Base de dados : MEDLINE
Pesquisa : N06.850.210 [Categoria DeCS]
Referências encontradas : 11328 [refinar]
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  1 / 11328 MEDLINE  
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[PMID]:29264907
[Au] Autor:Cwiek-Ludwicka K; Ludwicki JK
[Ad] Endereço:National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland
[Ti] Título:Nanomaterials in food contact materials; considerations for risk assessment
[So] Source:Rocz Panstw Zakl Hig;68(4):321-329, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Nanotechnology applications in the food industry, including food contact materials, offer many potential benefits for consumers and manufacturers alike. The article discusses the migration of nanoparticles from food contact materials and the possible health risks associated with in the context of insufficient knowledge of the potential exposure to nanomaterial. The importance of gaps in the general knowledge on the behaviour and biological interactions of nanomaterials in biological systems becomes crucial for risk assessment. The article also discussed numerous doubts concerning the measurements of biological reactions in animal tests and the need for new approaches in the interpretation of data from nanoparticles studies in vivo. The article underlines the need to develop predictive and validated toxicological tests that can be used to screen for potential hazards, and also to develop new methodology for measuring nanoparticles in biological matrices to assess human exposure. Further studies should focus on understanding the mechanisms of action. Nanoparticles exhibit chemical and physical properties that significantly differ from those substances at a large size. Different properties of nanoparticles may lead to different toxicological properties. From that reason nanoparticles, in each case, are individually assessed by the European Food Standard Agency (EFSA) in terms of health risk before the European Commission authorizes them to be used in food contact materials.
[Mh] Termos MeSH primário: Exposição Dietética/normas
Contaminação de Alimentos/prevenção & controle
Embalagem de Alimentos/normas
Nanoestruturas/normas
[Mh] Termos MeSH secundário: Segurança de Produtos ao Consumidor
Exposição Dietética/análise
Contaminação de Alimentos/análise
Seres Humanos
Nanoestruturas/efeitos adversos
Nanoestruturas/análise
Tamanho da Partícula
Polônia
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  2 / 11328 MEDLINE  
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[PMID]:29196498
[Au] Autor:Dyer O
[Ad] Endereço:Montreal.
[Ti] Título:US tobacco companies run court ordered advertisements.
[So] Source:BMJ;359:j5613, 2017 12 01.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Publicidade como Assunto/legislação & jurisprudência
Segurança de Produtos ao Consumidor/legislação & jurisprudência
Indústria do Tabaco/legislação & jurisprudência
[Mh] Termos MeSH secundário: Seres Humanos
Fumar/efeitos adversos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5613


  3 / 11328 MEDLINE  
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[PMID]:29216612
[Au] Autor:Allen LV
[Ad] Endereço:International Journal of Pharmaceutical Compounding. lallen@ijpc.com.
[Ti] Título:Child-safety Containers/Devices and Compounding.
[So] Source:Int J Pharm Compd;21(5):364-370, 2017 Sep-Oct.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The U.S. Consumer Product Safety Commission has been around since it was created in 1972 through the Consumer Product Safety Act. Its purpose is to protect "against unreasonable risks of injuries associated with consumer products." Manufactured drugs must meet the standards unless specifically exempted. Dispensing and compounding pharmacists must also meet the standards. Due to a smaller market size, compliant products to meet the U.S. Consumer Product Safety Commission's standards to aid compounding pharmacists have been slow in coming. However, now there are numerous different products, some introduced recently, which make it easier for compounding pharmacists to comply with the standards. The new technologies are innovative and serve a great need.
[Mh] Termos MeSH primário: Segurança de Produtos ao Consumidor
Composição de Medicamentos
Embalagem de Medicamentos
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Farmacêuticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


  4 / 11328 MEDLINE  
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[PMID]:29320637
[Au] Autor:Charo RA; Sipp D
[Ad] Endereço:From the University of Wisconsin Law School, Madison (R.A.C.); and the RIKEN Center for Developmental Biology, Kobe, and Keio University School of Medicine, Keio Global Research Institute, and the RIKEN Center for Advanced Intelligence Project, Tokyo - all in Japan (D.S.).
[Ti] Título:Rejuvenating Regenerative Medicine Regulation.
[So] Source:N Engl J Med;378(6):504-505, 2018 Feb 08.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Terapia Baseada em Transplante de Células e Tecidos
Regulamentação Governamental
Medicina Regenerativa/legislação & jurisprudência
Transplante de Células-Tronco/legislação & jurisprudência
United States Food and Drug Administration
[Mh] Termos MeSH secundário: Segurança de Produtos ao Consumidor/legislação & jurisprudência
Aprovação de Drogas
Seres Humanos
Consentimento Livre e Esclarecido
Marketing de Serviços de Saúde
Governo Estadual
Transplante Autólogo/legislação & jurisprudência
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMp1715736


  5 / 11328 MEDLINE  
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[PMID]:29328637
[Au] Autor:Filipovic M; Gledovic A; Lukic M; Tasic-Kostov M; Isailovic T; Pantelic I; Vuleta G; Savic S
[Ti] Título:Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficacy on normal and sodium lauryl sulfate - irritated skin?.
[So] Source:Vojnosanit Pregl;73(11):991-1002, 2016 11.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into li-posomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams' stabilization. Methods: With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepi-dermal water loss (TEWL), erythema index (EI) and viscoelas-ticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin. Results: After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, espe-cially for the squalene-containing cream. Conclusion: Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the in-vestigated actives incorporated into alkyl polyglucoside emulsi-fier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well. [Projekat Ministarstva nauke Republike Srbije, br. TR34031]
[Mh] Termos MeSH primário: Emulsificantes/administração & dosagem
Glucosídeos/administração & dosagem
Azeite de Oliva/química
Rhododendron/citologia
Creme para a Pele/administração & dosagem
Testes de Irritação da Pele/métodos
Pele/efeitos dos fármacos
Dodecilsulfato de Sódio/toxicidade
Esqualeno/administração & dosagem
Células-Tronco/fisiologia
[Mh] Termos MeSH secundário: Administração Cutânea
Adulto
Segurança de Produtos ao Consumidor
Método Duplo-Cego
Elasticidade
Emulsificantes/efeitos adversos
Feminino
Glucosídeos/efeitos adversos
Seres Humanos
Lipossomos
Fitoterapia
Plantas Medicinais
Medição de Risco
Sérvia
Pele/metabolismo
Pele/patologia
Creme para a Pele/efeitos adversos
Esqualeno/efeitos adversos
Esqualeno/isolamento & purificação
Fatores de Tempo
Viscosidade
Perda Insensível de Água/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Emulsifying Agents); 0 (Glucosides); 0 (Liposomes); 0 (Olive Oil); 368GB5141J (Sodium Dodecyl Sulfate); 7QWM220FJH (Squalene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150116122F


  6 / 11328 MEDLINE  
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[PMID]:28467183
[Au] Autor:Wu S; Zhang H; Zhou H; Jin J; Xie Y
[Ad] Endereço:Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, 102206, People's Republic of China.
[Ti] Título:Synergistic Effect of Plantaricin BM-1 Combined with Physicochemical Treatments on the Control of Listeria monocytogenes in Cooked Ham.
[So] Source:J Food Prot;80(6):976-981, 2017 06.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plantaricin BM-1, a typical IIa bacteriocin, is produced by Lactobacillus plantarum BM-1, which can be isolated from a traditionally fermented Chinese meat product. This bacteriocin exhibits perfect thermal stability and broad inhibitory activity against certain foodborne pathogens. In this study, we investigated the effect of plantaricin BM-1 combined with physicochemical treatments (sodium nitrite, heat treatment, ultrahigh pressure technology) on the control of Listeria monocytogenes populations in cooked ham. According to our results, the addition of sodium nitrite (0.075 or 0.15 mg/mL) significantly inhibited the growth of L. monocytogenes in broth, plantaricin BM-1 combined with heat treatment reduced the viable counts of L. monocytogenes more than plantaricin BM-1 alone, and plantaricin BM-1 combined with sodium nitrite and heat treatment had the greatest antibacterial effect in broth. However, the addition of sodium nitrite or heat treatment alone did not inhibit the growth of L. monocytogenes in cooked ham. The combined application of 5,120 arbitrary units per gram (AU/g) plantaricin BM-1 and 0.075 mg/g sodium nitrite reduced L. monocytogenes significantly more effectively (by 1.97 log CFU/g) than application of 5,120 AU/g plantaricin alone. Plantaricin BM-1 application combined with sodium nitrite and heat treatment led to viable counts of L. monocytogenes below the level of detection for 49 days of storage. Moreover, in cooked ham treated with 5,120 AU/g plantaricin BM-1, 0.075 mg/g sodium nitrite, and ultrahigh pressure technology (400 MPa for 5 min), viable counts of L. monocytogenes were reduced by 5.79 log CFU/g compared with control samples at the end of storage. In conclusion, the combination of plantaricin BM-1 with physicochemical treatments had a synergistic inhibitory effect on L. monocytogenes in cooked ham.
[Mh] Termos MeSH primário: Conservação de Alimentos
Listeria monocytogenes
[Mh] Termos MeSH secundário: Contagem de Colônia Microbiana
Segurança de Produtos ao Consumidor
Microbiologia de Alimentos
Produtos da Carne/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-434


  7 / 11328 MEDLINE  
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[PMID]:29102866
[Au] Autor:Negev M; Berman T; Reicher S; Sadeh M; Ardi R; Shammai Y
[Ad] Endereço:School of Public Health, University of Haifa, Mt. Carmel, 3498838 Israel. Electronic address: mnegev@univ.haifa.ac.il.
[Ti] Título:Concentrations of trace metals, phthalates, bisphenol A and flame-retardants in toys and other children's products in Israel.
[So] Source:Chemosphere;192:217-224, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trace metals and synthetic chemicals including phthalates, bisphenol A and flame retardants, are widely used in toys and childcare products, and may pose acute or chronic adverse health effects in children. In Israel, certain chemicals are regulated in childcare products, but there are still regulatory gaps. We tested regulated and unregulated contaminants in 174 item parts from 70 childcare items with potentially high oral or dermal exposure, including 22 children's jewelry items, 14 toys, 7 diaper-changing mats, 6 baby mattresses, 7 baby textiles and 14 feeding and bathing items. In children's jewelry, an unregulated product in Israel, 23% of samples exceeded the US standard for lead. In toys, a regulated product, we did not detect trace metals above the Israeli standard. In textiles, baby mattresses and diaper-changing mats, phthalates exceeded the European Union standard in 14-45% of tests with a mean of 6.74% by mass for diisononyl phthalate, and 1.32% by mass for di(2-ethylhexyl) phthalate. BPA migration exceeded the EU standard in 14-45% of tests with a mean of 1.03 ppm. The flame retardants polybrominated biphenyls, pentabromodiphenyl, octabromodiphenyl ether, tris(2,3-dibromopropyl) phosphate and tris-(aziridinyl)-phosphine oxide were not detected. For products regulated in Israel, our findings suggest general compliance with mandatory standards. However, a lack of comprehensive chemical regulation means that there are regulatory gaps, and products not regulated in Israel may contain high levels of chemical contamination, exceeding US or EU regulations. The results of this study have prompted the development of an Israeli safety standard for children's jewelry.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/análise
Segurança de Produtos ao Consumidor/normas
Retardadores de Chama/análise
Joias/análise
Fenóis/análise
Ácidos Ftálicos/análise
Jogos e Brinquedos
Oligoelementos/análise
[Mh] Termos MeSH secundário: Criança
União Europeia
Seres Humanos
Lactente
Israel
Metais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Flame Retardants); 0 (Metals); 0 (Phenols); 0 (Phthalic Acids); 0 (Trace Elements); 4010KIX4CK (diisononyl phthalate); 6O7F7IX66E (phthalic acid); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171106
[St] Status:MEDLINE


  8 / 11328 MEDLINE  
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[PMID]:29284235
[Au] Autor:Malkiewicz K; Wychowanski P; Olkowska-Truchanowicz J; Tykarska M; Czerwinski M; Wilczko M; Owoc A
[Ad] Endereço:Department of Orthodontics, Medical University of Warsaw, Poland. konrad.malkiewicz@interia.pl.
[Ti] Título:Uncompleted polymerization and cytotoxicity of dental restorative materials as potential health risk factors.
[So] Source:Ann Agric Environ Med;24(4):618-623, 2017 Dec 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Composite materials used in dentistry indicate adverse biological effects in laboratory conditions. One reason for this activity is incomplete conversion of their polymer matrix, favoring chemical instability and release of biologically harmful components to the external environment. AIM: The aim of the study was to assess the degree of conversion of restorative materials commonly available on the European market and to examine the cytotoxic effects of their eluates in vitro. MATERIAL AND METHODS: Using the Fournier transform infrared spectroscopy (FTIR) technique of analysis, the degree of polymer matrix conversion of 6 restorative materials was examined: Gradia Direct, Arkon, Filtek Z550, Herculite XRV, Tetric Evo Ceram, Charisma, polymerized with LED light. In order to assess the cytotoxicity of eluates of the studied materials obtained after 1 hour , 24 hours and 7 days, the MTT assay was used in cultured 3T3 cells. The results were statistically analyzed at significance level of p=0.05. RESULTS: The conversion degree of the assessed polymers ranged from 31.56% for Tetric Evo Ceram to 75.84% for Arcon. The strongest (p=0.05) cytotoxic effect was demonstrated after 7-day observation of Tetric Evo Ceram eluates, reducing the metabolic activity of cells down to 56%. A positive correlation (r(x, y) = 0.62) between the degree of conversion of composite materials and cytotoxic effects of their eluates on cell cultures was confirmed. CONCLUSIONS: 1. Restorative dental materials are chemically unstable in the conditions of the present study. 2. Polymer-based restorative dental materials available on the European market demonstrate cytotoxic properties constituting a potential threat to the patients' health.
[Mh] Termos MeSH primário: Resinas Compostas/toxicidade
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Resinas Compostas/química
Segurança de Produtos ao Consumidor
Europa (Continente)
Seres Humanos
Camundongos
Células NIH 3T3
Polimerização
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Composite Resins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE


  9 / 11328 MEDLINE  
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[PMID]:29260839
[Au] Autor:Food and Drug Administration, HHS.
[Ti] Título:Safety and Effectiveness of Health Care Antiseptics; Topical Antimicrobial Drug Products for Over-the-Counter Human Use. Final rule.
[So] Source:Fed Regist;82(242):60474-503, 2017 Dec 20.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Food and Drug Administration (FDA, the Agency, or we) is issuing this final rule establishing that certain active ingredients used in nonprescription (also known as over-the-counter or OTC) antiseptic products intended for use by health care professionals in a hospital setting or other health care situations outside the hospital are not generally recognized as safe and effective (GRAS/GRAE). FDA is issuing this final rule after considering the recommendations of the Nonprescription Drugs Advisory Committee (NDAC); public comments on the Agency's notices of proposed rulemaking; and all data and information on OTC health care antiseptic products that have come to the Agency's attention. This final rule finalizes the 1994 tentative final monograph (TFM) for OTC health care antiseptic drug products that published in the Federal Register of June 17, 1994 (the 1994 TFM) as amended by the proposed rule published in the Federal Register (FR) of May 1, 2015 (2015 Health Care Antiseptic Proposed Rule (PR)).
[Mh] Termos MeSH primário: Anti-Infecciosos Locais
Segurança de Produtos ao Consumidor/legislação & jurisprudência
Medicamentos sem Prescrição
[Mh] Termos MeSH secundário: Anti-Infecciosos Locais/uso terapêutico
Fármacos Dermatológicos/uso terapêutico
Seres Humanos
Medicamentos sem Prescrição/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Dermatologic Agents); 0 (Nonprescription Drugs)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


  10 / 11328 MEDLINE  
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[PMID]:28898466
[Au] Autor:Andrew J; Ismail NW; Djama M
[Ad] Endereço:Institute of Agricultural and Food Policy Studies, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
[Ti] Título:An overview of genetically modified crop governance, issues and challenges in Malaysia.
[So] Source:J Sci Food Agric;98(1):12-17, 2018 Jan.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The application of agricultural biotechnology attracts the interest of many stakeholders. Genetically modified (GM) crops, for example, have been rapidly increasing in production for the last 20 years. Despite their known benefits, GM crops also pose many concerns not only to human and animal health but also to the environment. Malaysia, in general, allows the use of GM technology applications but it has to come with precautionary and safety measures consistent with the international obligations and domestic legal frameworks. This paper provides an overview of GM crop technology from international and national context and explores the governance and issues surrounding this technology application in Malaysia. Basically, GM research activities in Malaysia are still at an early stage of research and development and most of the GM crops approved for release are limited for food, feed and processing purposes. Even though Malaysia has not planted any GM crops commercially, actions toward such a direction seem promising. Several issues concerning GM crops as discussed in this paper will become more complex as the number of GM crops and varieties commercialised globally increase and Malaysia starts to plant GM crops. © 2017 Society of Chemical Industry.
[Mh] Termos MeSH primário: Produção Agrícola/legislação & jurisprudência
Produtos Agrícolas/genética
Alimentos Geneticamente Modificados/normas
Plantas Geneticamente Modificadas/genética
[Mh] Termos MeSH secundário: Segurança de Produtos ao Consumidor
Produção Agrícola/organização & administração
Produção Agrícola/normas
Produtos Agrícolas/química
Produtos Agrícolas/metabolismo
Alimentos Geneticamente Modificados/economia
Seres Humanos
Malásia
Plantas Geneticamente Modificadas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.8666



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