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[PMID]:28621653
[Au] Autor:Benoit AC; Younger J; Beaver K; Jackson R; Loutfy M; Masching R; Nobis T; Nowgesic E; O'Brien-Teengs D; Whitebird W; Zoccole A; Hull M; Jaworsky D; Benson E; Rachlis A; Rourke SB; Burchell AN; Cooper C; Hogg RS; Klein MB; Machouf N; Montaner JSG; Tsoukas C; Raboud J
[Ad] Endereço:Women's College Research Institute, Women's College Hospital, Toronto, ON; Building Bridges Team, Toronto, ON and/or Vancouver, BC. anita.benoit@wchospital.ca.
[Ti] Título:Increased mortality among Indigenous persons in a multisite cohort of people living with HIV in Canada.
[So] Source:Can J Public Health;108(2):e169-e175, 2017 Jun 16.
[Is] ISSN:1920-7476
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Compare all-cause mortality between Indigenous participants and participants of other ethnicities living with HIV initiating combination antiretroviral therapy (cART) in an interprovincial multi-site cohort. METHODS: The Canadian Observational Cohort is a collaboration of 8 cohorts of treatment-naïve persons with HIV initiating cART after January 1, 2000. Participants were followed from the cART initiation date until death or last viral load (VL) test date on or before December 31, 2012. Cox proportional hazard models were used to estimate the effect of ethnicity on time until death after adjusting for age, gender, injection drug use, being a man who has sex with men, hepatitis C, province of origin, baseline VL and CD4 count, year of cART initiation and class of antiretroviral medication. RESULTS: The study sample consisted of 7080 participants (497 Indigenous, 2471 Caucasian, 787 African/Caribbean/Black (ACB), 629 other, and 2696 unknown ethnicity). Most Indigenous persons were from British Columbia (BC) (83%), with smaller numbers from Ontario (13%) and Québec (4%). During the study period, 714 (10%) participants died. The five-year survival probability was lower for Indigenous persons (0.77) than for Caucasian (0.94), ACB (0.98), other ethnicities (0.96) and unknown ethnicities (0.85) (p < 0.0001). In an adjusted proportional hazard model for which missing data were imputed, Indigenous persons were more likely to die than Caucasian participants (hazard ratio = 2.69, p < 0.0001). CONCLUSION: The mortality rate for Indigenous persons was higher than for other ethnicities and is largely reflective of the BC population. Addressing treatment challenges and identifying HIV- and non-HIV-related causes for mortality among Indigenous persons is required to optimize their clinical management.
[Mh] Termos MeSH primário: Infecções por HIV/etnologia
Disparidades nos Níveis de Saúde
Índios Norte-Americanos/estatística & dados numéricos
Inuítes/estatística & dados numéricos
Mortalidade/etnologia
[Mh] Termos MeSH secundário: Adulto
Fármacos Anti-HIV/uso terapêutico
Canadá/epidemiologia
Causas de Morte/tendências
Estudos de Coortes
Quimioterapia Combinada
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/mortalidade
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Anti-HIV Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.17269/cjph.108.5708


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[PMID]:28614392
[Au] Autor:Teh L; Pirkle C; Furgal C; Fillion M; Lucas M
[Ad] Endereço:Psychology Department, University of Hawai`i at Manoa, Honolulu, Hawaii, United States of America.
[Ti] Título:Psychometric validation of the household food insecurity access scale among Inuit pregnant women from Northern Quebec.
[So] Source:PLoS One;12(6):e0178708, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Globally, food insecurity is a major public health concern. In North America, it is particularly prevalent in certain sub-groups, including Indigenous communities. Although many Indigenous and remote communities harvest and share food, most food security assessment tools focus on economic access. This study describes the psychometric evaluation of a modified Household Food Insecurity Access Scale (HFIAS), developed for mixed economies, to assess food insecurity among pregnant Inuit women. METHODS: The HFIAS was administered to 130 pregnant women in Nunavik (Arctic region of Quebec), Canada. Data were fit to a Rasch Rating Scale Model (RSM) to determine the discrimination ability of the HFIAS. Person parameter (Theta) estimates were calculated based on the RSM to provide a more accurate scoring system of the modified HFIAS for this population. Theta values were compared to known correlates of food insecurity. RESULTS: Comparative fit indices showed preference for a modified version of the HFIAS over the original. Theta values displayed a continuum of severity estimates and those values indicating greater food insecurity were consistently linked to known correlates of food insecurity. Participants living in households with more than 1 hunter (Theta = -.45) or more than 1 fisher (Theta = -.43) experienced less food insecurity than those with no hunters (Theta = .48) or fishers (Theta = .49) in their household. The RSM indicated the scale showed good discriminatory ability. Subsequent analyses indicated that most scale items pertain to the classification of a household as moderately food insecure. CONCLUSIONS: The modified HFIAS shows potential for measuring food insecurity among pregnant women in Nunavik. This is an efficient instrument that can inform interventions targeting health conditions impacting groups that obtain food through both monetary and non-monetary means.
[Mh] Termos MeSH primário: Características da Família/etnologia
Abastecimento de Alimentos/estatística & dados numéricos
Inuítes/psicologia
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Abastecimento de Alimentos/economia
Seres Humanos
Fenômenos Fisiológicos da Nutrição Materna
Gravidez
Prevalência
Psicometria
Quebeque/etnologia
Fatores Socioeconômicos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178708


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[PMID]:28610584
[Au] Autor:Wielsøe M; Kern P; Bonefeld-Jørgensen EC
[Ad] Endereço:Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
[Ti] Título:Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study.
[So] Source:Environ Health;16(1):56, 2017 Jun 13.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Environmental Persistent Organic Pollutants (POPs) can alter the hormone homeostasis by mimicking, interfering or blocking the function of hormones; moreover POPs are hypothesized to modify the risk of breast cancer. The association between POPs and breast cancer has been widely studied but the conclusions are inconsistent. The present study examined the associations between serum levels of POPs and breast cancer with focus on the highly exposed Greenlandic Inuit population. METHODS: The study design was a case-control study of Inuit women from Greenland. The participants were asked to complete a questionnaire with information on reproductive history and lifestyle and to provide a blood sample. The sampling was carried out in two time periods (2000-2003 and 2011-2014). The serum levels were determined of 14 polychlorinated biphenyls (PCBs), 11 organochlorine pesticides (OCPs), 16 perfluoroalkyl acids (PFAAs), 1 polybrominated biphenyl (PBB), and 9 polybrominated diphenyl ethers (PBDEs). Independent samples t-test was used to compare differences between cases and controls and odds ratios (OR) adjusted for identified confounders were obtained using logistic regression. RESULTS: The study population included 77 breast cancer cases and 84 controls. The majority of the measured compounds declined significantly from 2000 - 2003 to 2011-2014. However, for the perfluorinated carboxylic acids (PFCAs) an increase was observed. The serum levels were significantly higher in cases compared to controls for the majority of the compounds, and after adjusting for age the difference was maintained for ∑OCP, dichlorodiphenyldichloroethylene (p,p'-DDE), ∑PFAA, ∑perfluorinated sulfonic acids (PFSA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS). For the lipophilic POPs, high serum levels (middel/highest vs. lowest tertile) of ∑PCB, ∑estrgoenicPCB, PCB99, PCB138, PCB153, PCB170, PCB170, and PCB183 was associated with breast cancer risk; for the amphiphilic PFAAs, high serum levels of ∑PFAA, ∑PFCA, ∑PFSA, perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), PFHxS, and PFOS were associated with breast cancer risk. CONCLUSION: Significant, positive associations between breast cancer risk and PCBs and PFAAs were observed. The associations indicate that environmental exposure to POPs can be a factor increasing the risk for breast cancer in Inuit women.
[Mh] Termos MeSH primário: Neoplasias da Mama/sangue
Neoplasias da Mama/epidemiologia
Exposição Ambiental
Poluentes Ambientais/sangue
Inuítes
[Mh] Termos MeSH secundário: Neoplasias da Mama/induzido quimicamente
Estudos de Casos e Controles
Monitoramento Ambiental
Feminino
Groenlândia/epidemiologia
Seres Humanos
Meia-Idade
Compostos Orgânicos/sangue
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Organic Chemicals)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1186/s12940-017-0269-6


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[PMID]:28603153
[Au] Autor:Nu J; Bersamin A
[Ti] Título:Collaborating With Alaska Native Communities to Design a Cultural Food Intervention to Address Nutrition Transition.
[So] Source:Prog Community Health Partnersh;11(1):71-80, 2017.
[Is] ISSN:1557-0541
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To address changing dietary patterns and declining dietary quality in indigenous communities, there is growing interest in implementing interventions that promote nutrient-dense, culturally important foods. OBJECTIVES: To describe formative research and an ongoing collaborative process to design a multilevel nutrition inter vention-Neqa Elicarvigmun or the Fish-to-School (F2S) Program-that reconnects students to their local food system in a remote Yup'ik community in Western Alaska. METHODS: Qualitative data that explored the connection between salmon and well-being were collected and collaboratively reviewed with a community work group and analyzed using thematic analysis. Findings were used to co-design the nutrition intervention. LESSONS LEARNED: Formative research Thndings and ongoing collaboration between academic and community partners informed the Thnal intervention design. CONCLUSIONS: Because people's behaviors and interactions with culturally signiThcant foods are embedded in cultural perceptions and local contexts, it is important for nutrition interventions to address local perceptions of these foods.
[Mh] Termos MeSH primário: Pesquisa Participativa Baseada na Comunidade
Características Culturais
Dieta
Promoção da Saúde/organização & administração
Inuítes/psicologia
Transtornos Nutricionais/prevenção & controle
[Mh] Termos MeSH secundário: Alaska
Relações Comunidade-Instituição
Preferências Alimentares
Abastecimento de Alimentos
Seres Humanos
Desenvolvimento de Programas
Avaliação de Programas e Projetos de Saúde
Projetos de Pesquisa
Fatores de Risco
População Rural
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1353/cpr.2017.0009


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[PMID]:28542407
[Au] Autor:Schæbel LK; Bonefeld-Jørgensen EC; Vestergaard H; Andersen S
[Ad] Endereço:Centre for Arctic Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
[Ti] Título:The influence of persistent organic pollutants in the traditional Inuit diet on markers of inflammation.
[So] Source:PLoS One;12(5):e0177781, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Concentrations of persistent organic pollutants (POPs) are high in Inuit living predominately on the traditional marine diet. Adverse effects of POPs include disruption of the immune system and cardiovascular diseases that are frequent in Greenland Inuit. We aimed to assess the association between exposure to POPs from the marine diet and inflammation, taking into account other factors such as vitamin D. We invited Inuit and non-Inuit living in settlements or the town in rural East Greenland or in the capital city Nuuk. Participants completed a food frequency questionnaire and donated a blood sample for measurement of the two markers of inflammation YKL-40 and hsCRP, 25-hydroxy-vitamin D, eleven organochlorine pesticides (OCPs), fourteen polychlorinated biphenyls (PCBs), one polybrominated biphenyl, and nine polybrominated diphenyl ethers (PBDEs) adjusted to the serum lipid content. Participants were 50 through 69 years old, living in settlements, town or city (n = 151/173/211; 95% participation rate). ΣOCP, ΣPCB and ΣPBDE serum levels were higher in Inuit than in non-Inuit (p<0.001/ p<0.001/ p<0.001), in older individuals (p<0.001/p<0.001/p = 0.002) and in participants with the highest intake of Greenlandic food items (p<0.001/p<0.001/p<0.001). Both YKL-40 and hsCRP serum levels were higher in Inuit compared to non-Inuit (p<0.001/p = 0.001), and increased with age (p<0.001/p = 0.001) and with the intake of Greenlandic food items (p<0.001/p = 0.002). Multivariate analysis conformed to a marked influence on both YKL-40 and hsCRP by ΣOCP (p<0.001/p<0.001) and ΣPCBs (p<0.001/p = 0.001) after adjusting for age, BMI, vitamin D, alcohol and smoking. POP levels were associated with the intake of the traditional Inuit diet and with markers of inflammation. This supports a pro-inflammatory role of POPs to promote chronic diseases common to populations in Greenland. These data inform guidelines on 'the Arctic dilemma' and encourage follow-up on the ageing Arctic populations.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Dieta/efeitos adversos
Poluentes Ambientais/sangue
Hidrocarbonetos Clorados/sangue
Inflamação/diagnóstico
Inuítes
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Inflamação/sangue
Inflamação/etiologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Environmental Pollutants); 0 (Hydrocarbons, Chlorinated)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177781


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[PMID]:28432368
[Au] Autor:Sarkar A; Wilton DH; Fitzgerald E
[Ad] Endereço:Division of Community Health and Humanities, Faculty of Medicine, Memorial University, St John's, NL, A1B 3V6, Canada. atanu.sarkar@med.mun.ca.
[Ti] Título:Indoor Radon in Micro-geological Setting of an Indigenous Community in Canada: A Pilot Study for Hazard Identification.
[So] Source:Int J Occup Environ Med;8(2):69-79, 2017 04.
[Is] ISSN:2008-6814
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Radon is the second leading cause of lung cancer after smoking. In Canada, the health authorities have no access to comprehensive profile of the communities built over uranium-rich micro-geological settings. The present indoor radon monitoring guideline is unable to provide an accurate identification of health hazards due to discounting several parameters of housing characteristics. OBJECTIVE: To explore indoor radon levels in a micro-geological setting known for high uranium in bedrock and to develop a theoretical model for a revised radon testing protocol. METHODS: We surveyed a remote community in Labrador, located in the midst of uranium belt. We selected 25 houses by convenience sampling and placed electret-ion-chamber radon monitoring devices in the lowest levels of the house (basement/crawl space). The standard radon study questionnaire developed and used by Health Canada was used. RESULTS: 7 (28%) houses had radon levels above the guideline value (range 249 to 574 Bq/m ). Housing characteristics, such as floors, sump holes, ventilation, and heating systems were suspected for high indoor radon levels and health consequences. CONCLUSION: There is a possibility of the existence of high-risk community in a low-risk region. The regional and provincial health authorities would be benefited by consulting geologists to identify potentially high-risk communities across the country. Placing testing devices in the lowest levels provides more accurate assessment of indoor radon level. The proposed protocol, based on synchronized testing of radon (at the lowest level of houses and in rooms of normal occupancy) and thorough inspection of the houses will be a more effective lung cancer prevention strategy.
[Mh] Termos MeSH primário: Poluentes Radioativos do Ar/análise
Poluição do Ar em Ambientes Fechados/análise
Habitação
Radônio/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental
Geologia
Guias como Assunto
Habitação/normas
Seres Humanos
Inuítes
Terra Nova e Labrador
Projetos Piloto
Urânio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Radioactive); 4OC371KSTK (Uranium); Q74S4N8N1G (Radon)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170916
[Lr] Data última revisão:
170916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.15171/ijoem.2017.1001


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[PMID]:28402800
[Au] Autor:Jiang Y; Rogers Van Katwyk S; Mao Y; Orpana H; Argwal G; de Groh M; Skinner M; Clarke R; Morrison H
[Ad] Endereço:Public Health Agency of Canada, Ottawa, Ontario, Canada.
[Ti] Título:Assessment of dysglycemia risk in the Kitikmeot region of Nunavut: using the CANRISK tool.
[Ti] Título:Évaluation du risque de dysglycémie dans la région de Kitikmeot (Nunavut) au moyen de l'outil CANRISK..
[So] Source:Health Promot Chronic Dis Prev Can;37(4):114-122, 2017 Apr.
[Is] ISSN:2368-738X
[Cp] País de publicação:Canada
[La] Idioma:eng; fre
[Ab] Resumo:INTRODUCTION: The Public Health Agency of Canada adapted a Finnish diabetes screening tool (FINDRISC) to create a tool (CANRISK) tailored to Canada's multi-ethnic population. CANRISK was developed using data collected in seven Canadian provinces. In an effort to extend the applicability of CANRISK to northern territorial populations, we completed a study with the mainly Inuit population in the Kitikmeot region of Nunavut. METHODS: We obtained CANRISK questionnaires, physical measures and blood samples from participants in five Nunavut communities in Kitikmeot. We used logistic regression to test model fit using the original CANRISK risk factors for dysglycemia (prediabetes and diabetes). Dysglycemia was assessed using fasting plasma glucose (FPG) alone and/or oral glucose tolerance test. We generated participants' CANRISK scores to test the functioning of this tool in the Inuit population. RESULTS: A total of 303 individuals participated in the study. Half were aged less than 45 years, two-thirds were female and 84% were Inuit. A total of 18% had prediabetes, and an additional 4% had undiagnosed diabetes. The odds of having dysglycemia rose exponentially with age, while the relationship with BMI was U-shaped. Compared with lab test results, using a cut-off point of 32 the CANRISK tool achieved a sensitivity of 61%, a specificity of 66%, a positive predictive value of 34% and an accuracy rate of 65%. CONCLUSION: The CANRISK tool achieved a similar accuracy in detecting dysglycemia in this mainly Inuit population as it did in a multi-ethnic sample of Canadians. We found the CANRISK tool to be adaptable to the Kitikmeot region, and more generally to Nunavut.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/diagnóstico
Inuítes
Estado Pré-Diabético/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Índice de Massa Corporal
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/etnologia
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Meia-Idade
Nunavut/epidemiologia
Obesidade/etnologia
Estado Pré-Diabético/sangue
Estado Pré-Diabético/etnologia
Estado Pré-Diabético/genética
Medição de Risco/métodos
Sensibilidade e Especificidade
Circunferência da Cintura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.24095/hpcdp.37.4.02


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[PMID]:28376131
[Au] Autor:Au NT; Reyes M; Boyer BB; Hopkins SE; Black J; O'Brien D; Fohner AE; Yracheta J; Thornton T; Austin MA; Burke W; Thummel KE; Rettie AE
[Ad] Endereço:Department of Medicinal Chemistry, University of Washington, Seattle, Washington, United States of America.
[Ti] Título:Dietary and genetic influences on hemostasis in a Yup'ik Alaska Native population.
[So] Source:PLoS One;12(4):e0173616, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fish and marine animals are important components of the subsistence diet of Alaska Native people, resulting in a high ω3 PUFA intake. The historical record for circumpolar populations highlights a tendency for facile bleeding, possibly related to ω3 PUFA effects on platelet activation and/or vitamin K-dependent clotting factors. To evaluate these two scenarios in Yup'ik people of southwestern Alaska, we examined the association between dietary ω3 PUFA intake and activities of clotting factor II, V, fibrinogen, PT, INR, PTT, and sP-selectin in 733 study participants, using the nitrogen isotope ratio of red blood cells as a biomarker of ω3 PUFA consumption. sP-selectin alone correlated strongly and inversely with ω3 PUFA consumption. Approximately 36% of study participants exhibited PIVKA-II values above the threshold of 2 ng/ml, indicative of low vitamin K status. To assess genetic influences on vitamin K status, study participants were genotyped for common vitamin K cycle polymorphisms in VKORC1, GGCX and CYP4F2. Only CYP4F2*3 associated significantly with vitamin K status, for both acute (plasma vitamin K) and long-term (PIVKA-II) measures. These findings suggest: (i) a primary association of ω3 PUFAs on platelet activation, as opposed to vitamin K-dependent clotting factor activity, (ii) that reduced CYP4F2 enzyme activity associates with vitamin K status. We conclude that high ω3 PUFA intake promotes an anti-platelet effect and speculate that the high frequency of the CYP4F2*3 allele in Yup'ik people (~45%) evolved in response to a need to conserve body stores of vitamin K due to environmental limitations on its availability.
[Mh] Termos MeSH primário: Nativos do Alasca/genética
Dieta
Hemostasia/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alaska
Animais
Biomarcadores/sangue
Coagulação Sanguínea/genética
Fatores de Coagulação Sanguínea/genética
Fatores de Coagulação Sanguínea/metabolismo
Carbono-Carbono Ligases/genética
Estudos Transversais
Família 4 do Citocromo P450/genética
Ácidos Graxos Ômega-3/administração & dosagem
Feminino
Genótipo
Seres Humanos
Inuítes/genética
Masculino
Meia-Idade
Selectina-P/sangue
Ativação Plaquetária/genética
Polimorfismo de Nucleotídeo Único
Precursores de Proteínas/sangue
Protrombina
Vitamina K/sangue
Vitamina K Epóxido Redutases/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Coagulation Factors); 0 (Fatty Acids, Omega-3); 0 (P-Selectin); 0 (Protein Precursors); 12001-79-5 (Vitamin K); 53230-14-1 (acarboxyprothrombin); 9001-26-7 (Prothrombin); EC 1.14.13.30 (CYP4F2 protein, human); EC 1.14.14.1 (Cytochrome P450 Family 4); EC 1.17.4.4 (VKORC1 protein, human); EC 1.17.4.4 (Vitamin K Epoxide Reductases); EC 6.4.- (Carbon-Carbon Ligases); EC 6.4.- (glutamyl carboxylase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173616


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[PMID]:28255598
[Au] Autor:Jamieson M; Chen SP; Murphy S; Maracle L; Mofina A; Hill J
[Ad] Endereço:School of Rehabilitation Therapy, Queen's University, 933 Mayfair Crescent, Kingston, ON K7M 5S5, Canada. Tel 613-634-8042. m.jamieson@queensu.ca.
[Ti] Título:Pilot Testing an Intervention on Cultural Safety and Indigenous Health in a Canadian Occupational Therapy Curriculum.
[So] Source:J Allied Health;46(1):e1-e7, 2017.
[Is] ISSN:1945-404X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:First-year Canadian occupational therapy students (n=27) rated their knowledge of and cultural/emotional responses to cultural safety and Indigenous health prior to and following an educational intervention led by a trained Indigenous educator. At post-intervention, students were also asked to comment on their learning experience. Pilot data of 40% of the class were analyzed using nonparametric approaches proposed by Koller and colleagues; qualitative data were explored using conventional methods. The majority of participant ratings reflected a perceived increase in knowledge and cultural/emotional responses, indicative of positive change following intervention. Student comments about their learning were in keeping with the positive findings. Although our sample size was small and our study examined perceived knowledge acquisition, preliminary results were consistent with related literature.
[Mh] Termos MeSH primário: Competência Cultural/educação
Serviços de Saúde do Indígena/normas
Disparidades nos Níveis de Saúde
Índios Norte-Americanos
Inuítes
Terapia Ocupacional/educação
Determinantes Sociais da Saúde/etnologia
Estudantes de Ciências da Saúde/psicologia
[Mh] Termos MeSH secundário: Canadá
Currículo
Seres Humanos
Projetos Piloto
Avaliação de Programas e Projetos de Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28222819
[Au] Autor:Andersen S; Noahsen P; Westergaard L; Laurberg P
[Ad] Endereço:1Arctic Health Research Centre,Institute of Clinical Medicine,Aalborg University Hospital,9000 Aalborg,Denmark.
[Ti] Título:Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status.
[So] Source:Br J Nutr;117(3):441-449, 2017 Feb.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The occurrence of thyroid disorders relies on I nutrition and monitoring of all populations is recommended. Measuring I in urine is standard but thyroglobulin in serum is an alternative. This led us to assess the reliability of studies using serum thyroglobulin compared with urinary I to assess the I nutrition level and calculate the number of participants needed in a study with repeated data sampling in the same individuals for 1 year. Diet, supplement use and life style factors were assessed by questionnaires. We measured thyroglobulin and thyroglobulin antibodies in serum and I in urine. Participants were thirty-three Caucasians and sixty-four Inuit living in Greenland aged 30-49 years. Serum thyroglobulin decreased with rising I excretion (Kendall's τ -0·29, P=0·005) and did not differ with ethnicity. Variation in individuals was lower for serum-thyroglobulin than for urinary I (mean individual CV: 15·1 v. 46·1 %; P<0·01). It required 245 urine samples to be 95 % certain of having a urinary I excretion within 10 % of the true mean of the population. For serum-thyroglobulin the same precision required 206 samples. In an individual ten times more samples were needed to depict I deficiency when using urinary I excretion compared with serum-thyroglobulin. In conclusion, more participants are need to portray I deficiency in a population when using urinary I compared with serum-thyroglobulin, and about ten times more samples are needed in an individual. Adding serum-thyroglobulin to urinary I may inform surveys of I nutrition by allowing subgroup analysis with similar reliability.
[Mh] Termos MeSH primário: Deficiências Nutricionais/sangue
Iodo/deficiência
Estado Nutricional
Tireoglobulina/sangue
[Mh] Termos MeSH secundário: Adulto
Anticorpos/sangue
Biomarcadores/sangue
Deficiências Nutricionais/etnologia
Deficiências Nutricionais/urina
Dieta
Suplementos Nutricionais
Grupo com Ancestrais do Continente Europeu
Feminino
Groenlândia
Seres Humanos
Inuítes
Iodo/sangue
Iodo/urina
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Biomarkers); 9010-34-8 (Thyroglobulin); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000162



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