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[PMID]:28749410
[Au] Autor:Garus-Pakowska A; Górajski M; Szatko F
[Ad] Endereço:Department of Hygiene and Health Promotion, Medical University of Lodz, 90-647 Lodz, Poland. anna.garus-pakowska@umed.lodz.pl.
[Ti] Título:Awareness of the Risk of Exposure to Infectious Material and the Behaviors of Polish Paramedics with Respect to the Hazards from Blood-Borne Pathogens-A Nationwide Study.
[So] Source:Int J Environ Res Public Health;14(8), 2017 07 27.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:(1) Background: To determine paramedics' frequency of contact with blood and other body fluids, as well as the analysis of knowledge of paramedics about blood-borne infections, their attitudes to patients infected with blood-borne viruses, and the post-exposure procedures implemented by paramedics; (2) Methods: An anonymous questionnaire among 190 paramedics working in various health care facilities in Poland (adjusted response rate, 76.3%); (3) Results: 78% of paramedics had contact with potentially infectious material at least several times a week. Paramedics' knowledge on transferring infection was insufficient. Paramedics with longer employment time and better professional experience suffered fewer injuries with used needles/medical tools ( = 0.079). Most frequently reported factors that prevented the use of personal protective equipment were emergency situations (19.5%), skin irritations and contact allergies (19%) and, in the case of protective gloves, reduced manual dexterity (16%). In total, 82% of paramedics were concerned about the risk of being infected with HIV, HBV or HCV as a result of performing their job. In total, 97% of paramedics behaved more carefully while caring for infected patients. In total, 90% of the paramedics never refrained from performing the specific procedures necessary to help the patient whom they knew to be infected; (4) Conclusions: Despite the paramedics' insufficient theoretical knowledge about the risk of blood-borne infections, the emphasis in the training of future paramedics should be on classes perfecting practical skills, because growing experience significantly reduces the risk of injury.
[Mh] Termos MeSH primário: Pessoal Técnico de Saúde/estatística & dados numéricos
Patógenos Transmitidos pelo Sangue
Transmissão de Doença Infecciosa/prevenção & controle
Comportamentos Relacionados com a Saúde
Conhecimentos, Atitudes e Prática em Saúde
Exposição Ocupacional/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Polônia
Risco
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


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[PMID]:28456705
[Au] Autor:Li QJ; Jiao WW; Yin QQ; Li YJ; Li JQ; Xu F; Sun L; Xiao J; Qi H; Wang T; Mokrousov I; Huang HR; Shen AD
[Ad] Endereço:Ministry of Education Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute
[Ti] Título:Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains.
[So] Source:Int J Antimicrob Agents;49(6):757-762, 2017 Jun.
[Is] ISSN:1872-7913
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mycobacterium tuberculosis Beijing genotype strains increasingly circulate in different world regions, either as historical endemic, e.g. in East Asia, or recently imported, e.g. in South America, and this family is regarded as the most successful lineage of the global tuberculosis (TB) epidemic. Here we analysed the transmission capacity of these strains in the context of their phylogenetic background and drug resistance mutations. The study collection included all multidrug resistant (MDR) strains of Beijing genotype isolated in Beijing Chest Hospital, the largest tertiary TB facility in North China, in 2011-2013 (n = 278). Strains were subjected to NTF/IS6110 and 24-loci MIRU-VNTR analysis. Drug resistance mutations were detected in rpoB, katG, inhA and oxyR-ahpC. A total of 58 and 220 strains were assigned to the ancient and modern Beijing sublineages, respectively. 24-MIRU-VNTR clustering was higher in modern versus ancient Beijing strains (35.9% vs. 12.1%; P <0.001). After taking into consideration the presence of rpoB and katG mutations, clustering decreased to 15.9% in modern and 0% in ancient strains. The most frequent combination of mutations (rpoB531-TTG and katG315-ACC) was more prevalent in clustered versus non-clustered isolates in the modern sublineage (23/35 vs. 47/185; P <0.0001). To conclude, a combination of the known low-fitness-cost rpoB531-TTG and katG315-ACC mutations likely facilitates the increased transmission ability of MDR strains of the modern but not ancient Beijing sublineage. Accordingly, positive epistasis of major low-cost drug resistance-conferring mutations is influenced by the phylogenetic background of M. tuberculosis strains.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Farmacorresistência Bacteriana Múltipla
Mutação
Mycobacterium tuberculosis/classificação
Mycobacterium tuberculosis/efeitos dos fármacos
Tuberculose Resistente a Múltiplos Medicamentos/epidemiologia
Tuberculose Resistente a Múltiplos Medicamentos/transmissão
[Mh] Termos MeSH secundário: Adulto
Idoso
China/epidemiologia
Análise por Conglomerados
Transmissão de Doença Infecciosa
Feminino
Seres Humanos
Masculino
Meia-Idade
Epidemiologia Molecular
Mycobacterium tuberculosis/genética
Mycobacterium tuberculosis/isolamento & purificação
Filogenia
Tuberculose Resistente a Múltiplos Medicamentos/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:27771517
[Au] Autor:Amraoui F; Failloux AB
[Ad] Endereço:Institut Pasteur, Department of Virology, Arboviruses and Insect Vectors, 25 rue du Dr Roux, 75724 Paris cedex 15, France.
[Ti] Título:Chikungunya: an unexpected emergence in Europe.
[So] Source:Curr Opin Virol;21:146-150, 2016 12.
[Is] ISSN:1879-6265
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Since the first outbreak of chikungunya in Italy in 2007, Europe has been facing an increase in local transmission of arboviral diseases. Dengue virus (DENV) and chikungunya virus (CHIKV) are both transmitted by the mosquito Aedes albopictus present in 20 European countries. CHIKV emergence in Europe was mainly associated with the East-Central-South African (ECSA) genotype, recently exemplified by the 11 CHIKV cases in southern France in 2014. Despite hundreds of travelers returning from the Americas where the Asian CHIKV genotype was responsible for more than one million cases, no autochthonous transmission associated with the Asian genotype was reported in Europe. Thus the pattern of transmission can be significantly different depending on the mosquito population, the virus genotype and environmental factors such as temperature.
[Mh] Termos MeSH primário: Aedes/crescimento & desenvolvimento
Febre de Chikungunya/epidemiologia
Febre de Chikungunya/transmissão
Vírus Chikungunya/isolamento & purificação
Transmissão de Doença Infecciosa
[Mh] Termos MeSH secundário: Animais
Vírus Chikungunya/classificação
Vírus Chikungunya/genética
França/epidemiologia
Itália/epidemiologia
Epidemiologia Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:27770704
[Au] Autor:Wichit S; Ferraris P; Choumet V; Missé D
[Ad] Endereço:Laboratory of MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France.
[Ti] Título:The effects of mosquito saliva on dengue virus infectivity in humans.
[So] Source:Curr Opin Virol;21:139-145, 2016 12.
[Is] ISSN:1879-6265
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.
[Mh] Termos MeSH primário: Culicidae/virologia
Vírus da Dengue/patogenicidade
Dengue/transmissão
Transmissão de Doença Infecciosa
Interações Hospedeiro-Patógeno
Saliva/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:28468285
[Au] Autor:Kennedy PTF; Litwin S; Dolman GE; Bertoletti A; Mason WS
[Ad] Endereço:Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine & Dentistry, QMUL, London E1 2AT, UK. p.kennedy@qmul.ac.uk.
[Ti] Título:Immune Tolerant Chronic Hepatitis B: The Unrecognized Risks.
[So] Source:Viruses;9(5), 2017 04 29.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Chronic infection with hepatitis B virus (HBV) progresses through multiple phases, including immune tolerant, immune active, immune control, and, in a subset of patients who achieve immune control, reactivation. The first, the immune tolerant phase, is considered to be prolonged in duration but essentially benign in nature, lacking long-term consequences, and thus not recommended for antiviral therapy. This review challenges the notion that the immune tolerant phase is truly benign and considers the possibility that events during this phase may contribute significantly to cirrhosis, hepatocellular carcinoma (HCC), and the premature death of 25% of HBV carriers worldwide. Thus, earlier treatment than recommended by current guidelines should be considered. Low therapeutic coverage exacerbated by restrictive treatment guidelines may facilitate disease progression in many patients but also increase the risk of neonatal and horizontal transmission from untreated mothers to their children. While a prophylactic vaccine exists, there are many areas worldwide where the treatment of adults and the delivery of an effective vaccination course to newborns present difficult challenges.
[Mh] Termos MeSH primário: Hepatite B Crônica/complicações
Hepatite B Crônica/imunologia
Tolerância Imunológica
[Mh] Termos MeSH secundário: Adulto
Animais
Carcinoma Hepatocelular/imunologia
Carcinoma Hepatocelular/virologia
Criança
Protocolos Clínicos
Progressão da Doença
Transmissão de Doença Infecciosa
Vírus da Hepatite B
Hepatite B Crônica/tratamento farmacológico
Hepatite B Crônica/transmissão
Seres Humanos
Recém-Nascido
Cirrose Hepática/imunologia
Cirrose Hepática/virologia
Neoplasias Hepáticas/imunologia
Neoplasias Hepáticas/virologia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:29267382
[Au] Autor:Zhang Z; Gu Q; de Manuel Montero M; Bravo IG; Marques-Bonet T; Häussinger D; Münk C
[Ad] Endereço:Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
[Ti] Título:Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humans.
[So] Source:PLoS Pathog;13(12):e1006746, 2017 12.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:APOBEC3s (A3s) are potent restriction factors of human immunodeficiency virus type 1/simian immunodeficiency viruses (HIV-1/SIV), and can repress cross-species transmissions of lentiviruses. HIV-1 originated from a zoonotic infection of SIV of chimpanzee (SIVcpz) to humans. However, the impact of human A3s on the replication of SIVcpz remains unclear. By using novel SIVcpz reporter viruses, we identified that human APOBEC3B (A3B) and APOBEC3H (A3H) haplotype II strongly reduced the infectivity of SIVcpz, because both of them are resistant to SIVcpz Vifs. We further demonstrated that human A3H inhibited SIVcpz by deaminase dependent as well independent mechanisms. In addition, other stably expressed human A3H haplotypes and splice variants showed strong antiviral activity against SIVcpz. Moreover, most SIV and HIV lineage Vif proteins could degrade chimpanzee A3H, but no Vifs from SIVcpz and SIV of gorilla (SIVgor) lineages antagonized human A3H haplotype II. Expression of human A3H hapII in human T cells efficiently blocked the spreading replication of SIVcpz. The spreading replication of SIVcpz was also restricted by stable A3H in human PBMCs. Thus, we speculate that stably expressed human A3H protects humans against the cross-species transmission of SIVcpz and that SIVcpz spillover to humans may have started in individuals that harbor haplotypes of unstable A3H proteins.
[Mh] Termos MeSH primário: Aminoidrolases/metabolismo
Transmissão de Doença Infecciosa
Síndrome de Imunodeficiência Adquirida dos Símios/transmissão
Vírus da Imunodeficiência Símia
Zoonoses
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Pan troglodytes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 3.5.4.- (APOBEC3H protein, human); EC 3.5.4.- (Aminohydrolases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006746


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[PMID]:28454578
[Au] Autor:Turner HC; Truscott JE; Bettis AA; Farrell SH; Deol AK; Whitton JM; Fleming FM; Anderson RM
[Ad] Endereço:London Centre for Neglected Tropical Disease Research, London, UK. hturner@oucru.org.
[Ti] Título:Evaluating the variation in the projected benefit of community-wide mass treatment for schistosomiasis: Implications for future economic evaluations.
[So] Source:Parasit Vectors;10(1):213, 2017 Apr 28.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The majority of schistosomiasis control programmes focus on targeting school-aged children. Expanding the use of community-wide mass treatment to reach more adults is under consideration. However, it should be noted that this would require a further increase in programmatic resources, international aid, and commitment for the provision of praziquantel. Consequently, it is important to understand (i) where a change of strategy would have the greatest benefit, and (ii) how generalisable the conclusions of field trials and analytical studies based on mathematical models investigating the impact of community-wide mass treatment, are to a broad range of settings. METHODS: In this paper, we employ a previously described deterministic fully age-structured schistosomiasis transmission model and evaluate the benefit of community-wide mass treatment both in terms of controlling morbidity and eliminating transmission for Schistosoma mansoni, across a wide range of epidemiological settings and programmatic scenarios. This included variation in the baseline relative worm pre-control burden in adults, the overall level of transmission in defined settings, choice of effectiveness metric (basing morbidity calculations on prevalence or intensity), the level of school enrolment and treatment compliance. RESULTS: Community-wide mass treatment was found to be more effective for controlling the transmission of schistosome parasites than using a school-based programme only targeting school-aged children. However, in the context of morbidity control, the potential benefit of switching to community-wide mass treatment was highly variable across the different scenarios analysed. In contrast, for areas where the goal is to eliminate transmission, the projected benefit of community-wide mass treatment was more consistent. CONCLUSION: Whether community-wide mass treatment is appropriate will depend on the local epidemiological setting (i.e. the relative pre-control burden in adults and transmission intensity), and whether the goal is morbidity control or eliminating transmission. This has important implications regarding the generalisability of cost-effectiveness analyses of schistosomiasis interventions. Our results indicate that areas with poor school-enrolment/coverage could benefit more from community-wide treatment of praziquantel and should potentially be prioritised for any change in strategy. This work highlights the importance of not over-generalising conclusions and policy in this area, but of basing decisions on high quality epidemiological data and quantitative analyses of the impact of interventions in a range of settings.
[Mh] Termos MeSH primário: Anti-Helmínticos/economia
Anti-Helmínticos/uso terapêutico
Transmissão de Doença Infecciosa/prevenção & controle
Administração Massiva de Medicamentos/economia
Esquistossomose/tratamento farmacológico
Esquistossomose/economia
[Mh] Termos MeSH secundário: Animais
Análise Custo-Benefício
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2141-5


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[PMID]:28454576
[Au] Autor:Chatzis MK; Psemmas D; Papadopoulos E; Navarro C; Saridomichelakis MN
[Ad] Endereço:Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, 224 Trikalon Str., GR-43132, Karditsa, Greece.
[Ti] Título:A field trial of a fixed combination of permethrin and fipronil (Effitix ) for the treatment and prevention of flea infestation in dogs living with sheep.
[So] Source:Parasit Vectors;10(1):212, 2017 Apr 28.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A large number of fleas parasitize dogs living with sheep in Greece. The primary aim of this randomized, blinded, placebo-controlled trial was to examine the efficacy of a permethrin-fipronil combination (Effitix ) for the treatment and prevention of flea infestation in dogs living with sheep and the secondary aim was to examine the efficacy of this intervention on flea infestation, pruritus and skin lesions of the people in contact with these dogs. METHODS: Thirty dogs living with sheep and infested by at least 10 fleas and all 80 sheep living on the same premises were randomly allocated into equal groups. Group A dogs were treated three times, every 4 weeks, with a spot-on containing 54.5% permethrin and 6.1% fipronil, group A sheep were treated, on the same days, with a pour-on containing 1% deltamethrin, whereas group B dogs were sham-treated and group B sheep were placebo-treated. Flea counting was performed at the beginning of the trial (day 0) and after 14, 28, 56 and 84 days and the first five fleas from each animal were used for species identification. At the same time points, flea infestation, pruritus and skin lesions of the people in contact with the dogs were assessed. RESULTS: The percentage of dogs with zero flea counts was significantly higher in group A than in group B on days 14, 28, 56 and 84 and flea counts were significantly lower in group A dogs than in group B dogs at the same time points. The percent efficacy of the permethrin-fipronil combination was higher than 78% (arithmetic means) or than 96% (geometric means) throughout the study. No adverse reactions were recorded. Between the two flea species found on dogs, Ctenocephalides canis was predominant over C. felis. Flea-infected sheep were not found at the beginning or during the study and no significant changes in flea infestation, pruritus and skin lesions of the people in contact with the dogs were witnessed throughout the study. CONCLUSIONS: A spot-on solution containing 54.5% permethrin and 6.1% fipronil is safe and effective for the treatment and prevention of C. canis and C. felis infestations in dogs living with sheep.
[Mh] Termos MeSH primário: Transmissão de Doença Infecciosa/prevenção & controle
Doenças do Cão/tratamento farmacológico
Infestações por Pulgas/veterinária
Inseticidas/administração & dosagem
Permetrina/administração & dosagem
Pirazóis/administração & dosagem
Doenças dos Ovinos/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/prevenção & controle
Cães
Combinação de Medicamentos
Infestações por Pulgas/tratamento farmacológico
Infestações por Pulgas/patologia
Infestações por Pulgas/prevenção & controle
Grécia
Seres Humanos
Inseticidas/efeitos adversos
Carga Parasitária
Permetrina/efeitos adversos
Placebos/administração & dosagem
Pirazóis/efeitos adversos
Ovinos
Doenças dos Ovinos/prevenção & controle
Resultado do Tratamento
Zoonoses/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Insecticides); 0 (Placebos); 0 (Pyrazoles); 509F88P9SZ (Permethrin); QGH063955F (fipronil)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2145-1


  9 / 7494 MEDLINE  
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[PMID]:29199281
[Au] Autor:Graham BS; Sullivan NJ
[Ad] Endereço:Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. bgraham@nih.gov.
[Ti] Título:Emerging viral diseases from a vaccinology perspective: preparing for the next pandemic.
[So] Source:Nat Immunol;19(1):20-28, 2018 Jan.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emerging infectious diseases will continue to threaten public health and are sustained by global commerce, travel and disruption of ecological systems. Most pandemic threats are caused by viruses from either zoonotic sources or vector-borne sources. Developing better ways to anticipate and manage the ongoing microbial challenge will be critical for achieving the United Nations Sustainable Development Goals and, conversely, each such goal will affect the ability to control infectious diseases. Here we discuss how technology can be applied effectively to better prepare for and respond to new viral diseases with a focus on new paradigms for vaccine development.
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes/imunologia
Vacinação/métodos
Vacinas Virais/imunologia
Viroses/imunologia
[Mh] Termos MeSH secundário: Animais
Doenças Transmissíveis Emergentes/prevenção & controle
Doenças Transmissíveis Emergentes/virologia
Transmissão de Doença Infecciosa/prevenção & controle
Seres Humanos
Pandemias/prevenção & controle
Saúde Pública/métodos
Vacinas Virais/uso terapêutico
Viroses/epidemiologia
Viroses/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Viral Vaccines)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1038/s41590-017-0007-9


  10 / 7494 MEDLINE  
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[PMID]:27776220
[Au] Autor:Lynch PA; Boots M
[Ad] Endereço:Department of Biosciences, University of Exeter, Cornwall Campus, Penryn, United Kingdom.
[Ti] Título:Using evolution to generate sustainable malaria control with spatial repellents.
[So] Source:Elife;5, 2016 10 25.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Evolution persistently undermines vector control programs through insecticide resistance. Here we propose a novel strategy which instead exploits evolution to generate and sustain new control tools. Effective spatial repellents are needed to keep vectors out of houses. Our approach generates such new repellents by combining a high-toxicity insecticide with a candidate repellent initially effective against only part of the vector population. By killing mosquitoes that enter treated properties the insecticide selects for vector phenotypes deflected by the repellent, increasing efficacy of the repellent against the target vector population and in turn protecting the insecticide against the spread of insecticide resistance. Using such evolved spatial repellents offers an evolutionarily sustainable, 'double-dip' system of disease control combining mortality and repellence. We formalize this idea using models which explore vector population genetics and disease transmission probabilities and show that using evolved spatial repellents is theoretically achievable, effective and sustainable.
[Mh] Termos MeSH primário: Transmissão de Doença Infecciosa/prevenção & controle
Repelentes de Insetos/farmacologia
Inseticidas/farmacologia
Malária/prevenção & controle
Controle de Mosquitos/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Malária/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Insecticides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE



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