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[PMID]:29309721
[Au] Autor:Heo J; Jeon SY; Oh CM; Hwang J; Oh J; Cho Y
[Ad] Endereço:JW LEE Center for Global Medicine, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Título:The unrealized potential: cohort effects and age-period-cohort analysis.
[So] Source:Epidemiol Health;39:e2017056, 2017.
[Is] ISSN:2092-7193
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:This study aims to provide a systematical introduction of age-period-cohort (APC) analysis to South Korean readers who are unfamiliar with this method (we provide an extended version of this study in Korean). As health data in South Korea has substantially accumulated, population-level studies that explore long-term trends of health status and health inequalities and identify macrosocial determinants of the trends are needed. Analyzing long-term trends requires to discern independent effects of age, period, and cohort using APC analysis. Most existing health and aging literature have used cross-sectional or short-term available panel data to identify age or period effects ignoring cohort effects. This under-use of APC analysis may be attributed to the identification (ID) problem caused by the perfect linear dependency across age, period, and cohort. This study explores recently developed three APC models to address the ID problem and adequately estimate the effects of A-P-C: intrinsic estimator-APC models for tabular age by period data; hierarchical cross-classified random effects models for repeated cross-sectional data; and hierarchical APC-growth curve models for accelerated longitudinal panel data. An analytic exemplar for each model was provided. APC analysis may contribute to identifying biological, historical, and socioeconomic determinants in long-term trends of health status and health inequalities as well as examining Korean's aging trajectories and temporal trends of period and cohort effects. For designing effective health policies that improve Korean population's health and reduce health inequalities, it is essential to understand independent effects of the three temporal factors by using the innovative APC models.
[Mh] Termos MeSH primário: Efeito de Coortes
Estudos de Coortes
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
República da Coreia/epidemiologia
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.4178/epih.e2017056


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[PMID]:29274634
[Ti] Título:The Multi-Generational Impacts of Medicaid.
[So] Source:Natl Bur Econ Res Bull Aging Health;(4):3, 2017.
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Peso ao Nascer
Efeito de Coortes
Saúde do Lactente
Saúde Materna
Medicaid
[Mh] Termos MeSH secundário: Definição da Elegibilidade
Feminino
Seres Humanos
Recém-Nascido
Cobertura do Seguro
Gravidez
Resultado da Gravidez
Determinantes Sociais da Saúde
Fatores Socioeconômicos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


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[PMID]:29028823
[Au] Autor:Leong IUS; Stuckey A; Ahanian T; Cederlöf M; Wikstrom JD
[Ad] Endereço:Dermatology and Venereology Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
[Ti] Título:Novel mutations in Darier disease and association to self-reported disease severity.
[So] Source:PLoS One;12(10):e0186356, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Darier disease is a rare and severe autosomal dominant skin disease characterised by malodorous keratotic papules in seborrheic areas of the skin. Darier disease affects up to 1 in 30 000 people and is caused by mutations in the ATP2A2 gene, which encodes to the sarco/endoplasmic reticulum calcium-ATPase isoform 2 that pumps calcium into the endoplasmic reticulum. Although many ATP2A2 variants have been described, it is not known if genotype correlates with phenotype, which could be important for prognosis and treatment. This is the first study to use whole exome sequencing to screen the ATP2A2 gene in a cohort of 28 clinically diagnosed Darier disease patients. Twenty-one different disease causing variants were identified and 15 of these were novel. Sixteen of the 21 variants were predicted to be pathogenic using in silico prediction programs. There were seven missense, four intronic/splice-sites, three frameshifts, two in-frame deletions, four nonsense and one synonymous mutations. This study also found ten patients who harbour more than one ATP2A2 variant. The phenotype of the patient cohort was assessed by photography and by patient questionnaires. The genotype-phenotype association was examined for all variants in relation to the patient's disease severity score, and no correlation could be established.
[Mh] Termos MeSH primário: Doença de Darier/genética
Mutação
ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/genética
Autorrelato
Índice de Gravidade de Doença
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Efeito de Coortes
Feminino
Genótipo
Seres Humanos
Masculino
Meia-Idade
Fenótipo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.6.3.8 (ATP2A2 protein, human); EC 3.6.3.8 (Sarcoplasmic Reticulum Calcium-Transporting ATPases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186356


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[PMID]:28566584
[Au] Autor:Sanagawa A; Ogasawara M; Kusahara Y; Yasumoto M; Iwaki S; Fujii S
[Ad] Endereço:Department of Molecular and Cellular Pathobiology and Therapeutics, Graduate School of Pharmaceutical Sciences, Nagoya City University.
[Ti] Título:Investigation into Differences in Level of Knowledge about Hypertension between High School Students and Elderly People.
[So] Source:Yakugaku Zasshi;137(6):783-789, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:As a major chronic non-communicable disease, hypertension is the most important risk factor for cardiovascular disease, chronic kidney disease, stroke and, if not treated appropriately, premature death. A population-based approach aimed at decreasing high blood pressure among the general population is an important component of any comprehensive plan to prevent hypertension. However, few studies have investigated generational differences in knowledge about, and consciousness of, hypertension. Thus, we conducted a questionnaire survey about hypertension, with the aim of clarifying differences of understanding about hypertension between high school students and elderly people. The results of this investigation suggested that there is indeed a generational difference: knowledge about hypertension, and awareness of its relationship with salt intake, was higher in elderly people than in high school students. Furthermore, our study showed that among high school students, salt intake consciousness correlated with a family history of hypertension. By contrast, in elderly people, salt intake consciousness is related to age and to an awareness of recommended daily salt intake. This study strongly showed that knowledge and consciousness of hypertension varied among generations, with the elderly being more aware and conscientious about salt intake. Acknowledgement of this generational diversity is critical to developing an effective overall preventive strategy for hypertension.
[Mh] Termos MeSH primário: Efeito de Coortes
Hipertensão/etiologia
Hipertensão/prevenção & controle
Conhecimento
Estudantes/psicologia
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Adolescente
Idoso
Conscientização
Doenças Cardiovasculares/etiologia
Feminino
Comportamentos Relacionados com a Saúde
Seres Humanos
Masculino
Meia-Idade
Insuficiência Renal Crônica/etiologia
Fatores de Risco
Cloreto de Sódio na Dieta/administração & dosagem
Cloreto de Sódio na Dieta/efeitos adversos
Acidente Vascular Cerebral/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium Chloride, Dietary)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00005


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[PMID]:28438157
[Au] Autor:Wei X; Zang Y; Jia X; He X; Zou S; Wang H; Shen M; Zang J
[Ad] Endereço:Gu Mei Community Service Center, 668 Longming Road, Shanghai, 200010, People's Republic of China.
[Ti] Título:Age, period and cohort effects and the predictors of physical activity and sedentary behaviour among Chinese children, from 2004 to 2011.
[So] Source:BMC Public Health;17(1):353, 2017 Apr 24.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Very few studies have explored the effects of age, time period, and cohort in association with biological, behavioral, economic, and environmental factors predictors on physical activity (PA) and sedentary behaviour (SB) among Chinese children. METHODS: We used data from a cohort study of the China Health and Nutrition Survey (CHNS) between 2004 and 2011 (2004, 2006, 2009 and 2011). The outcomes of interest were metabolic equivalent of task (MET) hours per week from both active and sedentary activities. Age, gender, individual characteristics, household size, asset ownership, and urbanisation were included as covariates. Age, period and cohort effects analyses for PA and SB of children (6-17 y, n = 3528) was conducted to explicitly assess differences in PA and SB due to age vs. period effects, and implicitly assess differences by cohorts due to the period-specific experiences across individuals of varying ages. RESULTS: The mean age of the sample in each time point fluctuated from 12.6 to 11.3 years and PA slightly decreased from 50.0 ± 63.2 MET hours per week (MET-hr./wk) in 2004 to 47.1 ± 54.9 MET-hr./wk. in 2011. However, SB increased from 31.8 ± 22.0 MET-hr./wk. to 37.6 ± 22.2 MET-hr./wk. Girls had lower PA and higher SB levels than boys. Controlling for age effects, marginal period effects on PA were observed in some survey years. Higher levels of urbanisation and number of household computers served as negative and positive predictors for PA and SB, respectively. Higher household income was a positive predictor of SB. Surprisingly, bigger household size was the only negative predictor of SB (P < 0.05). CONCLUSIONS: This longitudinal study followed a large cohort of children over a significant period of their childhood. We observed potential age and secular trends in PA levels. Higher community urbanisation and number of home computers were associated with both PA and SB levels. Larger household size was the only factor that was negatively associated with SB. These findings shed light on health policy and preventative health strategies for China and other countries that are now facing similar public health challenges.
[Mh] Termos MeSH primário: Meio Ambiente
Exercício
Comportamentos Relacionados com a Saúde
Estilo de Vida Sedentário
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Criança
China
Efeito de Coortes
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Estudos Longitudinais
Masculino
Equivalente Metabólico
Saúde Pública
Distribuição Espacial da População
Fatores Sexuais
Fatores Socioeconômicos
Urbanização
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4215-x


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[PMID]:28376186
[Au] Autor:Siegel RL; Fedewa SA; Anderson WF; Miller KD; Ma J; Rosenberg PS; Jemal A
[Ad] Endereço:Surveillance and Health Services Research, American Cancer Society, Atlanta, GA, USA.
[Ti] Título:Colorectal Cancer Incidence Patterns in the United States, 1974-2013.
[So] Source:J Natl Cancer Inst;109(8), 2017 08 01.
[Is] ISSN:1460-2105
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Colorectal cancer (CRC) incidence in the United States is declining rapidly overall but, curiously, is increasing among young adults. Age-specific and birth cohort patterns can provide etiologic clues, but have not been recently examined. Methods: CRC incidence trends in Surveillance, Epidemiology, and End Results areas from 1974 to 2013 (n = 490 305) were analyzed by five-year age group and birth cohort using incidence rate ratios (IRRs) and age-period-cohort modeling. Results: After decreasing in the previous decade, colon cancer incidence rates increased by 1.0% to 2.4% annually since the mid-1980s in adults age 20 to 39 years and by 0.5% to 1.3% since the mid-1990s in adults age 40 to 54 years; rectal cancer incidence rates have been increasing longer and faster (eg, 3.2% annually from 1974-2013 in adults age 20-29 years). In adults age 55 years and older, incidence rates generally declined since the mid-1980s for colon cancer and since 1974 for rectal cancer. From 1989-1990 to 2012-2013, rectal cancer incidence rates in adults age 50 to 54 years went from half those in adults age 55 to 59 to equivalent (24.7 vs 24.5 per 100 000 persons: IRR = 1.01, 95% confidence interval [CI] = 0.92 to 1.10), and the proportion of rectal cancer diagnosed in adults younger than age 55 years doubled from 14.6% (95% CI = 14.0% to 15.2%) to 29.2% (95% CI = 28.5% to 29.9%). Age-specific relative risk by birth cohort declined from circa 1890 until 1950, but continuously increased through 1990. Consequently, compared with adults born circa 1950, those born circa 1990 have double the risk of colon cancer (IRR = 2.40, 95% CI = 1.11 to 5.19) and quadruple the risk of rectal cancer (IRR = 4.32, 95% CI = 2.19 to 8.51). Conclusions: Age-specific CRC risk has escalated back to the level of those born circa 1890 for contemporary birth cohorts, underscoring the need for increased awareness among clinicians and the general public, as well as etiologic research to elucidate causes for the trend. Further, as nearly one-third of rectal cancer patients are younger than age 55 years, screening initiation before age 50 years should be considered.
[Mh] Termos MeSH primário: Neoplasias do Colo/epidemiologia
Neoplasias Retais/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Efeito de Coortes
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Programa de SEER
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1093/jnci/djw322


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[PMID]:28359262
[Au] Autor:Bahk J; Jang SM; Jung-Choi K
[Ad] Endereço:Department of Public Health, Keimyung University, 1095 Dalgubeol-Daero, Dalseo-Gu, Daegu, 42601, South Korea.
[Ti] Título:Increased breast cancer mortality only in the lower education group: age-period-cohort effect in breast cancer mortality by educational level in South Korea, 1983-2012.
[So] Source:Int J Equity Health;16(1):56, 2017 Mar 31.
[Is] ISSN:1475-9276
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A steadily increasing pattern of breast cancer mortality has been reported in South Korea since the late 1980s. This paper explored the trends of educational inequalities of female breast cancer mortality between 1983 and 2012 in Korea, and conducted age-period-cohort (APC) analysis by educational level. METHODS: Age-standardized mortality rates of breast cancer per 100,000 person-years were calculated. Relative index of inequality (RII) for breast cancer mortality was used as an inequality measure. APC analyses were conducted using the Web tool for APC analysis provided by the Division of Cancer Epidemiology and Genetics at the U.S. National Cancer Institute. RESULTS: An increasing trend in breast cancer mortality among Korean women between 1983 and 2012 was due to the increased mortality of the lower education groups (i.e., no formal education or primary education and secondary education groups), not the highest education group. The breast cancer mortality was higher in women with a tertiary education than in women with no education or a primary education during 1983-1992, and the reverse was true in 1993-2012. Consequently, RII was changed from positive to negative associations in the early 2000s. The lower education groups had the increased breast cancer mortality and significant cohort and period effects between 1983 and 2012, whereas the highest group did not. CONCLUSIONS: APC analysis by socioeconomic position used in this study could provide an important clue for the causes on breast cancer mortality. The long-term monitoring of socioeconomic patterning in breast cancer risk factors is urgently needed.
[Mh] Termos MeSH primário: Neoplasias da Mama/mortalidade
Escolaridade
[Mh] Termos MeSH secundário: Adulto
Efeito de Coortes
Estudos de Coortes
Feminino
Seres Humanos
Meia-Idade
República da Coreia/epidemiologia
Fatores de Risco
Classe Social
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1186/s12939-017-0554-6


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[PMID]:28270123
[Au] Autor:Jukkala T; Stickley A; Mäkinen IH; Baburin A; Sparén P
[Ad] Endereço:Stockholm Centre for Health and Social Change (SCOHOST), Södertörn University, Huddinge, Sweden. tanya.jukkala@sh.se.
[Ti] Título:Age, period and cohort effects on suicide mortality in Russia, 1956-2005.
[So] Source:BMC Public Health;17(1):235, 2017 Mar 07.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Russian suicide mortality rates changed rapidly over the second half of the twentieth century. This study attempts to differentiate between underlying period and cohort effects in relation to the changes in suicide mortality in Russia between 1956 and 2005. METHODS: Sex- and age-specific suicide mortality data were analyzed using an age-period-cohort (APC) approach. Descriptive analyses and APC modeling with log-linear Poisson regression were performed. RESULTS: Strong period effects were observed for the years during and after Gorbachev's political reforms (including the anti-alcohol campaign) and for those following the break-up of the Soviet Union. After mutual adjustment, the cohort- and period-specific relative risk estimates for suicide revealed differing underlying processes. While the estimated period effects had an overall positive trend, cohort-specific developments indicated a positive trend for the male cohorts born between 1891 and 1931 and for the female cohorts born between 1891 and 1911, but a negative trend for subsequent cohorts. CONCLUSIONS: Our results indicate that the specific life experiences of cohorts may be important for variations in suicide mortality across time, in addition to more immediate effects of changes in the social environment.
[Mh] Termos MeSH primário: Meio Social
Suicídio/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Idoso
Efeito de Coortes
Estudos de Coortes
Feminino
História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
Masculino
Meia-Idade
Política
Risco
Federação Russa
Distribuição por Sexo
Suicídio/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4158-2


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[PMID]:27943314
[Au] Autor:Johanson LS
[Ad] Endereço:Associate Professor of Nursing, Appalachian State University, Boone, NC.
[Ti] Título:Caring for Patients of the Millennial Generation: Considerations for Nurses.
[So] Source:Nurs Forum;52(3):207-210, 2017 Jul.
[Is] ISSN:1744-6198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Much has been written about teaching students of the Millennial Generation (those born between the years 1980 and 2000) and about intergenerational dynamics in the healthcare workforce. However, little can be found in the literature regarding generation-specific nursing care of Millennial patients. This article presents six categories of considerations for nurses caring for patients of the Millennial Generation based on the characteristics, attitudes, and values that have influenced them as well as the healthcare issues confronting this group of young adults.
[Mh] Termos MeSH primário: Efeito de Coortes
Educação em Enfermagem/organização & administração
Cuidados de Enfermagem/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Assistência à Saúde Culturalmente Competente
Seres Humanos
Relação entre Gerações
Relações Enfermeiro-Paciente
Cuidados de Enfermagem/psicologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1111/nuf.12190


  10 / 639 MEDLINE  
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[PMID]:27918974
[Au] Autor:Mostazir M; Jeffery A; Voss L; Wilkin T
[Ad] Endereço:Institute of Health Research, University of Exeter Medical School, Exeter, UK; College of Life and Environmental Sciences (CLES), University of Exeter, Exeter, UK. Electronic address: m.mostazir@exeter.ac.uk.
[Ti] Título:Generational change in fasting glucose and insulin among children at ages 5-16y: Modelled on the EarlyBird study (2015) and UK growth standards (1990) (EarlyBird 69).
[So] Source:Diabetes Res Clin Pract;123:18-23, 2017 Jan.
[Is] ISSN:1872-8227
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:AIM: Pre-diabetes is a state of beta-cell stress caused by excess demand for insulin. Body mass is an important determinant of insulin demand, and BMI has risen substantially over recent time. We sought to model changes in the parameters of glucose control against rising BMI over the past 25years. METHODS: Using random coefficient mixed models, we established the correlations between HbA1C, fasting glucose, fasting insulin, HOMA2-IR and BMI in contemporary (2015) children (N=307) at ages 5-16y from the EarlyBird study, and modelled their corresponding values 25years ago according to the distribution of BMI in the UK Growth Standards (1990). RESULTS: There was little change in HbA1C or fasting glucose over the 25y period at any age or in either gender. On the other hand, the estimates for fasting insulin and HOMA2-IR were substantially higher in both genders in 2015 compared with 1990. CONCLUSION: Insofar as it is determined by body mass, there has been a substantial rise in beta cell demand among children over the past 25years. The change could be detected by fasting insulin and HOMA2-IR, but not by fasting glucose or HbA1C.
[Mh] Termos MeSH primário: Glicemia/análise
Jejum/sangue
Insulina/sangue
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Índice de Massa Corporal
Criança
Pré-Escolar
Efeito de Coortes
Feminino
Teste de Tolerância a Glucose
Gráficos de Crescimento
Seres Humanos
Resistência à Insulina
Masculino
Modelos Teóricos
Estado Pré-Diabético/sangue
Estado Pré-Diabético/epidemiologia
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE



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