Base de dados : MEDLINE
Pesquisa : N03.540.514.481 [Categoria DeCS]
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  1 / 112 MEDLINE  
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[PMID]:28470514
[Au] Autor:Ates G; Vanhaecke T; Rogiers V; Rodrigues RM
[Ad] Endereço:Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
[Ti] Título:Assaying Cellular Viability Using the Neutral Red Uptake Assay.
[So] Source:Methods Mol Biol;1601:19-26, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The neutral red uptake assay is a cell viability assay that allows in vitro quantification of xenobiotic-induced cytotoxicity. The assay relies on the ability of living cells to incorporate and bind neutral red, a weak cationic dye, in lysosomes. As such, cytotoxicity is expressed as a concentration-dependent reduction of the uptake of neutral red after exposure to the xenobiotic under investigation. The neutral red uptake assay is mainly used for hazard assessment in in vitro toxicology applications. This method has also been introduced in regulatory recommendations as part of 3T3-NRU-phototoxicity-assay, which was regulatory accepted in all EU member states in 2000 and in the OECD member states in 2004 as a test guideline (TG 432). The present protocol describes the neutral red uptake assay using the human hepatoma cell line HepG2, which is often employed as an alternative in vitro model for human hepatocytes. As an example, the cytotoxicity of acetaminophen and acetyl salicylic acid is assessed.
[Mh] Termos MeSH primário: Sobrevivência Celular/efeitos dos fármacos
Corantes/metabolismo
Hepatócitos/efeitos dos fármacos
Vermelho Neutro/metabolismo
Testes de Toxicidade/métodos
Xenobióticos/toxicidade
[Mh] Termos MeSH secundário: Células 3T3
Acetaminofen/toxicidade
Animais
Bioensaio
Células Hep G2
Hepatócitos/metabolismo
Seres Humanos
Modelos Logísticos
Lisossomos/efeitos dos fármacos
Lisossomos/metabolismo
Camundongos
Organização para a Cooperação e Desenvolvimento Econômico
Ácido Salicílico/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Xenobiotics); 261QK3SSBH (Neutral Red); 362O9ITL9D (Acetaminophen); O414PZ4LPZ (Salicylic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-6960-9_2


  2 / 112 MEDLINE  
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[PMID]:28856987
[Au] Autor:Thévenot C
[Ad] Endereço:1 OECD, Paris, France.
[Ti] Título:Inequality in OECD countries.
[So] Source:Scand J Public Health;45(18_suppl):9-16, 2017 Aug.
[Is] ISSN:1651-1905
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:This article recalls the state of play of inequality levels and trends in OECD countries, with a special focus on Nordic countries. It sheds light on explaining the drivers of the rise in inequality and its economic consequences. It addresses in particular the issue of redistribution through taxes and transfers. It concludes with an overview of policy packages that should be considered to address the issue of rising inequalities.
[Mh] Termos MeSH primário: Renda/estatística & dados numéricos
Organização para a Cooperação e Desenvolvimento Econômico
[Mh] Termos MeSH secundário: Seres Humanos
Política Pública
Países Escandinavos e Nórdicos
Fatores Socioeconômicos
Impostos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1177/1403494817713108


  3 / 112 MEDLINE  
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[PMID]:28571048
[Au] Autor:Laugesen M; Grace RC
[Ad] Endereço:Adjunct Professor.
[Ti] Título:Reduced tobacco consumption, improved diet and life expectancy for 1988-1998: analysis of New Zealand and OECD data.
[So] Source:N Z Med J;130(1456):46-51, 2017 Jun 02.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:AIM: We compared changes in tobacco consumption and diet in relation to changes in life expectancy in 1988-1998 in 22 OECD (Organisation for Economic Cooperation and Development) countries. METHOD: Between 1985 and 1995 using regression analysis we estimated differences in tobacco consumption per adult and the differences in the sum of atherogenic and thrombogenic indices against life expectancy. Each index was derived from the various fats per gram of food from standard texts, and from the annual measurements of fat in the food balance sheets of each country. RESULTS: In 1985-1995, New Zealand showed the largest decrease in tobacco consumption per adult (41%) and the greatest decrease (except for Switzerland) in the sum of atherogenic and thrombogenic indices (17%) as a measure of diet. New Zealand ranked first for life expectancy increases from 1988-1998 for men (3.2 years), women (2.8 years) and both sexes combined. Regression analyses revealed that increases in life expectancy across the OECD for males, but not females, were strongly associated with decreases in tobacco consumption, with a weaker effect of diet improvement. CONCLUSION: These results suggest that reduced tobacco consumption in 1985-1995 likely contributed to New Zealand's gains in life expectancy from 1988-1998.
[Mh] Termos MeSH primário: Dieta/tendências
Expectativa de Vida/tendências
Uso de Tabaco/tendências
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Nova Zelândia
Organização para a Cooperação e Desenvolvimento Econômico
Análise de Regressão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE


  4 / 112 MEDLINE  
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[PMID]:28500914
[Au] Autor:Sydow M; Chrzanowski L; Cedergreen N; Owsianiak M
[Ad] Endereço:Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965, Poznan, Poland. Electronic address: mateusz.sydow@gmail.com.
[Ti] Título:Limitations of experiments performed in artificially made OECD standard soils for predicting cadmium, lead and zinc toxicity towards organisms living in natural soils.
[So] Source:J Environ Manage;198(Pt 2):32-40, 2017 Aug 01.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Development of comparative toxicity potentials of cationic metals in soils for applications in hazard ranking and toxic impact assessment is currently jeopardized by the availability of experimental effect data. To compensate for this deficiency, data retrieved from experiments carried out in standardized artificial soils, like OECD soils, could potentially be tapped as a source of effect data. It is, however, unknown whether such data are applicable to natural soils where the variability in pore water concentrations of dissolved base cations is large, and where mass transfer limitations of metal uptake can occur. Here, free ion activity models (FIAM) and empirical regression models (ERM, with pH as a predictor) were derived from total metal EC50 values (concentration with effects in 50% of individuals) using speciation for experiments performed in artificial OECD soils measuring ecotoxicological endpoints for terrestrial earthworms, potworms, and springtails. The models were validated by predicting total metal based EC50 values using backward speciation employing an independent set of natural soils with missing information about ionic composition of pore water, as retrieved from a literature review. ERMs performed better than FIAMs. Pearson's r for log -transformed total metal based EC50s values (ERM) ranged from 0.25 to 0.74, suggesting a general correlation between predicted and measured values. Yet, root-mean-square-error (RMSE) ranged from 0.16 to 0.87 and was either smaller or comparable with the variability of measured EC50 values, suggesting modest performance. This modest performance was mainly due to the omission of pore water concentrations of base cations during model development and their validation, as verified by comparisons with predictions of published terrestrial biotic ligand models. Thus, the usefulness of data from artificial OECD soils for global-scale assessment of terrestrial ecotoxic impacts of Cd, Pb and Zn in soils is limited due to relatively small variability of pore water concentrations of dissolved base cations in OECD soils, preventing their inclusion in development of predictive models. Our findings stress the importance of considering differences in ionic composition of soil pore water when characterizing terrestrial ecotoxicity of cationic metals in natural soils.
[Mh] Termos MeSH primário: Cádmio/toxicidade
Chumbo/toxicidade
Poluentes do Solo
Zinco/toxicidade
[Mh] Termos MeSH secundário: Animais
Previsões
Organização para a Cooperação e Desenvolvimento Econômico
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); 2P299V784P (Lead); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


  5 / 112 MEDLINE  
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[PMID]:28478235
[Au] Autor:Garcia-Velasco N; Peña-Cearra A; Bilbao E; Zaldibar B; Soto M
[Ad] Endereço:Cell Biology in Environmental Toxicology (CBET) Research Group, Dept. Zoology and Animal Cell Biology, Faculty of Science and Technology and Research Centre for Experimental Marine Biology and Biotechnology PIE-UPV/EHU, University of the Basque Country UPV/EHU, E-48080, Bilbao, Basque Country, Spain
[Ti] Título:Integrative assessment of the effects produced by Ag nanoparticles at different levels of biological complexity in Eisenia fetida maintained in two standard soils (OECD and LUFA 2.3).
[So] Source:Chemosphere;181:747-758, 2017 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is a potential risk to increase the release of silver nanoparticles (Ag NPs) into the environment: For instance. in soils receiving sludge models estimate 0.007 mg Ag NPs kg that will annually increase due to sludge or sludge incineration residues land-disposal. Thus, the concern about the hazards of nanosilver to soils and soil invertebrates is growing. Studies performed up to now have been focused in traditional endpoints, used limit range concentrations and employed different soil types that differ in physico-chemical characteristics. Presently, effects of Ag NPs have been measured at different levels of biological complexity in Eisenia fetida, exposed for 3 and 14 d to high but sublethal (50 mg Ag NPs kg ) and close to modeled environmental concentrations (0.05 mg Ag NPs kg ). Since characteristics of the exposure matrix may limit the response of the organisms to these concentrations, experiments were carried out in OECD and LUFA soils, the most used standard soils. High concentrations of Ag NPs increased catalase activity and DNA damage in OECD soils after 14 d while in LUFA 2.3 soils produced earlier effects (weight loss, decrease in cell viability and increase in catalase activity at day 3). At day 14, LUFA 2.3 (low clay and organic matter-OM-) could have provoked starvation of earthworms, masking Ag NPs toxicity. The concentration close to modeled environmental concentrations produced effects uniquely in LUFA 2.3 soil. Accurate physico-chemical characteristics of the standard soils are crucial to assess the toxicity exerted by Ag NPs in E. fetida since low clay and OM contents can be considered toxicity enhancers.
[Mh] Termos MeSH primário: Nanopartículas/toxicidade
Oligoquetos/efeitos dos fármacos
Esgotos
Prata/toxicidade
Solo/química
[Mh] Termos MeSH secundário: Animais
Catalase/efeitos dos fármacos
Catalase/metabolismo
Dano ao DNA/efeitos dos fármacos
Nanopartículas/química
Organização para a Cooperação e Desenvolvimento Econômico
Poluentes do Solo/análise
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sewage); 0 (Soil); 0 (Soil Pollutants); 3M4G523W1G (Silver); EC 1.11.1.6 (Catalase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


  6 / 112 MEDLINE  
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[PMID]:28472747
[Au] Autor:Ruppert K; Geiß C; Askem C; Benstead R; Brown R; Coke M; Ducrot V; Egeler P; Holbech H; Hutchinson TH; Kinnberg KL; Lagadic L; Le Page G; Macken A; Matthiessen P; Ostermann S; Schimera A; Schmitt C; Seeland-Fremer A; Smith AJ; Weltje L; Oehlmann J
[Ad] Endereço:Goethe University Frankfurt am Main, Department Aquatic Ecotoxicology, Biological Sciences Division, Max-von-Laue-Str. 13, 60348, Frankfurt, Germany. Electronic address: k.ruppert@bio.uni-frankfurt.de.
[Ti] Título:Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda).
[So] Source:Chemosphere;181:589-599, 2017 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mollusks are known to be uniquely sensitive to a number of reproductive toxicants including some vertebrate endocrine disrupting chemicals. However, they have widely been ignored in environmental risk assessment procedures for chemicals. This study describes the validation of the Potamopyrgus antipodarum reproduction test within the OECD Conceptual Framework for Endocrine Disrupters Testing and Assessment. The number of embryos in the brood pouch and adult mortality serve as main endpoints. The experiments are conducted as static systems in beakers filled with artificial medium, which is aerated trough glass pipettes. The test chemical is dispersed into the medium, and adult snails are subsequently introduced into the beakers. After 28 days the reproductive success is determined by opening the brood pouch and embryo counting. This study presents the results of two validation studies of the reproduction test with eleven laboratories and the chemicals tributyltin (TBT) with nominal concentrations ranging from 10 to 1000 ng TBT-Sn/L and cadmium with concentrations from 1.56 to 25 µg/L. The test design could be implemented by all laboratories resulting in comparable effect concentrations for the endpoint number of embryos in the brood pouch. After TBT exposure mean EC , EC , NOEC and LOEC were 35.6, 127, 39.2 and 75.7 ng Sn/L, respectively. Mean effect concentrations in cadmium exposed snails were, respectively, 6.53, 14.2, 6.45 and 12.6 µg/L. The effect concentrations are in good accordance with already published data. Both validation studies show that the reproduction test with P. antipodarum is a well-suited tool to assess reproductive effects of chemicals.
[Mh] Termos MeSH primário: Guias como Assunto/normas
Organização para a Cooperação e Desenvolvimento Econômico/normas
Caramujos/efeitos dos fármacos
Testes de Toxicidade/normas
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Cádmio/toxicidade
Disruptores Endócrinos/toxicidade
Reprodução/efeitos dos fármacos
Testes de Toxicidade/métodos
Compostos de Trialquitina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Trialkyltin Compounds); 0 (Water Pollutants, Chemical); 00BH33GNGH (Cadmium); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  7 / 112 MEDLINE  
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[PMID]:28368778
[Au] Autor:Mahlalela LC; Ngila JC; Dlamini LN
[Ad] Endereço:a Department of Applied Chemistry , University of Johannesburg , Doornfontein, Johannesburg , South Africa.
[Ti] Título:Monitoring the fate and behavior of TiO nanoparticles: Simulated in a WWTP with industrial dye-stuff effluent according to OECD 303A.
[So] Source:J Environ Sci Health A Tox Hazard Subst Environ Eng;52(8):794-803, 2017 Jul 03.
[Is] ISSN:1532-4117
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The use of nanoparticles (NPs) in several consumer products has led to them finding their way into wastewater treatment plants (WWTPs). Some of these NPs have photocatalytic properties, thus providing a possible solution to textile industries to photodegrade dyes from their wastewater. Thus, the interaction of NPs with industrial dye effluents is inevitable. The Organization for Economic Co-operation and development (OECD) guideline for testing of chemical 303A was employed to study the fate and behaviour of TiO NPs in industrial dye-stuff effluent. This was due to the unavailability of NPs' fate and behaviour test protocols. The effect of TiO NPs on the treatment process was ascertained by measuring chemical oxygen demand (COD) and 5-day biological oxygen demand (BOD5). Inductively coupled plasma optical emission spectroscopy (ICP-OES) was used to study the fate and behavior of TiO NPs. Acclimatization of bacteria to target pollutants was a crucial factor for the treatment efficiency of activated sludge in a simulated wastewater treatment plant (SWTP). The acclimatization of the activated sludge to the synthetic industrial dye-stuff effluent was successfully achieved. Effect of TiO NPs on the treatment process efficiency was then investigated. Addition of TiO NPs had no effect on the treatment process as chemical oxygen demand (COD) removal remained >80%. Measured total plate count (TPC) affirmed that the addition of TiO NPs had no effect on the treatment process. The removal of total nitrogen (TN) was not efficient as the treatment system was required to have an oxic and anoxic stage for efficient TN removal. Results from X-ray powder diffraction (XRD) confirmed that the anatase phase of the added TiO NPs remained unchanged even after exposure to the treatment plant. Removal of the NPs from the influent was facilitated by biosorption of the NPs on the activated sludge. Nanoparticles received by wastewater treatment plants will therefore reach the environment through sludge waste dumped in landfill. About 90% of TiO was retained in the activated sludge, and 10-11% escaped with the treated effluents. Scanning electron microscope (SEM) mapping micrographs together with an energy dispersive X-ray spectroscopy (EDS) confirmed the presence of Ti in the sludge.
[Mh] Termos MeSH primário: Corantes/análise
Modelos Teóricos
Nanopartículas/química
Titânio/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Análise da Demanda Biológica de Oxigênio
Nitrogênio/análise
Organização para a Cooperação e Desenvolvimento Econômico
Esgotos/química
Indústria Têxtil
Águas Residuais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium); N762921K75 (Nitrogen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1080/10934529.2017.1305176


  8 / 112 MEDLINE  
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[PMID]:28364593
[Au] Autor:Dieu-Hang T; Grafton RQ; Martínez-Espiñeira R; Garcia-Valiñas M
[Ad] Endereço:The National Centre for Social and Economic Modelling, The University of Canberra, Australia. Electronic address: Hang.To@anu.edu.au.
[Ti] Título:Household adoption of energy and water-efficient appliances: An analysis of attitudes, labelling and complementary green behaviours in selected OECD countries.
[So] Source:J Environ Manage;197:140-150, 2017 Jul 15.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Using a household-based data set of more than 12,000 households from 11 OECD countries, we analyse the factors underlying the decision by households to adopt energy-efficient and water-efficient equipment. We evaluate the roles of both attitudes and labelling schemes on the adoption of energy and water-efficient equipment, and also the interaction and complementarity between energy and water conservation behaviours. Our findings show: one, 'green' social norms and favourable attitudes towards the environment are associated with an increased likelihood of households' adoption of energy and water-efficient appliances; two, households' purchase decisions are positively affected by their awareness, understanding, and trust of labelling schemes; and three, there is evidence of complementarity between energy conservation and water conservation behaviours.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais
Abastecimento de Água
[Mh] Termos MeSH secundário: Atitude
Características da Família
Seres Humanos
Organização para a Cooperação e Desenvolvimento Econômico
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


  9 / 112 MEDLINE  
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[PMID]:28359801
[Au] Autor:Toropova AP; Toropov AA
[Ad] Endereço:IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, 20156, Via La Masa 19, Milano, Italy. Electronic address: alla.toropova@marionegri.it.
[Ti] Título:Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles.
[So] Source:Toxicol Lett;275:57-66, 2017 Jun 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Skin sensitization (allergic contact dermatitis) is a widespread problem arising from the contact of chemicals with the skin. The detection of molecular features with undesired effect for skin is complex task owing to unclear biochemical mechanisms and unclearness of conditions of action of chemicals to skin. The development of computational methods for estimation of this endpoint in order to reduce animal testing is recommended (Cosmetics Directive EC regulation 1907/2006; EU Regulation, Regulation, 1223/2009). The CORAL software (http://www.insilico.eu/coral) gives good predictive models for the skin sensitization. Simplified molecular input-line entry system (SMILES) together with molecular graph are used to represent the molecular structure for these models. So-called hybrid optimal descriptors are used to establish quantitative structure-activity relationships (QSARs). The aim of this study is the estimation of the predictive potential of the hybrid descriptors. Three different distributions into the training (≈70%), calibration (≈15%), and validation (≈15%) sets are studied. QSAR for these three distributions are built up with using the Monte Carlo technique. The statistical characteristics of these models for external validation set are used as a measure of predictive potential of these models. The best model, according to the above criterion, is characterized by n =29, r =0.8596, RMSE =0.489. Mechanistic interpretation and domain of applicability for these models are defined.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato
Modelos Moleculares
Compostos Orgânicos
Relação Quantitativa Estrutura-Atividade
Software
[Mh] Termos MeSH secundário: Alternativas aos Testes com Animais/normas
Dermatite Alérgica de Contato/etiologia
Estrutura Molecular
Método de Monte Carlo
Compostos Orgânicos/química
Compostos Orgânicos/toxicidade
Organização para a Cooperação e Desenvolvimento Econômico
Valor Preditivo dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organic Chemicals)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


  10 / 112 MEDLINE  
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[PMID]:28316137
[Au] Autor:Edwards PJ; Leopold A; Beavers JB; Springer TA; Chapman P; Maynard SK; Hubbard P
[Ad] Endereço:Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, United Kingdom.
[Ti] Título:More for less: Analysis of the performance of avian acute oral guideline OECD 223 from empirical data.
[So] Source:Integr Environ Assess Manag;13(5):906-914, 2017 Sep.
[Is] ISSN:1551-3793
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since the publication of the Organisation for Economic Co-operation and Development (OECD) avian acute oral guideline, OECD 223, empirical data have become available to compare the performance of OECD 223 with statistical simulations used to validate this guideline and with empirical data for US Environmental Protection Agency Office of Chemical Safety and Pollution Prevention (USEPA OCSPP) guideline OCSPP 850.2100. Empirical studies comprised 244 for Northern bobwhite, of which 73 were dose-response tests and 171 were limit tests. Of the dose-response tests, 26 were conducted to OECD 223 (using 3-4 stages) and 33 to OCSPP 850.2100 (using the single 50-bird design). Data were collected from 5 avian testing laboratories from studies performed between 2006 and 2013. The success with which the LD50 and slope could be determined was 100% and 96% for OECD 223 (mean 26 birds per test) and 100% and 51% for OCSPP 850.2100 (mean 50 birds per test). This was consistent with the statistical simulations. Control mortality across all species and designs amounted to 0.26% (n = 2655) with only single mortalities occurring in any 1 study and <1% for any 1 species. The simulations used to validate the OECD 223 design showed that control mortality up to 1% will have no observable impact on the performance. The distribution of time to death for Northern bobwhite, zebra finch, and canary were obtained from 90, 29, and 17 studies, and mortalities appeared within 3 d for 71%, 95%, and 91% of birds tested, respectively. Integr Environ Assess Manag 2017;13:906-914. © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
[Mh] Termos MeSH primário: Exposição Ambiental/análise
Poluentes Ambientais/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Aves
Relação Dose-Resposta a Droga
Guias como Assunto
Organização para a Cooperação e Desenvolvimento Econômico
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170320
[St] Status:MEDLINE
[do] DOI:10.1002/ieam.1930



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