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  1 / 1013 MEDLINE  
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[PMID]:29185667
[Au] Autor:Bastin JF; Barbier N; Couteron P; Adams B; Shapiro A; Bogaert J; De Cannière C
[Ti] Título:Aboveground biomass mapping of African forest mosaics using canopy texture analysis: toward a regional approach.
[So] Source:Ecol Appl;24(8):1984-2001, 2014.
[Is] ISSN:1051-0761
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the context of the reduction of greenhouse gas emissions caused by deforestation and forest degradation (the REDD+ program), optical very high resolution (VHR) satellite images provide an opportunity to characterize forest canopy structure and to quantify aboveground biomass (AGB) at less expense than methods based on airborne remote sensing data. Among the methods for processing these VHR images, Fourier textural ordination (FOTO) presents a good method to detect forest canopy structural heterogeneity and therefore to predict AGB variations. Notably, the method does not saturate at intermediate AGB values as do pixelwise processing of available space borne optical and radar signals. However, a regional-scale application requires overcoming two difficulties: (1) instrumental effects due to variations in sun­scene­sensor geometry or sensor-specific responses that preclude the use of wide arrays of images acquired under heterogeneous conditions and (2) forest structural diversity including monodominant or open canopy forests, which are of particular importance in Central Africa. In this study, we demonstrate the feasibility of a rigorous regional study of canopy texture by harmonizing FOTO indices of images acquired from two different sensors (Geoeye-1 and QuickBird-2) and different sun­scene­sensor geometries and by calibrating a piecewise biomass inversion model using 26 inventory plots (1 ha) sampled across very heterogeneous forest types. A good agreement was found between observed and predicted AGB (residual standard error [RSE] = 15%; R2 = 0.85; P < 0.001) across a wide range of AGB levels from 26 Mg/ha to 460 Mg/ha, and was confirmed by cross validation. A high-resolution biomass map (100-m pixels) was produced for a 400-km2 area, and predictions obtained from both imagery sources were consistent with each other (r = 0.86; slope = 1.03; intercept = 12.01 Mg/ha). These results highlight the horizontal structure of forest canopy as a powerful descriptor of the entire forest stand structure and heterogeneity. In particular, we show that quantitative metrics resulting from such textural analysis offer new opportunities to characterize the spatial and temporal variation of the structure of dense forests and may complement the toolbox used by tropical forest ecologists, managers or REDD+ national monitoring, reporting and verification bodies.
[Mh] Termos MeSH primário: Biomassa
Monitoramento Ambiental/métodos
Florestas
[Mh] Termos MeSH secundário: África Central
Conservação dos Recursos Naturais
Análise de Fourier
Mapeamento Geográfico
Tecnologia de Sensoriamento Remoto
Astronave
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  2 / 1013 MEDLINE  
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[PMID]:29184597
[Au] Autor:Hamze H; Mengiste A; Carter J
[Ad] Endereço:School of Public Health, University of Alberta, 11405-87 Ave Edmonton, Alberta, Canada.
[Ti] Título:The impact and cost-effectiveness of the Amref Health Africa-Smile Train Cleft Lip and Palate Surgical Repair Programme in Eastern and Central Africa.
[So] Source:Pan Afr Med J;28:35, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: Cleft lip with or without cleft palate (CLP) is a congenital malformation that causes significant morbidity in low and middle income countries. Amref Health Africa has partnered with Smile Train to provide CLP surgeries since 2006. Methods: We analyzed anonymized data of 37,274 CLP patients from the Smile Train database operated on in eastern and central Africa between 2006 and 2014. Cases were analyzed by age, gender, country and surgery type. The impact of cleft surgery was determined by measuring averted Disability-Adjusted Life Years (DALYs) and delayed averted DALYs. We used mean Smile Train costs to calculate cost-effectiveness. We calculated economic benefit using the human capital approach and Value of Statistical Life (VSL) methods. Results: The median age at time of primary surgery was 5.4 years. A total of 207,879 DALYs were averted at a total estimated cost of US$13 million. Mean averted DALYs per patient were 5.6, and mean cost per averted DALY was $62.8. Total delayed burden of disease from late age at surgery was 36,352 DALYs. Surgical correction resulted in $292 million in economic gain using the human capital approach and $2.4 billion using VSL methods. Conclusion: Cleft surgery is a cost-effective intervention to reduce disability and increase economic productivity in eastern and central Africa. Dedicated programs that provide essential CLP surgery can produce substantial clinical and economic benefits.
[Mh] Termos MeSH primário: Instituições de Caridade/economia
Fenda Labial/cirurgia
Fissura Palatina/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Mh] Termos MeSH secundário: Adolescente
África Central
África Oriental
Criança
Pré-Escolar
Fenda Labial/economia
Fissura Palatina/economia
Efeitos Psicossociais da Doença
Análise Custo-Benefício
Bases de Dados Factuais
Países em Desenvolvimento
Avaliação da Deficiência
Feminino
Seres Humanos
Lactente
Masculino
Anos de Vida Ajustados por Qualidade de Vida
Procedimentos Cirúrgicos Reconstrutivos/economia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.35.10344


  3 / 1013 MEDLINE  
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[PMID]:28827792
[Au] Autor:Falendysz EA; Lopera JG; Doty JB; Nakazawa Y; Crill C; Lorenzsonn F; Kalemba LN; Ronderos MD; Mejia A; Malekani JM; Karem K; Carroll DS; Osorio JE; Rocke TE
[Ad] Endereço:US Geological Survey, National Wildlife Health Center, Madison, Wisconsin, United States of America.
[Ti] Título:Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.).
[So] Source:PLoS Negl Trop Dis;11(8):e0005809, 2017 Aug.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent Orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, as serosurveillance data in Central Africa has confirmed the circulation of the virus in these rodent species [1,2]. In order to understand the tissue tropism and clinical signs associated with infection with MPXV in these species, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to express the luciferase gene. After infection, we monitored viral replication and shedding via in vivo bioluminescent imaging, viral culture and real time PCR. MPXV infection in African rope squirrels caused mortality and moderate to severe morbidity, with clinical signs including pox lesions in the skin, eyes, mouth and nose, dyspnea, and profuse nasal discharge. Both intranasal and intradermal exposures induced high levels of viremia, fast systemic spread, and long periods of viral shedding. Shedding and luminescence peaked at day 6 post infection and was still detectable after 15 days. Interestingly, one sentinel animal, housed in the same room but in a separate cage, also developed severe MPX disease and was euthanized. This study indicates that MPXV causes significant pathology in African rope squirrels and infected rope squirrels shed large quantities of virus, supporting their role as a potential source of MPXV transmission to humans and other animals in endemic MPX regions.
[Mh] Termos MeSH primário: Vírus da Varíola dos Macacos/fisiologia
Monkeypox/veterinária
Sciuridae/virologia
[Mh] Termos MeSH secundário: África Central
África Ocidental
Animais
Anticorpos Antivirais/sangue
DNA Viral/sangue
Seres Humanos
Sciuridae/imunologia
Replicação Viral
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170917
[Lr] Data última revisão:
170917
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005809


  4 / 1013 MEDLINE  
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[PMID]:28749939
[Au] Autor:Pedram B; Pasquetto V; Drame PM; Ji Y; Gonzalez-Moa MJ; Baldwin RK; Nutman TB; Biamonte MA
[Ad] Endereço:Drugs & Diagnostics for Tropical Diseases, San Diego, California, United States of America.
[Ti] Título:A novel rapid test for detecting antibody responses to Loa loa infections.
[So] Source:PLoS Negl Trop Dis;11(7):e0005741, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ivermectin-based mass drug administration (MDA) programs have achieved remarkable success towards the elimination of onchocerciasis and lymphatic filariasis. However, their full implementation has been hindered in Central Africa by the occurrence of ivermectin-related severe adverse events (SAEs) in a subset of individuals with high circulating levels of Loa loa microfilariae. Extending MDA to areas with coincident L. loa infection is problematic, and inexpensive point-of-care tests for L. loa are acutely needed. Herein, we present a lateral flow assay (LFA) to identify subjects with a serological response to Ll-SXP-1, a specific and validated marker of L. loa. The test was evaluated on serum samples from patients infected with L. loa (n = 109) and other helminths (n = 204), as well as on uninfected controls (n = 77). When read with the naked eye, the test was 94% sensitive for L. loa infection and was 100% specific when sera from healthy endemic and non-endemic controls or from those with S. stercoralis infections were used as the comparators. When sera of patients with O. volvulus, W. bancrofti, or M. perstans were used as the comparators, the specificity of the LFA was 82%, 87%, and 88%, respectively. A companion smartphone reader allowed measurement of the test line intensities and establishment of cutoff values. With a cutoff of 600 Units, the assay sensitivity decreased to 71%, but the specificity increased to 96% for O. volvulus, 100% for W. bancrofti, and 100% for M. perstans-infected individuals. The LFA may find applications in refining the current maps of L. loa prevalence, which are needed to eliminate onchocerciasis and lymphatic filariasis from the African continent.
[Mh] Termos MeSH primário: Anticorpos Anti-Helmínticos/sangue
Testes Diagnósticos de Rotina/métodos
Imunocromatografia/métodos
Loa/imunologia
Loíase/diagnóstico
Sistemas Automatizados de Assistência Junto ao Leito
[Mh] Termos MeSH secundário: África Central
Animais
Seres Humanos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Helminth)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005741


  5 / 1013 MEDLINE  
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[PMID]:28610374
[Au] Autor:Allen KE; N WPT; Welton LJ; Bauer AM
[Ad] Endereço:Department of Biology, Villanova University, 800 Lancaster Avenue, Villanova, Pennsylvania 19085, USA. Current address: Department of Ecology and Evolutionary Biology, University of Kansas, 1450 Jayhawk Boulevard, Lawrence, Kansas 66045, USA.. Kallen9@ku.edu.
[Ti] Título:A new species of Trachylepis (Squamata: Scincidae) from Central Africa and a key to the Trachylepis of West and Central Africa.
[So] Source:Zootaxa;4268(2):255-269, 2017 05 16.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:A new species of skink, Trachylepis gonwouoi sp. nov. is described from Cameroon and the Republic of the Congo. It differs from all other species of Trachylepis in Central-West Africa by a combination of number of keels on dorsal scales (3-5); moderate SVL (maximum size of 80 mm); number of scale rows at midbody (28-34); number of supracilliaries (6-10); a well defined lateral white stripe, bordered by black, extending from under the eye to the insertion of the hind limb; and a ventral color in life of bright blue-green. Trachylepis gonwouoi sp. nov. was found in association with disturbed forest at elevations from 50 to 1050m. This species is syntopic with T. affinis and T. maculilabris. In order to aid in the identification of Trachylepis in West and Central Africa with the addition of T. gonwouoi sp. nov., we provide an updated key to the Trachylepis found from Mauritania through the Democratic Republic of the Congo. This key combines previous literature that treated Western and Central African taxa separately and represents the most comprehensive key for Trachylepis in West-Central Africa to date.
[Mh] Termos MeSH primário: Lagartos
[Mh] Termos MeSH secundário: África Central
África Ocidental
Animais
Camarões
Congo
República Democrática do Congo
Mauritânia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4268.2.5


  6 / 1013 MEDLINE  
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[PMID]:28298599
[Au] Autor:Mossoun A; Calvignac-Spencer S; Anoh AE; Pauly MS; Driscoll DA; Michel AO; Nazaire LG; Pfister S; Sabwe P; Thiesen U; Vogler BR; Wiersma L; Muyembe-Tamfum JJ; Karhemere S; Akoua-Koffi C; Couacy-Hymann E; Fruth B; Wittig RM; Leendertz FH; Schubert G
[Ad] Endereço:Université Felix Houphouët Boigny, Abidjan, Côte d'Ivoire.
[Ti] Título:Bushmeat Hunting and Zoonotic Transmission of Simian T-Lymphotropic Virus 1 in Tropical West and Central Africa.
[So] Source:J Virol;91(10), 2017 May 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Simian T-lymphotropic virus 1 (STLV-1) enters human populations through contact with nonhuman primate (NHP) bushmeat. We tested whether differences in the extent of contact with STLV-1-infected NHP bushmeat foster regional differences in prevalence of human T-lymphotropic virus 1 (HTLV-1). Using serological and PCR assays, we screened humans and NHPs at two Sub-Saharan African sites where subsistence hunting was expected to be less (Taï region, Côte d'Ivoire [CIV]) or more (Bandundu region, Democratic Republic of the Congo [DRC]) developed. Only 0.7% of human participants were infected with HTLV-1 in CIV ( = 574), and 1.3% of humans were infected in DRC ( = 302). Two of the Ivorian human virus sequences were closely related to simian counterparts, indicating ongoing zoonotic transmission. Multivariate analysis of human demographic parameters and behavior confirmed that participants from CIV were less often exposed to NHPs than participants from DRC through direct contact, e.g., butchering. At the same time, numbers of STLV-1-infected NHPs were higher in CIV (39%; = 111) than in DRC (23%; = 39). We conclude that similar ultimate risks of zoonotic STLV-1 transmission-defined as the product of prevalence in local NHP and human rates of contact to fresh NHP carcasses-contribute to the observed comparable rates of HTLV-1 infection in humans in CIV and DRC. We found that young adult men and mature women are most likely exposed to NHPs at both sites. In view of the continued difficulties in controlling zoonotic disease outbreaks, the identification of such groups at high risk of NHP exposure may guide future prevention efforts. Multiple studies report a high risk for zoonotic transmission of blood-borne pathogens like retroviruses through contact with NHPs, and this risk seems to be particularly high in tropical Africa. Here, we reveal high levels of exposure to NHP bushmeat in two regions of Western and Central tropical Africa. We provide evidence for continued zoonotic origin of HTLV-1 in humans at CIV, and we found that young men and mature women represent risk groups for zoonotic transmission of pathogens from NHPs. Identifying such risk groups can contribute to mitigation of not only zoonotic STLV-1 transmission but also transmission of any blood-borne pathogen onto humans in Sub-Saharan Africa.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/transmissão
Infecções por HTLV-I/epidemiologia
Carne/virologia
Primatas/virologia
Vírus 1 Linfotrópico T de Símios/isolamento & purificação
Zoonoses
[Mh] Termos MeSH secundário: Adulto
África Central
África do Norte/epidemiologia
Animais
Animais Selvagens/virologia
Costa do Marfim/epidemiologia
Infecções por Deltaretrovirus/epidemiologia
Infecções por Deltaretrovirus/prevenção & controle
Infecções por Deltaretrovirus/virologia
República Democrática do Congo/epidemiologia
Surtos de Doenças/prevenção & controle
Feminino
Infecções por HTLV-I/prevenção & controle
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Seres Humanos
Masculino
Filogenia
Prevalência
Adulto Jovem
Zoonoses/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


  7 / 1013 MEDLINE  
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[PMID]:28108993
[Au] Autor:Barreix M; Tunçalp Ö; Mutombo N; Adegboyega AA; Say L; Reproductive Health Indicators Group
[Ad] Endereço:UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
[Ti] Título:Experience from a multi-country initiative to improve the monitoring of selected reproductive health indicators in Africa.
[So] Source:Int J Gynaecol Obstet;137(2):205-212, 2017 May.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Universal access to sexual and reproductive health remains part of the unfinished business of global development in Africa. To achieve it, health interventions should be monitored using programmatic indicators. WHO's Strengthening Measurement of Reproductive Health Indicators in Africa initiative, implemented in Ghana, Nigeria, Kenya, Uganda, and Zimbabwe, aimed to improve national information systems for routine monitoring of reproductive health indicators. Participating countries developed action plans employing a two-pronged strategy: (1) revising, standardizing, and harmonizing existing reproductive health indicators captured through routine information-systems; and (2) building data-collection capacity through training and supervision at select pilot sites. Country teams evaluated existing and new indicators, and outlined barriers to strengthening routine measurement. Activities included updating abortion-care guidelines (spontaneous and induced abortions), providing training on laws surrounding induced abortions, and improving feedback mechanisms. The country teams updated monitoring and evaluation frameworks, and attempted to build recording/reporting capacity in selected pilot areas. Barriers to implementing the initiative that were encountered included restrictive induced-abortion laws, staff turn-over, and administrative delays, including low capacity among healthcare staff and competing priorities for staff time. The areas identified for further improvement were up-scaling programs to a national level, creating scorecards to record data, increasing collaborations with the private sector, conducting related costing exercises, and performing ex-post evaluations.
[Mh] Termos MeSH primário: Serviços de Planejamento Familiar
Indicadores Básicos de Saúde
Vigilância da População/métodos
Cuidado Pré-Concepcional/normas
Regionalização/organização & administração
[Mh] Termos MeSH secundário: Adolescente
Adulto
África Central/epidemiologia
Feminino
Implementação de Plano de Saúde
Seres Humanos
Mortalidade Materna
Meia-Idade
Gravidez
Melhoria de Qualidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12105


  8 / 1013 MEDLINE  
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[PMID]:28081230
[Au] Autor:Adedimeji A; Edmonds A; Hoover D; Shi Q; Sinayobye JD; Nduwimana M; Lelo P; Nash D; Anastos K; Yotebieng M
[Ad] Endereço:Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.
[Ti] Título:Characteristics of HIV-Infected Children at Enrollment into Care and at Antiretroviral Therapy Initiation in Central Africa.
[So] Source:PLoS One;12(1):e0169871, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite the World Health Organization (WHO) regularly updating guidelines to recommend earlier initiation of antiretroviral therapy (ART) in children, timely enrollment into care and initiation of ART in sub-Saharan Africa in children lags behind that of adults. The impact of implementing increasingly less restrictive ART guidelines on ART initiation in Central Africa has not been described. MATERIALS AND METHODS: Data are from the Central Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) pediatric cohort of 3,426 children (0-15 years) entering HIV care at 15 sites in Burundi, DRC, and Rwanda. Measures include CD4 count, WHO clinical stage, age, and weight-for-age Z score (WAZ), each at enrollment into HIV care and at ART initiation. Changes in the medians or proportions of each measure by year of enrollment and year of ART initiation were assessed to capture potential impacts of changing ART guidelines. RESULTS: Median age at care enrollment decreased from 77.2 months in 2004-05 to 30.3 months in 2012-13. The median age at ART initiation (n = 2058) decreased from 83.0 months in 2004-05 to 66.9 months in 2012-13. The proportion of children ≤24 months of age at enrollment increased from 12.7% in 2004-05 to 46.7% in 2012-13, and from 9.6% in 2004-05 to 24.2% in 2012-13 for ART initiation. The median CD4 count at enrollment into care increased from 563 (IQR: 275, 901) in 2004-05 to 660 (IQR: 339, 1071) cells/µl in 2012-13, and the median CD4 count at ART initiation increased from 310 (IQR:167, 600) in 2004-05 to 589 (IQR: 315, 1113) cells/µl in 2012-13. From 2004-05 to 2012-13, median WAZ improved from -2 (IQR: -3.4, -1.1) to -1 (IQR: -2.5, -0.2) at enrollment in care and from -2 (IQR: -3.8, -1.6) to -1 (IQR: -2.6, -0.4) at ART initiation. DISCUSSION AND CONCLUSION: Although HIV-infected children ≤24 months of age accounted for half of all children enrolling in care in our cohort during 2012-13, they represented less than a quarter of all those who were initiated on ART during the same period. Further research is needed to identify barriers to timely diagnosis, linkage to care, and initiation of ART among children with HIV infection.
[Mh] Termos MeSH primário: Antirretrovirais/administração & dosagem
Assistência à Saúde
Infecções por HIV
HIV-1
[Mh] Termos MeSH secundário: Adolescente
África Central/epidemiologia
Burundi/epidemiologia
Criança
Pré-Escolar
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/epidemiologia
Seres Humanos
Lactente
Recém-Nascido
Masculino
Guias de Prática Clínica como Assunto
Estudos Retrospectivos
Ruanda/epidemiologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Anti-Retroviral Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169871


  9 / 1013 MEDLINE  
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[PMID]:28071788
[Au] Autor:Ayala D; Acevedo P; Pombi M; Dia I; Boccolini D; Costantini C; Simard F; Fontenille D
[Ad] Endereço:UMR 224 MIVEGEC/ESV, IRD, Montpellier, 34394, France.
[Ti] Título:Chromosome inversions and ecological plasticity in the main African malaria mosquitoes.
[So] Source:Evolution;71(3):686-701, 2017 Mar.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chromosome inversions have fascinated the scientific community, mainly because of their role in the rapid adaption of different taxa to changing environments. However, the ecological traits linked to chromosome inversions have been poorly studied. Here, we investigated the roles played by 23 chromosome inversions in the adaptation of the four major African malaria mosquitoes to local environments in Africa. We studied their distribution patterns by using spatially explicit modeling and characterized the ecogeographical determinants of each inversion range. We then performed hierarchical clustering and constrained ordination analyses to assess the spatial and ecological similarities among inversions. Our results show that most inversions are environmentally structured, suggesting that they are actively involved in processes of local adaptation. Some inversions exhibited similar geographical patterns and ecological requirements among the four mosquito species, providing evidence for parallel evolution. Conversely, common inversion polymorphisms between sibling species displayed divergent ecological patterns, suggesting that they might have a different adaptive role in each species. These results are in agreement with the finding that chromosomal inversions play a role in Anopheles ecotypic adaptation. This study establishes a strong ecological basis for future genome-based analyses to elucidate the genetic mechanisms of local adaptation in these four mosquitoes.
[Mh] Termos MeSH primário: Anopheles/genética
Inversão Cromossômica
Mosquitos Vetores/genética
Polimorfismo Genético
[Mh] Termos MeSH secundário: África Central
África Ocidental
Animais
Meio Ambiente
Evolução Molecular
Feminino
Cariótipo
Malária
Modelos Genéticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13176


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[PMID]:27887819
[Au] Autor:Zidouh S; Jidane S; Belkouch A; Bekkali H; Belyamani L
[Ad] Endereço:Emergency department, military hospital Mohammed V Rabat, Morocco. Electronic address: sazi26@hotmail.fr.
[Ti] Título:Spontaneous splenic rupture from Plasmodium ovalae malaria.
[So] Source:Am J Emerg Med;35(2):347-349, 2017 Feb.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Artemisininas/uso terapêutico
Etanolaminas/uso terapêutico
Fluorenos/uso terapêutico
Malária/complicações
Plasmodium ovale/isolamento & purificação
Esplenectomia
Ruptura Esplênica/etiologia
[Mh] Termos MeSH secundário: Abdome/diagnóstico por imagem
Adulto
África Central/epidemiologia
Antimaláricos/uso terapêutico
Quimioterapia Combinada
Doenças Endêmicas
Seres Humanos
Laparoscopia
Malária/diagnóstico
Malária/tratamento farmacológico
Malária/epidemiologia
Masculino
Ruptura Esplênica/diagnóstico
Ruptura Esplênica/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 0 (Ethanolamines); 0 (Fluorenes); C7D6T3H22J (artemether); F38R0JR742 (lumefantrine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE



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