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[PMID]:28450146
[Au] Autor:Brunette I; Roberts CJ; Vidal F; Harissi-Dagher M; Lachaine J; Sheardown H; Durr GM; Proulx S; Griffith M
[Ad] Endereço:Department of Ophthalmology, University of Montreal, 2900 Boul. Edouard-Montpetit, Montreal, QC H3T 1J4, Canada; Maisonneuve-Rosemont Hospital Research Center, 5415 Boul de l'Assomption, Montreal, QC H1T 2M4, Canada. Electronic address: i.brunett@videotron.ca.
[Ti] Título:Alternatives to eye bank native tissue for corneal stromal replacement.
[So] Source:Prog Retin Eye Res;59:97-130, 2017 Jul.
[Is] ISSN:1873-1635
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Corneal blindness is a major cause of blindness in the world and corneal transplantation is the only widely accepted treatment to restore sight in these eyes. However, it is becoming increasingly difficult for eye banks to meet the increasing demand for transplantable tissue, which is in part due to population aging. Donor tissue shortage is therefore a growing concern globally and there is a need for alternatives to human donor corneas. Biosynthetic corneal substitutes offer several significant advantages over native corneas: Large-scale production offers a powerful potential solution to the severe shortage of human donor corneas worldwide; Good manufacturing practices ensure sterility and quality control; Acellular corneal substitutes circumvent immune rejection induced by allogeneic cells; Optical and biomechanical properties of the implants can be adapted to the clinical need; and finally these corneal substitutes could benefit from new advances in biomaterials science, such as surface coating, functionalization and nanoparticles. This review highlights critical contributions from laboratories working on corneal stromal substitutes. It focuses on synthetic inert prostheses (keratoprostheses), acellular scaffolds with and without enhancement of endogenous regeneration, and cell-based replacements. Accent is put on the physical properties and biocompatibility of these biomaterials, on the functional and clinical outcome once transplanted in vivo in animal or human eyes, as well as on the main challenges of corneal stromal replacement. Regulatory and economic aspects are also discussed. All of these perspectives combined highlight the founding principles of the clinical application of corneal stromal replacement, a concept that has now become reality.
[Mh] Termos MeSH primário: Doenças da Córnea/cirurgia
Substância Própria/cirurgia
Transplante de Córnea/métodos
Bancos de Olhos/organização & administração
Engenharia Tecidual
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29245222
[Au] Autor:Liu Y; Zhang Y; Zhang J; Yu J; Liang Q; Pan Z
[Ad] Endereço:aBeijing Tongren Eye CenterbBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
[Ti] Título:Specific demographic factors could predict deceased potential cornea donors: A retrospective study from Beijing Tongren Hospital Eye Bank.
[So] Source:Medicine (Baltimore);96(49):e8607, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Compared with evident cornea donors (ECDs), deceased potential cornea donors (DPCDs) have no obvious donor identifications to reference, which causes many eligible cornea tissues to be wasted. The demographic characteristics of DPCDs might be different from those of ECDs owing to the following different features: donation consent provided by relatives and willingness to donate before death. Thus, the aim of this study is to reveal the demographic characteristics of DPCDs by comparing DPCDs and ECDs.The demographic factors of 138 donors (both DPCDs and ECDs) were collected from the Beijing Tongren Hospital Eye Bank database and analyzed. To differentiate DPCDs from ECDs using the above-mentioned features, we interviewed the relatives of the donors by telephone. The relatives' attitudes toward cornea donation and their suggestions for our donation service were also acquired during the interview. Two logistic regressions were performed to reveal the demographic factors influencing the 2 features and indicate DPCDs.The donors had certain demographic characteristics (elderly, secondary, or tertiary education level, central district resident), and the most frequent cause of death for the donors was a malignant tumor (n = 56, 43.1%). All the relatives had positive attitudes toward cornea donations, and they hoped to increase publicity efforts to encourage more people to donate and establish more convenient and efficient access for cornea donation. In univariate regressions, age (P = .004, >50 years: odds ratio [OR] = 6.89, 95% confidence interval [CI]: 1.82-26.05), marital status (P = .043, divorced: OR = 9.00,95% CI: 1.33-60.80) significantly influenced relative consent, whereas age (P = .001, >50 years: OR = 15.00, 95% CI: 3.00-74.98), and family address (P = .001, central district: OR = 1) were significant factors influencing the willingness to donate before death. In multivariate regression, age (P = .021, >50 years: OR = 8.14, 95% CI: 1.37-48.41) was the only significant factor influencing relative consent. Similarly, age (P = .02, >50 years: OR = 7.55, 95% CI: 1.21-47.25) was the only factor influencing willingness to donate before death.In conclusion, specific demographic factors could indicate DPCDs and might reveal directions and methods for cornea donation coordination in the future.
[Mh] Termos MeSH primário: Córnea
Seleção do Doador/métodos
Bancos de Olhos/estatística & dados numéricos
Doadores de Tecidos/psicologia
Obtenção de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Pequim
Demografia
Família/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Análise de Regressão
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008607


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[PMID]:27777123
[Au] Autor:Schwarz C; Aldrich BT; Burckart KA; Schmidt GA; Zimmerman MB; Reed CR; Greiner MA; Sander EA
[Ad] Endereço:Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
[Ti] Título:Descemet membrane adhesion strength is greater in diabetics with advanced disease compared to healthy donor corneas.
[So] Source:Exp Eye Res;153:152-158, 2016 Dec.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Descemet membrane endothelial keratoplasty (DMEK) is an increasingly popular surgical procedure for treating ocular diseases that require a corneal transplant. Previous studies have found that tissue tearing during surgical preparation is more likely elevated in eyes from donors with a history of diabetes mellitus. To quantify these potential differences, we established an experimental technique for quantifying the force required to separate the endothelium-Descemet membrane complex (EDM) from stroma in human donor corneal tissue, and we assessed differences in adhesion strength between diabetic and non-diabetic donor corneas. Transplant suitable corneas were obtained from 23 donors 50-75 years old with an average preservation to assay time of 11.5 days. Corneas were classified from a medical records review as non-diabetic (ND, n = 9), diabetic without evidence of advanced disease (NAD, n = 8), or diabetic with evidence of advanced disease (AD, n = 10). Corneas were sectioned into 3 mm wide strips and the EDM peeled from the stroma. Using the force-extension data obtained from mechanical peel testing, EDM elastic peel tension (T ), elastic stiffness (S ), average delamination tension (T ), and maximum tension (T ) were calculated. Mean T , S , T , and T values for ND corneas were 0.78 ± 0.07 mN/mm, 0.37 ± 0.05 mN/mm/mm, 0.78 ± 0.08 mN/mm, and 0.94 ± 0.17 mN/mm, respectively. NAD values did not differ significantly. However, AD values for T (1.01 ± 0.18 mN/mm), T (1.09 ± 0.21 mN/mm), and T (1.37 ± 0.24 mN/mm) were greater than ND and NAD corneas (P < 0.05). S did not differ significantly between groups. These findings provide proof of the concept that chronic hyperglycemia from diabetes mellitus results in a phenotypically more adhesive interface between Descemet membrane and the posterior stroma in donor corneal tissue. Results of this study provide a foundation for further investigations into the impact of diabetes on the posterior cornea, eye banking, and keratoplasty.
[Mh] Termos MeSH primário: Doenças da Córnea/cirurgia
Lâmina Limitante Posterior/fisiologia
Ceratoplastia Endotelial com Remoção da Lâmina Limitante Posterior/métodos
Diabetes Mellitus
Doadores de Tecidos
[Mh] Termos MeSH secundário: Idoso
Doenças da Córnea/fisiopatologia
Bancos de Olhos
Sobrevivência de Enxerto
Seres Humanos
Meia-Idade
Reprodutibilidade dos Testes
Coleta de Tecidos e Órgãos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:29075760
[Au] Autor:Olsen TW; Liao A; Robinson HS; Palejwala NV; Sprehe N
[Ad] Endereço:Mayo Clinic, Department of Ophthalmology, Rochester, Minnesota, United States.
[Ti] Título:The Nine-Step Minnesota Grading System for Eyebank Eyes With Age Related Macular Degeneration: A Systematic Approach to Study Disease Stages.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5497-5506, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods: A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human eyebank eyes that were graded according to definitions from the AREDS criteria in order to harmonize studies of disease progression for research involving human tissue. From 2005 through February 2017, we have analyzed 1159 human eyes, procured from two eyebanks. Each macula was imaged using high-resolution, stereoscopic color fundus photography with both direct- and transillumination. Fundus images were digitally overlaid with a grading template and triangulated for foveal centration. Results: We documented and stratified risk for each globe by applying the AREDS nine-step grading scale to the key clinical features from the MGS-9. We found a good distribution within the MGS categories (1-9) with few level eight globes. Eyes were processed within 12.1 ± 6.3, hours from the time of death through imaging, dissection, and freezing or fixation. Applying the MGS-9 to 331 pairs (662 eyes were simultaneously graded), 84% were within one-grading step and 93% within two steps of the fellow eye. We also document reticular pseudodrusen, basal laminar drusen, and pattern dystrophy. Conclusions: The MGS nine-step grading scale enables researchers using human tissue to refine the risk assessment of donor tissue. This analysis will harmonize results among researchers when grading human tissue using MGS criteria. Most importantly, the MGS-9 links directly to the known risk for progression from the AREDS.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Oftalmológico
Bancos de Olhos
Doadores de Tecidos
Degeneração Macular Exsudativa/diagnóstico
[Mh] Termos MeSH secundário: Assistência ao Convalescente
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Macula Lutea/patologia
Masculino
Meia-Idade
Minnesota
Reprodutibilidade dos Testes
Estudos Retrospectivos
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171028
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22161


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[PMID]:28890079
[Au] Autor:Margo JA; Whiting MF; Brown CH; Hoover CK; Munir WM
[Ad] Endereço:Department of Ophthalmology & Visual Sciences, University of Maryland, Baltimore, Maryland.
[Ti] Título:The Effect of Chronic Pulmonary Disease and Mechanical Ventilation on Corneal Donor Endothelial Cell Density and Transplant Suitability.
[So] Source:Am J Ophthalmol;183:65-70, 2017 Nov.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine how chronic obstructive pulmonary disease (COPD) and mechanical ventilation time affect corneal donor endothelial cell density (ECD) and transplant suitability. DESIGN: Retrospective cohort study. METHODS: Setting: Institutional. STUDY POPULATION: Total of 39 679 cornea donor eyes from SightLife Eye Bank between 2012 and 2016. Demographics, death-to-preservation time, ECD, lens status, medical history, time on mechanical ventilation, and suitability for transplantation were included. MAIN OUTCOME MEASURES: ECD and transplant suitability. RESULTS: Mean ECD was 2733 cells/mm . Mean age was 59 years. COPD affected 34.2% of donors. Mechanical ventilation was required in 35% of donors. Mean ventilation time was 1.3 days. After controlling for covariates, COPD was not found to be associated with poor transplant suitability (P = .22). Ventilation >7 days was associated with poor transplant suitability (P = .04). Donors with COPD and donors who were mechanically ventilated exhibited lower cell counts (P < .001, P < .01, respectively). Longer ventilation led to reduced endothelial cell density: ventilation time >7 days (-46.5 cells/mm , P < .001) and >30 days (-101.4 cells/mm , P = .02). Limitations of the study included the retrospective nature, dataset obtained from a single eye bank, and medical history documentation completed by eye bank technicians. CONCLUSIONS: A high proportion of cornea donors have respiratory disease prior to donation. Ventilation time >7 days affected transplant suitability but the presence of COPD did not. Donors with COPD and donors who were mechanically ventilated had reduced cell counts. Longer ventilation times lead to increased cell loss. The presence of respiratory disease may affect tissue oxygenation and endothelial cell health.
[Mh] Termos MeSH primário: Perda de Células Endoteliais da Córnea/patologia
Transplante de Córnea
Epitélio Posterior/patologia
Doença Pulmonar Obstrutiva Crônica/complicações
Respiração Artificial/efeitos adversos
Doadores de Tecidos
[Mh] Termos MeSH secundário: Contagem de Células
Doenças da Córnea/cirurgia
Perda de Células Endoteliais da Córnea/etiologia
Bancos de Olhos
Feminino
Seguimentos
Sobrevivência de Enxerto
Seres Humanos
Masculino
Meia-Idade
Doença Pulmonar Obstrutiva Crônica/terapia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE


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[PMID]:28715592
[Au] Autor:Yu PK; McAllister IL; Morgan WH; Cringle SJ; Yu DY
[Ad] Endereço:Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia 2Lions Eye Institute, The University of Western Australia, Perth, Australia.
[Ti] Título:Inter-Relationship of Arterial Supply to Human Retina, Choroid, and Optic Nerve Head Using Micro Perfusion and Labeling.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3565-3574, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The prevailing view is that the human retina is supplied by the central retinal artery (CRA), the short posterior ciliary arteries (SPCAs) support the choroid, and both the CRA and the SPCAs are so-called "end artery" systems. In this study, we investigate whether vascular connections among the retina, choroid, and the optic nerve head (ONH) exist, using selective cannulation and microperfusion-labeling techniques. Methods: The CRA and/or one or more of the SPCAs were selected for cannulation in 18 human donor eyes. Fluorescent probes with different excitation wavelengths were perfused through different arteries on the same eye to distinguish the supply sources of different vascular beds. After labeling and fixation, the ONH region was dissected either longitudinally or transversely as thick sections for confocal microscopy. Retina, choroid, and ONH were imaged from whole-mount specimens. Results: Probes perfused through the CRA or the SPCA alone labeled the microvessels in the retina, choroid, and ONH regions, as well as the optic nerve trunk. The vessels of the lamina cribrosa and the optic nerve trunk were labeled when probes were perfused through the SPCA. Perfusion through both the CRA and SPCA produced double labeling of vessels in the retina, the choroid, and the ONH. Conclusions: The results indicate an inter-relationship of arterial supply to the retina, choroid, and ONH in the human eye. This has important implications in understanding clinical observations and disease mechanisms such as that of glaucoma and ischemic optic nerve disease.
[Mh] Termos MeSH primário: Corioide/irrigação sanguínea
Artérias Ciliares/fisiologia
Disco Óptico/irrigação sanguínea
Retina/fisiologia
Artéria Retiniana/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Cateterismo
Artérias Ciliares/anatomia & histologia
Circulação Colateral
Bancos de Olhos
Feminino
Corantes Fluorescentes
Seres Humanos
Masculino
Microscopia Confocal
Meia-Idade
Imagem de Perfusão
Artéria Retiniana/anatomia & histologia
Doadores de Tecidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22191


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Rizzo, Luiz Vicente
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[PMID]:28508165
[Au] Autor:Costa DF; Nascimento H; Sutili A; Nobrega FAJ; Fowler F; Nobrega MJ; Garrido C; de Oliveira Dias J; Adán CBD; Rizzo LV; Silveira C; Belfort R; Commodaro AG
[Ad] Endereço:Department of Ophthalmology, Federal University of Sao Paulo and Vision Institute, Rua Botucatu, 821, São Paulo, SP, 04023-062, Brazil.
[Ti] Título:Frequency of Toxoplasma gondii in the retina in eye banks in Brazil.
[So] Source:Parasitol Res;116(7):2031-2033, 2017 Jul.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Ocular toxoplasmosis is the main cause of posterior uveitis worldwide frequently leading to vision loss. In Brazil, the seroprevalence of Toxoplasma gondii infection ranges from 50 to 80% depending of the region studied. The frequency of toxoplasmic retinal scar may reach 18% of the adults in the South of Brazil. Our goal was to determine the frequency of T. gondii DNA in retinas from eye banks from different regions in Brazil. A total of 162 eyes were obtained from eye banks in Manaus (n = 60), Sao Paulo (n = 60), Chapeco (n = 26), and Joinville (n = 16). The retinas were macroscopically analyzed and collected for DNA extraction. Real-time PCR (qPCR) was performed using the T. gondii B1 marker. By qPCR, a higher frequency of T. gondii DNA in the retinas from the eye bank of Joinville (25%) was found when compared to Manaus (5%). The retinas from Sao Paulo and Chapeco were qPCR negative. Clinical examination determined the retina lesions to be compatible with toxoplasmosis in the following frequencies: Joinville (62.5%), Manaus (10%), Sao Paulo (6.7%), and Chapeco (15.4%).
[Mh] Termos MeSH primário: Bancos de Olhos
Retina/parasitologia
Toxoplasma/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Animais
Brasil
Corioidite/parasitologia
DNA de Protozoário/análise
Seres Humanos
Reação em Cadeia da Polimerase em Tempo Real
Estudos Soroepidemiológicos
Toxoplasma/genética
Toxoplasmose Ocular/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Protozoan)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-017-5474-2


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[PMID]:28489792
[Au] Autor:Regnier M; Auxenfans C; Maucort-Boulch D; Marty AS; Damour O; Burillon C; Kocaba V
[Ad] Endereço:aService d'ophtalmologie bBanque de Tissus et de Cellules des Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon cUniversité Claude-Bernard Lyon-I, Villeurbanne dService de Biostatistique, Hospices Civils de Lyon, Lyon eCNRS UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, Villeurbanne, France.
[Ti] Título:Eye bank prepared versus surgeon cut endothelial graft tissue for Descemet membrane endothelial keratoplasty: An observational study.
[So] Source:Medicine (Baltimore);96(19):e6885, 2017 May.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this article is to examine outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed with cornea bank (CB) prestripped tissue and surgeon stripped tissue (SST).This retrospective study examined subjects who underwent DMEK with CB or surgeon prepared tissue for Fuchs endothelial corneal dystrophy. Best-corrected visual acuity (BCVA), corneal thickness, endothelial cell count (ECC), and complications were examined before and throughout a 6-month postoperative period.Eleven CB and 22 SST subjects were included. Six months after surgery, BCVA was 20/20 or better in 36.4% of CB and 22.7% of SST subjects (P = .43). Median logMAR BCVA was 0.10 (0.00-0.20, 20/25) in group CB and 0.10 (0.10-0.30, 20/25) in group SST. Median preoperative corneal thickness was 614.0 µm (577.5-662.0 µm) and 658.0 µm (606.0-689.0 µm) in CB and SST subjects, respectively (P = .37). Six months after surgery, median corneal thickness was lower in the CB group (571.0 µm [478.0-592.0 µm]), than in the SST group (576.0 µm [531.0-607.0 µm], P = .02). At 6 months, median ECC was 1500.0 cell/mm (1321.5-2049.0 cell/mm, 41% decrease) in group CB and 1403.0 cell/mm (972.5-2010.7 cell/mm, 46% decrease) in group SST (P = .70). Rebubbling was required in 5 CB (45.5%) and 15 SST (68.2%) subjects (P = .39).Fuchs' dystrophy patients have good anatomic and functional DMEK results. Similar outcomes and complication rates occurred with eye bank and surgeon prepared donor tissue.
[Mh] Termos MeSH primário: Lâmina Limitante Posterior
Ceratoplastia Endotelial com Remoção da Lâmina Limitante Posterior/métodos
Bancos de Olhos
Distrofia Endotelial de Fuchs/cirurgia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Lâmina Limitante Posterior/patologia
Lâmina Limitante Posterior/cirurgia
Epitélio Posterior/patologia
Epitélio Posterior/cirurgia
Feminino
Distrofia Endotelial de Fuchs/patologia
Rejeição de Enxerto
Seres Humanos
Masculino
Meia-Idade
Tamanho do Órgão
Complicações Pós-Operatórias
Estudos Retrospectivos
Cirurgiões
Resultado do Tratamento
Acuidade Visual
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006885


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[PMID]:28345565
[Au] Autor:Tandon R; Singh A; Gupta N; Vanathi M; Gupta V
[Ad] Endereço:Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Título:Upgradation and modernization of eye banking services: Integrating tradition with innovative policies and current best practices.
[So] Source:Indian J Ophthalmol;65(2):109-115, 2017 Feb.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources. METHODS: Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements. Periodic situational analysis with contextual relevance and interpretation of outcomes was done pertaining to national goals and international standards. RESULTS: The NEB and cornea services have played a key leadership role in furthering the development of eye banking and corneal transplantation services. The contribution extends beyond routine patient care to education, training, generation of resources, advocacy, and policymaking. In quantifiable terms, the overall performance has steadily increased over the years. Major contributions include training of doctors, eye bank staff and corneal surgeons, introduction of innovative techniques for corneal transplantation, setting of national standards for eye banking and provision of preservation media, customized corneal, and ocular surface cell replacement therapy in collaboration with other departments and institutes. CONCLUSION: The eye banking and corneal transplantation facilities have evolved with time providing quality services, modernized as appropriate with updated knowledge and incorporating technological advances supported by the systematic evidence-based approach.
[Mh] Termos MeSH primário: Transplante de Córnea
Bancos de Olhos/organização & administração
Doadores de Tecidos
Obtenção de Tecidos e Órgãos/organização & administração
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_862_16


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[PMID]:28306601
[Au] Autor:Liaboe CA; Aldrich BT; Carter PC; Skeie JM; Burckart KA; Schmidt GA; Reed CR; Zimmerman MB; Greiner MA
[Ad] Endereço:*Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA; †Cornea Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA; ‡Iowa Lions Eye Bank, Coralville, IA; and §Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA.
[Ti] Título:Assessing the Impact of Diabetes Mellitus on Donor Corneal Endothelial Cell Density.
[So] Source:Cornea;36(5):561-566, 2017 May.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To quantify changes in endothelial cell density (ECD) of donor corneal tissue in relation to the presence or absence of a medical history of diabetes mellitus diagnosis, treatment, and complications. METHODS: A retrospective review was performed for all corneas collected at Iowa Lions Eye Bank between January 2012 and December 2015. For purposes of analysis, donor corneas were divided into 4 groups: nondiabetic, non-insulin-dependent diabetic, insulin-dependent diabetic without medical complications due to diabetes, and insulin-dependent diabetic with medical complications due to diabetes. ECD values (obtained through specular microscopy) and transplant suitability for endothelial transplantation (determined by the standard protocol of the eye bank) were compared among groups using linear mixed model analysis. RESULTS: In total, 4185 corneas from 2112 donors were included for analysis. Insulin-dependent diabetic samples with medical complications due to diabetes (N = 231 from 119 donors) showed lower ECD values compared with nondiabetic samples (-102 cells/mm, P = 0.049) and non-insulin-dependent diabetic samples (-117 cells/mm, P = 0.031). ECD values did not differ significantly among the remaining groups. The likelihood of suitability for endothelial transplantation did not differ among all 4 groups. CONCLUSIONS: Corneas from donors with insulin-dependent diabetes mellitus and medical complications resulting from the disease have lower mean ECD values compared with other donors. However, our analysis suggests that these corneas are equally likely to be included in the donor pool for corneal transplantation. Additional studies are needed to determine the mechanism(s) contributing to cell loss in donors with advanced diabetes and to assess associated endothelial cell functional impairment.
[Mh] Termos MeSH primário: Córnea/patologia
Complicações do Diabetes/patologia
Diabetes Mellitus Tipo 1/patologia
Células Endoteliais/citologia
Epitélio Posterior/citologia
[Mh] Termos MeSH secundário: Idoso
Contagem de Células
Bancos de Olhos/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Doadores de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001174



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