Base de dados : MEDLINE
Pesquisa : N01.400.300 [Categoria DeCS]
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  1 / 21978 MEDLINE  
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[PMID]:29380037
[Au] Autor:Miyashita N; Onozawa M; Hayasaka K; Yamada T; Migita O; Hata K; Okada K; Goto H; Nakagawa M; Hashimoto D; Kahata K; Kondo T; Kunishima S; Teshima T
[Ad] Endereço:Department of Hematology, Hokkaido University Faculty of Medicine, Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 0608638, Japan.
[Ti] Título:A novel heterozygous ITGB3 p.T720del inducing spontaneous activation of integrin αIIbß3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction.
[So] Source:Ann Hematol;97(4):629-640, 2018 Apr.
[Is] ISSN:1432-0584
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We identified a novel heterozygous ITGB3 p.T720del mutation in a pedigree with macrothrombocytopenia exhibiting aggregation dysfunction. Platelet aggregation induced by ADP and collagen was significantly reduced, while ristocetin aggregation was normal. Integrin αIIbß3 was partially activated in a resting status, but platelet expression of αIIbß3 was downregulated. Functional analysis using a cell line showed spontaneous phosphorylation of FAK in αIIb/ß3 (p.T720del)-transfected 293T cells in suspension conditions. Abnormal cytoplasmic protrusions, membrane ruffling, and cytoplasmic localization of αIIbß3 were observed in αIIb/ß3 (p.T720del)-transfected CHO cells. Such morphological changes were reversed by treatment with an FAK inhibitor. These findings imply spontaneous, but partial, activation of αIIbß3 followed by phosphorylation of FAK as the initial mechanism of abnormal thrombopoiesis. Internalization and decreased surface expression of αIIbß3 would contribute to aggregation dysfunction. We reviewed the literature of congenital macrothrombocytopenia associated with heterozygous ITGA2B or ITGB3 mutations. Reported mutations were highly clustered at the membrane proximal region of αIIbß3, which affected the critical interaction between αIIb R995 and ß3 D723, resulting in a constitutionally active form of the αIIbß3 complex. Macrothrombocytopenia caused by a heterozygous activating mutation of ITGA2B or ITGB3 at the membrane proximal region forms a distinct entity of rare congenital thrombocytopenia.
[Mh] Termos MeSH primário: Deleção de Genes
Genes Dominantes
Heterozigoto
Integrina beta3/genética
Complexo Glicoproteico GPIIb-IIIa de Plaquetas/agonistas
Trombocitopenia/genética
[Mh] Termos MeSH secundário: Adulto
Animais
Células CHO
Cricetulus
Saúde da Família
Feminino
Células HEK293
Seres Humanos
Integrina beta3/metabolismo
Japão
Masculino
Meia-Idade
Mutagênese Sítio-Dirigida
Linhagem
Complexo Glicoproteico GPIIb-IIIa de Plaquetas/metabolismo
Proteínas Recombinantes/metabolismo
Trombocitopenia/sangue
Trombocitopenia/metabolismo
Trombocitopenia/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ITGB3 protein, human); 0 (Integrin beta3); 0 (Platelet Glycoprotein GPIIb-IIIa Complex); 0 (Recombinant Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-017-3214-4


  2 / 21978 MEDLINE  
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[PMID]:29236902
[Au] Autor:Zanin LE; Albuquerque IMN; Carneiro MDSM; Melo DH
[Ad] Endereço:Universidade Federal do Ceará - UFC - Sobral (CE), Brasil.
[Ti] Título:Evaluation of speech-language pathology care in the family health strategy from user perspective.
[Ti] Título:Avaliação da assistência fonoaudiológica na estratégia de saúde da família pela perspectiva do usuário..
[So] Source:Codas;29(6):e20160192, 2017 Dec 07.
[Is] ISSN:2317-1782
[Cp] País de publicação:Brazil
[La] Idioma:por; eng
[Ab] Resumo:PURPOSE: To evaluate the satisfaction of users assisted by speech-language pathologists during their Multi-professional Residency in Family Health, considering the structural, organizational and relational categories. METHODS: Qualitative assessment conducted with 30 Family Health Strategy (FHS) users. Data were analyzed using Bardin's content analysis. RESULTS: The organizational category presented aspects associated with the organization of speech-language pathology (SLP) services, describing the specific practice and role of speech-language therapists in the FHS, as well as referral and waiting time for care, speech-language therapy actions, clarification of problems, and promotion of self-care. The relational category showed the relationship between residents and users, with emphasis on humanized care and bonding. The structural category described the dimensioning of speech-language pathologists in the FHS and the aspects related to the resources available in the health unit. CONCLUSION: User satisfaction was associated with the rapid access to the service and the humanized care provided by the residents, promoting a welcoming service and bonding between residents and community. User dissatisfaction was associated with the reduced number of speech-language pathologists available at FHS.
[Mh] Termos MeSH primário: Saúde da Família
Satisfação do Paciente
Patologia da Fala e Linguagem
[Mh] Termos MeSH secundário: Atitude do Pessoal de Saúde
Brasil
Seres Humanos
Atenção Primária à Saúde
Garantia da Qualidade dos Cuidados de Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  3 / 21978 MEDLINE  
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[PMID]:29302025
[Au] Autor:Guéant JL; Chéry C; Oussalah A; Nadaf J; Coelho D; Josse T; Flayac J; Robert A; Koscinski I; Gastin I; Filhine-Tresarrieu P; Pupavac M; Brebner A; Watkins D; Pastinen T; Montpetit A; Hariri F; Tregouët D; Raby BA; Chung WK; Morange PE; Froese DS; Baumgartner MR; Benoist JF; Ficicioglu C; Marchand V; Motorin Y; Bonnemains C; Feillet F; Majewski J; Rosenblatt DS
[Ad] Endereço:INSERM, UMR_S954 Nutrition-Genetics-Environmental Risk Exposure and Reference Centre of Inborn Metabolism Diseases, University of Lorraine and University Hospital Centre of Nancy (CHRU Nancy), 54505, Nancy, France. jean-louis.gueant@univ-lorraine.fr.
[Ti] Título:APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients.
[So] Source:Nat Commun;9(1):67, 2018 01 04.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To date, epimutations reported in man have been somatic and erased in germlines. Here, we identify a cause of the autosomal recessive cblC class of inborn errors of vitamin B metabolism that we name "epi-cblC". The subjects are compound heterozygotes for a genetic mutation and for a promoter epimutation, detected in blood, fibroblasts, and sperm, at the MMACHC locus; 5-azacytidine restores the expression of MMACHC in fibroblasts. MMACHC is flanked by CCDC163P and PRDX1, which are in the opposite orientation. The epimutation is present in three generations and results from PRDX1 mutations that force antisense transcription of MMACHC thereby possibly generating a H3K36me3 mark. The silencing of PRDX1 transcription leads to partial hypomethylation of the epiallele and restores the expression of MMACHC. This example of epi-cblC demonstrates the need to search for compound epigenetic-genetic heterozygosity in patients with typical disease manifestation and genetic heterozygosity in disease-causing genes located in other gene trios.
[Mh] Termos MeSH primário: Proteínas de Transporte/genética
Epistasia Genética
Erros Inatos do Metabolismo/genética
Mutação
Peroxirredoxinas/genética
Vitamina B 12/metabolismo
[Mh] Termos MeSH secundário: Alelos
Azacitidina/farmacologia
Sequência de Bases
Inibidores Enzimáticos/farmacologia
Saúde da Família
Feminino
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Heterozigoto
Seres Humanos
Masculino
Erros Inatos do Metabolismo/metabolismo
Linhagem
Sequenciamento Completo do Genoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Enzyme Inhibitors); 0 (MMACHC protein, human); EC 1.11.1.15 (PRDX1 protein, human); EC 1.11.1.15 (Peroxiredoxins); M801H13NRU (Azacitidine); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02306-5


  4 / 21978 MEDLINE  
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[PMID]:29443477
[Au] Autor:Farrell AF; Randall KG; Britner PA; Cronin B; Somaroo-Rodriguez SK; Hansen L
[Ti] Título:Integrated Solutions for Intertwined Challenges: A Statewide Collaboration in Supportive Housing for Child Welfare-Involved Families.
[So] Source:Child Welfare;94(1):141-165, 2015.
[Is] ISSN:0009-4021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper describes Connecticut's Supportive Housing for Families (SHF) program, which is one of five national sites comprising a federally- funded demonstration of housing and child welfare. Evaluations of supportive housing (SH) interventions are complicated by contextual factors that make it difficult to isolate their effects. 'Ihese and other challenges complicate efforts to conduct rigorous research and establish external validity, and to date, few studies examine the impact of SH interventions for child- welfare involved families. We describe retrospectively the development of SHF using. six stages of imple- mentation articulated within an implementation science framework, noting both the core components of the program and its expansion from a small pilot exploration, to a statewide initiative, and now to the center of a systems change effort with potential to influence national policy and implementation.
[Mh] Termos MeSH primário: Bem-Estar da Criança
Saúde da Família
Habitação Popular
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Connecticut
Demografia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE


  5 / 21978 MEDLINE  
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[PMID]:29206825
[Au] Autor:Cabrera-Pivaral CE; Orozco-Valerio MJ; Celis-de la Rosa A; Covarrubias-Bermúdez MLÁ; Zavala-González MA
[Ad] Endereço:Unidad de Investigación, Instituto Guatemalteco de Seguridad Social, Ciudad de Guatemala, Guatemala, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México.
[Ti] Título:Clinical competence of Guatemalan and Mexican physicians for family dysfunction management.
[Ti] Título:Competencia clínica de médicos guatemaltecos y mexicanos para el manejo de la disfunción familiar..
[So] Source:Gac Med Mex;153(6):683-687, 2017 Nov-Dec.
[Is] ISSN:0016-3813
[Cp] País de publicação:Mexico
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the clinical competence of Mexican and Guatemalan physicians to management the family dysfunction. METHODS: Cross comparative study in four care units first in Guadalajara, Mexico, and four in Guatemala, Guatemala, based on a purposeful sampling, involving 117 and 100 physicians, respectively. Clinical competence evaluated by validated instrument integrated for 187 items. Non-parametric descriptive and inferential statistical analysis was performed. RESULTS: The percentage of Mexican physicians with high clinical competence was 13.7%, medium 53%, low 24.8% and defined by random 8.5%. For the Guatemalan physicians'14% was high, average 63%, and 23% defined by random. There were no statistically significant differences between healthcare country units, but between the medium of Mexicans (0.55) and Guatemalans (0.55) (p = 0.02). CONCLUSION: The proportion of the high clinical competency of Mexican physicians' was as Guatemalans.
[Mh] Termos MeSH primário: Competência Clínica
Saúde da Família
Médicos/normas
[Mh] Termos MeSH secundário: Feminino
Guatemala
Seres Humanos
Masculino
México
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.24875/GMM.17002659


  6 / 21978 MEDLINE  
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[PMID]:29355681
[Au] Autor:Fan LL; Huang H; Jin JY; Li JJ; Chen YQ; Zhao SP; Xiang R
[Ad] Endereço:Department of Cell Biology, The School of Life Sciences, Central South University, Changsha 410013, China.
[Ti] Título:Whole exome sequencing identifies a novel mutation (c.333 + 2T > C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease.
[So] Source:Gene;648:63-67, 2018 Mar 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dilated Cardiomyopathy (DCM) and cardiac conduction disease (CCD) are two kinds if diseases that can induce heart failure, syncope and even sudden cardiac death (SCD). DCM patients can experience CCD at the same time. In recent research, some disease-causing genes and variants have been identified in patients with DCM and CCD, such as Alpha-Actinin-2 and TNNI3 Interacting Kinase (TNNI3K). In this study, we employed whole-exome sequencing (WES) to explore the potential causative genes in a Chinese family with DCM and CCD. A novel splice site mutation (c.333 + 2 T > C) of TNNI3K was identified and co-segregated with the affected family members. This novel mutation was also absent in 200 healthy local controls and predicted to be disease-causing by Mutationtaster. The splice site mutation (c.333 + 2 T > C) may result in a premature stop codon in exon 4 of the TNNI3K gene and can induce nonsense-mediated mRNA decay. Real-time qPCR also confirmed that the level of TNNI3K mRNA expression was decreased significantly compared with the controls, which may lead to myocardial structural disorder and arrhythmia. In this study we reported the third novel mutation of TNNI3K in DCM and CCD patients which further supported the important role of TNNI3K in heart development and expanded the spectrum of TNNI3K mutations. The results may contribute to the genetic diagnosis and counseling of families with DCM and CCD.
[Mh] Termos MeSH primário: Doença do Sistema de Condução Cardíaco/genética
Cardiomiopatia Dilatada/genética
MAP Quinase Quinase Quinases/genética
Mutação
Sequenciamento Completo do Exoma/métodos
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Asiático/genética
Sequência de Bases
Doença do Sistema de Condução Cardíaco/etnologia
Cardiomiopatia Dilatada/etnologia
China
Saúde da Família
Feminino
Seres Humanos
Masculino
Degradação do RNAm Mediada por Códon sem Sentido/genética
Linhagem
Sítios de Splice de RNA/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA Splice Sites); EC 2.7.11.1 (TNNI3K protein, human); EC 2.7.11.25 (MAP Kinase Kinase Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


  7 / 21978 MEDLINE  
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[PMID]:28448458
[Au] Autor:Gao M; Li Y; Zhang S; Gu L; Zhang J; Li Z; Zhang W; Tian D
[Ad] Endereço:School of Social Development and Public Policy, China Institute of Health, Beijing Normal University, Beijing 100875, China. vivianhbs@126.com.
[Ti] Título:Does an Empty Nest Affect Elders' Health? Empirical Evidence from China.
[So] Source:Int J Environ Res Public Health;14(5), 2017 04 27.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The "empty-nest" elderly family has become increasingly prevalent among old people in China. This study aimed to explore the causality between empty nests and elders' health using effective instrumental variables, including "whether old parents talk with their families when they are upset" and "ownership of housing". The results showed that empty nests had a significantly adverse influence on elders' physical health, cognitive ability and psychological health. Furthermore, urban elders' cognitive ability was more influenced by empty nests than that of rural elders. Additionally, the effects of an empty nest on elders" health were more significant among female, single elders and senior rural elders. "Living resources", "availability of medical treatment" and "social activity engagement" were found to be significant mediators between empty nests and elders' health, accounting for 35% of the total effect.
[Mh] Termos MeSH primário: Idoso/psicologia
Saúde da Família
Habitação
Saúde Mental
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
China
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  8 / 21978 MEDLINE  
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Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
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[PMID]:28464887
[Au] Autor:Mahabee-Gittens EM; Ammerman RT; Khoury JC; Stone L; Meyers GT; Witry JK; Merianos AL; Mancuso TF; Stackpole KMW; Bennett BL; Akers L; Gordon JS
[Ad] Endereço:Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA. Melinda.Mahabee-Gittens@cchmc.org.
[Ti] Título:Healthy families: study protocol for a randomized controlled trial of a screening, brief intervention, and referral to treatment intervention for caregivers to reduce secondhand smoke exposure among pediatric emergency patients.
[So] Source:BMC Public Health;17(1):374, 2017 05 02.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Involuntary exposure to secondhand smoke (SHSe) is an important cause of morbidity in children who present to the pediatric emergency department (PED) and urgent care (UC). SHSe interventions delivered in the PED and UC would benefit both the smoker and child, but there have been no large trials testing the efficacy of such interventions. The Healthy Families program is the first randomized controlled trial to test whether a screening, brief intervention, and referral to treatment (SBIRT) intervention delivered in the PED and UC will be effective in decreasing SHSe in children and increasing cessation in smokers. METHODS/DESIGN: This trial uses a randomized, two-group design in which caregiver-smokers of children 0-17 years old are recruited from the PED and UC. Eligible caregiver-smokers are randomized to either the: 1) SBIRT Condition with face-to-face, tailored counseling that focuses on the child's illness, the importance of reducing child SHSe, caregiver smoking cessation, and the option to receive nicotine replacement therapy; or 2) Healthy Habits Control Condition which includes face-to-face, tailored attention control "5-2-1-0" counseling that focuses on improving the child's health. Dyadic assessments are conducted in-person at baseline, and via email, phone, or in-person at 6-weeks and 6-months. The primary outcomes are biochemically-verified, 7-day point prevalence and prolonged smoking abstinence. Secondary outcomes are cigarettes smoked per week, 24 h quit attempts, and biochemically validated child SHSe at each time point. The costs of this intervention will also be analyzed. DISCUSSION: This study will test an innovative, multilevel intervention designed to reduce child SHSe and increase smoking cessation in caregivers. If effective and routinely used, this SBIRT model could reach at least one million smokers a year in the U.S., resulting in significant reductions in caregivers' tobacco use, SHSe-related pediatric illness, and healthcare costs in this population of children. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02531594. Date of registration: August 4, 2015.
[Mh] Termos MeSH primário: Assistência Ambulatorial/organização & administração
Cuidadores
Encaminhamento e Consulta/organização & administração
Abandono do Hábito de Fumar/métodos
Poluição por Fumaça de Tabaco/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Serviço Hospitalar de Emergência
Saúde da Família
Seres Humanos
Lactente
Recém-Nascido
Masculino
Projetos de Pesquisa
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180121
[Lr] Data última revisão:
180121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4278-8


  9 / 21978 MEDLINE  
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[PMID]:29253866
[Au] Autor:Klauke B; Gaertner-Rommel A; Schulz U; Kassner A; Zu Knyphausen E; Laser T; Kececioglu D; Paluszkiewicz L; Blanz U; Sandica E; van den Bogaerdt AJ; van Tintelen JP; Gummert J; Milting H
[Ad] Endereço:Erich and Hanna Klessmann Institute for Cardiovascular Research & Development (EHKI), Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.
[Ti] Título:High proportion of genetic cases in patients with advanced cardiomyopathy including a novel homozygous Plakophilin 2-gene mutation.
[So] Source:PLoS One;12(12):e0189489, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cardiomyopathies might lead to end-stage heart disease with the requirement of drastic treatments like bridging up to transplant or heart transplantation. A not precisely known proportion of these diseases are genetically determined. We genotyped 43 index-patients (30 DCM, 10 ARVC, 3 RCM) with advanced or end stage cardiomyopathy using a gene panel which covered 46 known cardiomyopathy disease genes. Fifty-three variants with possible impact on disease in 33 patients were identified. Of these 27 (51%) were classified as likely pathogenic or pathogenic in the MYH7, MYL2, MYL3, NEXN, TNNC1, TNNI3, DES, LMNA, PKP2, PLN, RBM20, TTN, and CRYAB genes. Fifty-six percent (n = 24) of index-patients carried a likely pathogenic or pathogenic mutation. Of these 75% (n = 18) were familial and 25% (n = 6) sporadic cases. However, severe cardiomyopathy seemed to be not characterized by a specific mutation profile. Remarkably, we identified a novel homozygous PKP2-missense variant in a large consanguineous family with sudden death in early childhood and several members with heart transplantation in adolescent age.
[Mh] Termos MeSH primário: Cardiomiopatias/diagnóstico
Cardiomiopatias/genética
Mutação
Placofilinas/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Estudos de Coortes
Saúde da Família
Feminino
Genótipo
Insuficiência Cardíaca/genética
Transplante de Coração
Sequenciamento de Nucleotídeos em Larga Escala
Homozigoto
Seres Humanos
Recém-Nascido
Masculino
Meia-Idade
Mutação de Sentido Incorreto
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PKP2 protein, human); 0 (Plakophilins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189489


  10 / 21978 MEDLINE  
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[PMID]:28741918
[Ti] Título:Extrafamilial, Interfamilial Transmission of S. mutans.
[So] Source:J Calif Dent Assoc;44(9):542, 2016 Sep.
[Is] ISSN:1043-2256
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções Estreptocócicas/transmissão
Streptococcus mutans
[Mh] Termos MeSH secundário: Criança
Saúde da Família
Seres Humanos
Streptococcus mutans/classificação
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde