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[PMID]: 27779318 [Au] Autor: Hendrick CE; Potter JE [Ad] Endereço: Population Research Center, The University of Texas at Austin, Austin, TX, USA. [Ti] Título: Nativity, Country of Education, and Mexican-Origin Women's Breastfeeding Behaviors in the First 10 Months Postpartum. [So] Source: Birth;44(1):68-77, 2017 Mar. [Is] ISSN: 1523-536X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Breastfeeding is associated with numerous health benefits for the infant and mother. Latina women in the United States have historically had high overall rates of initiation and duration of breastfeeding. However, these rates vary by nativity and time lived in the United States. Exclusive breastfeeding patterns among Latina women are unclear. In this study, we investigate the current and exclusive breastfeeding patterns of Mexican-origin women at four time points from delivery to 10 months postpartum to determine the combined association of nativity and country of education with breastfeeding duration and supplementation. METHODS: Data are from the Postpartum Contraception Study, a prospective cohort study of postpartum women ages 18-44 recruited from three hospitals in Austin and El Paso, Texas. We included Mexican-origin women who were born in either the United States or Mexico in the analytic sample (n = 593). RESULTS: Women completing schooling in Mexico had higher rates of overall breastfeeding throughout the study period than women educated in the United States, regardless of country of birth. This trend held in multivariate models while diminishing over time. Women born in Mexico who completed their schooling in the United States were least likely to exclusively breastfeed. DISCUSSION: Country of education should also be considered when assessing Latina women's risk for breastfeeding discontinuation. Efforts should be made to identify the barriers and facilitators to breastfeeding among US-educated Mexican-origin women to enhance existing breastfeeding promotion efforts in the United States. [Mh] Termos MeSH primário: Aleitamento Materno/etnologia Conhecimentos, Atitudes e Prática em Saúde Disparidades nos Níveis de Saúde Americanos Mexicanos/estatística & dados numéricos Mães/educação [Mh] Termos MeSH secundário: Adolescente Adulto Feminino Seres Humanos Recém-Nascido Modelos Logísticos Análise Multivariada Período Pós-Parto Gravidez Estudos Prospectivos Fatores Socioeconômicos Inquéritos e Questionários Texas Fatores de Tempo Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161026 [St] Status: MEDLINE [do] DOI: 10.1111/birt.12261

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[PMID]: 29194150 [Au] Autor: Torregosa MB; Ynalvez MA; Schiffman R; Morin K [Ti] Título: English-Language Proficiency, Academic Networks, and Academic Performance of Mexican American Baccalaureate Nursing Students. [So] Source: Nurs Educ Perspect;36(1):8-15, 2015 Jan/Feb. [Is] ISSN: 1536-5026 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: AIM: We examine how academic networks mediate between English-language proficiency and academic performance. BACKGROUND: The relationship between English-language proficiency and academic performance remains inconclusive; it is possible that academic networks play a role in this relationship. Filling this knowledge gap is central to building best practices in teaching, and to evaluating the impact of networks on success. METHOD: Data were analyzed from 164 Mexican American nursing students. We used English Language Acculturation Scale (ELAS) items as predictors, interaction with academic networks as the mediating variable, and course grade as the outcome; regression analyses were performed. RESULTS: Interaction with academic networks correlated with grades; ELAS was not significant. Instead, academic networks mediated between entrance GPA and grades, an unexpected finding. CONCLUSION: Academic networks are critical in academic performance. However, only those students who have a history of high performance are likely to have or to activate academic networks. [Mh] Termos MeSH primário: Desempenho Acadêmico/estatística & dados numéricos Aculturação Bacharelado em Enfermagem/organização & administração Bacharelado em Enfermagem/estatística & dados numéricos Avaliação Educacional/estatística & dados numéricos Americanos Mexicanos/estatística & dados numéricos Estudantes de Enfermagem/estatística & dados numéricos [Mh] Termos MeSH secundário: Adulto Feminino Seres Humanos Masculino Meia-Idade Multilinguismo Estados Unidos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: N [Da] Data de entrada para processamento: 171202 [St] Status: MEDLINE [do] DOI: 10.5480/13-1136.1

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[PMID]: 28449915 [Au] Autor: Lisabeth LD; Sánchez BN; Chervin RD; Morgenstern LB; Zahuranec DB; Tower SD; Brown DL [Ad] Endereço: Department of Epidemiology, University of Michigan School of Public Health, MI, USA; Stroke Program, University of Michigan Health System, MI, USA. Electronic address: llisabet@umich.edu. [Ti] Título: High prevalence of poststroke sleep-disordered breathing in Mexican Americans. [So] Source: Sleep Med;33:97-102, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The purpose of this study is to compare sleep-disordered breathing (SDB) prevalence and severity after stroke between Mexican Americans (MAs) and non-Hispanic whites (NHWs). PATIENTS/METHODS: Ischemic stroke (IS) patients within ∼30 days of onset were identified from the population-based BASIC Project (2010-2014) and offered screening with an overnight cardiopulmonary monitoring device, ApneaLink Plus™. The number of apneas and hypopneas per hour, as reflected by the apnea/hypopnea index (AHI), was used to measure SDB severity; SDB was defined as AHI ≥10. Ethnicity, demographics, and risk factors were collected from interviews and medical records. Log and negative-binomial regression models were used to determine prevalence ratios (PRs) and apnea/hypopnea event rate ratios (RRs) comparing MAs with NHWs after adjustment for demographics, risk factors, and stroke severity. RESULTS: A total of 549 IS cases had AHI data. The median age was 65 years (interquartile range (IQR): 57-76), 55% were men, and 65% were MA. The MAs had a higher prevalence of SDB (68.5%) than NHWs (49.5%) in unadjusted (PR = 1.38; 95% confidence interval (CI): 1.14-1.67) and adjusted analyses (PR = 1.21; 95% CI: 1.01-1.46). The median AHI was 16 (IQR: 7-31) in MAs and nine (IQR: 5-24) in NHWs. The severity of SDB (rate of apneas/hypopneas) was higher in MAs than NHWs in unadjusted (RR = 1.31; 95% CI: 1.09-1.58) but not adjusted analysis (RR = 1.14; 95% CI: 0.95-1.38). There was no ethnic difference in severity among subjects with SDB. CONCLUSION: More than two-thirds of MA stroke patients had SDB, which was almost 40% more common among MAs than NHWs. Physicians treating MA patients after stroke should have a high index of suspicion for SDB, a treatable condition that could otherwise have adverse impact. [Mh] Termos MeSH primário: Isquemia Encefálica/complicações Americanos Mexicanos/estatística & dados numéricos Polissonografia/instrumentação Prevalência Síndromes da Apneia do Sono/complicações Acidente Vascular Cerebral/complicações [Mh] Termos MeSH secundário: Idoso Grupos de Populações Continentais/etnologia Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos Feminino Seres Humanos Masculino Meia-Idade Polissonografia/métodos Fatores de Risco Índice de Gravidade de Doença Síndromes da Apneia do Sono/epidemiologia Síndromes da Apneia do Sono/fisiopatologia Acidente Vascular Cerebral/epidemiologia Acidente Vascular Cerebral/etnologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28464243 [Au] Autor: Villalobos BT; Ullman J; Krick TW; Alcántara D; Kopelowicz A; López SR [Ad] Endereço: University of Arkansas, Fayetteville, Arkansas, USA. [Ti] Título: Caregiver criticism, help-giving, and the burden of schizophrenia among Mexican American families. [So] Source: Br J Clin Psychol;56(3):273-285, 2017 Sep. [Is] ISSN: 0144-6657 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: This study tested an attribution model of help-giving in family caregivers of persons with schizophrenia as it relates to caregivers' reported burden. We hypothesized (a) that caregivers' attributions of their ill relatives' responsibility for their symptoms would be associated with more negative and less positive affective reactions, (b) that affective reactions would be related to perceptions of administered support, and (c) that support would in turn predict greater burden. METHODS: We examined 60 family caregivers of Mexican origin living in Southern California. Mexican Americans were chosen because of their high degree of contact with their ill relative, thereby facilitating the examination of help-giving and burden. Contrary to past studies, caregivers' attributions and affective stance were assessed independently, the former based on self-report and the latter based on codes drawn from the Camberwell Family Interview. Caregiver burden was assessed at baseline and one year later. RESULTS: Path analyses showed partial support for the attribution model of help-giving. Specifically, attributions of responsibility negatively predicted caregiver's warmth, which in turn predicted more administered support. Contrary to hypotheses, attributions were not associated with caregiver criticism, and criticism was positively related to administered support. In addition, caregiver support was not related to burden at either baseline or a year later. Criticism was a significant predictor of burden at follow-up through burden at baseline. CONCLUSION: The emotional stance of caregivers predicts burden independent of the help they provide. Caregiver criticism not only predicts negative patient outcomes but can predict negative caregiver outcomes as well. PRACTITIONER POINTS: Positive clinical implications In family treatment, it is important to address caregiver criticism not only because of its relationship to poor clinical outcomes of ill relatives but also because of its relationship to greater caregiver burden. Integrating a balanced rationale for family interventions - to improve ill relatives' and caregivers' outcomes - may promote further engagement of both parties as some caregivers may be additionally motivated to improve their own well-being, and some ill relatives may appreciate more equitably distributing the treatment focus. Limitations The caregiver sample was in general low in criticism; therefore, the findings may not be generalizable to families with a higher degree of criticism. There was a 35% sample attrition at the one-year follow-up. [Mh] Termos MeSH primário: Cuidadores/psicologia Esquizofrenia/terapia [Mh] Termos MeSH secundário: Adulto Feminino Seres Humanos Masculino Americanos Mexicanos Meia-Idade Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180131 [Lr] Data última revisão: 180131 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1111/bjc.12137

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[PMID]: 28935697 [Au] Autor: Patel RC; Sánchez BN; Morgenstern LB; Li C; Lisabeth LD [Ad] Endereço: From the Virginia Commonwealth University School of Medicine, Fairfax (R.C.P.); and Department of Epidemiology (L.B.M., C.L., L.D.L.) and Department of Biostatistics (B.N.S.), University of Michigan School of Public Health, Ann Arbor. patelrc2@vcu.edu. [Ti] Título: Impact of Stroke Risk Factors on Ethnic Stroke Disparities Among Midlife Mexican Americans and Non-Hispanic Whites. [So] Source: Stroke;48(10):2872-2874, 2017 Oct. [Is] ISSN: 1524-4628 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND AND PURPOSE: We examined the contribution of stroke risk factors to midlife (age 45-59 years) Mexican American and non-Hispanic White ischemic stroke (IS) rate disparities from 2000 to 2010. METHODS: Incident IS cases (n=707) and risk factors were identified from the Brain Attack Surveillance in Corpus Christi Project, Nueces County, TX (2000-2010). US Census data (2000-2010) were used to estimate the population at-risk for IS, and the Behavioral Risk Factor Surveillance System (2000-2010) was used to estimate risk factor prevalence in the stroke-free population. Poisson regression models combined IS counts (numerator) and population at-risk counts (denominator) classified by ethnicity and risk factor status to estimate unadjusted and risk factor-adjusted associations between ethnicity and IS rates. Separate models were run for each risk factor and extended to include an interaction term between ethnicity and risk factor. RESULTS: The crude rate ratio (RR) for ethnicity (Mexican American versus non-Hispanic White) was 2.01 (95% confidence interval [CI], 1.71-2.36) and was attenuated in models that adjusted for diabetes mellitus (RR: 1.50; 95% CI, 1.26-1.78) and hypertension (RR: 1.84; 95% CI, 1.50-2.26). In addition, diabetes mellitus had a stronger association with IS rates among Mexican Americans (RR: 6.42; 95% CI, 5.31-7.76) compared with non-Hispanic Whites (RR: 4.07; 95% CI, 3.68-4.51). CONCLUSIONS: The higher prevalence of diabetes mellitus and hypertension and stronger association of diabetes mellitus with IS among midlife Mexican Americans likely contribute to persistent midlife ethnic stroke disparities. [Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Europeu/etnologia Disparidades nos Níveis de Saúde Americanos Mexicanos Acidente Vascular Cerebral/etnologia [Mh] Termos MeSH secundário: Estudos Transversais Diabetes Mellitus/diagnóstico Diabetes Mellitus/etnologia Feminino Seres Humanos Hipertensão/diagnóstico Hipertensão/etnologia Masculino Meia-Idade Fatores de Risco Acidente Vascular Cerebral/diagnóstico Texas/etnologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170923 [St] Status: MEDLINE [do] DOI: 10.1161/STROKEAHA.117.018861

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[PMID]: 28614177 [Au] Autor: McKenna RM; Alcalá HE; Lê-Scherban F; Roby DH; Ortega AN [Ad] Endereço: Departments of *Health Management and Policy ‡Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA †Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA §Department of Health Services Administration, School of Public Health, University of Maryland, College Park, MD. [Ti] Título: The Affordable Care Act Reduces Hypertension Treatment Disparities for Mexican-heritage Latinos. [So] Source: Med Care;55(7):654-660, 2017 Jul. [Is] ISSN: 1537-1948 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVES: Mexican-heritage Latinos have lower prevalence of hypertension, but have worse patterns of treatment and control compared with non-Latino whites. This study examined the impact of the Affordable Care Act (ACA) insurance expansion on reducing disparities in treatment and medication use among Mexican-heritage Latinos with hypertension. RESEARCH DESIGN: Using the 2009-2014 waves of the California Health Interview Survey, we examine health care access, utilization, and medication use among Mexican-heritage Latinos and non-Latino whites with hypertension. Multivariable logistic regression analyses were performed to adjust for socioeconomic and demographic factors. Interactions between race/ethnicity and year variables were conducted to capture the effects of the passage of the ACA. RESULTS: Among those with hypertension, the full implementation of the ACA (year 2014) is associated with a greater likelihood of being insured, but the race/ethnicity interaction indicates that this gain is less substantial for Mexican-heritage Latinos. The odds of having a usual source of care other than the emergency department increased after the passage of the ACA, and interaction effects indicate that this gain was more substantial for Mexican-heritage Latinos. The odds of having any physician visit and taking blood pressure mediations decreased among non-Latino whites but increased among Mexican-heritage Latinos. CONCLUSIONS: The implementation of the ACA in California has helped reduce some of the disparities in health care access, utilization, and medication use between non-Latino whites and Mexican-heritage Latinos with hypertension. However, sustained progress is threatened by looming repeals of ACA provisions. [Mh] Termos MeSH primário: Disparidades em Assistência à Saúde/tendências Hipertensão/tratamento farmacológico Americanos Mexicanos Patient Protection and Affordable Care Act [Mh] Termos MeSH secundário: Adolescente Adulto Idoso California Estudos Transversais Feminino Acesso aos Serviços de Saúde Seres Humanos Hipertensão/economia Modelos Logísticos Masculino Meia-Idade Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170728 [Lr] Data última revisão: 170728 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170615 [St] Status: MEDLINE [do] DOI: 10.1097/MLR.0000000000000726

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[PMID]: 28613924 [Au] Autor: LaVange L; Davis SM; Hankinson J; Enright P; Wilson R; Barr RG; Aldrich TK; Kalhan R; Lemus H; Ni A; Smith LJ; Talavera GA [Ad] Endereço: 1 Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. [Ti] Título: Spirometry Reference Equations from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). [So] Source: Am J Respir Crit Care Med;196(8):993-1003, 2017 Oct 15. [Is] ISSN: 1535-4970 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Accurate reference values for spirometry are important because the results are used for diagnosing common chronic lung diseases such as asthma and chronic obstructive pulmonary disease, estimating physiologic impairment, and predicting all-cause mortality. Reference equations have been established for Mexican Americans but not for others with Hispanic/Latino backgrounds. OBJECTIVES: To develop spirometry reference equations for adult Hispanic/Latino background groups in the United States. METHODS: The HCHS/SOL (Hispanic Community Health Study/Study of Latinos) recruited a population-based probability sample of 16,415 Hispanics/Latinos aged 18-74 years living in the Bronx, Chicago, Miami, and San Diego. Participants self-identified as being of Puerto Rican, Cuban, Dominican, Mexican, or Central or South American background. Spirometry was performed using standardized methods with central quality control monitoring. Spirometric measures from a subset of 6,425 never-smoking participants without respiratory symptoms or disease were modeled as a function of sex, age, height, and Hispanic/Latino background to produce background-specific reference equations for the predicted value and lower limit of normal. MEASUREMENTS AND MAIN RESULTS: Dominican and Puerto Rican Americans had substantially lower predicted and lower limit of normal values for FVC and FEV than those in other Hispanic/Latino background groups and also than Mexican American values from NHANES III (Third National Health and Nutrition Examination Survey). CONCLUSIONS: For patients of Dominican and Puerto Rican background who present with pulmonary symptoms in clinical practice, use of background-specific spirometry reference equations may provide more appropriate predicted and lower limit of normal values, enabling more accurate diagnoses of abnormality and physiologic impairment. [Mh] Termos MeSH primário: Emigrantes e Imigrantes Pneumopatias/diagnóstico Pneumopatias/etnologia Padrões de Referência [Mh] Termos MeSH secundário: Adolescente Adulto Idoso América Central Feminino Hispano-Americanos Seres Humanos Masculino Americanos Mexicanos México Meia-Idade América do Sul Espirometria Estados Unidos/etnologia Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171103 [Lr] Data última revisão: 171103 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170615 [St] Status: MEDLINE [do] DOI: 10.1164/rccm.201610-1987OC

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[PMID]: 28541586 [Au] Autor: Crist JD; Pasvogel A; Szalacha LA; Finley BA [Ti] Título: Depression in Family Caregivers of Mexican Descent: Exacerbated by Stress and Mitigated by Mutuality. [So] Source: Res Gerontol Nurs;10(3):106-113, 2017 May 01. [Is] ISSN: 1938-2464 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Despite common assumptions that non-paid family caregivers of Mexican descent benefit spiritually from their roles according to cultural familistic norms, there is also evidence of caregiver stress resulting in depression. Depression has the potential to seriously affect caregivers' health and their ability to continue to provide care. The current study's purpose was to examine the relationships among depression, stress, and mutuality (i.e., the quality of the caregiver-care recipient relationship) (N = 74 caregivers of Mexican descent in the southwestern United States). Multiple regression models and exploratory mediational analyses indicated that the stress-depression relationship can be significantly mediated by mutuality. Results support culturally appropriate interventions to decrease caregiver stress and depression by promoting mutuality. In addition, with changing trends in outside work roles and mobility of caregivers of Mexican descent, policy should make services truly accessible to support caregiving families of Mexican descent. [Res Gerontol Nurs. 2017; 10(3):106-113.]. [Mh] Termos MeSH primário: Cuidadores/psicologia Relações Familiares/etnologia Relação entre Gerações/etnologia Americanos Mexicanos/psicologia [Mh] Termos MeSH secundário: Adaptação Psicológica Relações Familiares/psicologia Seres Humanos Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171023 [Lr] Data última revisão: 171023 [Sb] Subgrupo de revista: IM; N [Da] Data de entrada para processamento: 170526 [St] Status: MEDLINE [do] DOI: 10.3928/19404921-20170412-01

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[PMID]: 28525987 [Au] Autor: Kulkarni H; Mamtani M; Wong G; Weir JM; Barlow CK; Dyer TD; Almasy L; Mahaney MC; Comuzzie AG; Duggirala R; Meikle PJ; Blangero J; Curran JE [Ad] Endereço: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, 78520, USA. hemant.kulkarni@mnhresearch.com. [Ti] Título: Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families. [So] Source: BMC Genet;18(1):48, 2017 May 19. [Is] ISSN: 1471-2156 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits. RESULTS: We used plasma lipidomic data (1202 pedigreed individuals, 319 lipid species representing 23 lipid classes) from San Antonio Family Heart Study in Mexican Americans. Bivariate trait analyses were used to estimate the genetic and environmental correlation of all lipid species with three T2D-related traits: risk of T2D, presence of prediabetes and homeostatic model of assessment - insulin resistance. We found that 44 lipid species were significantly genetically correlated with one or more of the three T2D-related traits. Majority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TAG, 17 species) classes. Six lipid species (all belonging to the triacylglycerol class and containing palmitate at the first position) were significantly genetically correlated with all the T2D-related traits. CONCLUSIONS: Our results imply that: a) not all plasma lipid species are genetically informative for T2D pathogenesis; b) the DAG and TAG lipid classes partially share genetic basis of T2D; and c) 1-palmitate containing TAGs may provide additional insights into the genetic basis of T2D. [Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/genética Resistência à Insulina/genética Lipídeos/sangue Americanos Mexicanos/genética Estado Pré-Diabético/genética Característica Quantitativa Herdável [Mh] Termos MeSH secundário: Adulto Diabetes Mellitus Tipo 2/sangue Diabetes Mellitus Tipo 2/etnologia Feminino Interação Gene-Ambiente Seres Humanos Resistência à Insulina/etnologia Masculino Estado Pré-Diabético/sangue Estado Pré-Diabético/etnologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Lipids) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171006 [Lr] Data última revisão: 171006 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170521 [St] Status: MEDLINE [do] DOI: 10.1186/s12863-017-0515-5

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[PMID]: 28515064 [Au] Autor: Farook VS; Reddivari L; Mummidi S; Puppala S; Arya R; Lopez-Alvarenga JC; Fowler SP; Chittoor G; Resendez RG; Kumar BM; Comuzzie AG; Curran JE; Lehman DM; Jenkinson CP; Lynch JL; DeFronzo RA; Blangero J; Hale DE; Duggirala R; Vanamala JK [Ad] Endereço: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of. [Ti] Título: Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children. [So] Source: Am J Clin Nutr;106(1):52-58, 2017 Jul. [Is] ISSN: 1938-3207 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Dietary intake of phytonutrients present in fruits and vegetables, such as carotenoids, is associated with a lower risk of obesity and related traits, but the impact of genetic variation on these associations is poorly understood, especially in children. We estimated common genetic influences on serum carotenoid concentrations and obesity-related traits in Mexican American (MA) children. Obesity-related data were obtained from 670 nondiabetic MA children, aged 6-17 y. Serum α- and ß-carotenoid concentrations were measured in ∼570 (α-carotene in 565 and ß-carotene in 572) of these children with the use of an ultraperformance liquid chromatography-photodiode array. We determined heritabilities for both carotenoids and examined their genetic relation with 10 obesity-related traits [body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL) cholesterol, triglycerides, fat mass (FM), systolic and diastolic blood pressure, fasting insulin and glucose, and homeostasis model assessment of insulin resistance] by using family data and a variance components approach. For these analyses, carotenoid values were inverse normalized, and all traits were adjusted for significant covariate effects of age and sex. Carotenoid concentrations were highly heritable and significant [α-carotene: heritability ( ) = 0.81, = 6.7 × 10 ; ß-carotene: = 0.90, = 3.5 × 10 ]. After adjusting for multiple comparisons, we found significant ( ≤ 0.05) negative phenotypic correlations between carotenoid concentrations and the following traits: BMI, WC, FM, and triglycerides (range: α-carotene = -0.19 to -0.12; ß-carotene = -0.24 to -0.13) and positive correlations with HDL cholesterol (α-carotene = 0.17; ß-carotene = 0.24). However, when the phenotypic correlations were partitioned into genetic and environmental correlations, we found marginally significant ( = 0.051) genetic correlations only between ß-carotene and BMI (-0.27), WC (-0.30), and HDL cholesterol (0.31) after accounting for multiple comparisons. None of the environmental correlations were significant. The findings from this study suggest that the serum carotenoid concentrations were under strong additive genetic influences based on variance components analyses, and that the common genetic factors may influence ß-carotene and obesity and lipid traits in MA children. [Mh] Termos MeSH primário: Carotenoides/genética Americanos Mexicanos/genética Estado Nutricional Obesidade/genética Fenótipo Característica Quantitativa Herdável beta Caroteno/genética [Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo Adolescente Índice de Massa Corporal Carotenoides/sangue Criança Meio Ambiente Feminino Interação Gene-Ambiente Seres Humanos Masculino Obesidade/sangue Obesidade/metabolismo Triglicerídeos/sangue Circunferência da Cintura beta Caroteno/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Triglycerides); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); 45XWE1Z69V (alpha-carotene) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170824 [Lr] Data última revisão: 170824 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170519 [St] Status: MEDLINE [do] DOI: 10.3945/ajcn.116.144006

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