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[PMID]:29185815
[Au] Autor:Gummin DD; Mowry JB; Spyker DA; Brooks DE; Fraser MO; Banner W
[Ad] Endereço:a Wisconsin Poison Center , Milwaukee , WI , USA.
[Ti] Título:2016 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 34th Annual Report.
[So] Source:Clin Toxicol (Phila);55(10):1072-1252, 2017 Dec.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: This is the 34th Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of 1 January 2016, 55 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 9.50 [7.33, 14.6] (median [25%, 75%]) min, facilitating a near real-time national exposure and information database and surveillance system. METHODS: We analyzed the case data tabulating specific indices from NPDS. The methodology was similar to that of previous years. Where changes were introduced, the differences are identified. Cases with medical outcomes of death were evaluated by a team of medical and clinical toxicologist reviewers using an ordinal scale of 1-6 to assess the Relative Contribution to Fatality (RCF) of the exposure. RESULTS: In 2016, 2,710,042 closed encounters were logged by NPDS: 2,159,032 human exposures, 54,019 animal exposures, 490,215 information cases, 6687 human confirmed non-exposures, and 89 animal confirmed non-exposures. US PCs also made 2,718,022 follow-up calls in 2016. Total encounters showed a 2.94% decline from 2015, while health care facility (HCF) human exposure cases increased by 3.63% from 2015. All information calls decreased by 12.5% but HCF information calls increased 0.454%, and while medication identification requests (Drug ID) decreased 29.6%, human exposure cases were essentially flat, decreasing by 0.431%. Human exposures with less serious outcomes have decreased 2.59% per year since 2008 while those with more serious outcomes (moderate, major or death) have increased by 4.39% per year since 2000. The top five substance classes most frequently involved in all human exposures were analgesics (11.2%), household cleaning substances (7.54%), cosmetics/personal care products (7.20%), sedatives/hypnotics/antipsychotics (5.84%), and antidepressants (4.74%). As a class, sedative/hypnotics/antipsychotics exposures increased most rapidly, by 10.7% per year (2088 cases/year), over the last 15 years for cases showing more serious outcomes. The top five most common exposures in children age 5 years or less were cosmetics/personal care products (13.3%), household cleaning substances (11.1%), analgesics (9.21%), foreign bodies/toys/miscellaneous (6.48%), and topical preparations (5.07%). Drug identification requests comprised 28.1% of all information calls. NPDS documented 1977 human exposures resulting in death; 1492 (75.5%) of these were judged as related (RCF of 1 - undoubtedly responsible, 2 - probably responsible, or 3 - contributory). CONCLUSIONS: These data support the continued value of PC expertise and need for specialized medical toxicology information to manage more serious exposures, despite a decrease in cases involving less serious exposures. Unintentional and intentional exposures continue to be a significant cause of morbidity and mortality in the US. The near real-time, always current status of NPDS represents a national public health resource for collecting and monitoring US exposure cases and information calls. The continuing mission of NPDS is to provide a nationwide infrastructure for surveillance for all types of exposures (e.g. foreign body, infectious, venomous, chemical agent, or commercial product), and the identification and tracking of significant public health events. NPDS is a model system for the real-time surveillance of national and global public health.
[Mh] Termos MeSH primário: Relatórios Anuais como Assunto
Preparações Farmacêuticas
Centros de Controle de Intoxicações/estatística & dados numéricos
Envenenamento/epidemiologia
[Mh] Termos MeSH secundário: Animais
Bases de Dados Factuais
Seres Humanos
Preparações Farmacêuticas/classificação
Envenenamento/etiologia
Envenenamento/terapia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1388087


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[PMID]:28950006
[Au] Autor:Saheb Sharif-Askari F; Saheb Sharif-Askari N; Javadi M; Gholami K
[Ad] Endereço:Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:Adverse drug reactions reported to the drug and poison information center of Tehran, Iran.
[So] Source:PLoS One;12(9):e0185450, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Burden of adverse drug reactions (ADRs), in home-environment and domestic settings, is unknown. OBJECTIVE: To discuss the epidemiology of reported ADRs to 13-Aban drug and poison information center (DPIC) and to discuss the burden of hospitalization caused by these ADRs from commonly implicated therapeutic groups. METHODS: A retrospective analysis of the yellow card schemes of suspected ADRs reported to the 13-Aban DPIC was conducted from 21 March 2013 to 21 November 2016 inclusive. MAIN OUTCOME MEASURES: Characteristics of the ADRs, such as the sex and age of the patient, the therapeutic group involved, and the medical outcome of the exposure, were examined. ADR Hospitalization (ADRH) index was calculated for each drug group by dividing the number of ADR-related hospitalizations with total number of reported ADR cases (n = 748), and then multiplying by 100. RESULTS: ADRs were reported for 748 patients representing 5 cases per 1000 enquiries to the 13-Aban DPIC over almost 4-years of the study period. Public were responsible for reporting every 4 out of 5 ADR cases (n = 651, 87%) and the remaining 1 out of 5 ADR cases was reported by the health care professionals (n = 97, 13%). Most of the ADRs had a medical outcome documented as having a minor effect or were minimally bothersome to the patients (n = 509, 68%), and less than 4.9% (n = 37) were documented as having a major effect or were life-threatening. Overall, 7.4% (n = 55) of ADRs were resulted in hospitalization. Antibacterials for systemic use represented the therapeutic group with the highest hospitalization index (1.7%). CONCLUSIONS: The study concluded that ADRs to antibiotics are common and some of them resulted in hospitalization.
[Mh] Termos MeSH primário: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Centros de Controle de Intoxicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Irã (Geográfico)
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185450


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[PMID]:28858755
[Au] Autor:Gribble MO; Deshpande A; Stephan WB; Hunter CM; Weisman RS
[Ad] Endereço:Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA. Electronic address: matt.gribble@emory.edu.
[Ti] Título:Calls to Florida Poison Control Centers about mercury: Trends over 2003-2013.
[So] Source:Environ Res;159:422-426, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this analysis was to contrast trends in exposure-report calls and informational queries (a measure of public interest) about mercury to the Florida Poison Control Centers over 2003-2013. MATERIALS AND METHODS: Poison-control specialists coded calls to Florida Poison Control Centers by substance of concern, caller demographics, and whether the call pertained to an exposure event or was an informational query. For the present study, call records regarding mercury were de-identified and provided along with daily total number of calls for statistical analysis. We fit Poisson models using generalized estimating equations to summarize changes across years in counts of daily calls to Florida Poison Control Centers, adjusting for month. In a second stage of analysis, we further adjusted for the total number of calls each day. We also conducted analyses stratified by age of the exposed. RESULTS: There was an overall decrease over 2003-2013 in the number of total calls about mercury [Ratio per year: 0.89, 95% CI: (0.88, 0.90)], and calls about mercury exposure [Ratio per year: 0.84, 95% CI: (0.83, 0.85)], but the number of informational queries about mercury increased over this time [Ratio per year: 1.15 (95% CI: 1.12, 1.18)]. After adjusting for the number of calls of that type each day (e.g., call volume), the associations remained similar: a ratio of 0.88 (95% CI: 0.87, 0.89) per year for total calls, 0.85 (0.83, 0.86) for exposure-related calls, and 1.17 (1.14, 1.21) for informational queries. CONCLUSION: Although, the number of exposure-related calls decreased, informational queries increased over 2003-2013. This might suggest an increased public interest in mercury health risks despite a decrease in reported exposures over this time period.
[Mh] Termos MeSH primário: Exposição Ambiental
Mercúrio
Centros de Controle de Intoxicações/tendências
Centros de Controle de Intoxicações/utilização
[Mh] Termos MeSH secundário: Florida
Seres Humanos
Distribuição de Poisson
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE


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[PMID]:28763096
[Au] Autor:Olsson E; Beck O; Elmgren A; Hansson T; Helander A
[Ad] Endereço:- Stockholm, Sweden - Stockholm, Sweden.
[Ti] Título:Tillgång till snabb laboratorieanalys vid akut förgiftning ger bättre och säkrare vård - Men möjligheten till akuta prov­­svar varierar över landet..
[So] Source:Lakartidningen;114, 2017 Jul 26.
[Is] ISSN:1652-7518
[Cp] País de publicação:Sweden
[La] Idioma:swe
[Ab] Resumo:Access to rapid laboratory analytical services in cases of acute poisoning provides better and safer patient care The Swedish Poisons Information Centre, a nationwide 24/7 service to healthcare providers and the public, answers many questions about serious cases of acute poisoning. In some of these, prompt and proper treatment recommendations can be crucial for the clinical outcome. In cases where self-reported information is missing or considered unreliable, more emphasis is placed on the clinical symptoms and results of toxicological analyses. However, rapid access to toxicological analysis for the most common set of poisoning agents varies between hospitals and laboratories. A priority list of toxic agents for which improved analytical techniques could offer a more widespread availability and rapid access to clinically important test results is presented.
[Mh] Termos MeSH primário: Serviços de Laboratório Clínico/normas
Envenenamento/diagnóstico
[Mh] Termos MeSH secundário: Acetaminofen/envenenamento
Analgésicos não Entorpecentes/envenenamento
Disparidades em Assistência à Saúde
Seres Humanos
Centros de Controle de Intoxicações
Envenenamento/terapia
Suécia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 362O9ITL9D (Acetaminophen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE


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[PMID]:28594246
[Au] Autor:Heise CW; Malashock H; Brooks DE
[Ad] Endereço:a Center for Toxicology & Pharmacology Education and Research , College of Medicine - Phoenix, University of Arizona , Phoenix , AZ , USA.
[Ti] Título:A review of vilazodone exposures with focus on serotonin syndrome effects.
[So] Source:Clin Toxicol (Phila);55(9):1004-1007, 2017 Nov.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vilazodone is an antidepressant with selective serotonin reuptake inhibition and partial 5HT1A agonism. Serotonin syndrome is believed to be due to excessive stimulation of 5-HT2A and 5-HT1A receptors, resulting in the clinical triad of altered mentation, autonomic instability and neuromuscular abnormalities. The goal of this study is to define serotonergic effects after vilazodone exposure. METHODS: A retrospective review of two databases: the American Association of Poison Controls Centers' National Poison Data System (NPDS) and the American College of Medical Toxicology's Toxicology Investigators Consortium (ToxIC Registry). A case series of four patients from one medical toxicology service is also presented. RESULTS: During the 52-month study period, a total of 3192 vilazodone human exposures were reported to NPDS. Of these, 1734 (54%) were isolated vilazodone cases. The clinical effects of vilazodone toxicity included drowsiness (20%), vomiting (14%), tachycardia (11%) and agitation (10%). Most patients (71%) had symptoms for between 2 and 24 h, though some (14%) remained symptomatic for more than 24 h. The most common treatment was intravenous fluids (15%) and the most serious intubation (2%). From the ToxIC Registry, a total of 23 cases of vilazodone exposures were identified. Of these, 17 (74%) had vilazodone listed as the first (primary) agent and 10 (43%) involved vilazodone-only ingestions. Nine (39%) cases documented serotonin syndrome; and most (8/9; 89%) listed vilazodone as the primary agent. All (n = 4) subjects in the case series with acute vilazodone toxicity had serotonin syndrome. CONCLUSIONS: Vilazodone overdose, including vilazodone-only ingestions, are associated with serotonin syndrome. Serotonergic toxicity and appropriate treatments should be considered when caring for patients with vilazodone ingestions.
[Mh] Termos MeSH primário: Antidepressivos/envenenamento
Agonistas de Receptores 5-HT1 de Serotonina/envenenamento
Síndrome da Serotonina/induzido quimicamente
Inibidores da Captação de Serotonina/envenenamento
Cloridrato de Vilazodona/envenenamento
[Mh] Termos MeSH secundário: Acidentes Domésticos
Adolescente
Adulto
Criança
Pré-Escolar
Bases de Dados Factuais
Overdose de Drogas
Agonismo Parcial de Drogas
Feminino
Hidratação
Seres Humanos
Masculino
Centros de Controle de Intoxicações
Estudos Retrospectivos
Síndrome da Serotonina/sangue
Síndrome da Serotonina/diagnóstico
Tentativa de Suicídio
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Serotonin 5-HT1 Receptor Agonists); 0 (Serotonin Uptake Inhibitors); U8HTX2GK8J (Vilazodone Hydrochloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1332369


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[PMID]:28535077
[Au] Autor:Carstairs SD; Koh C; Qian L; Qozi M; Seivard G; Cantrell FL
[Ad] Endereço:a Division of Medical Toxicology, Department of Emergency Medicine , University of California , San Diego , CA , USA.
[Ti] Título:Sticky situations: cyanoacrylate exposures reported to a poison control system.
[So] Source:Clin Toxicol (Phila);55(9):1001-1003, 2017 Nov.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Cyanoacrylate (Super Glue ) exposures are commonly reported to poison control centers, but little has been published in the medical literature regarding these exposures. We sought to characterize cyanoacrylate exposures reported to a poison control system. METHODS: We performed a retrospective review of a poison system's database for all cases of single-substance human exposure to cyanoacrylate-containing products from 2005 to 2015. Data collected included age, gender, route of exposure, clinical effects, treatments recommended and medical outcome. RESULTS: There were a total of 893 patients, 505 (56.6%) of which were female. Patient ages ranged from 6 months to 88 years with a median of 11 years. The vast majority of exposures (n = 871, 97.5%) were unintentional, but a small number of exposures (n = 22, 2.5%) were due to intentional misuse (such as trying to stop a bleeding cut) or malicious intent (such as purposefully gluing a person's eyes shut as a prank). Routes of exposure included: ingestion, n = 337 (37.7%); ocular, n = 322 (36.1%); dermatologic, n = 285 (31.9%); inhalation, n = 16 (1.8%); nasal, n = 1 (0.1%); and otic, n = 1 (0.1%); some patients had multiple routes of exposure. Treatments recommended by the poison center included irrigation (n = 411), petroleum jelly (n = 143), mineral oil (n = 131), topical antibiotic ointment (n = 82), peanut butter (n = 6), acetone (n = 4) and WD-40 (n = 2). A total of 657 patients (73.6%) were managed on-site, while 236 (26.4%) were seen in a health care facility. Among all exposures, effects were classified as none (n = 287), minor (n = 529) and moderate (n = 77). No major effects or deaths were reported. CONCLUSIONS: In this case series, the majority of cases occurred in children and most exposures did not result in significant morbidity. Notably, there was wide variation in terms of recommended treatments; further study is needed to determine the optimal treatment method and to standardize poison center recommendations for treating patients with cyanoacrylate exposures.
[Mh] Termos MeSH primário: Adesivos/envenenamento
Cianoacrilatos/envenenamento
Centros de Controle de Intoxicações
Envenenamento/etiologia
[Mh] Termos MeSH secundário: Acidentes
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
California
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Meia-Idade
Envenenamento/diagnóstico
Envenenamento/terapia
Estudos Retrospectivos
Fatores de Risco
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Adhesives); 0 (Cyanoacrylates)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1327067


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[PMID]:28506507
[Au] Autor:Moore PQ; Weber J; Cina S; Aks S
[Ad] Endereço:1900 W Polk St., 10th Floor, Administration Building, Chicago, IL 60612, USA. Electronic address: moore.quincy@gmail.com.
[Ti] Título:Syndrome surveillance of fentanyl-laced heroin outbreaks: Utilization of EMS, Medical Examiner and Poison Center databases.
[So] Source:Am J Emerg Med;35(11):1706-1708, 2017 Nov.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Describe surveillance data from three existing surveillance systems during an unexpected fentanyl outbreak in a large metropolitan area. METHODS: We performed a retrospective analysis of three data sets: Chicago Fire Department EMS, Cook County Medical Examiner, and Illinois Poison Center. Each included data from January 1, 2015 through December 31, 2015. EMS data included all EMS responses in Chicago, Illinois, for suspected opioid overdose in which naloxone was administered and EMS personnel documented other criteria indicative of opioid overdose. Medical Examiner data included all deaths in Cook County, Illinois, related to heroin, fentanyl or both. Illinois Poison Center data included all calls in Chicago, Illinois, related to fentanyl, heroin, and other prescription opioids. Descriptive statistics using Microsoft Excel® were used to analyze the data and create figures. RESULTS: We identified a spike in opioid-related EMS responses during an 11-day period from September 30-October 10, 2015. Medical Examiner data showed an increase in both fentanyl and mixed fentanyl/heroin related deaths during the months of September and October, 2015 (375% and 550% above the median, respectively.) Illinois Poison Center data showed no significant increase in heroin, fentanyl, or other opioid-related calls during September and October 2015. CONCLUSION: Our data suggests that EMS data is an effective real-time surveillance mechanism for changes in the rate of opioid overdoses. Medical Examiner's data was found to be valuable for confirmation of EMS surveillance data and identification of specific intoxicants. Poison Center data did not correlate with EMS or Medical Examiner data.
[Mh] Termos MeSH primário: Surtos de Doenças
Overdose de Drogas/epidemiologia
Fentanila/envenenamento
Heroína/envenenamento
Entorpecentes/envenenamento
[Mh] Termos MeSH secundário: Chicago/epidemiologia
Médicos Legistas
Estudos Transversais
Bases de Dados Factuais
Contaminação de Medicamentos
Overdose de Drogas/tratamento farmacológico
Overdose de Drogas/etiologia
Overdose de Drogas/mortalidade
Serviços Médicos de Emergência
Seres Humanos
Illinois/epidemiologia
Naloxona/uso terapêutico
Antagonistas de Entorpecentes/uso terapêutico
Centros de Controle de Intoxicações
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Narcotic Antagonists); 0 (Narcotics); 36B82AMQ7N (Naloxone); 70D95007SX (Heroin); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE


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[PMID]:28443378
[Au] Autor:Day RC; Bradberry SM; Sandilands EA; Thomas SHL; Thompson JP; Vale JA
[Ad] Endereço:a NPIS (Birmingham Unit) , City Hospital , Birmingham , UK.
[Ti] Título:Toxicity resulting from exposure to oven cleaners as reported to the UK National Poisons Information Service (NPIS) from 2009 to 2015.
[So] Source:Clin Toxicol (Phila);55(7):645-651, 2017 Aug.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Oven cleaning products contain corrosive substances, typically sodium or potassium hydroxide. OBJECTIVE: To determine the reported toxicity from exposure to oven cleaning products. METHODS: Telephone enquiries to the UK National Poisons Information Service regarding oven cleaning products were analysed retrospectively for the period January 2009 to December 2015. RESULTS: There were 796 enquiries relating to 780 patients. Ninety-six percent of the products involved in the reported exposures contained sodium hydroxide and/or potassium hydroxide. Ingestion alone (n = 285) or skin contact alone (n = 208) accounted for the majority of cases; inhalation alone (n = 101), eye contact alone (n = 97), and multiple routes of exposure (n = 89) accounted for the remainder. Ninety-five percent of patients exposed by inhalation, 94% exposed dermally and 85% reporting eye exposure, developed features of toxicity. Patients exposed by multiple routes developed symptoms in 70% of cases. Only 103 of the 285 patients ingested oven cleaner directly, whereas 182 patients ingested food they considered to have been contaminated with oven cleaner. In 100 of the 103 direct ingestions where the features and World Health Organisation/International Programme on Chemical Safety/European Commission/European Association of Poison Centres and Clinical Toxicologists Poisoning Severity Score were known, 56 reported symptoms which were minor in 51 cases. The most common features following ingestion were vomiting (n = 26), abdominal pain (n = 22) or pharyngitis (n = 15). Skin burns (n = 91) predominantly involving the hands or arms, occurred in 44% of dermal exposures. Following inhalation, patients frequently developed respiratory features (n = 52) including coughing and chest pain/tightness. Eye pain (n = 43) and conjunctivitis (n = 33) commonly occurred following ocular exposure. CONCLUSIONS: Most (71%) patients exposed to an oven cleaner irrespective of the route of exposure developed features of toxicity, though in most cases only minor features developed; moderate or severe features ensued in ∼4%. Those patients exposed dermally, ophthalmically or by inhalation developed features more frequently (≥85%) than those who ingested a product directly (56%).
[Mh] Termos MeSH primário: Acidentes Domésticos/estatística & dados numéricos
Cáusticos/envenenamento
Culinária/instrumentação
Exposição Ambiental/efeitos adversos
Utensílios Domésticos
Produtos Domésticos/envenenamento
Centros de Controle de Intoxicações/estatística & dados numéricos
Envenenamento/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Desenho de Equipamento
Feminino
Seres Humanos
Lactente
Exposição por Inalação/efeitos adversos
Masculino
Meia-Idade
Envenenamento/diagnóstico
Estudos Retrospectivos
Índice de Gravidade de Doença
Fatores de Tempo
Reino Unido/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caustics)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1306070


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[PMID]:28421837
[Au] Autor:Russell JL; Spiller HA; Chounthirath T; Casavant MJ
[Ad] Endereço:a Nationwide Children's Hospital , Columbus , OH , USA.
[Ti] Título:Pediatric ingestion of vilazodone compared to other selective serotonin reuptake inhibitor medications.
[So] Source:Clin Toxicol (Phila);55(5):352-356, 2017 Jun.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Unintentional ingestion of selective serotonin reuptake inhibitor (SSRI) medications is common amongst children <6 years of age. Current evidence-based management guidelines are based on a low incidence of significant medical outcomes in these children. OBJECTIVE: To describe and compare outcomes of pediatric exposures to vilazodone with other SSRIs. METHODS: A retrospective observational case series analysis of both single and polysubstance SSRI exposures amongst children <6 years old reported to the National Poison Data System (NPDS). RESULTS: 11,384 SSRI exposures in children <6 years of age reported to NPDS between January 2012 and June 2016 were assessed. Vilazodone only accounted for 5.9% of all exposures, but resulted in the highest proportion of health care facility admission compared to other SSRIs, both in single substance (165 of 531 (31.1%); OR 9.0 [7.3-11.2]) and polysubstance (57 of 107 (53.3%); OR 4.1 [2.7-6.2]) exposures. Children exposed to vilazodone also have higher odds of experiencing a major or moderate outcome in single (134 of 531 (25.2%); OR 20.5 [15.5-27.1]) and polysubstance (37 of 107 (35.6%); OR 5.9 [3.7-9.0]) exposures compared to other SSRIs. Several severe clinical outcomes, such as seizure and coma, were more common among the vilazodone exposures. CONCLUSIONS: Exposure to vilazodone in this age group results in an increased rate of hospitalization as well as more severe clinical effects as compared to other SSRIs. Current evidence-based SSRI exposure management guidelines may not be appropriate for the management of vilazodone ingestion in this age group.
[Mh] Termos MeSH primário: Inibidores da Captação de Serotonina/envenenamento
Cloridrato de Vilazodona/envenenamento
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Citalopram/envenenamento
Coma/induzido quimicamente
Coma/tratamento farmacológico
Relação Dose-Resposta a Droga
Medicina Baseada em Evidências
Feminino
Fluoxetina/envenenamento
Fluvoxamina/envenenamento
Seguimentos
Hospitalização
Seres Humanos
Lactente
Masculino
Paroxetina/envenenamento
Centros de Controle de Intoxicações
Estudos Retrospectivos
Convulsões/induzido quimicamente
Convulsões/tratamento farmacológico
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Serotonin Uptake Inhibitors); 01K63SUP8D (Fluoxetine); 0DHU5B8D6V (Citalopram); 41VRH5220H (Paroxetine); O4L1XPO44W (Fluvoxamine); U8HTX2GK8J (Vilazodone Hydrochloride)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1287375


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[PMID]:28393553
[Au] Autor:Pringle K; Caupp S; Shi J; Wheeler KK; Spiller HA; Casavant MJ; Xiang H
[Ad] Endereço:a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.
[Ti] Título:Analysis of intentional drug poisonings using Ohio Poison Control Center Data, 2002-2014.
[So] Source:Clin Toxicol (Phila);55(7):652-658, 2017 Aug.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Pharmaceutical drug poisonings, especially those that are intentional, are a serious problem for adolescents and young adults. Poison control center data is a viable tool to track intentional drug poisonings in near real-time. OBJECTIVE: To determine intentional drug poisoning rates among adolescents and young adults in Ohio using poison control center data. METHODS: We analyzed data from 2002 to 2014 obtained by Ohio's three poison control centers. Inclusion variables were calls made to the centers that had appropriate subject age (10-29 years old), subject sex, involved substance (all drug classes), and medical outcome (no effect, minor effect, moderate effect, major effect, and death). Intentional drug poisoning reports were also separated into subgroups to compare suspected suicide reports to misuse and abuse reports. Finally, resident population estimates were used to generate 2014 intentional drug poisoning rates for each county in Ohio. RESULTS: The most common age group for intentional drug poisonings was 18-24. Females reported more suspected suicide drug poisonings while males reported more misuse/abuse drug poisonings. The most reported drug class across all ages was analgesics. Of the 88 counties in Ohio, Hamilton, Williams, Washington, and Guernsey counties had the highest rates of intentional drug poisonings. CONCLUSIONS: The high report rate of suspected suicides and analgesic class drugs demonstrates the need for preventative measures for adolescents and young adults in Ohio. Any interventions, along with legislative changes, will need to take place in our local communities.
[Mh] Termos MeSH primário: Comportamento do Adolescente
Overdose de Drogas/epidemiologia
Intenção
Centros de Controle de Intoxicações/estatística & dados numéricos
Tentativa de Suicídio/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Criança
Overdose de Drogas/diagnóstico
Overdose de Drogas/psicologia
Feminino
Seres Humanos
Masculino
Ohio/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Distribuição por Sexo
Tentativa de Suicídio/psicologia
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1309050



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