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[PMID]:28455171
[Au] Autor:Moberley S; Licciardi PV; Balloch A; Andrews R; Leach AJ; Kirkwood M; Binks P; Mulholland K; Carapetis J; Tang MLK; Skull S
[Ad] Endereço:Menzies School of Health Research, Child Health Division, Charles Darwin University, Northern Territory, Australia.
[Ti] Título:Repeat pneumococcal polysaccharide vaccine in Indigenous Australian adults is associated with decreased immune responsiveness.
[So] Source:Vaccine;35(22):2908-2915, 2017 05 19.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Indigenous adults residing in the Northern Territory of Australia experience elevated rates of invasive pneumococcal disease despite the routine use of 23-valent pneumococcal polysaccharide vaccine (23vPPV). We hypothesised that the limited protection from 23vPPV may be due to hyporesponsiveness as a result of vaccine failure from repeated vaccination. To explore this possibility, we evaluated the immune response to a first and second dose of 23vPPV in Indigenous adults and a first dose of 23vPPV in non-Indigenous adults. METHODS: Serotype-specific IgG was measured by ELISA for all 23 vaccine serotypes at baseline and at one month post-vaccination. Individuals were considered to have an adequate immune response if paired sera demonstrated either: a four-fold rise in antibody concentration; a two-fold rise if the post vaccination antibody was >1.3µg/ml but <4.0µg/ml; or a post-vaccination antibody concentration >4.0µg/ml for at least half of the serotypes tested (12/23). Our per-protocol analysis included the comparison of outcomes for three groups: Indigenous adults receiving a second 23vPPV dose (N=20) and Indigenous (N=60) and non-Indigenous adults (N=25) receiving their first 23vPPV dose. RESULTS: All non-Indigenous adults receiving a first dose of 23vPPV mounted an adequate immune response (25/25). There was no significant difference in the proportion of individuals with an adequate response using our definition (primary endpoint), with 88% of Indigenous adults mounted an adequate response following first dose 23vPPV (53/60) compared to 70% having an adequate response following a second dose of 23vPPV (14/20; p=0.05). The risk difference between Indigenous participants receiving first dose compared to non-Indigenous participants receiving first dose was significant when comparing a response threshold of at least 70% (-27%, 95% CI: -43% to -11%; p=0.01) and 90% (-38%, 95% CI: -60% to -16%; p=0.006) of serotypes with a positive response. CONCLUSION: Indigenous participants demonstrated a poorer response to a first dose 23vPPV compared to their non-Indigenous counterparts, with lower IgG following a second 23vPPV dose. These findings highlight the critical need to evaluate the efficacy of future pneumococcal vaccine programs in the Australian Indigenous populations that recommend repeated doses of 23vPPV.
[Mh] Termos MeSH primário: Imunidade Humoral
Imunogenicidade da Vacina
Grupo com Ancestrais Oceânicos
Infecções Pneumocócicas/prevenção & controle
Vacinas Pneumocócicas/imunologia
Streptococcus pneumoniae/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticorpos Antibacterianos/sangue
Feminino
Seres Humanos
Imunoglobulina G/sangue
Masculino
Meia-Idade
Northern Territory/epidemiologia
Infecções Pneumocócicas/etnologia
Infecções Pneumocócicas/imunologia
Infecções Pneumocócicas/microbiologia
Vacinas Pneumocócicas/administração & dosagem
Vacinas Pneumocócicas/efeitos adversos
Sorotipagem
Vacinação
Potência de Vacina
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (23-valent pneumococcal capsular polysaccharide vaccine); 0 (Antibodies, Bacterial); 0 (Immunoglobulin G); 0 (Pneumococcal Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:27770298
[Au] Autor:Henwood W; Moewaka Barnes H; Brockbank T; Gregory W; Hooper K; McCreanor T
[Ad] Endereço:Te Runanga o Te Rarawa, Kaitaia, New Zealand. tirairaka@vodafone.co.nz.
[Ti] Título:Ko Tangonge Te Wai: Indigenous and Technical Data Come Together in Restoration Efforts.
[So] Source:Ecohealth;13(4):623-632, 2016 12.
[Is] ISSN:1612-9210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In Aotearoa New Zealand, Maori aspirations around land and water conflict with settler interests. As indigenous people, Maori struggle to enact agency over resources, despite Treaty (Treaty of Waitangi/Te Tiriti o Waitangi is an 1840 agreement between Maori and the crown) settlement processes returning some lands. Returns are complex since changes wrought by dispossession may be extreme, requiring multiple stakeholder engagements. Tangonge, a heavily modified wetland, in northern Aotearoa New Zealand has been the subject of iwi (tribe or tribes) claims since the 1890s. Reparation processes have returned significant areas surrounding Tangonge to key iwi, Te Rarawa and Ngai Takoto, who formed the Tangonge Restoration Group to plan management and restoration. The vision of the iwi is to restore Tangonge as a wetland to rekindle usage by manawhenua (people with demonstrated authority and tribal links to the area in question) and local communities. However, perceived Maori privilege, distrust in Maori praxis and fear of alienation of stakeholders mean the situation presents challenges as well as opportunities. Understanding that various parties view knowledge in particular ways, the Restoration Group sought to juxtapose technical data and manawhenua knowledge about Tangonge. Hydrology findings and local aspirations were aligned to produce ideas for actions that encompassed the broad concerns. This integration of knowledge provides strategic steps for working with administrative authorities who have historical and ongoing interests.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais
Agricultura Florestal
Cooperação Internacional
Grupo com Ancestrais Oceânicos
[Mh] Termos MeSH secundário: Seres Humanos
Conhecimento
Nova Zelândia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:29253401
[Au] Autor:Brimblecombe J; Ferguson M; Chatfield MD; Liberato SC; Gunther A; Ball K; Moodie M; Miles E; Magnus A; Mhurchu CN; Leach AJ; Bailie R; SHOP@RIC research collaborative
[Ad] Endereço:Wellbeing and Preventable Chronic Diseases Division, Royal Darwin Hospital Campus, Tiwi, NT, Australia. Electronic address: julie.brimblecombe@menzies.edu.au.
[Ti] Título:Effect of a price discount and consumer education strategy on food and beverage purchases in remote Indigenous Australia: a stepped-wedge randomised controlled trial.
[So] Source:Lancet Public Health;2(2):e82-e95, 2017 Feb.
[Is] ISSN:2468-2667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Evidence is mounting that price discounts can be effective in improving diet. This study examined the effectiveness of a 20% price discount on food and drink purchases with and without consumer education in remote Indigenous Australia. METHODS: A 20% discount on fruit, vegetables, water, and artificially sweetened soft drinks was applied for 24 weeks in 20 communities in remote Indigenous Australia where the community store was managed by the Arnhem Land Progress Aboriginal Corporation (ALPA) or Outback Stores (OBS) in a stepped-wedge randomised trial. Communities were randomly allocated to a fixed framework of five sets of four stratified by store association; ten stores (two in each set) were randomly assigned to receive consumer education. A store from each of the ALPA and OBS store groups (contained in separate opaque envelopes) was selected, and stores in turn continued to be consecutively allocated to the fixed store set framework, starting with the first store slot in the first store set, until all stores had been allocated. The effect of the discount on the weight of fruit and vegetables purchased (the primary endpoint) was assessed using weekly store sales data and mixed models per protocol. We did sensitivity analyses by repeating the analyses with the outliers included and repeating the analyses for the primary outcome measure removing each store one at a time. This trial was registered with Australian New Zealand Clinical Trials Registry, number ACTRN12613000694718. FINDINGS: Weekly store sales data on all food and drink products sold in 20 stores were collected from July 1, 2012, to Dec 28, 2014. Price discount alone was associated with a 12·7% (95% CI 4·1-22·1) increase in purchases in grams of fruit and vegetables combined (primary outcome), and a 19·8% (6·2-35·1) increase post discount (after vs before); an effect of 12 g and 18 g per capita per day. Sensitivity analyses did not modify the results for the primary outcome measure. INTERPRETATION: A 20% discount can only increase fruit and vegetable purchases to help protect against obesity and diet related disease to a certain extent. Large discounts might have a greater impact than small discounts. Creative merchandising approaches to consumer education could also be considered alongside fiscal interventions to achieve marked improvements in diet. FUNDING: Australian National Health and Medical Research Council.
[Mh] Termos MeSH primário: Comércio/estatística & dados numéricos
Comportamento do Consumidor/economia
Dieta/etnologia
Preferências Alimentares/etnologia
Educação em Saúde
Grupo com Ancestrais Oceânicos/psicologia
População Rural
[Mh] Termos MeSH secundário: Adulto
Austrália
Bebidas/economia
Bebidas Gaseificadas/economia
Dieta/psicologia
Dieta/estatística & dados numéricos
Água Potável
Feminino
Frutas/economia
Seres Humanos
Masculino
Grupo com Ancestrais Oceânicos/estatística & dados numéricos
População Rural/estatística & dados numéricos
Edulcorantes/economia
Verduras/economia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drinking Water); 0 (Sweetening Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29178642
[Au] Autor:Thompson JA; De Roach JN; McLaren TL; Montgomery HE; Hoffmann LH; Campbell IR; Chen FK; Mackey DA; Lamey TM
[Ad] Endereço:Australian Inherited Retinal Disease Registry and DNA Bank, Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
[Ti] Título:The genetic profile of Leber congenital amaurosis in an Australian cohort.
[So] Source:Mol Genet Genomic Med;5(6):652-667, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Leber congenital amaurosis (LCA) is a severe visual impairment responsible for infantile blindness, representing ~5% of all inherited retinal dystrophies. LCA encompasses a group of heterogeneous disorders, with 24 genes currently implicated in pathogenesis. Such clinical and genetic heterogeneity poses great challenges for treatment, with personalized therapies anticipated to be the best treatment candidates. Unraveling the individual genetic etiology of disease is a prerequisite for personalized therapies, and could identify potential treatment candidates, inform patient management, and discriminate syndromic forms of disease. METHODS: We have genetically analyzed 45 affected and 82 unaffected individuals from 34 unrelated LCA pedigrees using predominantly next-generation sequencing and Array CGH technology. RESULTS: We present the molecular findings for an Australian LCA cohort, sourced from the Australian Inherited Retinal Disease Registry & DNA Bank. CEP290 and GUCY2D mutations, each represent 19% of unrelated LCA cases, followed by NMNAT1 (12%). Genetic subtypes were consistent with other reports, and were resolved in 90% of this cohort. CONCLUSION: The high resolution rate achieved, equivalent to recent findings using whole exome/genome sequencing, reflects the progression from hypothesis (LCA Panel) to non-hypothesis (RD Panel) testing and, coupled with Array CGH analysis, is a highly effective first-tier test for LCA.
[Mh] Termos MeSH primário: Amaurose Congênita de Leber/genética
Grupo com Ancestrais Oceânicos/genética
[Mh] Termos MeSH secundário: Antígenos de Neoplasias/genética
Austrália/epidemiologia
Estudos de Coortes
Análise Mutacional de DNA
Bases de Dados Genéticas
Proteínas do Olho/genética
Guanilato Ciclase/genética
Heterozigoto
Sequenciamento de Nucleotídeos em Larga Escala
Homozigoto
Seres Humanos
Amaurose Congênita de Leber/diagnóstico
Amaurose Congênita de Leber/epidemiologia
Proteínas Associadas aos Microtúbulos/genética
Proteínas de Neoplasias/genética
Nicotinamida-Nucleotídeo Adenililtransferase/genética
Linhagem
Fenótipo
Prevalência
Receptores de Superfície Celular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Neoplasm); 0 (Cep290 protein, human); 0 (Eye Proteins); 0 (Microtubule-Associated Proteins); 0 (Neoplasm Proteins); 0 (Receptors, Cell Surface); 0 (guanylate cyclase 1); 0 (lebercilin protein, human); EC 2.7.7.1 (NMNAT1 protein, human); EC 2.7.7.1 (Nicotinamide-Nucleotide Adenylyltransferase); EC 4.6.1.2 (Guanylate Cyclase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.321


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[PMID]:29274220
[Au] Autor:Middleton R; Stephens M; Mackay M
[Ti] Título:INCORPORATING THE NURSING AND MIDWIFERY ABORIGINAL AND TORRES STRAIT ISLANDER HEALTH CURRICULUM FRAMEWORK INTO A BN PROGRAM.
[So] Source:Aust Nurs Midwifery J;24(9):44, 2017 04.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Preparing nursing students for authentic person-centred practice demands an awareness and understanding of Australian culture and history and the impact of these things on the health of Aboriginal and Torres Strait Islander peoples.
[Mh] Termos MeSH primário: Competência Cultural
Currículo
Bacharelado em Enfermagem
Serviços de Saúde do Indígena
Grupo com Ancestrais Oceânicos
[Mh] Termos MeSH secundário: Austrália
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


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[PMID]:29274219
[Au] Autor:Kelly J
[Ti] Título:USING MAPPING TOOLS TO IMPROVE ABORIGINAL PATIENT JOURNEYS.
[So] Source:Aust Nurs Midwifery J;24(9):43, 2017 04.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Nurses and midwives play a central role in ensuring effective healthcare for Aboriginal patients in urban, rural and remote locations. However, at times they feel underequipped to fully support Aboriginal patients and their families with the skills and knowledge and resources available (Dwyer et at 2014).
[Mh] Termos MeSH primário: Continuidade da Assistência ao Paciente/organização & administração
Serviços de Saúde do Indígena/organização & administração
[Mh] Termos MeSH secundário: Austrália
Seres Humanos
Grupo com Ancestrais Oceânicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


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[PMID]:29274218
[Au] Autor:Stuart L; Sengstock B
[Ti] Título:HOW CAN SCHOOLS OF NURSING AND MIDWIFERY PREPARE THEIR GRADUATES TO ENCOURAGE MEDICATION ADHERENCE FOR AUSTRALIAN ABORIGINAL AND TORRES STRAIT ISLANDER CLIENTS?
[So] Source:Aust Nurs Midwifery J;24(9):42, 2017 04.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Research undertaken in mainstream Australian studies show that the overall rate of medication non-adherence has been reported to be high, for Aboriginal and Torres Strait Islander peoples of Australia leading to adverse and critical health outcomes (AIHW 2010).
[Mh] Termos MeSH primário: Adesão à Medicação
Papel do Profissional de Enfermagem
Grupo com Ancestrais Oceânicos
[Mh] Termos MeSH secundário: Austrália
Seres Humanos
Escolas de Enfermagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


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[PMID]:29274216
[Au] Autor:Sivertsen N; Lawrence M; McDermott D
[Ti] Título:CHALLENGES TO INDIGENOUS HEALTH CURRICULUM DESIGN -- BRINGING THE ABORIGINAL AND TORRES STRAIT ISLANDER HEALTH CURRICULUM FRAMEWORK TO LIFE.
[So] Source:Aust Nurs Midwifery J;24(9):41, 2017 04.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:While it is our responsibility to produce culturally safe graduates with a nuanced grasp of Aboriginal and Torres Strait Islander health needs, there are central challenges in curriculum writing for indigenous health today.
[Mh] Termos MeSH primário: Competência Cultural
Currículo
Educação em Enfermagem
Serviços de Saúde do Indígena
Grupo com Ancestrais Oceânicos
[Mh] Termos MeSH secundário: Austrália
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


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[PMID]:29272093
[Au] Autor:Grant J; Deverix J; Nottage C; Sivertsen N; Spurrier N; Steeb A; Stuart-Butler D
[Ti] Título:COLLABORATION AND CULTURAL SAFETY: SAFE SLEEP SPACE ALTERNATIVES WITH ABORIGINAL FAMILIES.
[So] Source:Aust Nurs Midwifery J;24(9):40, 2017 04.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Despite a marked reduction in Aboriginal and Torres Strait Islander infant deaths from 1998 to 2012 (AIHW 2015) Aboriginal and Torres Strait Islander infants remain over-represented in sudden and unexpected infant death rates.
[Mh] Termos MeSH primário: Educação em Saúde/organização & administração
Serviços de Saúde do Indígena
Sono
Morte Súbita do Lactente/etnologia
Morte Súbita do Lactente/prevenção & controle
[Mh] Termos MeSH secundário: Austrália
Competência Cultural
Seres Humanos
Lactente
Grupo com Ancestrais Oceânicos
Desenvolvimento de Programas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE


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[PMID]:29272092
[Au] Autor:Piercey C; Robinson M
[Ti] Título:INDIGENOUS NURSING WORKFORCE, TO ACHIEVE EQUALITY IN HEALTHCARE SERVICES.
[So] Source:Aust Nurs Midwifery J;24(9):39, 2017 04.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Inequities and poor health outcomes of Aboriginal people in Western Australia are well documented. Indigenous Australians continue to experience poorer health and higher death rates than non-indigenous Australians (AHW 2008).
[Mh] Termos MeSH primário: Serviços de Saúde do Indígena/recursos humanos
Enfermeiras e Enfermeiros/provisão & distribuição
Grupo com Ancestrais Oceânicos
[Mh] Termos MeSH secundário: Austrália
Escolha da Profissão
Seres Humanos
Evasão Escolar
Estudantes de Enfermagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE



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