cases. CONCLUSION: Comprehensive methods that include intensive case-finding provide more credible estimates of SLE in Hispanics and Asians, and confirm racial and ethnic disparities in SLE. The disease burden of SLE is highest in black women, followed by Hispanic women, Asian women, and white women.
[Mh] Termos MeSH primário: Grupos Étnicos/estatística & dados numéricos
Lúpus Eritematoso Sistêmico/epidemiologia
Sistema de Registros
[Mh] Termos MeSH secundário: Adulto
Afroamericanos/estatística & dados numéricos
Nativos do Alasca/estatística & dados numéricos
Americanos Asiáticos/estatística & dados numéricos
California/epidemiologia
Monitoramento Epidemiológico
Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos
Feminino
Hispano-Americanos/estatística & dados numéricos
Seres Humanos
Incidência
Índios Norte-Americanos/estatística & dados numéricos
Lúpus Eritematoso Sistêmico/etnologia
Masculino
Meia-Idade
Grupo com Ancestrais Oceânicos/estatística & dados numéricos
Prevalência
São Francisco/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1002/art.40191


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[PMID]:28801345
[Au] Autor:Scally SW; Law SC; Ting YT; Heemst JV; Sokolove J; Deutsch AJ; Bridie Clemens E; Moustakas AK; Papadopoulos GK; van der Woude D; Smolik I; Hitchon CA; Robinson DB; Ferucci ED; Bernstein CN; Meng X; Anaparti V; Huizinga T; Kedzierska K; Reid HH; Raychaudhuri S; Toes RE; Rossjohn J; El-Gabalawy H; Thomas R
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Biomedicine Discovery Institute Monash University, Clayton, Australia.
[Ti] Título:Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.
[So] Source:Ann Rheum Dis;76(11):1915-1923, 2017 11.
[Is] ISSN:1468-2060
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The pathogenetic mechanisms by which alleles are associated with anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) are incompletely understood. RA high-risk alleles are known to share a common motif, the 'shared susceptibility epitope (SE)'. Here, the electropositive P4 pocket of HLA-DRB1 accommodates self-peptide residues containing citrulline but not arginine. HLA-DRB1 His/Phe13ß stratifies with ACPA-positive RA, while His13ßSer polymorphisms stratify with ACPA-negative RA and RA protection. Indigenous North American (INA) populations have high risk of early-onset ACPA-positive RA, whereby HLA-DRB1*04:04 and HLA-DRB1*14:02 are implicated as risk factors for RA in INA. However, HLA-DRB1*14:02 has a His13ßSer polymorphism. Therefore, we aimed to verify this association and determine its molecular mechanism. METHODS: HLA genotype was compared in 344 INA patients with RA and 352 controls. Structures of HLA-DRB1*1402-class II loaded with vimentin-64Arg , vimentin-64Cit and fibrinogen ß-74Cit were solved using X-ray crystallography. Vimentin-64Cit -specific and vimentin -specific CD4+ T cells were characterised by flow cytometry using peptide-histocompatibility leukocyte antigen (pHLA) tetramers. After sorting of antigen-specific T cells, TCRα and ß-chains were analysed using multiplex, nested PCR and sequencing. RESULTS: ACPA RA in INA was independently associated with . Consequent to the His13ßSer polymorphism and altered P4 pocket of HLA-DRB1*14:02, both citrulline and arginine were accommodated in opposite orientations. Oligoclonal autoreactive CD4+ effector T cells reactive with both citrulline and arginine forms of vimentin were observed in patients with HLA-DRB1*14:02 RA and at-risk ACPA first-degree relatives. HLA-DRB1*14:02-vimentin -specific and HLA-DRB1*14:02-vimentin-64Cit -specific CD4+ memory T cells were phenotypically distinct populations. CONCLUSION: HLA-DRB1*14:02 broadens the capacity for citrullinated and native self-peptide presentation and T cell expansion, increasing risk of ACPA+ RA.
[Mh] Termos MeSH primário: Nativos do Alasca/genética
Artrite Reumatoide/etnologia
Artrite Reumatoide/genética
Predisposição Genética para Doença/etnologia
Cadeias HLA-DRB1/genética
Índios Norte-Americanos/genética
[Mh] Termos MeSH secundário: Alaska/etnologia
Alelos
Arginina/genética
Arginina/imunologia
Autoanticorpos/sangue
Autoanticorpos/imunologia
Linfócitos T CD4-Positivos/imunologia
Canadá/etnologia
Estudos de Casos e Controles
Citrulina/genética
Citrulina/imunologia
Feminino
Citometria de Fluxo
Genótipo
Seres Humanos
Masculino
Peptídeos Cíclicos/imunologia
Polimorfismo Genético
Fatores de Risco
Vimentina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (HLA-DRB1 Chains); 0 (Peptides, Cyclic); 0 (Vimentin); 0 (cyclic citrullinated peptide); 29VT07BGDA (Citrulline); 94ZLA3W45F (Arginine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1136/annrheumdis-2017-211300


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[PMID]:28727519
[Au] Autor:Bullock A; Sheff K; Moore K; Manson S
[Ad] Endereço:Ann Bullock and Karen Sheff are with the Division of Diabetes Treatment and Prevention, Office of Clinical and Preventive Services, Indian Health Service, Rockville, MD. Kelly Moore and Spero Manson are with the Centers for American Indian and Alaska Native Health, Colorado School of Public Health,
[Ti] Título:Obesity and Overweight in American Indian and Alaska Native Children, 2006-2015.
[So] Source:Am J Public Health;107(9):1502-1507, 2017 Sep.
[Is] ISSN:1541-0048
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To estimate obesity and overweight prevalence in American Indian and Alaska Native (AI/AN) children across genders, ages, and geographic regions in the Indian Health Service active clinical population. METHODS: We obtained data from the Indian Health Service National Data Warehouse. At least 184 000 AI/AN children aged 2 to 19 years had body mass index data for each year studied, 2006 to 2015. We calculated body mass index percentiles with the 2000 Centers for Disease Control and Prevention growth charts. RESULTS: In 2015, the prevalence of overweight and obesity in AI/AN children aged 2 to 19 years was 18.5% and 29.7%, respectively. Boys had higher obesity prevalence than girls (31.5% vs 27.9%). Children aged 12 to 19 years had a higher prevalence of overweight and obesity than younger children. The AI/AN children in our study had a higher prevalence of obesity than US children overall in the National Health and Nutrition Examination Survey. Results for 2006 through 2014 were similar. CONCLUSIONS: The prevalence of overweight and obesity among AI/AN children in this population may have stabilized, while remaining higher than prevalence for US children overall.
[Mh] Termos MeSH primário: Nativos do Alasca/estatística & dados numéricos
Índios Norte-Americanos/estatística & dados numéricos
Obesidade/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Índice de Massa Corporal
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Inquéritos Nutricionais
Prevalência
Estados Unidos/epidemiologia
United States Indian Health Service
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.2105/AJPH.2017.303904


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[PMID]:28376131
[Au] Autor:Au NT; Reyes M; Boyer BB; Hopkins SE; Black J; O'Brien D; Fohner AE; Yracheta J; Thornton T; Austin MA; Burke W; Thummel KE; Rettie AE
[Ad] Endereço:Department of Medicinal Chemistry, University of Washington, Seattle, Washington, United States of America.
[Ti] Título:Dietary and genetic influences on hemostasis in a Yup'ik Alaska Native population.
[So] Source:PLoS One;12(4):e0173616, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fish and marine animals are important components of the subsistence diet of Alaska Native people, resulting in a high ω3 PUFA intake. The historical record for circumpolar populations highlights a tendency for facile bleeding, possibly related to ω3 PUFA effects on platelet activation and/or vitamin K-dependent clotting factors. To evaluate these two scenarios in Yup'ik people of southwestern Alaska, we examined the association between dietary ω3 PUFA intake and activities of clotting factor II, V, fibrinogen, PT, INR, PTT, and sP-selectin in 733 study participants, using the nitrogen isotope ratio of red blood cells as a biomarker of ω3 PUFA consumption. sP-selectin alone correlated strongly and inversely with ω3 PUFA consumption. Approximately 36% of study participants exhibited PIVKA-II values above the threshold of 2 ng/ml, indicative of low vitamin K status. To assess genetic influences on vitamin K status, study participants were genotyped for common vitamin K cycle polymorphisms in VKORC1, GGCX and CYP4F2. Only CYP4F2*3 associated significantly with vitamin K status, for both acute (plasma vitamin K) and long-term (PIVKA-II) measures. These findings suggest: (i) a primary association of ω3 PUFAs on platelet activation, as opposed to vitamin K-dependent clotting factor activity, (ii) that reduced CYP4F2 enzyme activity associates with vitamin K status. We conclude that high ω3 PUFA intake promotes an anti-platelet effect and speculate that the high frequency of the CYP4F2*3 allele in Yup'ik people (~45%) evolved in response to a need to conserve body stores of vitamin K due to environmental limitations on its availability.
[Mh] Termos MeSH primário: Nativos do Alasca/genética
Dieta
Hemostasia/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alaska
Animais
Biomarcadores/sangue
Coagulação Sanguínea/genética
Fatores de Coagulação Sanguínea/genética
Fatores de Coagulação Sanguínea/metabolismo
Carbono-Carbono Ligases/genética
Estudos Transversais
Família 4 do Citocromo P450/genética
Ácidos Graxos Ômega-3/administração & dosagem
Feminino
Genótipo
Seres Humanos
Inuítes/genética
Masculino
Meia-Idade
Selectina-P/sangue
Ativação Plaquetária/genética
Polimorfismo de Nucleotídeo Único
Precursores de Proteínas/sangue
Protrombina
Vitamina K/sangue
Vitamina K Epóxido Redutases/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Coagulation Factors); 0 (Fatty Acids, Omega-3); 0 (P-Selectin); 0 (Protein Precursors); 12001-79-5 (Vitamin K); 53230-14-1 (acarboxyprothrombin); 9001-26-7 (Prothrombin); EC 1.14.13.30 (CYP4F2 protein, human); EC 1.14.14.1 (Cytochrome P450 Family 4); EC 1.17.4.4 (VKORC1 protein, human); EC 1.17.4.4 (Vitamin K Epoxide Reductases); EC 6.4.- (Carbon-Carbon Ligases); EC 6.4.- (glutamyl carboxylase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173616


  9 / 76 MEDLINE  
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[PMID]:28314573
[Au] Autor:Wyatt CM
[Ad] Endereço:Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: christina.wyatt@mssm.edu.
[Ti] Título:Decreased incidence of end-stage renal disease in American Indians with diabetes: a model for other high-risk populations?
[So] Source:Kidney Int;91(4):766-768, 2017 Apr.
[Is] ISSN:1523-1755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Indigenous populations in North America have very high rates of diabetes and diabetic complications, including end-stage renal disease. A promising new report demonstrates a substantial decline in the incidence of diabetic end-stage renal disease among American Indians and Alaska Natives, coinciding with a public health intervention targeting diabetes management in this population. This success may offer a model for interventions to improve kidney disease outcomes in other high-risk populations.
[Mh] Termos MeSH primário: Nativos do Alasca
Diabetes Mellitus/etnologia
Nefropatias Diabéticas/etnologia
Índios Norte-Americanos
Falência Renal Crônica/etnologia
[Mh] Termos MeSH secundário: Diabetes Mellitus/diagnóstico
Diabetes Mellitus/terapia
Nefropatias Diabéticas/diagnóstico
Nefropatias Diabéticas/prevenção & controle
Serviços de Saúde do Indígena
Seres Humanos
Incidência
Falência Renal Crônica/diagnóstico
Falência Renal Crônica/prevenção & controle
Prognóstico
Saúde Pública
Medição de Risco
Fatores de Risco
Fatores de Tempo
Estados Unidos/epidemiologia
United States Indian Health Service
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170319
[St] Status:MEDLINE


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[PMID]:28263280
[Au] Autor:O'Connell J; Rockell J; Ouellet JC; LeBeau M
[Ad] Endereço:*Colorado School of Public Health, Centers for American Indian and Alaska Native Health, University of Colorado, Aurora †Department of Health & Behavioral Sciences, University of Colorado Denver, Denver, CO ‡California Rural Indian Health Board, Sacramento, CA.
[Ti] Título:Disparities in Potentially Preventable Hospitalizations Between American Indian and Alaska Native and Non-Hispanic White Medicare Enrollees.
[So] Source:Med Care;55(6):569-575, 2017 Jun.
[Is] ISSN:1537-1948
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: A number of health care initiatives seek to improve health outcomes by increasing access to outpatient services while reducing preventable acute events. We evaluated disparities between American Indian and Alaska Native (AI/AN) and non-Hispanic white (white) Medicare enrollees in access to outpatient preventive, primary, and specialty services by comparing their potentially preventable hospitalizations (PPHs). RESEARCH DESIGN: The study population included 121,311 adult AI/AN Medicare enrollees registered to use services funded by the Indian Health Service and 5,915,011 adult white enrollees living in the same counties. Medicare 2010 data and a nationally recognized algorithm were used to identify PPHs. RESULTS: Among AI/AN Medicare enrollees, 58.6% had either diabetes, cardiovascular disease, or both conditions; the AI/AN age-adjusted prevalence of either or both conditions was 1.2 times that of the white enrollees (P<0.001). The age-adjusted PPH rate for all AI/ANs was 74 admissions per 1000 adults, 1.5 times that of white enrollees (P<0.001). Nearly 90% of AI/AN PPHs were among AI/ANs with diabetes, cardiovascular disease, or both conditions; their PPH rate was 114 admissions per 1000 adults, 1.2 times that of white enrollees (P<0.001) with those conditions. CONCLUSIONS: Differences in disease burden and access to outpatient services may partly explain the higher PPH rates for AI/AN Medicare enrollees. The health care quality measure used in this study (PPH) was developed for the US general population. It is important to consider AI/AN socioeconomic and other characteristics when interpreting findings for such measures and enhancing programs and policies to improve AI/AN health outcomes.
[Mh] Termos MeSH primário: Nativos do Alasca
Disparidades nos Níveis de Saúde
Hospitalização/tendências
Índios Norte-Americanos
Medicare
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Doença Crônica
Bases de Dados Factuais
Feminino
Pesquisa sobre Serviços de Saúde
Seres Humanos
Masculino
Meia-Idade
Estados Unidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1097/MLR.0000000000000698



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