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[PMID]:29422654
[Au] Autor:Marcou Q; Mora T; Walczak AM
[Ad] Endereço:Laboratoire de Physique Théorique, CNRS, Sorbonne Université and École Normale Supérieure (PSL), 24, Rue Lhomond, 75005, Paris, France.
[Ti] Título:High-throughput immune repertoire analysis with IGoR.
[So] Source:Nat Commun;9(1):561, 2018 02 08.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:High-throughput immune repertoire sequencing is promising to lead to new statistical diagnostic tools for medicine and biology. Successful implementations of these methods require a correct characterization, analysis, and interpretation of these data sets. We present IGoR (Inference and Generation Of Repertoires)-a comprehensive tool that takes B or T cell receptor sequence reads and quantitatively characterizes the statistics of receptor generation from both cDNA and gDNA. It probabilistically annotates sequences and its modular structure can be used to investigate models of increasing biological complexity for different organisms. For B cells, IGoR returns the hypermutation statistics, which we use to reveal co-localization of hypermutations along the sequence. We demonstrate that IGoR outperforms existing tools in accuracy and estimate the sample sizes needed for reliable repertoire characterization.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Receptores de Antígenos de Linfócitos B/genética
Receptores de Antígenos de Linfócitos T/genética
Software
Linfócitos T/imunologia
Recombinação V(D)J
[Mh] Termos MeSH secundário: Linfócitos B/citologia
Sequência de Bases
Benchmarking
DNA Complementar/genética
DNA Complementar/imunologia
Expressão Gênica
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Imunidade Inata
Anotação de Sequência Molecular
Receptores de Antígenos de Linfócitos B/imunologia
Receptores de Antígenos de Linfócitos T/imunologia
Linfócitos T/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Receptors, Antigen, B-Cell); 0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-018-02832-w


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[PMID]:29220442
[Au] Autor:Wiewiórka MS; Wysakowicz DP; Okoniewski MJ; Gambin T
[Ad] Endereço:Institute of Computer Science, Warsaw University of Technology, Nowowiejska 15/19, Warsaw 00-665, Poland.
[Ti] Título:Benchmarking distributed data warehouse solutions for storing genomic variant information.
[So] Source:Database (Oxford);2017, 2017 Jan 01.
[Is] ISSN:1758-0463
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Database URL: https://github.com/ZSI-Bio/variantsdwh.
[Mh] Termos MeSH primário: Armazenamento de Dados
Sistemas de Gerenciamento de Base de Dados
Bases de Dados Genéticas
Genômica/métodos
[Mh] Termos MeSH secundário: Benchmarking
Seres Humanos
Medicina de Precisão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1093/database/bax049


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[PMID]:28461523
[Au] Autor:Favier G; Gladman DD; Merola JF; Armstrong AW; Boehncke WH; Helliwell PS
[Ad] Endereço:From the Strategy Group, Healthcare and Life Sciences, KPMG LLP ( UK), London; University of Leeds, Leeds; Bradford Hospitals UK National Health Service (NHS) Foundation Trust, Bradford, UK; University of Toronto; Krembil Research Institute; Psoriatic Disease Program, Toronto Western Hospital, Toron
[Ti] Título:Benchmarking Care in Psoriatic Arthritis - The QUANTUM Report: A Report from the GRAPPA 2016 Annual Meeting.
[So] Source:J Rheumatol;44(5):674-678, 2017 May.
[Is] ISSN:0315-162X
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), in partnership with KPMG LLP (UK), conducted interviews at selected research centers around the globe to analyze the process of care in psoriasis and psoriatic arthritis (PsA): pre-diagnosis, referral and diagnosis, treatment, and followup. Ten major challenges emerged, many of which were universally recognized across centers; the top 4 included limited awareness of PsA among non-rheumatologists, a disparate approach to care, late referral and diagnosis, and an inadequate management of comorbidities.
[Mh] Termos MeSH primário: Artrite Psoriásica/terapia
Benchmarking
Psoríase/terapia
Qualidade da Assistência à Saúde
[Mh] Termos MeSH secundário: Artrite Psoriásica/diagnóstico
Dermatologia
Seres Humanos
Psoríase/diagnóstico
Reumatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.3899/jrheum.170142


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[PMID]:29419978
[Au] Autor:Wiedemann LA
[Ti] Título:In Data Analytics and Informatics, One is the Loneliest Number.
[So] Source:J AHIMA;88(5):44-7, 2017 05.
[Is] ISSN:1060-5487
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Conjuntos de Dados como Assunto/estatística & dados numéricos
Informática Médica/estatística & dados numéricos
Estatística como Assunto
[Mh] Termos MeSH secundário: Benchmarking/estatística & dados numéricos
Custos e Análise de Custo/estatística & dados numéricos
Fraude/estatística & dados numéricos
Gastos em Saúde/estatística & dados numéricos
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE


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[PMID]:29194304
[Au] Autor:Palmer EA; Shanty JA; Labant A; Rossiter B
[Ad] Endereço:About the Authors The authors are faculty at Indiana University of Pennsylvania Nursing and Allied Health Professions, Indiana, Pennsylvania. Elizabeth A. Palmer, PhD, RN, CNE, is a professor. Joyce A Shanty, PhD, RN, is an associate professor and allied health coordinator. Amy Labant, PhD, RNC, is an assistant professor. Beverly Rossiter, MN, MSN, CPNP, is an assistant professor. For more information, contact Dr. Palmer at lpalmer@iup.edu.
[Ti] Título:Fostering Student Success: Turning Off Practice Assessment Rationales to Improve Proctored Assessment Scores.
[So] Source:Nurs Educ Perspect;38(2):90-92, 2017 Mar/Apr.
[Is] ISSN:1536-5026
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preparing students with opportunities to practice critical thinking skills is essential to success on the National Council Licensure Examination. This pilot study was conducted to explore the effectiveness of turning off practice assessment answers and rationales on a standardized examination. A retrospective study compared students' scores when rationales were turned on and turned off. Eighty-one percent of the students were able to achieve the benchmark when the answers and rationales were turned off as compared to 71 percent when turned on. Faculty can utilize these findings to inform remediation strategies.
[Mh] Termos MeSH primário: Bacharelado em Enfermagem/métodos
Avaliação Educacional/métodos
[Mh] Termos MeSH secundário: Benchmarking
Seres Humanos
Pesquisa em Educação de Enfermagem
Projetos Piloto
Estudos Retrospectivos
Pensamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1097/01.NEP.0000000000000113


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[PMID]:29194246
[Au] Autor:Eisert SL; Bartlett Ellis RJ; Geers JW; Werskey KL
[Ad] Endereço:About the Authors Shelly L. Eisert, EdD, MSN/MHA, RN, FNP-BC, CNE, is a professor and director, Simulation Center for Medical Education, Ivy Tech Community College School of Nursing, Lawrenceburg, Indiana. Rebecca J. Bartlett Ellis, PhD, RN, ACNS-BC, is an assistant professor, Indiana University School of Nursing, Indianapolis. Jennifer W. Geers, MHA, is a simulation consultant, East Indiana Area Health Education Centers, Southeast Indiana Simulation Consortium, Batesville. Karen L. Werskey, MSN, RN, CNOR, is a clinical resource educator, Schneck Medical Center, Seymour, Indiana. For more information, contact Dr. Eisert at seisert@ivytech.edu.
[Ti] Título:Using National Measures of Patients' Perceptions of Health Care to Design and Debrief Clinical Simulations.
[So] Source:Nurs Educ Perspect;38(1):44-46, 2017 Jan/Feb.
[Is] ISSN:1536-5026
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article describes an innovative approach to using national measures of patients' perspectives of quality health care. Nurses from a regional simulation consortium designed and executed a simulation using the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey to prepare nurses to improve care and, in turn, enhance patients' perceptions of care. The consortium is currently revising the reporting mechanism to collect data about specific learning objectives based on national quality indicator benchmarks, specifically HCAHPS. This revision reflects the changing needs of health care to include quality metrics in simulation.
[Mh] Termos MeSH primário: Educação em Enfermagem/normas
Satisfação do Paciente
Qualidade da Assistência à Saúde
Treinamento por Simulação/normas
[Mh] Termos MeSH secundário: Benchmarking
Seres Humanos
Avaliação de Programas e Projetos de Saúde
Inquéritos e Questionários
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1097/01.NEP.0000000000000078


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[PMID]:28466536
[Au] Autor:Laubach JP; Moslehi JJ; Francis SA; San Miguel JF; Sonneveld P; Orlowski RZ; Moreau P; Rosiñol L; Faber EA; Voorhees P; Mateos MV; Marquez L; Feng H; Desai A; van de Velde H; Elliott J; Shi H; Dow E; Jobanputra N; Esseltine DL; Niculescu L; Anderson KC; Lonial S; Richardson PG
[Ad] Endereço:Dana-Farber Cancer Institute, Boston, MA, USA.
[Ti] Título:A retrospective analysis of 3954 patients in phase 2/3 trials of bortezomib for the treatment of multiple myeloma: towards providing a benchmark for the cardiac safety profile of proteasome inhibition in multiple myeloma.
[So] Source:Br J Haematol;178(4):547-560, 2017 08.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This retrospective analysis aimed to establish the overall cardiac safety profile of bortezomib using patient-level data from one phase 2 and seven phase 3 studies in previously untreated and relapsed/refractory multiple myeloma (MM). Seven clinically relevant primary [congestive heart failure (CHF), arrhythmias, ischaemic heart disease (IHD), cardiac death] and secondary (hypertension, dyspnoea, oedema) cardiac endpoints were defined based on MedDRA v16.0 preferred terms. 2509 bortezomib-treated patients and 1445 patients in non-bortezomib-based control arms were included. The incidence of grade ≥3 CHF was 1·3-4·0% in studies in relapsed/refractory MM and 1·2-4·7% in previously untreated MM (2·0-7·6% all grades), with no significant differences between bortezomib- and non-bortezomib-based arms in comparative studies. Incidences of arrhythmias (1·3-5·9% grade ≥2; 0·6-4·1% grade ≥3), IHD (1·2-2·9% all grades; 0·4-2·7% grade ≥3) and cardiac death (0-1·4%) were low, with no differences between bortezomib-based and non-bortezomib-based arms. Higher rates of oedema (mostly grade 1/2) were seen in bortezomib-based versus non-bortezomib-based arms in one study and a pooled transplant study analysis. Logistic regression analyses of comparative studies showed no impact on cardiac risk with bortezomib-based versus non-bortezomib-based treatment. Bortezomib-based treatment was associated with low incidences of cardiac events.
[Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos
Bortezomib/efeitos adversos
Doenças Cardiovasculares/induzido quimicamente
Mieloma Múltiplo/tratamento farmacológico
Inibidores de Proteassoma/efeitos adversos
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Benchmarking
Bortezomib/uso terapêutico
Ensaios Clínicos Fase II como Assunto
Ensaios Clínicos Fase III como Assunto
Dispneia/induzido quimicamente
Insuficiência Cardíaca/induzido quimicamente
Seres Humanos
Inibidores de Proteassoma/uso terapêutico
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Proteasome Inhibitors); 69G8BD63PP (Bortezomib)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14708


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[PMID]:28450390
[Au] Autor:East JE; Atkin WS; Bateman AC; Clark SK; Dolwani S; Ket SN; Leedham SJ; Phull PS; Rutter MD; Shepherd NA; Tomlinson I; Rees CJ
[Ad] Endereço:Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
[Ti] Título:British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
[So] Source:Gut;66(7):1181-1196, 2017 07.
[Is] ISSN:1468-3288
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Serrated polyps have been recognised in the last decade as important premalignant lesions accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical need for guidance on how to manage these lesions; however, the evidence base is limited. A working group was commission by the British Society of Gastroenterology (BSG) Endoscopy section to review the available evidence and develop a position statement to provide clinical guidance until the evidence becomes available to support a formal guideline. The scope of the position statement was wide-ranging and included: evidence that serrated lesions have premalignant potential; detection and resection of serrated lesions; surveillance strategies after detection of serrated lesions; special situations-serrated polyposis syndrome (including surgery) and serrated lesions in colitis; education, audit and benchmarks and research questions. Statements on these issues were proposed where the evidence was deemed sufficient, and re-evaluated modified via a Delphi process until >80% agreement was reached. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tool was used to assess the strength of evidence and strength of recommendation for finalised statements. : we suggest that until further evidence on the efficacy or otherwise of surveillance are published, patients with sessile serrated lesions (SSLs) that appear associated with a higher risk of future neoplasia or colorectal cancer (SSLs ≥10 mm or serrated lesions harbouring dysplasia including traditional serrated adenomas) should be offered a one-off colonoscopic surveillance examination at 3 years ( ).
[Mh] Termos MeSH primário: Pólipos do Colo/diagnóstico
Pólipos do Colo/cirurgia
Pólipos/diagnóstico
Pólipos/cirurgia
Doenças Retais/diagnóstico
Doenças Retais/cirurgia
[Mh] Termos MeSH secundário: Adenoma/diagnóstico
Adenoma/genética
Adenoma/cirurgia
Polipose Adenomatosa do Colo/diagnóstico
Benchmarking
Biomarcadores/análise
Transformação Celular Neoplásica
Colite/complicações
Pólipos do Colo/genética
Colonoscopia
Ilhas de CpG/genética
DNA/isolamento & purificação
Metilação de DNA
Fezes/química
Seres Humanos
Parassimpatolíticos/uso terapêutico
Pólipos/genética
Lesões Pré-Cancerosas/diagnóstico
Lesões Pré-Cancerosas/cirurgia
Doenças Retais/genética
Terminologia como Assunto
Conduta Expectante
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Parasympatholytics); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1136/gutjnl-2017-314005


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[PMID]:29351177
[Au] Autor:Jeffery AD; Mosier S; Baker A; Korwek K; Borum C; Englebright J
[Ad] Endereço:Author Affiliations: Interim Assistant Vice President (Dr Jeffery), Assistant Chief Nurse Executive (Ms Mosier), Data Scientist (Ms Baker), Medical Writer (Dr Korwek), Assistant Vice President (Ms Borum), Senior Vice President and Chief Nurse Executive (Dr Englebright), Clinical Services Group, HCA, Nashville, Tennessee.
[Ti] Título:Units of Distinction: Creating a Blueprint for Recognition of High-Performing Medical-Surgical Nursing Units.
[So] Source:J Nurs Adm;48(2):68-74, 2018 Feb.
[Is] ISSN:1539-0721
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hospital medical-surgical (M/S) nursing units are responsible for up to 28 million encounters annually, yet receive little attention from professional organizations and national initiatives targeted to improve quality and performance. OBJECTIVE: We sought to develop a framework recognizing high-performing units within our large hospital system. METHODS: This was a retrospective data analysis of M/S units throughout a 168-hospital system. Measures represented patient experience, employee engagement, staff scheduling, nursing-sensitive patient outcomes, professional practices, and clinical process measures. RESULTS: Four hundred ninety units from 129 hospitals contributed information to test the framework. A manual scoring system identified the top 5% and recognized them as a "Unit of Distinction." Secondary analyses with machine learning provided validation of the proposed framework. CONCLUSIONS: Similar to external recognition programs, this framework and process provide a holistic evaluation useful for meaningful recognition and lay the groundwork for benchmarking in improvement efforts.
[Mh] Termos MeSH primário: Competência Clínica/normas
Enfermagem Médico-Cirúrgica/normas
Cuidados de Enfermagem/normas
Recursos Humanos de Enfermagem no Hospital/normas
Competência Profissional/normas
Qualidade da Assistência à Saúde/normas
[Mh] Termos MeSH secundário: Adulto
Benchmarking
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1097/NNA.0000000000000576


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[PMID]:29241229
[Au] Autor:Smart D
[Ad] Endereço:Department of Diving and Hyperbaric Medicine, Royal Hobart Hospital, PO Box 1061, Hobart, TAS 7001, Australia, david.smart@ths.tas.gov.au.
[Ti] Título:Back to the future: occupational diver training in Australia.
[So] Source:Diving Hyperb Med;47(4):214-215, 2017 12.
[Is] ISSN:1833-3516
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:The Australian Diver Accreditation Scheme (ADAS) had its genesis in the 1990s in response to a need to produce occupational divers who were trained to international standards with the necessary skills to safely undertake complex work in high-risk environments. Well-trained dive teams who are 'fit-for-purpose' can be regarded as the highest level of risk control in preventing accidents and workplace morbidity. Without such training, work site risks are not detected, with potentially disastrous consequences. In September 2017, the only civilian ADAS level 3 and 4 training facility in Australia, The Underwater Centre Tasmania (TUCT), closed its doors. The reasons for TUCT closure were multifactorial. However, the loss of higher level training capability in this country and its benefits to industry will have a future adverse impact. As industry pushes for more complex diving to improve productivity, Australian occupational diver training processes are becoming 'streamlined' and are losing parity with international benchmarks. This is a potentially fatal combination.
[Mh] Termos MeSH primário: Acidentes de Trabalho/prevenção & controle
Acreditação
Benchmarking
Mergulho/educação
Mergulho/normas
[Mh] Termos MeSH secundário: Austrália
Eficiência
Seres Humanos
Internacionalidade
Local de Trabalho
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.28920/dhm47.4.214-215



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