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Pesquisa : N06.850.780.200.450.850.375 [Categoria DeCS]
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[PMID]:29278907
[Au] Autor:Chojecka A; Tarka P; Kierzkowska A; Nitsch-Osuch A; Kanecki K
[Ad] Endereço:National Institute of Public Health ­ National Institute of Hygiene, Department of Bacteriology, Warsaw, Poland
[Ti] Título:Neutralization efficiency of alcohol based products used for rapid hand disinfection
[So] Source:Rocz Panstw Zakl Hig;68(4):389-394, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Alcohols are the most commonly used active substances in preparations for quick hand disinfection. They should be bactericidal in very short contact time. PN-EN 13727 + A2: 2015-12 standard, for testing hygienic and surgical handrub disinfection preparations, provides mandatory test conditions of disinfectants in contact times with the range of 30 s to 60 s (hygienic handrub disinfection) and 60 s to 5 min (surgical handrub disinfection). A short contact times for hand hygiene products require a short time of neutralization process. For contact times less than or equal to 10 minutes, the estimated neutralization time is 10 s ± 1 s. Neutralization is a process that abolishes the action of disinfectants. Correct application of this process allows for proper use of disinfectants in practice and its biocidal effect. Objectives. Verification of the effectiveness of 10-second neutralization time of alcohol based preparations for hygienic handrub disinfection Materials and Method: Neutralization of two products with different ethanol content (89% and 70%) for hygienic handrub disinfection according to PN-EN 13727 + A2: 2015-12 was investigated. The effectiveness of the neutralizer was assessed by determining toxicity of neutralizer, activity of residual effects of the tested products and their derivatives produced during neutralization (10 s) for test organisms (Staphylococcus aureus ATCC 6538; Pseudomonas aeruginosa ATCC 15442; Enterococcus hirae ATCC 10541; Escherichia coli K12 NCTC 10538) Results: The 10-second neutralization time was sufficient to eliminate the residual activity of products for hygienic handrub disinfection with differentiated ethanol concentration. The neutralizer used did not show toxicity to bacteria and did not produce toxic products with tested preparations after neutralization Conclusions: Conclusions. The use of 10-second neutralization time allows in a precise way designate the contact times for hygienic handrub disinfection products
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Etanol/farmacologia
Desinfecção das Mãos
Higiene das Mãos/métodos
Higienizadores de Mão/farmacologia
[Mh] Termos MeSH secundário: Bactérias/crescimento & desenvolvimento
Contagem de Colônia Microbiana
Desinfecção/métodos
Seres Humanos
Testes de Neutralização/métodos
Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hand Sanitizers); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE


  2 / 11769 MEDLINE  
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[PMID]:28946119
[Au] Autor:Wanag A; Rokicka P; Kusiak-Nejman E; Kapica-Kozar J; Wrobel RJ; Markowska-Szczupak A; Morawski AW
[Ad] Endereço:West Pomeranian University of Technology, Szczecin, Faculty of Chemical Technology and Engineering, Institute of Inorganic Technology and Environment Engineering, Pulaskiego 10, 70-322 Szczecin, Poland. Electronic address: awanag@zut.edu.pl.
[Ti] Título:Antibacterial properties of TiO modified with reduced graphene oxide.
[So] Source:Ecotoxicol Environ Saf;147:788-793, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this paper, the antibacterial activity of titanium dioxide modified with reduced graphene oxide (rGO) was presented. TiO /rGO photocatalysts were prepared by the hydrothermal method under elevated pressure at 180°C and heated at 100°C in Ar flow. The obtained photocatalysts were characterized by means of XRD, FTIR/DRS, UV-vis/DR, Raman spectroscopy and scanning electron microscopy (SEM). The carbon content was also examined. FTIR/DRS and Raman analysis confirmed the presence of rGO in the TiO structure, suggesting a successful modification. The antimicrobial photoactivity of photocatalysts was conducted against E. coli under an artificial solar light. The results show that all TiO /rGO photocatalysts exhibited an antibacterial activity higher than unmodified TiO . The best result was found for sample with 1.5wt% additive of reduced graphene oxide. In this case, total inactivation of E. coli was noticed after 75min of irradiation. It was found that the presence of rGO in sample improves the antimicrobial activity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Desinfecção/métodos
Escherichia coli/efeitos dos fármacos
Grafite/química
Titânio/farmacologia
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Antibacterianos/química
Catálise
Escherichia coli/efeitos da radiação
Óxidos/química
Propriedades de Superfície
Titânio/química
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oxides); 15FIX9V2JP (titanium dioxide); 7782-42-5 (Graphite); D1JT611TNE (Titanium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


  3 / 11769 MEDLINE  
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[PMID]:29275280
[Au] Autor:Papaioannou E; Giaouris ED; Berillis P; Boziaris IS
[Ad] Endereço:Department of Ichthyology and Aquatic Environment, School of Agricultural Sciences, University of Thessaly, Greece.
[Ti] Título:Dynamics of biofilm formation by Listeria monocytogenes on stainless steel under mono-species and mixed-culture simulated fish processing conditions and chemical disinfection challenges.
[So] Source:Int J Food Microbiol;267:9-19, 2018 Feb 21.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The progressive ability of a six-strains L. monocytogenes cocktail to form biofilm on stainless steel (SS), under fish-processing simulated conditions, was investigated, together with the biocide tolerance of the developed sessile communities. To do this, the pathogenic bacteria were left to form biofilms on SS coupons incubated at 15°C, for up to 240h, in periodically renewable model fish juice substrate, prepared by aquatic extraction of sea bream flesh, under both mono-species and mixed-culture conditions. In the latter case, L. monocytogenes cells were left to produce biofilms together with either a five-strains cocktail of four Pseudomonas species (fragi, savastanoi, putida and fluorescens), or whole fish indigenous microflora. The biofilm populations of L. monocytogenes, Pseudomonas spp., Enterobacteriaceae, H S producing and aerobic plate count (APC) bacteria, both before and after disinfection, were enumerated by selective agar plating, following their removal from surfaces through bead vortexing. Scanning electron microscopy was also applied to monitor biofilm formation dynamics and anti-biofilm biocidal actions. Results revealed the clear dominance of Pseudomonas spp. bacteria in all the mixed-culture sessile communities throughout the whole incubation period, with the in parallel sole presence of L. monocytogenes cells to further increase (ca. 10-fold) their sessile growth. With respect to L. monocytogenes and under mono-species conditions, its maximum biofilm population (ca. 6logCFU/cm ) was reached at 192h of incubation, whereas when solely Pseudomonas spp. cells were also present, its biofilm formation was either slightly hindered or favored, depending on the incubation day. However, when all the fish indigenous microflora was present, biofilm formation by the pathogen was greatly hampered and never exceeded 3logCFU/cm , while under the same conditions, APC biofilm counts had already surpassed 7logCFU/cm by the end of the first 96h of incubation. All here tested disinfection treatments, composed of two common food industry biocides gradually applied for 15 to 30min, were insufficient against L. monocytogenes mono-species biofilm communities, with the resistance of the latter to significantly increase from the 3rd to 7th day of incubation. However, all these treatments resulted in no detectable L. monocytogenes cells upon their application against the mixed-culture sessile communities also containing the fish indigenous microflora, something probably associated with the low attached population level of these pathogenic cells before disinfection (<10 CFU/cm ) under such mixed-culture conditions. Taken together, all these results expand our knowledge on both the population dynamics and resistance of L. monocytogenes biofilm cells under conditions resembling those encountered within the seafood industry and should be considered upon designing and applying effective anti-biofilm strategies.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Desinfetantes/farmacologia
Desinfecção/normas
Indústria de Processamento de Alimentos
Listeria monocytogenes/efeitos dos fármacos
Listeria monocytogenes/fisiologia
Aço Inoxidável
[Mh] Termos MeSH secundário: Animais
Contagem de Colônia Microbiana
Peixes/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 12597-68-1 (Stainless Steel)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


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[PMID]:28985537
[Au] Autor:Sillanpää M; Ncibi MC; Matilainen A; Vepsäläinen M
[Ad] Endereço:Laboratory of Green Chemistry, School of Engineering Science, Lappeenranta University of Technology, Sammonkatu 12, 50130, Mikkeli, Finland; Department of Civil and Environmental Engineering, Florida International University, Miami FL, 33174, USA.
[Ti] Título:Removal of natural organic matter in drinking water treatment by coagulation: A comprehensive review.
[So] Source:Chemosphere;190:54-71, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Natural organic matter (NOM) is a complex matrix of organic substances produced in (or channeled to) aquatic ecosystems via various biological, geological and hydrological cycles. Such variability is posing a serious challenge to most water treatment technologies, especially the ones designed to treat drinking water supplies. Lately, in addition to the fluctuating composition of NOM, a substantial increase of its concentration in fresh waters, and also municipal wastewater effluents, has been reported worldwide, which justifies the urgent need to develop highly efficient and versatile water treatment processes. Coagulation is among the most applied processes for water and wastewater treatment. The application of coagulation to remove NOM from drinking water supplies has received a great deal of attention from researchers around the world because it was efficient and helped avoiding the formation of disinfection by products (DBPs). Nonetheless, with the increased fluctuation of NOM in water (concentration and composition), the efficiency of conventional coagulation was substantially reduced, hence the need to develop enhanced coagulation processes by optimizing the operating conditions (mainly the amount coagulants and pH), developing more efficient inorganic or organic coagulants, as well as coupling coagulation with other water treatment technologies. In the present review, recent research studies dealing with the application of coagulation for NOM removal from drinking water supplies are presented and compared. In addition, integration schemes combining coagulation and other water treatment processes are presented, including membrane filtration, oxidation, adsorption and others processes.
[Mh] Termos MeSH primário: Substâncias Húmicas/normas
Purificação da Água/métodos
Abastecimento de Água/normas
[Mh] Termos MeSH secundário: Adsorção
Desinfecção
Água Potável/química
Água Potável/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Drinking Water); 0 (Humic Substances)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  5 / 11769 MEDLINE  
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[PMID]:29478664
[Au] Autor:Xue R; Donovan A; Zhang H; Ma Y; Adams C; Yang J; Hua B; Inniss E; Eichholz T; Shi H
[Ad] Endereço:Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, MO 65409, USA; Center for Single Nanoparticle, Single Cell, and Single Molecule Monitoring (CS(3)M), Missouri University of Science and Technology, Rolla, MO 65409, USA. Electronic addres
[Ti] Título:Simultaneous removal of ammonia and N-nitrosamine precursors from high ammonia water by zeolite and powdered activated carbon.
[So] Source:J Environ Sci (China);64:82-91, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:When adding sufficient chlorine to achieve breakpoint chlorination to source water containing high concentration of ammonia during drinking water treatment, high concentrations of disinfection by-products (DBPs) may form. If N-nitrosamine precursors are present, highly toxic N-nitrosamines, primarily N-nitrosodimethylamine (NDMA), may also form. Removing their precursors before disinfection should be a more effective way to minimize these DBPs formation. In this study, zeolites and activated carbon were examined for ammonia and N-nitrosamine precursor removal when incorporated into drinking water treatment processes. The test results indicate that Mordenite zeolite can remove ammonia and five of seven N-nitrosamine precursors efficiently by single step adsorption test. The practical applicability was evaluated by simulation of typical drinking water treatment processes using six-gang stirring system. The Mordenite zeolite was applied at the steps of lime softening, alum coagulation, and alum coagulation with powdered activated carbon (PAC) sorption. While the lime softening process resulted in poor zeolite performance, alum coagulation did not impact ammonia and N-nitrosamine precursor removal. During alum coagulation, more than 67% ammonia and 70%-100% N-nitrosamine precursors were removed by Mordenite zeolite (except 3-(dimethylaminomethyl)indole (DMAI) and 4-dimethylaminoantipyrine (DMAP)). PAC effectively removed DMAI and DMAP when added during alum coagulation. A combination of the zeolite and PAC selected efficiently removed ammonia and all tested seven N-nitrosamine precursors (dimethylamine (DMA), ethylmethylamine (EMA), diethylamine (DEA), dipropylamine (DPA), trimethylamine (TMA), DMAP, and DMAI) during the alum coagulation process.
[Mh] Termos MeSH primário: Amônia/análise
Nitrosaminas/análise
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Compostos de Alúmen
Amônia/química
Carvão Vegetal/química
Dimetilnitrosamina
Desinfecção
Água Potável
Nitrosaminas/química
Poluentes Químicos da Água/química
Zeolitas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Drinking Water); 0 (Nitrosamines); 0 (Water Pollutants, Chemical); 1318-02-1 (Zeolites); 16291-96-6 (Charcoal); 34S289N54E (aluminum sulfate); 7664-41-7 (Ammonia); M43H21IO8R (Dimethylnitrosamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


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[PMID]:29424987
[Au] Autor:Balakayeva AV; Rusakov NV
[Ti] Título:[Comparative evaluation of the efficacy of plants for disinfection of medical waste].
[So] Source:Gig Sanit;95(7):614-7, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There are presented results of the comparative evaluation of the effectiveness of plants for disinfection of medical waste which use 4 most common hardware technologies: treatment by saturated steam pressure, moist heat, microwave exposure and chemical disinfection with refinement. The efficiency ofplants using physical methods of influence was shown to be higher in comparison with hardware chemical disinfection.
[Mh] Termos MeSH primário: Desinfecção
Eliminação de Resíduos de Serviços de Saúde
[Mh] Termos MeSH secundário: Pesquisa Comparativa da Efetividade
Desinfecção/instrumentação
Desinfecção/métodos
Desinfecção/organização & administração
Seres Humanos
Eliminação de Resíduos de Serviços de Saúde/métodos
Eliminação de Resíduos de Serviços de Saúde/normas
Eliminação de Resíduos de Serviços de Saúde/estatística & dados numéricos
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Medical Waste Disposal)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  7 / 11769 MEDLINE  
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[PMID]:29424504
[Au] Autor:Kolesnikov VA; Yakushin RV; Brodsky VA; Babusenko ES; Chistolinov AV
[Ti] Título:[Research of the inactivation of pathogens in water under exposure to low temperature plasma].
[So] Source:Gig Sanit;95(6):588-92, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There was investigated the effect of barrier and spark discharge low temperature plasma on water containing the cells of Escherichia coli (Escherichia coli), hay bacillus (Bacillus subtilis) and yeast (Saccharomyces cerevisiae). There was shown a general decline in the concentration of viable microbial cells after the treatment of suspensions. There was especially marked the detrimental effect of the method on the viability of sanitary-indicative coliform bacteria in the water.
[Mh] Termos MeSH primário: Desinfecção
Água Potável/normas
Gases em Plasma/farmacologia
Purificação da Água
[Mh] Termos MeSH secundário: Contagem de Colônia Microbiana/métodos
Pesquisa Comparativa da Efetividade
Desinfecção/instrumentação
Desinfecção/métodos
Água Potável/microbiologia
Seres Humanos
Purificação da Água/instrumentação
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); 0 (Plasma Gases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:27774620
[Au] Autor:Vendramin C; McGuckin S; Alwan F; Westwood JP; Thomas M; Scully M
[Ad] Endereço:Department of Haematology, University College London Hospital.
[Ti] Título:A single-center prospective study on the safety of plasma exchange procedures using a double-viral-inactivated and prion-reduced solvent/detergent fresh-frozen plasma as the replacement fluid in the treatment of thrombotic microangiopathy.
[So] Source:Transfusion;57(1):131-136, 2017 01.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients presenting with acute episodes of thrombotic microangiopathies (TMAs) require urgent access to plasma exchange (PEX). OctaplasLG, a solvent/detergent fresh-frozen plasma product that has undergone viral inactivation and prion reduction step, has been used in our institution since 2013, replacing Octaplas. STUDY DESIGN AND METHODS: We prospectively reviewed 981 PEX procedures where OctaplasLG was the replacement fluid in 90 patients admitted acutely with a TMA presentation within our institution from January 1, 2013, to December 31, 2015. We recorded citrate toxicities, plasma reactions, viral transfer, complications related to central venous catheter, and venous thrombotic events (VTEs). RESULTS: Citrate toxicities were 5.4%, plasma reactions were 2%, and all were classified as Grade 1 or 2. VTE had an incidence of 12.2%, although 50% of the episodes occurred in early remission when patients were not receiving PEX. No line insertions complications were recorded. Line-associated infections were 2.2%. Hepatitis B and C serology and human immunodeficiency virus (HIV) were checked on admission. There were four patients who may have had passive transient transfer of hepatitis B antibodies from pooled plasma. No hepatitis C or HIV viral transfer was documented after treatment and no seroconversion was detected after treatment. CONCLUSION: Our data have demonstrated that the incidence of complications during PEX is low and using OctaplasLG is comparable to the low incidence of reactions. No cases of anaphylaxis, transfusion-related acute lung injury, or fatal plasma reactions were seen. There was no evidence of viral transmission or seroconversion after treatment.
[Mh] Termos MeSH primário: Desinfecção/métodos
Troca Plasmática/métodos
Plasma
Príons
Microangiopatias Trombóticas/terapia
Inativação de Vírus
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Detergentes/química
Feminino
HIV
Infecções por HIV/prevenção & controle
Hepacivirus
Hepatite B/prevenção & controle
Vírus da Hepatite B
Hepatite C/prevenção & controle
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Solventes/química
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Detergents); 0 (Prions); 0 (Solvents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/trf.13877


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[PMID]:29406093
[Au] Autor:Ge F; Xiao Y; Yang Y; Wang W; Moe B; Li XF
[Ad] Endereço:College of Environment and Resources, Xiangtan University, Xiangtan, Hunan 411105, China. Electronic address: gefei@xtu.edu.cn.
[Ti] Título:Formation of water disinfection byproduct 2,6-dichloro-1,4-benzoquinone from chlorination of green algae.
[So] Source:J Environ Sci (China);63:1-8, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report that green algae in lakes and rivers can serve as precursors of halobenzoquinone (HBQ) disinfection byproducts (DBPs) produced during chlorination. Chlorination of a common green alga, Chlorella vulgaris, produced 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ), the most prevalent HBQ DBP in disinfected water. Under varying pH conditions (pH6.0-9.0), 2,6-DCBQ formation ranged from 0.3 to 2.1µg/mg C with maximum formation at pH8.0. To evaluate the contribution of organic components of C. vulgaris to 2,6-DCBQ formation, we separated the organics into two fractions, the protein-rich fraction of intracellular organic matter (IOM) and the polysaccharide-laden fraction of extracellular organic matter (EOM). Chlorination of IOM and EOM produced 1.4µg/mg C and 0.7µg/mg C of 2,6-DCBQ, respectively. The IOM generated a two-fold higher 2,6-DCBQ formation potential than the EOM fraction, suggesting that proteins are potent 2,6-DCBQ precursors. This was confirmed by the chlorination of proteins extracted from C. vulgaris: the amount of 2,6-DCBQ produced is linearly correlated with the concentration of total algal protein (R =0.98). These results support that proteins are the primary precursors of 2,6-DCBQ in algae, and control of green algal bloom outbreaks in source waters is important for management of HBQ DBPs.
[Mh] Termos MeSH primário: Benzoquinonas/metabolismo
Chlorella vulgaris/fisiologia
Desinfetantes/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Benzoquinonas/análise
Clorófitas
Desinfetantes/análise
Desinfecção
Halogenação
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoquinones); 0 (Disinfectants); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  10 / 11769 MEDLINE  
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[PMID]:28921575
[Au] Autor:Quist AJL; Inoue-Choi M; Weyer PJ; Anderson KE; Cantor KP; Krasner S; Freeman LEB; Ward MH; Jones RR
[Ad] Endereço:Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
[Ti] Título:Ingested nitrate and nitrite, disinfection by-products, and pancreatic cancer risk in postmenopausal women.
[So] Source:Int J Cancer;142(2):251-261, 2018 Jan 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nitrate and nitrite are precursors of N-nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by-products (DBP) exposures have also been linked with digestive system cancers, but few studies have evaluated relationships with pancreatic cancer. We investigated the association of pancreatic cancer with these drinking water contaminants and dietary nitrate/nitrite in a cohort of postmenopausal women in Iowa (1986-2011). We used historical monitoring and treatment data to estimate levels of long-term average nitrate and total trihalomethanes (TTHM; the sum of the most prevalent DBP class) and the duration exceeding one-half the maximum contaminant level (>½ MCL; 5 mg/L nitrate-nitrogen, 40 µg/L TTHM) among participants on public water supplies (PWS) >10 years. We estimated dietary nitrate and nitrite intakes using a food frequency questionnaire. We computed hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression and evaluated nitrate interactions with smoking and vitamin C intake. We identified 313 cases among 34,242 women, including 152 with >10 years PWS use (N = 15,710). Multivariable models of average nitrate showed no association with pancreatic cancer (HR = 1.16, 95% CI: 0.51-2.64). Associations with average TTHM levels were also null (HR = 0.70, 95% CI:0.42-1.18). We observed no trend with increasing years of exposure to either contaminant at levels >½ MCL. Positive associations were suggested in the highest dietary nitrite intake from processed meat (HR = 1.66, 95% CI 1.00-2.75;p = 0.05). We found no interactions of nitrate with known modifiers of endogenous NOC formation. Our results suggest that nitrite intake from processed meat may be a risk factor for pancreatic cancer.
[Mh] Termos MeSH primário: Desinfecção/métodos
Nitratos/efeitos adversos
Nitritos/efeitos adversos
Neoplasias Pancreáticas/etiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seguimentos
Seres Humanos
Iowa
Meia-Idade
Estadiamento de Neoplasias
Pós-Menopausa
Prognóstico
Estudos Prospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Nitrates); 0 (Nitrites)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.31055



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