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| [PMID]: | 28746259 |
| [Au] Autor: | Fleming-Dutra KE; Demirjian A; Bartoces M; Roberts RM; Taylor TH; Hicks LA |
| [Ad] Endereço: | From the *Office of Antibiotic Stewardship, Division of Healthcare Quality Promotion, National Center for Emerging and Infectious Diseases, Centers for Disease Control and Prevention, †Epidemic Intelligence Service, Centers for Disease Control and Prevention, ‡Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, and §Division of Laboratory Systems, Center for Surveillance, Epidemiology and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia. |
| [Ti] Título: | Variations in Antibiotic and Azithromycin Prescribing for Children by Geography and Specialty-United States, 2013. |
| [So] Source: | Pediatr Infect Dis J;37(1):52-58, 2018 Jan. | | [Is] ISSN: | 1532-0987 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | BACKGROUND: Using antibiotics appropriately is critical to slow spread of antibiotic resistance, a major public health problem. Children, especially young children, receive more antibiotics than other age groups. Our objective was to describe antibiotic use in children in the United States and use of azithromycin, which is recommended infrequently for pediatric conditions. METHODS: We used QuintilesIMS Xponent 2013 data to calculate the number and rate of oral antibiotic prescriptions for children by age (0-2, 3-9 and 10-19 years) and agent. We used log-binomial regression to calculate adjusted prevalence ratios and 95% confidence intervals to determine if specialty and patient age were associated with azithromycin selection when an antibiotic was prescribed. RESULTS: In 2013, 66.8 million antibiotics were prescribed to US children ≤19 years of age (813 antibiotic prescriptions per 1000 children). Amoxicillin and azithromycin were the 2 most commonly prescribed agents (23.1 million courses, 35% of all antibiotics; 12.2 million, 18%, respectively). Most antibiotics for children were prescribed by pediatricians (39%) and family practitioners (15%). Family practitioners were more likely to select azithromycin when an antibiotic was prescribed in all age groups than pediatricians (for children 0-2 years of age: prevalence ratio: 1.79, 95% confidence interval: 1.78-1.80; 3-9 years: 1.40, 1.40-1.40 and 10-19 years: 1.18, 1.18-1.18). CONCLUSION: Despite infrequent pediatric recommendations, variations in pediatric azithromycin use may suggest inappropriate antibiotic selection. Public health interventions focused on improving antibiotic selection in children as well as reducing antibiotic overuse are needed. |
| [Mh] Termos MeSH primário: |
Antibacterianos/uso terapêutico
Azitromicina/uso terapêutico
Prescrições de Medicamentos/estatística & dados numéricos
Medicina/estatística & dados numéricos
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| [Mh] Termos MeSH secundário: |
Adolescente
Adulto
Gestão de Antimicrobianos
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Padrões de Prática Médica/estatística & dados numéricos
Estados Unidos/epidemiologia
Adulto Jovem
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| [Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Anti-Bacterial Agents); 83905-01-5 (Azithromycin) |
| [Em] Mês de entrada: | 1801 |
| [Cu] Atualização por classe: | 180110 |
[Lr] Data última revisão:
| 180110 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 170727 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1097/INF.0000000000001708 |
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