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[PMID]: | 28515064 |
[Au] Autor: | Farook VS; Reddivari L; Mummidi S; Puppala S; Arya R; Lopez-Alvarenga JC; Fowler SP; Chittoor G; Resendez RG; Kumar BM; Comuzzie AG; Curran JE; Lehman DM; Jenkinson CP; Lynch JL; DeFronzo RA; Blangero J; Hale DE; Duggirala R; Vanamala JK |
[Ad] Endereço: | South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX; Departments of. |
[Ti] Título: | Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children. |
[So] Source: | Am J Clin Nutr;106(1):52-58, 2017 Jul. | [Is] ISSN: | 1938-3207 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Dietary intake of phytonutrients present in fruits and vegetables, such as carotenoids, is associated with a lower risk of obesity and related traits, but the impact of genetic variation on these associations is poorly understood, especially in children. We estimated common genetic influences on serum carotenoid concentrations and obesity-related traits in Mexican American (MA) children. Obesity-related data were obtained from 670 nondiabetic MA children, aged 6-17 y. Serum α- and ß-carotenoid concentrations were measured in ∼570 (α-carotene in 565 and ß-carotene in 572) of these children with the use of an ultraperformance liquid chromatography-photodiode array. We determined heritabilities for both carotenoids and examined their genetic relation with 10 obesity-related traits [body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL) cholesterol, triglycerides, fat mass (FM), systolic and diastolic blood pressure, fasting insulin and glucose, and homeostasis model assessment of insulin resistance] by using family data and a variance components approach. For these analyses, carotenoid values were inverse normalized, and all traits were adjusted for significant covariate effects of age and sex. Carotenoid concentrations were highly heritable and significant [α-carotene: heritability ( ) = 0.81, = 6.7 × 10 ; ß-carotene: = 0.90, = 3.5 × 10 ]. After adjusting for multiple comparisons, we found significant ( ≤ 0.05) negative phenotypic correlations between carotenoid concentrations and the following traits: BMI, WC, FM, and triglycerides (range: α-carotene = -0.19 to -0.12; ß-carotene = -0.24 to -0.13) and positive correlations with HDL cholesterol (α-carotene = 0.17; ß-carotene = 0.24). However, when the phenotypic correlations were partitioned into genetic and environmental correlations, we found marginally significant ( = 0.051) genetic correlations only between ß-carotene and BMI (-0.27), WC (-0.30), and HDL cholesterol (0.31) after accounting for multiple comparisons. None of the environmental correlations were significant. The findings from this study suggest that the serum carotenoid concentrations were under strong additive genetic influences based on variance components analyses, and that the common genetic factors may influence ß-carotene and obesity and lipid traits in MA children. |
[Mh] Termos MeSH primário: |
Carotenoides/genética Americanos Mexicanos/genética Estado Nutricional Obesidade/genética Fenótipo Característica Quantitativa Herdável beta Caroteno/genética
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[Mh] Termos MeSH secundário: |
Tecido Adiposo/metabolismo Adolescente Índice de Massa Corporal Carotenoides/sangue Criança Meio Ambiente Feminino Interação Gene-Ambiente Seres Humanos Masculino Obesidade/sangue Obesidade/metabolismo Triglicerídeos/sangue Circunferência da Cintura beta Caroteno/sangue
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Triglycerides); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); 45XWE1Z69V (alpha-carotene) |
[Em] Mês de entrada: | 1707 |
[Cu] Atualização por classe: | 170824 |
[Lr] Data última revisão:
| 170824 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 170519 |
[St] Status: | MEDLINE |
[do] DOI: | 10.3945/ajcn.116.144006 |
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