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  1 / 4632 MEDLINE  
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[PMID]:29202715
[Au] Autor:Talla Nzussouo N; Duque J; Adedeji AA; Coulibaly D; Sow S; Tarnagda Z; Maman I; Lagare A; Makaya S; Elkory MB; Kadjo Adje H; Shilo PA; Tamboura B; Cisse A; Badziklou K; Maïnassara HB; Bara AO; Keita AM; Williams T; Moen A; Widdowson MA; McMorrow M
[Ad] Endereço:Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. tallus5@yahoo.fr.
[Ti] Título:Epidemiology of influenza in West Africa after the 2009 influenza A(H1N1) pandemic, 2010-2012.
[So] Source:BMC Infect Dis;17(1):745, 2017 12 04.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Over the last decade, capacity for influenza surveillance and research in West Africa has strengthened. Data from these surveillance systems showed influenza A(H1N1)pdm09 circulated in West Africa later than in other regions of the continent. METHODS: We contacted 11 West African countries to collect information about their influenza surveillance systems (number of sites, type of surveillance, sampling strategy, populations sampled, case definitions used, number of specimens collected and number of specimens positive for influenza viruses) for the time period January 2010 through December 2012. RESULTS: Of the 11 countries contacted, 8 responded: Burkina Faso, Cote d'Ivoire, Mali, Mauritania, Niger, Nigeria, Sierra Leone and Togo. Countries used standard World Health Organization (WHO) case definitions for influenza-like illness (ILI) and severe acute respiratory illness (SARI) or slight variations thereof. There were 70 surveillance sites: 26 SARI and 44 ILI. Seven countries conducted SARI surveillance and collected 3114 specimens of which 209 (7%) were positive for influenza viruses. Among influenza-positive SARI patients, 132 (63%) were influenza A [68 influenza A(H1N1)pdm09, 64 influenza A(H3N2)] and 77 (37%) were influenza B. All eight countries conducted ILI surveillance and collected 20,375 specimens, of which 2278 (11%) were positive for influenza viruses. Among influenza-positive ILI patients, 1431 (63%) were influenza A [820 influenza A(H1N1)pdm09, 611 influenza A(H3N2)] and 847 (37%) were influenza B. A majority of SARI and ILI case-patients who tested positive for influenza (72% SARI and 59% ILI) were children aged 0-4 years, as were a majority of those enrolled in surveillance. The seasonality of influenza and the predominant influenza type or subtype varied by country and year. CONCLUSIONS: Influenza A(H1N1)pdm09 continued to circulate in West Africa along with influenza A(H3N2) and influenza B during 2010-2012. Although ILI surveillance systems produced a robust number of samples during the study period, more could be done to strengthen surveillance among hospitalized SARI case-patients. Surveillance systems captured young children but lacked data on adults and the elderly. More data on risk groups for severe influenza in West Africa are needed to help shape influenza prevention and clinical management policies and guidelines.
[Mh] Termos MeSH primário: Influenza Humana/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
África Ocidental/epidemiologia
Idoso
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Vírus da Influenza A Subtipo H1N1/patogenicidade
Vírus da Influenza A Subtipo H3N2/patogenicidade
Influenza Humana/virologia
Masculino
Meia-Idade
Estações do Ano
Síndrome Respiratória Aguda Grave/epidemiologia
Síndrome Respiratória Aguda Grave/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2839-1


  2 / 4632 MEDLINE  
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[PMID]:28462731
[Au] Autor:Pettey WBP; Carter ME; Toth DJA; Samore MH; Gundlapalli AV
[Ad] Endereço:University of Utah School of Medicine,Salt Lake City, Utah,USA.
[Ti] Título:Constructing Ebola transmission chains from West Africa and estimating model parameters using internet sources.
[So] Source:Epidemiol Infect;145(10):1993-2002, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:During the recent Ebola crisis in West Africa, individual person-level details of disease onset, transmissions, and outcomes such as survival or death were reported in online news media. We set out to document disease transmission chains for Ebola, with the goal of generating a timely account that could be used for surveillance, mathematical modeling, and public health decision-making. By accessing public web pages only, such as locally produced newspapers and blogs, we created a transmission chain involving two Ebola clusters in West Africa that compared favorably with other published transmission chains, and derived parameters for a mathematical model of Ebola disease transmission that were not statistically different from those derived from published sources. We present a protocol for responsibly gleaning epidemiological facts, transmission model parameters, and useful details from affected communities using mostly indigenously produced sources. After comparing our transmission parameters to published parameters, we discuss additional benefits of our method, such as gaining practical information about the affected community, its infrastructure, politics, and culture. We also briefly compare our method to similar efforts that used mostly non-indigenous online sources to generate epidemiological information.
[Mh] Termos MeSH primário: Ebolavirus/fisiologia
Doença pelo Vírus Ebola/transmissão
Modelos Teóricos
Saúde Pública/métodos
[Mh] Termos MeSH secundário: África Ocidental
Doença pelo Vírus Ebola/virologia
Seres Humanos
Internet
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180303
[Lr] Data última revisão:
180303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000760


  3 / 4632 MEDLINE  
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[PMID]:29186206
[Au] Autor:Bullock KK; Shaffer CL; Brooks AW; Secka O; Forsyth MH; McClain MS; Cover TL
[Ad] Endereço:Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
[Ti] Título:Genetic signatures for Helicobacter pylori strains of West African origin.
[So] Source:PLoS One;12(11):e0188804, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Helicobacter pylori is a genetically diverse bacterial species that colonizes the stomach in about half of the human population. Most persons colonized by H. pylori remain asymptomatic, but the presence of this organism is a risk factor for gastric cancer. Multiple populations and subpopulations of H. pylori with distinct geographic distributions are recognized. Genetic differences among these populations might be a factor underlying geographic variation in gastric cancer incidence. Relatively little is known about the genomic features of African H. pylori strains compared to other populations of strains. In this study, we first analyzed the genomes of H. pylori strains from seven globally distributed populations or subpopulations and identified encoded proteins that exhibited the highest levels of sequence divergence. These included secreted proteins, an LPS glycosyltransferase, fucosyltransferases, proteins involved in molybdopterin biosynthesis, and Clp protease adaptor (ClpS). Among proteins encoded by the cag pathogenicity island, CagA and CagQ exhibited the highest levels of sequence diversity. We then identified proteins in strains of Western African origin (classified as hspWAfrica by MLST analysis) with sequences that were highly divergent compared to those in other populations of strains. These included ATP-dependent Clp protease, ClpS, and proteins of unknown function. Three of the divergent proteins sequences identified in West African strains were characterized by distinct insertions or deletions up to 8 amino acids in length. These polymorphisms in rapidly evolving proteins represent robust genetic signatures for H. pylori strains of West African origin.
[Mh] Termos MeSH primário: Helicobacter pylori/genética
[Mh] Termos MeSH secundário: África Ocidental
Sequência de Aminoácidos
Proteínas de Bactérias/química
Genes Bacterianos
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188804


  4 / 4632 MEDLINE  
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[PMID]:28922385
[Au] Autor:Gale TV; Horton TM; Grant DS; Garry RF
[Ad] Endereço:Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, United States of America.
[Ti] Título:Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers.
[So] Source:PLoS Negl Trop Dis;11(9):e0005943, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lassa fever afflicts tens of thousands of people in West Africa annually. The rapid progression of patients from febrile illness to fulminant syndrome and death provides incentive for development of clinical prognostic markers that can guide case management. The small molecule profile of serum from febrile patients triaged to the Viral Hemorrhagic Fever Ward at Kenema Government Hospital in Sierra Leone was assessed using untargeted Ultra High Performance Liquid Chromatography Mass Spectrometry. Physiological dysregulation resulting from Lassa virus (LASV) infection occurs at the small molecule level. Effects of LASV infection on pathways mediating blood coagulation, and lipid, amino acid, nucleic acid metabolism are manifest in changes in the levels of numerous metabolites in the circulation. Several compounds, including platelet activating factor (PAF), PAF-like molecules and products of heme breakdown emerged as candidates that may prove useful in diagnostic assays to inform better care of Lassa fever patients.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Heme/metabolismo
Febre Lassa/diagnóstico
Metabolômica/métodos
Fator de Ativação de Plaquetas/análise
[Mh] Termos MeSH secundário: Adolescente
Adulto
África Ocidental/epidemiologia
Anticorpos Antivirais/sangue
Antígenos Virais/sangue
Feminino
Heme/química
Seres Humanos
Imunoglobulina M/sangue
Febre Lassa/epidemiologia
Febre Lassa/imunologia
Febre Lassa/metabolismo
Vírus Lassa/imunologia
Vírus Lassa/isolamento & purificação
Vírus Lassa/fisiologia
Masculino
Espectrometria de Massas
Fator de Ativação de Plaquetas/metabolismo
RNA Viral/sangue
Serra Leoa/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (Biomarkers); 0 (Immunoglobulin M); 0 (Platelet Activating Factor); 0 (RNA, Viral); 42VZT0U6YR (Heme)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005943


  5 / 4632 MEDLINE  
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[PMID]:28880303
[Au] Autor:Maxmen A
[Ti] Título:Massive Ebola data site planned to combat outbreaks.
[So] Source:Nature;549(7670):15, 2017 09 04.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Pesquisa Biomédica/organização & administração
Bases de Dados Factuais
Surtos de Doenças
Doença pelo Vírus Ebola
Disseminação de Informação/métodos
[Mh] Termos MeSH secundário: África Ocidental/epidemiologia
Ebolavirus/fisiologia
Doença pelo Vírus Ebola/diagnóstico
Doença pelo Vírus Ebola/epidemiologia
Doença pelo Vírus Ebola/psicologia
Doença pelo Vírus Ebola/terapia
Seres Humanos
Liderança
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1038/nature.2017.22545


  6 / 4632 MEDLINE  
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[PMID]:28827792
[Au] Autor:Falendysz EA; Lopera JG; Doty JB; Nakazawa Y; Crill C; Lorenzsonn F; Kalemba LN; Ronderos MD; Mejia A; Malekani JM; Karem K; Carroll DS; Osorio JE; Rocke TE
[Ad] Endereço:US Geological Survey, National Wildlife Health Center, Madison, Wisconsin, United States of America.
[Ti] Título:Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.).
[So] Source:PLoS Negl Trop Dis;11(8):e0005809, 2017 Aug.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent Orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, as serosurveillance data in Central Africa has confirmed the circulation of the virus in these rodent species [1,2]. In order to understand the tissue tropism and clinical signs associated with infection with MPXV in these species, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to express the luciferase gene. After infection, we monitored viral replication and shedding via in vivo bioluminescent imaging, viral culture and real time PCR. MPXV infection in African rope squirrels caused mortality and moderate to severe morbidity, with clinical signs including pox lesions in the skin, eyes, mouth and nose, dyspnea, and profuse nasal discharge. Both intranasal and intradermal exposures induced high levels of viremia, fast systemic spread, and long periods of viral shedding. Shedding and luminescence peaked at day 6 post infection and was still detectable after 15 days. Interestingly, one sentinel animal, housed in the same room but in a separate cage, also developed severe MPX disease and was euthanized. This study indicates that MPXV causes significant pathology in African rope squirrels and infected rope squirrels shed large quantities of virus, supporting their role as a potential source of MPXV transmission to humans and other animals in endemic MPX regions.
[Mh] Termos MeSH primário: Vírus da Varíola dos Macacos/fisiologia
Monkeypox/veterinária
Sciuridae/virologia
[Mh] Termos MeSH secundário: África Central
África Ocidental
Animais
Anticorpos Antivirais/sangue
DNA Viral/sangue
Seres Humanos
Sciuridae/imunologia
Replicação Viral
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170917
[Lr] Data última revisão:
170917
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005809


  7 / 4632 MEDLINE  
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[PMID]:28797235
[Au] Autor:Yang C; Zhang H; Zhou R; Qian D; Liu Y; Zhao Y; Li S; Xu B
[Ad] Endereço:Department of Parasite Disease Control and Prevention, Henan Province Center for Disease Control and Prevention, Zhengzhou, 450016, People's Republic of China.
[Ti] Título:Polymorphisms of Plasmodium falciparum k13-propeller gene among migrant workers returning to Henan Province, China from Africa.
[So] Source:BMC Infect Dis;17(1):560, 2017 Aug 10.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Henan Province has been in the malaria elimination stage, with all reports of the disease being imported since 2012 and over 90% coming from Africa. Surveillance and population studies are essential for the early detection and subsequent prevention of the spread of drug resistance. The K13-propeller gene was recently identified as a proposed molecular marker of artemisinin (ART) resistance. In this study, we detected mutations of the K13-propeller gene in samples taken from imported malaria cases in Henan Province from 2012 to 2015. METHODS: There were 483 samples that were obtained from Plasmodium falciparum-infected malaria migrant workers who returned to Henan Province from Africa between 2012 and 2015. The single nucleotide polymorphisms in the K13-propeller gene were assessed by nested PCR with DNA sequencing. Frequency and geographic difference of K13-propeller gene mutant types were analyzed. RESULTS: Of 483 patients, 476 were cured and 7 died. There were no K13-propeller mutations in the blood samples from the 7 patients who died, but there were 23 different genotypes of the K13-propeller that were observed in 24 (4.97%) of the samples. C580Y, which was the predominant one in the resistance of ART, was not detected in the samples, but R539T and P574L which have also been associated with ART resistance, were observed in two samples from Angola and Equatorial Guinea. No mutations were detected in 11 samples from North Africa. The frequency of the K13-propeller was 6.50% (8/123) in Central Africa, followed by East Africa (1/19, 5.26%), West Africa (9/198, 4.55%) and South Africa (6/132, 4.55%). There was no significant difference among these four areas (P = 0.795). CONCLUSION: R539T and P574L were found in migrant workers who traveled from Africa to Henan Province, although the frequency of the K13-propeller mutants was low. These data may enrich the molecular surveillance of antimalarial resistance and will be helpful for developing and updating the antimalarial policy in Henan Province.
[Mh] Termos MeSH primário: Resistência Microbiana a Medicamentos/genética
Malária Falciparum/parasitologia
Plasmodium falciparum/genética
Polimorfismo de Nucleotídeo Único
Proteínas de Protozoários/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
África Ocidental
Idoso
Angola
Antimaláricos/farmacologia
Artemisininas/farmacologia
China/epidemiologia
Resistência Microbiana a Medicamentos/efeitos dos fármacos
Feminino
Genótipo
Seres Humanos
Malária Falciparum/epidemiologia
Masculino
Meia-Idade
Plasmodium falciparum/efeitos dos fármacos
Mutação Puntual
Reação em Cadeia da Polimerase
África do Sul
Migrantes/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 0 (Protozoan Proteins); 9RMU91N5K2 (artemisinine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2634-z


  8 / 4632 MEDLINE  
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[PMID]:28723900
[Au] Autor:Skrable K; Roshania R; Mallow M; Wolfman V; Siakor M; Levine AC
[Ad] Endereço:Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.
[Ti] Título:The natural history of acute Ebola Virus Disease among patients managed in five Ebola treatment units in West Africa: A retrospective cohort study.
[So] Source:PLoS Negl Trop Dis;11(7):e0005700, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Previous studies of Ebola Virus Disease (EVD) have focused on clinical symptoms and Ebola virus (EBOV) cycle threshold (CT) values recorded at patient triage. Our study explores EVD symptoms and EBOV CT values from onset of illness to recovery or death in a diverse population of patients. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed clinical care data from EBOV positive patients admitted to five Ebola treatment units in West Africa from 2014-2015. Prevalence of clinical signs/symptoms and CT values were explored using descriptive statistics. Logistic regression was used to examine their association with mortality. Survival was analyzed using Kaplan-Meier estimators from symptom onset date to death. During the first week of illness, dyspnea (OR = 2.44, 95% CI: 1.07-5.85) and tachycardia (OR = 10.22, 95% CI: 2.20-56.71) were associated with higher odds of mortality. Dyspnea (OR = 2.33, 95% CI: 1.210-4.581), bleeding (OR = 2.51, 95% CI: 1.219-5.337), and diarrhoea (OR = 2.79, 95% CI: 1.171-6.970) at any point during the illness course were associated with higher odds of mortality. Higher initial (OR = 0.85, 95% CI: 0.81-0.89) and mean (OR = 0.60, 95% CI: 0.53-0.66) CT values were associated with lower odds of mortality. CT values reached their nadir after 3-5 days of illness and then rose in both survivors and non-survivors until recovery or death. CONCLUSIONS/SIGNIFICANCE: Our study demonstrates the population prevalence of clinical signs/symptoms and EBOV CT values over time in a large, diverse cohort of patients with EVD, as well as associations between symptoms/EBOV CT values and mortality. These findings have implications on surveillance, operational planning, and clinical care for future EVD outbreaks.
[Mh] Termos MeSH primário: Doença pelo Vírus Ebola/mortalidade
Doença pelo Vírus Ebola/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
África Ocidental
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Estudos Retrospectivos
Análise de Sobrevida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005700


  9 / 4632 MEDLINE  
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[PMID]:28662044
[Au] Autor:Spangler GL; Rosen BD; Ilori MB; Hanotte O; Kim ES; Sonstegard TS; Burke JM; Morgan JLM; Notter DR; Van Tassell CP
[Ad] Endereço:Animal Genomics and Improvement Laboratory, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland, United States of America.
[Ti] Título:Whole genome structural analysis of Caribbean hair sheep reveals quantitative link to West African ancestry.
[So] Source:PLoS One;12(6):e0179021, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hair sheep of Caribbean origin have become an important part of the U.S. sheep industry. Their lack of wool eliminates a number of health concerns and drastically reduces the cost of production. More importantly, Caribbean hair sheep demonstrate robust production performance even in the presence of drug-resistant gastrointestinal nematodes, a rising concern to the industry. Despite the growing importance of hair sheep in the Americas their genetic origins have remained speculative. Prior to this report no genetic studies were able to identify a unique geographical origin of hair sheep in the New World. Our study clarifies the African and European ancestry of Caribbean hair sheep. Whole-genome structural analysis was conducted on four established breeds of hair sheep from the Caribbean region. Using breeds representing Africa and Europe we establish an objective measure indicating Caribbean hair sheep are derived from Iberian and West African origins. Caribbean hair sheep result from West African introgression into established ecotypes of Iberian descent. Genotypes from 47,750 autosomal single nucleotide polymorphism markers scored in 290 animals were used to characterize the population structure of the St. Croix, Barbados Blackbelly, Morada Nova, and Santa Ines. Principal components, admixture, and phylogenetic analyses results correlate with historical patterns of colonization and trade. These patterns support co-migration of these sheep with humans.
[Mh] Termos MeSH primário: Ovinos/genética
[Mh] Termos MeSH secundário: África Ocidental
Animais
Análise de Componente Principal
Índias Ocidentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179021


  10 / 4632 MEDLINE  
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[PMID]:28653454
[Au] Autor:Eholié SP; Ello FN; Coffie PA; Héma A; Minta DK; Sawadogo A
[Ad] Endereço:Département de Dermatologie-Infectiologie, Unité de Formation et de Recherche des Sciences Médicales, Université Félix Houphouet-Boigny, Abidjan, Côte d'Ivoire.
[Ti] Título:Effect of cotrimoxazole prophylaxis on malaria occurrence among HIV-infected adults in West Africa: the MALHIV Study.
[So] Source:Trop Med Int Health;22(9):1186-1195, 2017 Sep.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Cotrimoxazole (CTX) should be given to all HIV-infected adults with mild or severe HIV-disease or those with CD4 counts below 350/mm according to 2006 WHO guidelines. We assessed the impact of CTX prophylaxis on the risk of malaria episodes in HIV-1-infected adults from four West African countries with different patterns of malaria transmission. METHOD: Multicentric cohort study, conducted between September 2007 and March 2010 in four West African cities. Antiretroviral therapy (ART) naïve HIV-infected adults started CTX at enrolment (CTX group) if they had CD4 < 350 cells/mm or were at WHO clinical stage ≥2. For patients who did not start CTX at enrolment (non-CTX group) and started CTX afterwards, follow-up was censored at CTX initiation. We used Cox's proportional hazard model to compare the risk of malaria between CTX groups. RESULTS: A total of 514 participants (median CD4 count 238 cells/mm ) were followed for a median of 15 months. At enrolment, 347 started CTX, and 261 started ART. During the follow-up, 28 started CTX. The incidence of malaria was 8.7/100 PY (95%CI 6.3-11.5) overall, 5.2/100 PY (95%CI 3.1-8.3) in the CTX group and 15.5/100 PY (95%CI 10.3-22.1) in the non-CTX group. In multivariate analysis, CTX led to a 69% reduction in the risk of malaria (aHR 0.31, 95%CI 0.10-0.90). CONCLUSION: Patients in the CTX group had an adjusted risk of malaria three times lower than those in the non-CTX group. The prolonged large-scale use of CTX did not blunt the efficacy of CTX to prevent malaria in this region.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Infecções por HIV/complicações
Malária/prevenção & controle
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
África Ocidental
Fármacos Anti-HIV/uso terapêutico
Contagem de Linfócito CD4
Estudos de Coortes
Feminino
Infecções por HIV/tratamento farmacológico
Infecções por HIV/virologia
HIV-1
Seres Humanos
Incidência
Malária/complicações
Malária/epidemiologia
Masculino
Análise Multivariada
Modelos de Riscos Proporcionais
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Antimalarials); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12919



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