Base de dados : MEDLINE
Pesquisa : N01.400.625 [Categoria DeCS]
Referências encontradas : 2203 [refinar]
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  1 / 2203 MEDLINE  
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[PMID]:29309558
[Au] Autor:Sanchez-Garrido MA; Ruiz-Pino F; Velasco I; Barroso A; Fernandois D; Heras V; Manfredi-Lozano M; Vazquez MJ; Castellano JM; Roa J; Pinilla L; Tena-Sempere M
[Ad] Endereço:Instituto Maimónides de Investigación Biomédica de Cordoba, University of Cordoba, Cordoba, Spain.
[Ti] Título:Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways.
[So] Source:Endocrinology;159(2):1005-1018, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity and its comorbidities are reaching epidemic proportions worldwide. Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance. This intergenerational transmission has also been suggested for paternal obesity, with a potential negative impact on the metabolic and, eventually, reproductive health of the offspring, likely via epigenetic changes in spermatozoa. However, the neuroendocrine component of such phenomenon and whether paternal obesity sensitizes the offspring to the disturbances induced by high-fat diet (HFD) remain poorly defined. We report in this work the metabolic and reproductive impact of HFD in the offspring from obese fathers, with attention to potential sex differences and alterations of hypothalamic Kiss1 system. Lean and obese male rats were mated with lean virgin female rats; male and female offspring were fed HFD from weaning onward and analyzed at adulthood. The increases in body weight and leptin levels, but not glucose intolerance, induced by HFD were significantly augmented in the male, but not female, offspring from obese fathers. Paternal obesity caused a decrease in luteinizing hormone (LH) levels and exacerbated the drop in circulating testosterone and gene expression of its key biosynthetic enzymes caused by HFD in the male offspring. LH responses to central kisspeptin-10 administration were also suppressed in HFD males from obese fathers. In contrast, paternal obesity did not significantly alter gonadotropin levels in the female offspring fed HFD, although these females displayed reduced LH responses to kisspeptin-10. Our findings suggest that HFD-induced metabolic and reproductive disturbances are exacerbated by paternal obesity preferentially in males, whereas kisspeptin effects are affected in both sexes.
[Mh] Termos MeSH primário: Pai
Kisspeptinas/fisiologia
Obesidade
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Reprodução/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Obesidade/complicações
Gravidez
Ratos
Ratos Wistar
Saúde Reprodutiva
Caracteres Sexuais
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Kiss1 protein, rat); 0 (Kisspeptins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00705


  2 / 2203 MEDLINE  
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[PMID]:28451048
[Au] Autor:Ndongmo TN; Ndongmo CB; Michelo C
[Ad] Endereço:Department of Public Health, School of Medicine, University of Zambia, Lusaka, Zambia.
[Ti] Título:Sexual and reproductive health knowledge and behavior among adolescents living with HIV in Zambia: a case study.
[So] Source:Pan Afr Med J;26:71, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: As HIV infected adolescents mature into adulthood, they are confronted with issues related to sexuality and sexual reproductive health (SRH). An estimated 68,000 adolescents aged 10-19 years are living with HIV in Zambia. The current study explores their sexuality and SRH experience and needs. METHODS: This was a mixed method analytical cross-sectional study. Adolescents at a tertiary hospital were surveyed on their sexuality and SRH experiences. Bivariate analyses on SPSS were used to assess factors associated with selected behaviors. Emerging themes from open-ended questions qualitative data were explored using content analysis. RESULTS: A total of 148 adolescents (63.5% females) aged 15-19 years were surveyed. Majority (77.0%) had secondary education; 77.2% currently in school; 40.1 % had a boy or girlfriend; 15.1% have ever had sex, of whom only 61.1 % reported consistent condom use. About 68.9 % expressed intention to have children; 2.1% of girls had been pregnant before. Of 52 respondents, 19.2% had a sexually transmitted infection (STI) before. Not being in school was a significant predictor, for knowing where to access information about sex (OR= 2.53; 95% CI:1.10-5.82; p=0.02), and also for ever gone there (OR=2.61; 95% CI:1.04-6.58; p=0.03). CONCLUSION: The survey of HIV infected adolescents attending a tertiary hospital in Zambia found that their sexuality and SRH needs remain similar to those of the general adolescent population in terms of counseling in sexual matters, family planning and STI services. More efforts are needed to provide for adolescent health care needs, especially those living with HIV.
[Mh] Termos MeSH primário: Infecções por HIV/epidemiologia
Conhecimentos, Atitudes e Prática em Saúde
Saúde Reprodutiva/estatística & dados numéricos
Comportamento Sexual/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Criança
Estudos Transversais
Feminino
Necessidades e Demandas de Serviços de Saúde
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Gravidez
Gravidez na Adolescência/estatística & dados numéricos
Doenças Sexualmente Transmissíveis/epidemiologia
Adulto Jovem
Zâmbia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.26.71.11312


  3 / 2203 MEDLINE  
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[PMID]:29266079
[Au] Autor:Committee on Health Care for Underserved Women
[Ti] Título:ACOG Committee Opinion No. 729: Importance of Social Determinants of Health and Cultural Awareness in the Delivery of Reproductive Health Care.
[So] Source:Obstet Gynecol;131(1):e43-e48, 2018 01.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Awareness of the broader contexts that influence health supports respectful, patient-centered care that incorporates lived experiences, optimizes health outcomes, improves communication, and can help reduce health and health care inequities. Although there is little doubt that genetics and lifestyle play an important role in shaping the overall health of individuals, interdisciplinary researchers have demonstrated how the conditions in the environment in which people are born, live, work, and age, play equally as important a role in shaping health outcomes. These factors, referred to as social determinants of health, are shaped by historical, social, political, and economic forces and help explain the relationship between environmental conditions and individual health. Recognizing the importance of social determinants of health can help obstetrician-gynecologists and other health care providers better understand patients, effectively communicate about health-related conditions and behavior, and improve health outcomes.
[Mh] Termos MeSH primário: Conscientização
Guias de Prática Clínica como Assunto
Serviços de Saúde Reprodutiva/normas
Saúde Reprodutiva
Determinantes Sociais da Saúde/ética
[Mh] Termos MeSH secundário: Comitês Consultivos/normas
Competência Cultural
Feminino
Ginecologia/normas
Seres Humanos
Obstetrícia/normas
Assistência Centrada no Paciente
Gravidez
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002459


  4 / 2203 MEDLINE  
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[PMID]:29266073
[Ti] Título:ACOG Committee Opinion No. 729 Summary: Importance Of Social Determinants Of Health And Cultural Awareness In The Delivery Of Reproductive Health Care.
[So] Source:Obstet Gynecol;131(1):198-199, 2018 Jan.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Awareness of the broader contexts that influence health supports respectful, patient-centered care that incorporates lived experiences, optimizes health outcomes, improves communication, and can help reduce health and health care inequities. Although there is little doubt that genetics and lifestyle play an important role in shaping the overall health of individuals, interdisciplinary researchers have demonstrated how the conditions in the environment in which people are born, live, work, and age, play equally as important a role in shaping health outcomes. These factors, referred to as social determinants of health, are shaped by historical, social, political, and economic forces and help explain the relationship between environmental conditions and individual health. Recognizing the importance of social determinants of health can help obstetrician-gynecologists and other health care providers better understand patients, effectively communicate about health-related conditions and behavior, and improve health outcomes.
[Mh] Termos MeSH primário: Assistência à Saúde/métodos
Guias de Prática Clínica como Assunto
Serviços de Saúde Reprodutiva/normas
Saúde Reprodutiva
[Mh] Termos MeSH secundário: Adulto
Comitês Consultivos
Conscientização
Características Culturais
Feminino
Seres Humanos
Gravidez
Determinantes Sociais da Saúde
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002453


  5 / 2203 MEDLINE  
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[PMID]:29199806
[Au] Autor:Sarvilinna N; Unkila-Kallio; Härkki P; Tiitinen A; Heikinheimo O
[Ti] Título:Selective progesterone receptor modulators: new possibilities for gynecologic hormone therapy.
[So] Source:Duodecim;133(1):27-33, 2017.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:Progesterone regulates several female reproductive functions. Progesterone and synthetic progestins derived from it have long been utilized in gynecology. The effects of these steroids in target cells are mediated via progesterone receptors, Progesterone receptors are also the target of action of selective progesterone receptor modulators. Of the molecules of this newer group of drugs, two are presently in clinical use. Mifepristone is used in nonsurgical abortion, in softening of the cervix before surgical abortion, and in the induction of labor in cases of intrauterine death. The indications of ulipristal acetate are postcoital contraception and treatment of uterine myomas and the resulting symptoms.
[Mh] Termos MeSH primário: Antagonistas de Hormônios/uso terapêutico
Mifepristona/uso terapêutico
Norpregnadienos/uso terapêutico
Receptores de Progesterona/efeitos dos fármacos
Saúde Reprodutiva
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Saúde da Mulher
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hormone Antagonists); 0 (Norpregnadienes); 0 (Receptors, Progesterone); 320T6RNW1F (Mifepristone); 6J5J15Q2X8 (ulipristal)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  6 / 2203 MEDLINE  
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[PMID]:28449598
[Au] Autor:Siegfried N; Narasimhan M; Kennedy CE; Welbourn A; Yuvraj A
[Ad] Endereço:a Independent Clinical Epidemiologist , Cape Town , South Africa.
[Ti] Título:Using GRADE as a framework to guide research on the sexual and reproductive health and rights (SRHR) of women living with HIV - methodological opportunities and challenges.
[So] Source:AIDS Care;29(9):1088-1093, 2017 Sep.
[Is] ISSN:1360-0451
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In March 2016, WHO reviewed evidence to develop global recommendations on the sexual and reproductive health and rights (SRHR) of women living with HIV. Systematic reviews and a global survey of women living with HIV informed the guideline development decision-making process. New recommendations covered abortion, Caesarean section, safe disclosure, and empowerment and self-efficacy interventions. Identification of key research gaps is part of the WHO guidelines development process, but consistent methods to do so are lacking. Our method aimed to ensure consistency and comprised the systematic application of a framework based on GRADE (Grading of Recommendations, Assessment, Development and Evaluation) to the process. The framework incorporates the strength and quality rating of recommendations and the priorities reported by women in the survey to inform research prioritisation. For each gap, we also articulated: (1) the most appropriate and robust study design to answer the question; (2) alternative pragmatic designs if the ideal design is not feasible; and (3) the methodological challenges facing researchers through identifying potential biases. We found 12 research gaps and identified five appropriate study designs to address the related questions: (1) Cross-sectional surveys; (2) Qualitative interview-driven studies; (3) Registries; (4) Randomised controlled trials; and (5) Medical record audit. Methodological challenges included selection, recruitment, misclassification, measurement and contextual biases, and confounding. In conclusion, a framework based on GRADE can provide a systematic approach to identifying research gaps from a WHO guideline. Incorporation of the priorities of women living with HIV into the framework systematically ensures that women living with HIV can shape future policy decisions affecting their lives. Implementation science and participatory research are appropriate over-arching approaches to enhance uptake of interventions and to ensure inclusion of women living with HIV at all stages of the research process.
[Mh] Termos MeSH primário: Infecções por HIV/psicologia
Direitos Sexuais e Reprodutivos
Direitos da Mulher
[Mh] Termos MeSH secundário: Pesquisa Biomédica
Estudos Transversais
Feminino
Guias como Assunto
Infecções por HIV/diagnóstico
Seres Humanos
Saúde Reprodutiva
Pesquisa
Comportamento Sexual
Saúde Sexual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/09540121.2017.1317711


  7 / 2203 MEDLINE  
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[PMID]:28468987
[Au] Autor:Abrams SI
[Ad] Endereço:Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA scott.abrams@roswellpark.org.
[Ti] Título:Editorial: The rebirth of myeloid-derived suppressor cells: from adversary in cancer to ally in reproductive health.
[So] Source:J Leukoc Biol;101(5):1079, 2017 05.
[Is] ISSN:1938-3673
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Células Supressoras Mieloides
Saúde Reprodutiva
[Mh] Termos MeSH secundário: Seres Humanos
Células Mieloides
Neoplasias
[Pt] Tipo de publicação:EDITORIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1189/jlb.1CE1216-525R


  8 / 2203 MEDLINE  
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[PMID]:28467163
[Au] Autor:Restar AJ; Tocco JU; Mantell JE; Lafort Y; Gichangi P; Masvawure TB; Chabeda SV; Sandfort TGM
[Ad] Endereço:Brown School of Public Health, Brown University, Providence, Rhode Island.
[Ti] Título:Perspectives on HIV Pre- and Post-Exposure Prophylaxes (PrEP and PEP) Among Female and Male Sex Workers in Mombasa, Kenya: Implications for Integrating Biomedical Prevention into Sexual Health Services.
[So] Source:AIDS Educ Prev;29(2):141-153, 2017 Apr.
[Is] ISSN:1943-2755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pre- and post-exposure prophylaxes (PrEP and PEP) can reduce the risk of HIV acquisition, yet often are inaccessible to and underutilized by most-vulnerable populations, including sex workers in sub-Saharan Africa. Based on in-depth interviews with 21 female and 23 male HIV-negative sex workers in Mombasa, Kenya, we found that awareness and knowledge of PrEP and PEP were low, although willingness to use both was high. Participants felt PrEP would be empowering and give added protection against infection, although some expressed concerns about side effects. Despite PEP's availability, few knew about it and even fewer had used it, but most who had would use it again. Sex workers valued confidentiality, privacy, trustworthiness, and convenient location in health services and wanted thorough HIV/STI assessments. These findings suggest the importance of situating PrEP and PEP within sex worker-friendly health services and conducting outreach to promote these biomedical prevention methods for Kenyan sex workers.
[Mh] Termos MeSH primário: Infecções por HIV/prevenção & controle
Profilaxia Pós-Exposição
Profilaxia Pré-Exposição
Serviços Preventivos de Saúde
Profissionais do Sexo
Comportamento Sexual
[Mh] Termos MeSH secundário: Adulto
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/etnologia
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Entrevistas como Assunto
Quênia
Masculino
Pesquisa Qualitativa
Saúde Reprodutiva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1521/aeap.2017.29.2.141


  9 / 2203 MEDLINE  
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[PMID]:29093054
[Au] Autor:Collins RL; Strasburger VC; Brown JD; Donnerstein E; Lenhart A; Ward LM
[Ad] Endereço:RAND Corporation, Santa Monica, California; collins@rand.org.
[Ti] Título:Sexual Media and Childhood Well-being and Health.
[So] Source:Pediatrics;140(Suppl 2):S162-S166, 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sexual content is highly prevalent in traditional media, and portrayals rarely depict the responsibilities and risks (eg, condom use, pregnancy) associated with sexual activity. Exposure to such content is linked with shifts in attitudes about sex and gender, earlier progression to sexual activity, pregnancy, and sexually transmitted infection among adolescents. However, little information is available about moderators and mediators of these effects. We also know little about digital media, their sex-related content, and their potential influence on youth. Data from a few studies of older youth indicate that sexual displays on social media sites are related to problematic beliefs and behaviors among those who post this content and among viewers. Online pornography appears to be more problematic for youth than off-line sources. Given the vast and increasing amount of time youth spend online and their developmental openness to influence, more research attention to digital sexual media is needed. Those who undertake this work should identify potential negative consequences of use and opportunities to improve adolescent sexual health through digital media. Studies of on- and off-line media in which researchers examine younger media audiences, identify processes explaining sexual media effects on behavior, and moderators of effects are needed. Such studies could be used to inform interventions to reduce negative outcomes and increase positive media effects. Policy makers should stimulate the development of such interventions, including tools to help parents identify and manage negative media influences on their children's sexual well-being and development and dissemination of innovative media literacy programs related to sexual health.
[Mh] Termos MeSH primário: Comportamento do Adolescente/psicologia
Comportamento Infantil/psicologia
Bem-Estar da Criança/psicologia
Meios de Comunicação/utilização
Comportamento Sexual/psicologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Seres Humanos
Saúde Reprodutiva/educação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1542/peds.2016-1758X


  10 / 2203 MEDLINE  
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[PMID]:29061870
[Au] Autor:Marcell AV; Burstein GR; COMMITTEE ON ADOLESCENCE
[Ti] Título:Sexual and Reproductive Health Care Services in the Pediatric Setting.
[So] Source:Pediatrics;140(5), 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pediatricians are an important source of health care for adolescents and young adults and can play a significant role in addressing their patients' sexual and reproductive health needs, including preventing unintended pregnancies and sexually transmitted infections (STIs), including HIV, and promoting healthy relationships. STIs, HIV, and unintended pregnancy are all preventable health outcomes with potentially serious permanent sequelae; the highest rates of STIs, HIV, and unintended pregnancy are reported among adolescents and young adults. Office visits present opportunities to provide comprehensive education and health care services to adolescents and young adults to prevent STIs, HIV, and unintended pregnancies. The American Academy of Pediatrics, other professional medical organizations, and the government have guidelines and recommendations regarding the provision of sexual and reproductive health information and services. However, despite these recommendations, recent studies have revealed that there is substantial room for improvement in actually delivering the recommended services. The purpose of this clinical report is to assist pediatricians to operationalize the provision of various aspects of sexual and reproductive health care into their practices and to provide guidance on overcoming barriers to providing this care routinely while maximizing opportunities for confidential health services delivery in their offices.
[Mh] Termos MeSH primário: Educação de Pacientes como Assunto/normas
Pediatria/normas
Saúde Reprodutiva/normas
Doenças Sexualmente Transmissíveis/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Anticoncepção/normas
Anticoncepção/tendências
Feminino
Seres Humanos
Masculino
Visita a Consultório Médico/tendências
Educação de Pacientes como Assunto/tendências
Pediatria/tendências
Gravidez
Gravidez não Planejada
Saúde Reprodutiva/tendências
Comportamento Sexual
Doenças Sexualmente Transmissíveis/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE



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