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[PMID]:29278028
[Au] Autor:Borda B; Németh T; Ottlakan A; Keresztes C; Kemény É; Lázár G
[Ad] Endereço:1 Faculty of Medicine, Department of Surgery, University of Szeged , Szeged, Hungary.
[Ti] Título:Post-transplantation morphological and functional changes in kidneys from expanded criteria donors.
[So] Source:Physiol Int;104(4):329-333, 2017 Dec 01.
[Is] ISSN:2498-602X
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:Introduction Despite an increase in the number of cadaver donors and overall organ transplantations, the dramatic increase in the waiting list makes it necessary to reconsider donor criteria. The authors wanted to examine whether differences could exist in the function and/or morphology of transplanted kidneys originated from expanded criteria donors (ECDs) and ideal donors 1 and 5 years after transplantation. Methods Kidney function and histopathologic findings were analyzed and compared 1 and 5 years after transplantation in 97 patients having ECD kidneys and in 178 patients who received ideal donor kidneys (IDK). Results Serum creatinine level was significantly higher (p = 0.001) and estimated glomerular filtration rate was significantly lower (p = 0.003) in patients having ECD kidneys as compared with those with IDK 5 years after transplantation. Morphological changes in the transplanted kidneys, such as tubulitis (p = 0.025) and interstitial inflammation (p = 0.002), were significantly more frequently present in patients with ECD kidneys than in those with IDK 1 year after transplantation. Conclusion Despite an absence of differences in kidney function 1 year after kidney transplantation between patients having ECD and IDK, morphological differences in the transplanted kidneys can be detected between the two groups of patients.
[Mh] Termos MeSH primário: Sobrevivência de Enxerto/fisiologia
Falência Renal Crônica/patologia
Falência Renal Crônica/fisiopatologia
Transplante de Rim
Rim/patologia
Rim/cirurgia
Doadores de Tecidos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Taxa de Filtração Glomerular
Seres Humanos
Falência Renal Crônica/cirurgia
Masculino
Meia-Idade
Tamanho do Órgão
Obtenção de Tecidos e Órgãos/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE
[do] DOI:10.1556/2060.104.2017.4.4


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[PMID]:29292950
[Au] Autor:Barlöv K
[Ti] Título:Anhörigveto försvårar organdonation..
[So] Source:Lakartidningen;114, 2017 11 27.
[Is] ISSN:1652-7518
[Cp] País de publicação:Sweden
[La] Idioma:swe
[Mh] Termos MeSH primário: Consentimento Presumido
Obtenção de Tecidos e Órgãos/legislação & jurisprudência
[Mh] Termos MeSH secundário: Família
Seres Humanos
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


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[PMID]:29233812
[Au] Autor:Iacobucci G
[Ad] Endereço:The BMJ.
[Ti] Título:Proposals for opt-out organ donation launched for England.
[So] Source:BMJ;359:j5764, 2017 12 12.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Legislação Médica/ética
Obtenção de Tecidos e Órgãos/legislação & jurisprudência
[Mh] Termos MeSH secundário: Inglaterra/epidemiologia
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Opinião Pública
Obtenção de Tecidos e Órgãos/estatística & dados numéricos
Estados Unidos
United States Dept. of Health and Human Services
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5764


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[PMID]:29360304
[Au] Autor:Seiler LW; Thomson Reuters Accelus.
[Ti] Título:Long-Term Care: End-of-Life Issues.
[So] Source:Issue Brief Health Policy Track Serv;2017:1-96, 2017 Dec 26.
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Assistência de Longa Duração/organização & administração
Assistência Terminal/organização & administração
[Mh] Termos MeSH secundário: Diretivas Antecipadas
Afroamericanos
Moradias Assistidas
Canadá
Capitação
Ensaios de Uso Compassivo
Comportamento do Consumidor
Aconselhamento
Demência/terapia
Depressão
Europa (Continente)
Grupo com Ancestrais do Continente Europeu
Custos de Cuidados de Saúde
Hispano-Americanos
Cuidados Paliativos na Terminalidade da Vida
Seres Humanos
Reembolso de Seguro de Saúde
Maconha Medicinal
Medicare/economia
Musicoterapia
Enfermagem/recursos humanos
Casas de Saúde
Cuidados Paliativos
Planejamento de Assistência ao Paciente
Direitos do Paciente
Prisioneiros
Qualidade da Assistência à Saúde
Ordens quanto à Conduta (Ética Médica)
Cônjuges
Governo Estadual
Suicídio Assistido
Telemedicina
Doente Terminal
Obtenção de Tecidos e Órgãos
Estados Unidos
Veteranos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Medical Marijuana)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE


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[PMID]:28464877
[Au] Autor:Merdad L; Aldakhil L; Gadi R; Assidi M; Saddick SY; Abuzenadah A; Vaught J; Buhmeida A; Al-Qahtani MH
[Ad] Endereço:Department of Dental Public Health, Faculty of Dentistry, King Abdulaziz University, P.O. Box 80209, Jeddah, 21589, Saudi Arabia.
[Ti] Título:Assessment of knowledge about biobanking among healthcare students and their willingness to donate biospecimens.
[So] Source:BMC Med Ethics;18(1):32, 2017 May 02.
[Is] ISSN:1472-6939
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Biobanks and biospecimen collections are becoming a primary means of delivering personalized diagnostics and tailoring individualized therapeutics. This shift towards precision medicine (PM) requires interactions among a variety of stakeholders, including the public, patients, healthcare providers, government, and donors. Very few studies have investigated the role of healthcare students in biobanking and biospecimen donations. The main aims of this study were (1) to evaluate the knowledge of senior healthcare students about biobanks and (2) to assess the students' willingness to donate biospecimens and the factors influencing their attitudes. METHODS: A cross-sectional study was conducted among senior healthcare students at King Abdulaziz University (KAU), Saudi Arabia. The data were obtained using a self-administered questionnaire in English. In addition to the respondents' biographical data section, the questionnaire assessed the respondents' general knowledge about biobanking, the factors influencing their willingness to donate biospecimens to biobanks and their general attitudes towards biomedical research. RESULTS: A total of 597 senior healthcare students were included in the study. The general knowledge score was 3.2 (±1.6) out of 7. Only approximately 44% and 27% of students were aware of the terms "Human Genome Project" (HGP) and "biobank," respectively. The majority of the students (89%) were willing to donate biospecimens to biobanks. Multiple factors were significantly associated with their willingness to donate, including their perceived general health (p < 0.001), past experience with both tissue testing (p < 0.04) and tissue donation (p < 0.001), biobanking knowledge score (p < 0.001) and biomedical research attitude score (p < 0.001). The main reasons for students' willingness to donate were advancement of medical research and societal benefits, whereas misuse of biospecimens and confidentiality breaches were the main reasons for a reluctance to donate. CONCLUSION: Despite their strong willingness to donate biospecimens, students exhibited a notable lack of knowledge about biobanking and the HGP. To expedite the transition towards PM, it is highly recommended to enhance healthcare curricula by including more educational and awareness programmes to familiarize students with OMICs technologies in addition to the scope of research and clinical applications.
[Mh] Termos MeSH primário: Bancos de Espécimes Biológicos
Conhecimentos, Atitudes e Prática em Saúde
Estudantes de Ciências da Saúde/psicologia
Obtenção de Tecidos e Órgãos
[Mh] Termos MeSH secundário: Estudos Transversais
Feminino
Seres Humanos
Masculino
Arábia Saudita
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12910-017-0195-8


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[PMID]:27779574
[Au] Autor:Mittal S; Adamusiak A; Horsfield C; Loukopoulos I; Karydis N; Kessaris N; Drage M; Olsburgh J; Watson CJ; Callaghan CJ
[Ad] Endereço:1 Department of Nephrology and Transplantation, Guy's Hospital, London, United Kingdom. 2 Department of Histopathology, Guy's Hospital, London, United Kingdom. 3 Department of Surgery University of Cambridge, Cambridge, United Kingdom. 4 NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.
[Ti] Título:A Re-evaluation of Discarded Deceased Donor Kidneys in the UK: Are Usable Organs Still Being Discarded?
[So] Source:Transplantation;101(7):1698-1703, 2017 07.
[Is] ISSN:1534-6080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A significant proportion of procured deceased donor kidneys are subsequently discarded. The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012, enabling kidneys at risk of discard to be simultaneously offered to participating centers. We undertook an analysis of discarded kidneys to determine if unnecessary organ discard was still occurring since the KFTS was introduced. METHODS: Between April and June 2015, senior surgeons independently inspected 31 consecutive discarded kidneys from throughout the United Kingdom. All kidneys were biopsied. Organs were categorized as usable, possibly usable pending histology, or not usable for implantation. After histology reports were available, final assessments of usability were made. RESULTS: There were 19 donors (6 donations after brain death, 13 donations after circulatory death), with a median (range) donor age of 67 (29-83) years and Kidney Donor Profile Index of 93 (19-100). Reasons for discard were variable. Only 3 discarded kidneys had not entered the KFTS. After initial assessment postdiscard, 11 kidneys were assessed as usable, with 9 kidneys thought to be possibly usable. Consideration of histological data reduced the number of kidneys thought usable to 10 (10/31; 32%). CONCLUSIONS: The KFTS scheme is successfully identifying organs at high risk of discard, though potentially transplantable organs are still being discarded. Analyses of discarded organs are essential to identify barriers to organ utilization and develop strategies to reduce unnecessary discard.
[Mh] Termos MeSH primário: Seleção do Doador
Transplante de Rim/métodos
Doadores de Tecidos/provisão & distribuição
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Causas de Morte
Técnicas de Apoio para a Decisão
Feminino
Sobrevivência de Enxerto
Seres Humanos
Transplante de Rim/efeitos adversos
Masculino
Meia-Idade
Complicações Pós-Operatórias/etiologia
Valor Preditivo dos Testes
Avaliação de Programas e Projetos de Saúde
Medição de Risco
Fatores de Risco
Fatores de Tempo
Obtenção de Tecidos e Órgãos
Resultado do Tratamento
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1097/TP.0000000000001542


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[PMID]:29364794
[Au] Autor:Moreira Fonseca N; Nolasco F
[Ad] Endereço:Nephrology Department. Centro Hospitalar Lisboa Central. Lisboa. Portugal.
[Ti] Título:Kidney Allocation: New Contributions to an Ongoing Challenge.
[So] Source:Acta Med Port;30(12):833-834, 2017 12 29.
[Is] ISSN:1646-0758
[Cp] País de publicação:Portugal
[La] Idioma:eng
[Mh] Termos MeSH primário: Transplante de Rim
Rim
[Mh] Termos MeSH secundário: Seres Humanos
Seleção de Pacientes
Obtenção de Tecidos e Órgãos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.20344/amp.9947


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[PMID]:29280879
[Au] Autor:Plana NM; Kimberly LL; Parent B; Khouri KS; Diaz-Siso JR; Fryml EM; Motosko CC; Ceradini DJ; Caplan A; Rodriguez ED
[Ad] Endereço:New York, N.Y. From the Hansjörg Wyss Department of Plastic Surgery and the Division of Medical Ethics, New York University Langone Medical Center.
[Ti] Título:The Public Face of Transplantation: The Potential of Education to Expand the Face Donor Pool.
[So] Source:Plast Reconstr Surg;141(1):176-185, 2018 01.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite the growing success of facial transplantation, organ donor shortages remain challenging. Educational health campaigns can effectively inform the general public and institute behavioral modifications. A brief educational introduction to facial transplantation may positively influence the public's position on facial donation. METHODS: The authors anonymously surveyed 300 participants, gathering basic demographic information, donor registration status, awareness of facial transplantation, and willingness to donate solid organs and facial allografts. Two-hundred of these participants were presented an educational video and subsequently resurveyed on facial donation. Factorial parametric analyses were performed to compare exposure responses before and after watching video exposure. RESULTS: Among participants completing the survey alone (control group), 49 percent were registered donors, 78 percent reported willingness to donate solid organs, and 52 percent reported willingness to donate facial allograft. Of participants who watched the video (video group) 52 percent were registered; 69 and 51 percent were willing to donate solid organs and face, respectively. Following educational intervention, 69 percent of participants in the video group reported willingness to donate facial tissue, an 18 percent increase (p < 0.05), that equated to those willing to donate solid organs. The greatest increase was observed among younger participants (23 percent); women (22 percent); Jewish (22 percent), Catholic (22 percent), and black/African American (25 percent) participants; and respondents holding a higher degree. No significant differences according to gender or ethnicity were observed. CONCLUSION: Educational interventions hold much promise for increasing the general public's awareness of facial transplantation and willingness to participate in donation of facial allografts.
[Mh] Termos MeSH primário: Transplante de Face/psicologia
Educação em Saúde/métodos
Conhecimentos, Atitudes e Prática em Saúde
Doadores de Tecidos/psicologia
Obtenção de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Cidade de Nova Iorque
Inquéritos e Questionários
Gravação em Vídeo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003954


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[PMID]:29202255
[Au] Autor:Corkery-Lavender T; Millar J; Cavazzoni E; Gelbart B
[Ad] Endereço:The Northern Hospital, Melbourne, VIC, Australia. ben.gelbart@rch.org.au.
[Ti] Título:Patterns of organ donation in children in Australia and New Zealand.
[So] Source:Crit Care Resusc;19(4):296-302, 2017 Dec.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Paediatric organ donation (OD) represents a small proportion of total OD in Australia and New Zealand. Our aim was to describe the patterns of paediatric OD, specifically, the demographic characteristics and donation outcomes over two time periods. DESIGN: We performed a retrospective study using national OD and intensive care registry data from intensive care units in Australia and New Zealand from 1 January 2000 to 31 December 2015. Data were analysed between two time periods. Paediatric data were compared with adult data. PARTICIPANTS: Organ donors aged under 16 years in paediatric and mixed adult and paediatric ICUs. RESULTS: There were 267 paediatric organ donors, representing 5.4% of all donors. The rate of OD as a percentage of ICU deaths was comparable to adults (6.0% v 4.6%; P < 0.001). Over the entire period, donations after brain death totalled 244 (91.4%), and donations after circulatory death (DCDs) totalled 23 (8.6%). DCDs increased from 0.7% to 17% between the time periods (P < 0.001). Children aged under 2 years had a lower rate of donation than the general paediatric cohort (1.2% v 6.0%; P < 0.001). CONCLUSIONS: Paediatric OD rates have not changed over time but are comparable to adults when expressed as a percentage of ICU deaths. Paediatric DCD has increased significantly over time.
[Mh] Termos MeSH primário: Doadores de Tecidos/estatística & dados numéricos
Obtenção de Tecidos e Órgãos/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Austrália/epidemiologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Unidades de Terapia Intensiva
Masculino
Nova Zelândia/epidemiologia
Sistema de Registros
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:27773831
[Au] Autor:Parsons RF; Locke JE; Redfield RR; Roll GR; Levine MH
[Ad] Endereço:Emory University, Surgery Department, United States.
[Ti] Título:Kidney transplantation of highly sensitized recipients under the new kidney allocation system: A reflection from five different transplant centers across the United States.
[So] Source:Hum Immunol;78(1):30-36, 2017 Jan.
[Is] ISSN:1879-1166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deceased donor kidney allocation was reorganized in the United States to address several problems, including the highly sensitized patients disadvantaged with large, diverse repertoires of antibodies. Here, five transplant surgeons review their center's experience with the new allocation changes: highlighting areas of accomplishment, opportunities for improvement and, in some cases, stark differences in practice. Across these five centers the highly sensitized patients (CPRA ⩾98%) range from 5.5 to 9.2% of the 12,364 candidates on their collective waitlist. All centers reported greater rates of kidney transplantations in highly sensitized patients (12.4-27%). Three of the programs (Emory, UCSF, UW) relied upon the virtual crossmatch prior to organ acceptance in a majority of cases (70-86%)-the mere presence of antibody on HLA antibody screen was sufficient to exclude the donor in most cases at Emory and UCSF. Penn and UAB relied upon the physical flow crossmatch in almost all cases prior to proceeding with transplantation. Current or historical donor-specific antibody was occasionally crossed in certain cases at UW and UAB necessitating IVIG/plasmapheresis and/or B cell depletion perioperatively. Some authors raised concerns for cost efficiency given the increased need for organ/specimen transportation, and extensive use of hospital resources and ancillary services. In general, we found that the new allocation system has successfully achieved one of its primary goals-increased kidney transplantation in the disadvantaged, highly sensitized patients; the long-term outcomes in all patients and the cost ramifications of these changes will require continued reassessment and clarification.
[Mh] Termos MeSH primário: Tipagem e Reações Cruzadas Sanguíneas
Transplante de Rim
Obtenção de Tecidos e Órgãos
[Mh] Termos MeSH secundário: Análise Custo-Benefício
Regulamentação Governamental
Antígenos HLA/imunologia
Teste de Histocompatibilidade
Seres Humanos
Imunização
Isoanticorpos/metabolismo
Doadores de Tecidos
Transplantados
Resultado do Tratamento
Estados Unidos
Listas de Espera
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HLA Antigens); 0 (Isoantibodies)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE



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