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[PMID]:27771146
[Au] Autor:Sardell RJ; Nittala MG; Adams LD; Laux RA; Cooke Bailey JN; Fuzzell D; Fuzzell S; Reinhart-Mercer L; Caywood LJ; Horst V; Mackay T; Dana D; Sadda SR; Scott WK; Stambolian D; Haines JL; Pericak-Vance MA
[Ad] Endereço:John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida.
[Ti] Título:Heritability of Choroidal Thickness in the Amish.
[So] Source:Ophthalmology;123(12):2537-2544, 2016 12.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the heritability of choroidal thickness and its relationship to age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: Six hundred eighty-nine individuals from Amish families with early or intermediate AMD. METHODS: Ocular coherence tomography was used to quantify choroidal thickness, and fundus photography was used to classify eyes into categories using a modified Clinical Age-Related Maculopathy Staging (CARMS) system. Repeatability and heritability of choroidal thickness and its phenotypic and genetic correlations with the AMD phenotype (CARMS category) were estimated using a generalized linear mixed model (GLMM) approach that accounted for relatedness, repeated measures (left and right eyes), and the effects of age, gender, and refraction. MAIN OUTCOME MEASURES: Heritability of choroidal thickness and its phenotypic and genetic correlation with the AMD phenotype (CARMS category). RESULTS: Phenotypic correlation between choroidal thickness and CARMS category was moderate (Spearman's rank correlation, r = -0.24; n = 1313 eyes) and significant (GLMM posterior mean, -4.27; 95% credible interval [CI], -7.88 to -0.79; P = 0.02) after controlling for relatedness, age, gender, and refraction. Eyes with advanced AMD had thinner choroids than eyes without AMD (posterior mean, -73.8; 95% CI, -94.7 to -54.6; P < 0.001; n = 1178 eyes). Choroidal thickness was highly repeatable within individuals (repeatability, 0.78; 95% CI, 0.68 to 0.89) and moderately heritable (heritability, 0.40; 95% CI, 0.14 to 0.51), but did not show significant genetic correlation with CARMS category, although the effect size was moderate (genetic correlation, -0.18; 95% CI, -0.49 to 0.16). Choroidal thickness also varied with age, gender, and refraction. The CARMS category showed moderate heritability (heritability, 0.49; 95% CI, 0.26 to 0.72). CONCLUSIONS: We quantify the heritability of choroidal thickness for the first time, highlighting a heritable, quantitative trait that is measurable in all individuals regardless of AMD affection status, and moderately phenotypically correlated with AMD severity. Choroidal thickness therefore may capture variation not captured by the CARMS system. However, because the genetic correlation between choroidal thickness and AMD severity was not significant in our data set, genes associated with the 2 traits may not overlap substantially. Future studies should therefore test for genetic variation associated with choroidal thickness to determine the overlap in genetic basis with AMD.
[Mh] Termos MeSH primário: Amish/genética
Corioide/patologia
Característica Quantitativa Herdável
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Corioide/diagnóstico por imagem
Estudos de Coortes
Feminino
Seres Humanos
Degeneração Macular/genética
Masculino
Meia-Idade
Tamanho do Órgão/genética
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28768853
[Au] Autor:Williamson G; Ahmed B; Kumar PS; Ostrov BE; Ericson JE
[Ad] Endereço:College of Medicine, Pennsylvania State University, Hershey, Pennsylvania; and.
[Ti] Título:Vaccine-Preventable Diseases Requiring Hospitalization.
[So] Source:Pediatrics;140(3), 2017 Sep.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plain children often have lower immunization rates than non-Plain children. Penn State Health Children's Hospital is a tertiary medical center with large nearby Plain (Amish and Mennonite) communities. We sought to describe the characteristics of children hospitalized with vaccine-preventable diseases (VPDs). We hypothesized that Amish children would have a higher risk of VPDs than non-Amish children. METHODS: codes were used to identify patients <18 years diagnosed with a VPD from January 1, 2005, to December 31, 2015, at Penn State Children's Hospital. Demographic information, immunization status, and outcomes were obtained from medical records. By using the number of children in our primary service area, we calculated the risk of VPD requiring hospitalization for Amish and non-Amish children. We assessed the relationship between Plain affiliation and vaccination status by using the Pearson correlation coefficient. RESULTS: There were 215 children with 221 VPDs. Most occurred in non-Plain children: 179 of 221 (81%). Except for pneumococcal infections, VPD occurred mostly in unvaccinated or immunocompromised children, regardless of Plain affiliation. There were 15 type b and 5 tetanus infections that occurred in children with an unvaccinated or unknown vaccination status. The risk of a VPD requiring hospitalization was greater for Amish than for non-Plain children (risk ratio: 2.67 [95% confidence interval: 1.87-3.82]). There was a strong correlation between Plain affiliation and lack of vaccination ( = -0.63, < .01). CONCLUSIONS: Amish children had an increased risk of a VPD requiring hospitalization than non-Plain children. With the exception of those with pneumococcal disease, most vaccinated children hospitalized with a VPD were immunocompromised.
[Mh] Termos MeSH primário: Doenças Transmissíveis/epidemiologia
Hospitalização/estatística & dados numéricos
Vacinação/estatística & dados numéricos
[Mh] Termos MeSH secundário: Amish
Criança
Pré-Escolar
Doenças Transmissíveis/imunologia
Feminino
Seres Humanos
Programas de Imunização
Lactente
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE


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[PMID]:28495136
[Au] Autor:Raheja UK; Fuchs D; Lowry CA; Stephens SH; Pavlovich MA; Mohyuddin H; Yousufi H; Ryan KA; O'Connell J; Brenner LA; Punzalan C; Hoisington AJ; Nijjar GK; Groer M; Shuldiner AR; Pollin TI; Stiller JW; Mitchell BD; Postolache TT
[Ad] Endereço:Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Child and Adolescent Psychiatry Residency Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive, Atlan
[Ti] Título:Heritability of plasma neopterin levels in the Old Order Amish.
[So] Source:J Neuroimmunol;307:37-41, 2017 Jun 15.
[Is] ISSN:1872-8421
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We examined the heritability of neopterin, a biomarker for cell-mediated immunity and oxidative stress, and potentially for psychiatric disorders, in the Old Order Amish. METHODS: Plasma neopterin levels were determined in 2015 Old Order Amish adults. Quantitative genetic procedures were used to estimate heritability of neopterin. RESULTS: Heritability of log-neopterin was estimated at 0.07 after adjusting for age, gender, and household (p=0.03). The shared household effect was 0.06 (p<0.02). CONCLUSIONS: We found a low heritability of neopterin and small household effect, suggesting that non-household environmental factors are more important determinants of variance of neopterin levels in the Amish.
[Mh] Termos MeSH primário: Envelhecimento/sangue
Amish/estatística & dados numéricos
Neopterina/sangue
[Mh] Termos MeSH secundário: Adulto
Envelhecimento/imunologia
Meio Ambiente
Feminino
Seres Humanos
Masculino
Meia-Idade
Neopterina/genética
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
670-65-5 (Neopterin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


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[PMID]:28428224
[Au] Autor:Xu H; Ryan KA; Jaworek TJ; Southam L; Reid JG; Overton JD; Baras A; Puurunen MK; Zeggini E; Taylor SI; Shuldiner AR; Mitchell BD
[Ad] Endereço:Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes & Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
[Ti] Título:Familial Hypercholesterolemia and Type 2 Diabetes in the Old Order Amish.
[So] Source:Diabetes;66(7):2054-2058, 2017 Jul.
[Is] ISSN:1939-327X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alleles associated with lower levels of LDL cholesterol (LDL-C) have recently been associated with an increased risk of type 2 diabetes (T2D), highlighting the complex relationship between LDL-C and diabetes. This observation begs the question of whether LDL-C-raising alleles are associated with a decreased risk of T2D. This issue was recently addressed in a large familial hypercholesterolemia (FH) screening study, which reported a lower prevalence of self-reported diabetes in FH subjects than in age-matched relatives without FH. To extend this observation, we tested the association of FH with diabetes status and glycemia in a large Amish population enriched for the FH-associated R3527Q variant that included 640 R3527Q carriers and 4,683 noncarriers. Each copy of the R3527Q T allele was associated with a 74.9 mg/dL increase in LDL-C. There was little difference in T2D prevalence between subjects with (5.2%) and without (4.5%) the R3527Q allele ( = 0.23), and there was no association between R3527Q variant and impaired fasting glucose, fasting glucose or insulin, or oral glucose tolerance test-derived measures. Our data provide no evidence supporting an association between the R3527Q variant and T2D or glycemia and highlight the asymmetry of the LDL-C-T2D relationship and/or the gene/variant-dependent specificity of the LDL-C-T2D association.
[Mh] Termos MeSH primário: Amish/genética
Apolipoproteínas B/genética
Diabetes Mellitus Tipo 2/genética
Hiperlipoproteinemia Tipo II/genética
[Mh] Termos MeSH secundário: Glicemia/metabolismo
LDL-Colesterol/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Predisposição Genética para Doença
Genótipo
Hemoglobina A Glicada/metabolismo
Seres Humanos
Hiperlipoproteinemia Tipo II/metabolismo
Insulina/metabolismo
Modelos Logísticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins B); 0 (Blood Glucose); 0 (Cholesterol, LDL); 0 (Glycated Hemoglobin A); 0 (Insulin); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.2337/db17-0173


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[PMID]:28403451
[Au] Autor:Lyon J
[Ti] Título:The Lung Microbiome: Key to Respiratory Ills?
[So] Source:JAMA;317(17):1713-1714, 2017 May 02.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pneumopatias/microbiologia
Pulmão/microbiologia
Microbiota
[Mh] Termos MeSH secundário: Amish
Asma/etnologia
Asma/microbiologia
Asma/terapia
Disbiose/etiologia
Seres Humanos
Pneumopatias/terapia
Microbiota/imunologia
Microbiota/fisiologia
Micobioma
[Pt] Tipo de publicação:INTERVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.3023


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[PMID]:28362870
[Au] Autor:Reed RM; Dransfield MT; Eberlein M; Miller M; Netzer G; Pavlovich M; Pollin TI; Scharf SM; Shuldiner AR; Sin D; Mitchell BD
[Ad] Endereço:University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States of America.
[Ti] Título:Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking.
[So] Source:PLoS One;12(3):e0174354, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Due to their relatively homogeneous lifestyle and living environment, the Amish offer a novel opportunity to study the health associations of tobacco smoke exposure, particularly secondhand smoke. We hypothesized that secondhand smoke exposure is associated with worse pulmonary and cardiometabolic health. We examined cross-sectional data on 3568 Amish study participants, including tobacco use and secondhand smoke exposure from family members included in the study. Thirty-four percent of Amish men reported ever smoking. Of this proportion, 64% used cigars, 46% cigarettes, and 21% pipes. Less than 1% of women reported ever smoking. Smoking was associated with lower spirometric lung function, higher body mass index, lower HDL cholesterol, higher heart rate, lower ankle-brachial index, and larger aortic diameter in men. A greater number of sources of secondhand smoke exposure (defined from the total of spouses, parents, and siblings who smoke) was associated with higher body mass index (p = 0.03) and with higher fasting glucose in men (p = 0.01), but not in women (p = 0.007 for sex*secondhand smoke interaction). Secondhand smoke exposure was also associated with reduced HDL cholesterol only in women (p = 0.002) and a lower heart rate only in men (p = 0.006). Smoking habits among the Old Order Amish are notable for the absence of female participation and a high proportion of cigar and pipe use. Smoking is associated with decreased spirometric indices of lung function and increased cardiovascular risk in this population and secondhand smoke exposure is associated with a greater burden of risk factors for cardiovascular disease. Sex differences in correlations could reflect differences in exposure patterns, mechanisms, or susceptibilities.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Poluição por Fumaça de Tabaco/efeitos adversos
[Mh] Termos MeSH secundário: Amish
Índice Tornozelo-Braço
Estudos Transversais
Feminino
Seres Humanos
Pulmão/efeitos dos fármacos
Masculino
Fatores de Risco
Uso de Tabaco/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174354


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[PMID]:28027084
[Au] Autor:Weller GER
[Ad] Endereço:From the Department of Anesthesiology and Perioperative Medicine, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, Pennsylvania.
[Ti] Título:Caring for the Amish: What Every Anesthesiologist Should Know.
[So] Source:Anesth Analg;124(5):1520-1528, 2017 May.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Amish are a relatively isolated group with cultural and religious customs that differ significantly from the mainstream American population. Functioning as tight-knit communities with strong conservative Christian beliefs, the Amish maintain a culture based on intentional separateness from the outside world. Key aspects of Amish life include distinct clothing and behaviors, a unique language, an agrarian lifestyle, limited formal education, nonviolence/nonaggression, and a general lack of modern technology, as exemplified by the use of the traditional horse-and-buggy. The Amish have distinct health care practices, beliefs, and goals, and because of differing genetics and lifestyle, also have a distinct constellation of health and disease characteristics. This article reviews the core beliefs, community and lifestyle, health care beliefs and practices, and health characteristics of this unique and medically challenging population. Generalizable strategies for providing culturally competent care for any such ethnically, socially, or medically unique community are presented.
[Mh] Termos MeSH primário: Amish/estatística & dados numéricos
Anestesia/métodos
Anestesiologistas
[Mh] Termos MeSH secundário: Amish/genética
Atitude Frente à Saúde
Cultura
Seres Humanos
Estilo de Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000001808


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[PMID]:26525584
[Au] Autor:Hess RF
[Ad] Endereço:1 Research For Health, Inc., Cuyahoga Falls, OH, USA.
[Ti] Título:Amish-Initiated Burn Care Project: Case Report and Lessons Learned in Participatory Research.
[So] Source:J Transcult Nurs;28(2):212-219, 2017 Mar.
[Is] ISSN:1552-7832
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This case report describes the phases of an Amish Burn Care Project and the lessons learned throughout the process. METHOD: Data sources to construct the case report included participant observation, interviews, archival documents, and a focus group. RESULTS: The narrative is organized into five phases of a participatory research approach: engagement, formalization, mobilization, maintenance, and expansion. LESSONS LEARNED: Community-initiated research led to legitimate change, working together for change took time, team members grew in mutual trust and respect for each other, cultural humility brought personal and professional growth, and capacity building took place through mutually supported efforts.
[Mh] Termos MeSH primário: Amish/psicologia
Queimaduras/terapia
Pesquisa Participativa Baseada na Comunidade/métodos
Comportamento Cooperativo
Desenvolvimento de Programas/métodos
Confiança
[Mh] Termos MeSH secundário: Arctium
Pesquisa Participativa Baseada na Comunidade/normas
Relações Comunidade-Instituição
Grupos Focais
Seres Humanos
Pesquisa Qualitativa
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:151104
[St] Status:MEDLINE
[do] DOI:10.1177/1043659615613417


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[PMID]:27705270
[Au] Autor:Gastañaduy PA; Budd J; Fisher N; Redd SB; Fletcher J; Miller J; McFadden DJ; Rota J; Rota PA; Hickman C; Fowler B; Tatham L; Wallace GS; de Fijter S; Parker Fiebelkorn A; DiOrio M
[Ad] Endereço:From the Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta (P.A.G., S.B.R., J.R., P.A.R., C.H., G.S.W., A.P.F.); and the Ohio Department of Health, Columbus (J.B., N.F., B.F., L.T., S.F., M.D.), Knox County Health Department, Mount Vernon (J.F., J.M.), and Holmes County
[Ti] Título:A Measles Outbreak in an Underimmunized Amish Community in Ohio.
[So] Source:N Engl J Med;375(14):1343-1354, 2016 10 06.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although measles was eliminated in the United States in 2000, importations of the virus continue to cause outbreaks. We describe the epidemiologic features of an outbreak of measles that originated from two unvaccinated Amish men in whom measles was incubating at the time of their return to the United States from the Philippines and explore the effect of public health responses on limiting the spread of measles. METHODS: We performed descriptive analyses of data on demographic characteristics, clinical and laboratory evaluations, and vaccination coverage. RESULTS: From March 24, 2014, through July 23, 2014, a total of 383 outbreak-related cases of measles were reported in nine counties in Ohio. The median age of case patients was 15 years (range, <1 to 53); a total of 178 of the case patients (46%) were female, and 340 (89%) were unvaccinated. Transmission took place primarily within households (68% of cases). The virus strain was genotype D9, which was circulating in the Philippines at the time of the reporting period. Measles-mumps-rubella (MMR) vaccination coverage with at least a single dose was estimated to be 14% in affected Amish households and more than 88% in the general (non-Amish) Ohio community. Containment efforts included isolation of case patients, quarantine of susceptible persons, and administration of the MMR vaccine to more than 10,000 persons. The spread of measles was limited almost exclusively to the Amish community (accounting for 99% of case patients) and affected only approximately 1% of the estimated 32,630 Amish persons in the settlement. CONCLUSIONS: The key epidemiologic features of a measles outbreak in the Amish community in Ohio were transmission primarily within households, the small proportion of Amish people affected, and the large number of people in the Amish community who sought vaccination. As a result of targeted containment efforts, and high baseline coverage in the general community, there was limited spread beyond the Amish community. (Funded by the Ohio Department of Health and the Centers for Disease Control and Prevention.).
[Mh] Termos MeSH primário: Amish/estatística & dados numéricos
Surtos de Doenças
Vacina contra Sarampo-Caxumba-Rubéola/administração & dosagem
Sarampo/epidemiologia
Vacinação/utilização
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Sarampo/transmissão
Meia-Idade
Ohio/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Measles-Mumps-Rubella Vaccine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE


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[PMID]:27414491
[Au] Autor:Gupta S; Heiman M; Duncan N; Hinckley J; Di Paola J; Shapiro AD
[Ad] Endereço:Indiana Hemophilia and Thrombosis Center, Indianapolis. sgupta@ihtc.org.
[Ti] Título:Variable bleeding phenotype in an Amish pedigree with von Willebrand disease.
[So] Source:Am J Hematol;91(10):E431-5, 2016 Oct.
[Is] ISSN:1096-8652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Through a cross-sectional study design, the bleeding phenotype in the Amish in Indiana (IN) and Wisconsin (WI) was described using two different bleeding scores. von Willebrand factor (VWF) testing was performed and bleeding questionnaires from Centers for Disease Control and Prevention (CDC) and European MCMDM-1 (Tosetto bleeding score (BS)) were administered to the IN and WI cohort respectively. Seven hundred and seventy nine subjects were recruited, 17% were diagnosed with VWD based on Ristocetin cofactor, VWF:RCo < 30 IU/dl. Majority of the affected (AF), 67%, were tested and had a common mutation c.4120 C > T. The WI AF were much younger at a mean age 15 years vs 26 years in IN AF cohort. The AF subjects had a median VWF:RCo of 13IU/dl with a statistically significant higher median BS 1 versus 0 in the WI AF vs WI Unaffected (UA), 2 vs 1 in the IN AF vs IN UA, P < 0.01. Adults had a higher median BS compared to children in the WI and IN cohort, 2 vs 1 and 3 vs 1 respectively (P < 0.05) but there was no statistically significant difference in the BS between males and females in either cohort. The common symptoms reported were epistaxis and gingival oozing. BS ≥ 3 and BS ≥ 4 were observed in 46% of AF IN and 16.6% of AF WI, respectively. There was significant variability in the bleeding phenotype, with an overall low BS in the affected Amish with VWD, despite a unifying mutation. Am. J. Hematol. 91:E431-E435, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Hemorragia/diagnóstico
Doenças de von Willebrand/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Amish
Criança
Pré-Escolar
Estudos Transversais
Feminino
Hemorragia/etiologia
Seres Humanos
Indiana
Lactente
Recém-Nascido
Masculino
Meia-Idade
Linhagem
Fenótipo
Mutação Puntual
Fatores Sexuais
Inquéritos e Questionários
Wisconsin
Adulto Jovem
Doenças de von Willebrand/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE
[do] DOI:10.1002/ajh.24474



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