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[PMID]:28455169
[Au] Autor:Lee BY; Wedlock PT; Haidari LA; Elder K; Potet J; Manring R; Connor DL; Spiker ML; Bonner K; Rangarajan A; Hunyh D; Brown ST
[Ad] Endereço:HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, United States; Global Obesity Prevention Center (GOPC) at Johns Hopkins University, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: brucelee@jhu.edu.
[Ti] Título:Economic impact of thermostable vaccines.
[So] Source:Vaccine;35(23):3135-3142, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: While our previous work has shown that replacing existing vaccines with thermostable vaccines can relieve bottlenecks in vaccine supply chains and thus increase vaccine availability, the question remains whether this benefit would outweigh the additional cost of thermostable formulations. METHODS: Using HERMES simulation models of the vaccine supply chains for the Republic of Benin, the state of Bihar (India), and Niger, we simulated replacing different existing vaccines with thermostable formulations and determined the resulting clinical and economic impact. Costs measured included the costs of vaccines, logistics, and disease outcomes averted. RESULTS: Replacing a particular vaccine with a thermostable version yielded cost savings in many cases even when charging a price premium (two or three times the current vaccine price). For example, replacing the current pentavalent vaccine with a thermostable version without increasing the vaccine price saved from $366 to $10,945 per 100 members of the vaccine's target population. Doubling the vaccine price still resulted in cost savings that ranged from $300 to $10,706, and tripling the vaccine price resulted in cost savings from $234 to $10,468. As another example, a thermostable rotavirus vaccine (RV) at its current (year) price saved between $131 and $1065. Doubling and tripling the thermostable rotavirus price resulted in cost savings ranging from $102 to $936 and $73 to $808, respectively. Switching to thermostable formulations was highly cost-effective or cost-effective in most scenarios explored. CONCLUSION: Medical cost and productivity savings could outweigh even significant price premiums charged for thermostable formulations of vaccines, providing support for their use.
[Mh] Termos MeSH primário: Vacinas contra Rotavirus/economia
Vacinas contra Rotavirus/provisão & distribuição
Potência de Vacina
[Mh] Termos MeSH secundário: Benin/epidemiologia
Simulação por Computador
Análise Custo-Benefício
Seres Humanos
Índia/epidemiologia
Lactente
Níger/epidemiologia
Infecções por Rotavirus/epidemiologia
Infecções por Rotavirus/prevenção & controle
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Rotavirus Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29384307
[Au] Autor:Otti A; Pirson M; Piette D; Coppieters T Wallant Y
[Ti] Título:[Analysis of interventions designed to improve clinical supervision of student nurses in Benin].
[Ti] Título:Analyse d?interventions pour améliorer l?encadrement clinique des étudiants infirmiers au Bénin..
[So] Source:Sante Publique;29(5):731-739, 2017 Dec 05.
[Is] ISSN:0995-3914
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: The absence of an explicit and coherent conception of the articulation between theory and practice in the reform of nursing training in Benin has resulted in poor quality clinical supervision of student nurses. The objective of this article is to analyze two interventions designed to improve the quality of supervision. METHODS: A student welcome booklet developed by means of a consultative and provocative participatory approach was tested with twelve student nurses versus a control group. Content analysis of the data collected by individual semi-directed interviews and during two focus groups demonstrated the value of this tool. Student nurses were also taught to use to training diaries inspired by the ?experiential learning? MODEL: Training diaries were analysed using a grid based on the descriptive elements of the five types of Scheepers training diaries (2008). RESULTS: According to the student nurses, the welcome booklet provided them with structured information to be used as a reference during their training and a better understanding of their teachers, and allowed them to situate the resources of the training course with a lower level of stress. Fifty-eight per cent of the training diaries were are mosaics, reflecting the reflective practice and self-regulated learning of student nurses. This activity also promoted metacognitive dialogue with their supervisors. CONCLUSION: The student welcome booklet appeared to facilitate integration of student nurses into the clinical setting and promoted professional and organizational socialization. The training diary improved the quality of clinical learning by repeated reflective observation of student nurses and helped to maintain permanent communication with the supervisors.
[Mh] Termos MeSH primário: Folhetos
Preceptoria
Estudantes de Enfermagem
[Mh] Termos MeSH secundário: Benin
Estudos de Casos e Controles
Seres Humanos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.3917/spub.175.0731


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[PMID]:29384306
[Au] Autor:Houngnihin RA; Sossou AJ
[Ti] Título:[Understanding failure of obstetric referral to the Cotonou University gynaecology and obstetrics clinic].
[Ti] Título:Comprendre le renoncement à la référence obstétricale à la Clinique universitaire de gynécologie et d?obstétrique de Cotonou..
[So] Source:Sante Publique;29(5):719-729, 2017 Dec 05.
[Is] ISSN:0995-3914
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Since 2000, in the context of the Millennium development goals, Benin has reinforced its obstetric referral system in order to reduce maternal mortality. However, structural, sociocultural and economic problems continue to affect this strategy. The Cotonou University gynaecology and obstetrics clinic (CUGO), at the top of the health pyramid, is emblematic of this situation. This study was designed to elucidate the stakes involved in referral to this hospital based on analysis of the perceptions and experiences of referral personnel. METHODS: Essentially qualitative data collection was conducted by means of in-depth semi-structured interviews from July to December 2015 involving 37 people, including referred women, healthcare personnel and caregivers. RESULTS: The poor quality of information given to women concerning the reasons for referral, the fear of caesarean section, considered to be inevitable, and the difficult relationships with health workers contribute to failure to comply with referral. Rumours concerning reception, waiting times and hospitalization conditions are other factors that must be taken into account. Finally, the distance from the woman's home is a decisive element in acceptance of referral by women and their families. CONCLUSION: Referral is generally perceived as necessary in the case of complications during pregnancy, by both referred women and healthcare personnel. However, differences in points of view are observed when the woman is referred to CUGO.
[Mh] Termos MeSH primário: Serviços de Saúde Materna
Ambulatório Hospitalar
Cooperação do Paciente
Encaminhamento e Consulta
[Mh] Termos MeSH secundário: Adolescente
Adulto
Benin
Comunicação
Feminino
Seres Humanos
Educação de Pacientes como Assunto
Gravidez
Complicações na Gravidez
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.3917/spub.175.0719


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[PMID]:29346406
[Au] Autor:Aleza K; Villamor GB; Nyarko BK; Wala K; Akpagana K
[Ad] Endereço:West African Science Service Centre for Climate Change and Adapted Land Use (WASCAL) Graduate Research Programme, School of Agriculture, Department of Soil Science, University of Cape Coast, Ghana.
[Ti] Título:Shea (Vitellaria paradoxa Gaertn C. F.) fruit yield assessment and management by farm households in the Atacora district of Benin.
[So] Source:PLoS One;13(1):e0190234, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitellaria paradoxa (Gaertn C. F.), or shea tree, remains one of the most valuable trees for farmers in the Atacora district of northern Benin, where rural communities depend on shea products for both food and income. To optimize productivity and management of shea agroforestry systems, or "parklands," accurate and up-to-date data are needed. For this purpose, we monitored120 fruiting shea trees for two years under three land-use scenarios and different soil groups in Atacora, coupled with a farm household survey to elicit information on decision making and management practices. To examine the local pattern of shea tree productivity and relationships between morphological factors and yields, we used a randomized branch sampling method and applied a regression analysis to build a shea yield model based on dendrometric, soil and land-use variables. We also compared potential shea yields based on farm household socio-economic characteristics and management practices derived from the survey data. Soil and land-use variables were the most important determinants of shea fruit yield. In terms of land use, shea trees growing on farmland plots exhibited the highest yields (i.e., fruit quantity and mass) while trees growing on Lixisols performed better than those of the other soil group. Contrary to our expectations, dendrometric parameters had weak relationships with fruit yield regardless of land-use and soil group. There is an inter-annual variability in fruit yield in both soil groups and land-use type. In addition to observed inter-annual yield variability, there was a high degree of variability in production among individual shea trees. Furthermore, household socioeconomic characteristics such as road accessibility, landholding size, and gross annual income influence shea fruit yield. The use of fallow areas is an important land management practice in the study area that influences both conservation and shea yield.
[Mh] Termos MeSH primário: Ericales
Fazendas
[Mh] Termos MeSH secundário: Benin
Características da Família
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190234


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[PMID]:29253027
[Au] Autor:Panteli M; Benetos E; Dixon S
[Ad] Endereço:Centre for Digital Music, School of Electronic Engineering and Computer Science, Queen Mary University of London, London, United Kingdom.
[Ti] Título:A computational study on outliers in world music.
[So] Source:PLoS One;12(12):e0189399, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The comparative analysis of world music cultures has been the focus of several ethnomusicological studies in the last century. With the advances of Music Information Retrieval and the increased accessibility of sound archives, large-scale analysis of world music with computational tools is today feasible. We investigate music similarity in a corpus of 8200 recordings of folk and traditional music from 137 countries around the world. In particular, we aim to identify music recordings that are most distinct compared to the rest of our corpus. We refer to these recordings as 'outliers'. We use signal processing tools to extract music information from audio recordings, data mining to quantify similarity and detect outliers, and spatial statistics to account for geographical correlation. Our findings suggest that Botswana is the country with the most distinct recordings in the corpus and China is the country with the most distinct recordings when considering spatial correlation. Our analysis includes a comparison of musical attributes and styles that contribute to the 'uniqueness' of the music of each country.
[Mh] Termos MeSH primário: Música
Processamento de Sinais Assistido por Computador
[Mh] Termos MeSH secundário: Algoritmos
Benin
Botsuana
China
Análise por Conglomerados
Características Culturais
Geografia
Guiné
Seres Humanos
Linguagem
Modelos Estatísticos
Software
Sudão do Sul
Zimbábue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189399


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[PMID]:29252986
[Au] Autor:Ngufor C; Fongnikin A; Rowland M; N'Guessan R
[Ad] Endereço:London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.
[Ti] Título:Indoor residual spraying with a mixture of clothianidin (a neonicotinoid insecticide) and deltamethrin provides improved control and long residual activity against pyrethroid resistant Anopheles gambiae sl in Southern Benin.
[So] Source:PLoS One;12(12):e0189575, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: There is an urgent need for new insecticides for indoor residual spraying (IRS) which can provide improved and prolonged control of malaria vectors that have developed resistance to existing insecticides. The neonicotinoid, clothianidin represents a class of chemistry new to public health. Clothianidin acts as an agonist on nicotinic acetyl choline receptors. IRS with a mixture of Clothianidin and another WHO approved insecticide such as deltamethrin could provide improved control of insecticide resistant malaria vector populations and serve as a tool for insecticide resistance management. METHODS: The efficacy and residual activity of a novel IRS mixture of deltamethrin and clothianidin was evaluated against wild pyrethroid resistant An. gambiae sl in experimental huts in Cove, Benin. Two application rates of the mixture were tested and comparison was made with clothianidin and deltamethrin applied alone. To assess the residual efficacy of the treatments on different local wall substrates, the inner walls of the experimental huts were covered with either cement, mud or plywood. RESULTS: Clothianidin demonstrated a clear delayed expression in mortality of wild pyrethroid resistant An. gambiae sl in the experimental huts which reached its full effect 120 hours after exposure. Overall mortality over the 12-month hut trial was 15% in the control hut and 24-29% in the deltamethrin-treated huts. The mixture of clothianidin 200mg/m2 and deltamethrin 25mg/m2 induced high overall hut mortality rates (87% on mud walls, 82% on cement walls and 61% on wooden walls) largely due to the clothianidin component and high hut exiting rates (67-76%) mostly due to the deltamethrin component. Mortality rates remained >80% for 8-9 months on mud and cement walls. The residual activity trend was confirmed by results from monthly in situ cone bioassays with laboratory susceptible An. gambiae Kisumu strain. CONCLUSION: IRS campaigns with the mixture of clothianidin plus deltamethrin have the potential to provide prolonged control of malaria transmitted by pyrethroid resistant mosquito populations.
[Mh] Termos MeSH primário: Anopheles
Culex
Guanidinas
Resistência a Inseticidas
Inseticidas
Controle de Mosquitos/métodos
Neonicotinoides
Piretrinas
Tiazóis
[Mh] Termos MeSH secundário: Animais
Benin
Habitação
Seres Humanos
Malária/prevenção & controle
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Guanidines); 0 (Insecticides); 0 (Neonicotinoids); 0 (Pyrethrins); 0 (Thiazoles); 2V9906ABKQ (clothianidin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189575


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[PMID]:29028166
[Ti] Título:Continuing risk of meningitis due to Neisseria meningitidis serogroup C in Africa: revised recommendations from a WHO expert consultation.
[Ti] Título:Risque persistant de méningite due à Neisseria meningitidis sérogroupe C en Afrique: recommandations révisées à l'issue d'une consultation d'experts de l'OMS..
[So] Source:Wkly Epidemiol Rec;92(41):612-7, 2017 10 13.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Meningite Meningocócica/epidemiologia
Meningite Meningocócica/microbiologia
Neisseria meningitidis Sorogrupo C
[Mh] Termos MeSH secundário: Comitês Consultivos
África/epidemiologia
Antibacterianos/uso terapêutico
Benin/epidemiologia
Burkina Faso/epidemiologia
Ciprofloxacino/uso terapêutico
Epidemias
Seres Humanos
Mali/epidemiologia
Meningite Meningocócica/tratamento farmacológico
Meningite Meningocócica/prevenção & controle
Níger/epidemiologia
Nigéria/epidemiologia
Vigilância da População
Risco
Vacinação
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:28991911
[Au] Autor:Dechavanne C; Dechavanne S; Sadissou I; Lokossou AG; Alvarado F; Dambrun M; Moutairou K; Courtin D; Nuel G; Garcia A; Migot-Nabias F; King CL
[Ad] Endereço:Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America.
[Ti] Título:Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin.
[So] Source:PLoS Med;14(10):e1002403, 2017 Oct.
[Is] ISSN:1549-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transplacental transfer of maternal immunoglobulin G (IgG) to the fetus helps to protect against malaria and other infections in infancy. Recent studies have emphasized the important role of malaria-specific IgG3 in malaria immunity, and its transfer may reduce the risk of malaria in infancy. Human IgGs are actively transferred across the placenta by binding the neonatal Fc receptor (FcRn) expressed within the endosomes of the syncytiotrophoblastic membrane. Histidine at position 435 (H435) provides for optimal Fc-IgG binding. In contrast to other IgG subclasses, IgG3 is highly polymorphic and usually contains an arginine at position 435, which reduces its binding affinity to FcRn in vitro. The reduced binding to FcRn is associated with reduced transplacental transfer and reduced half-life of IgG3 in vivo. Some haplotypes of IgG3 have histidine at position 435. This study examines the hypotheses that the IgG3-H435 variant promotes increased transplacental transfer of malaria-specific antibodies and a prolonged IgG3 half-life in infants and that its presence correlates with protection against clinical malaria during infancy. METHODS AND FINDINGS: In Benin, 497 mother-infant pairs were included in a longitudinal birth cohort. Both maternal and cord serum samples were assayed for levels of IgG1 and IgG3 specific for MSP119, MSP2 (both allelic families, 3D7 and FC27), MSP3, GLURP (both regions, R0 and R2), and AMA1 antigens of Plasmodium falciparum. Cord:maternal ratios were calculated. The maternal IgG3 gene was sequenced to identify the IgG3-H435 polymorphism. A multivariate logistic regression was used to examine the association between maternal IgG3-H435 polymorphism and transplacental transfer of IgG3, adjusting for hypergammaglobulinemia, maternal malaria, and infant malaria exposure. Twenty-four percent of Beninese women living in an area highly endemic for malaria had the IgG3-H435 allele (377 women homozygous for the IgG3-R435 allele, 117 women heterozygous for the IgG3-R/H alleles, and 3 women homozygous for the IgG3-H435 allele). Women with the IgG3-H435 allele had a 78% (95% CI 17%, 170%, p = 0.007) increased transplacental transfer of GLURP-R2 IgG3 compared to those without the IgG3-H435 allele. Furthermore, in infants born to mothers with the IgG3-H435 variant, a 28% longer IgG3 half-life was noted (95% CI 4%, 59%, p = 0.02) compared to infants born to mothers homozygous for the IgG3-R435 allele. Similar findings were observed for AMA1, MSP2-3D7, MSP3, GLURP-R0, and GLURP-R2 but not for MSP119 and MSP2-FC27. Infants born to women with IgG3-H435 had a 32% lower risk of symptomatic malaria during infancy (incidence rate ratio [IRR] = 0.68 [95% CI 0.51, 0.91], p = 0.01) compared to infants born to mothers homozygous for IgG3-R435. We did not find a lower risk of asymptomatic malaria in infants born to women with or without IgG3-H435. Limitations of the study were the inability to determine (i) the actual amount of IgG3-H435 relative to IgG-R435 in serum samples and (ii) the proportion of malaria-specific IgG produced by infants versus acquired from their mothers. CONCLUSIONS: An arginine-to-histidine replacement at residue 435 in the binding domain of IgG3 to FcRn increases the transplacental transfer and half-life of malaria-specific IgG3 in young infants and is associated with reduced risk of clinical malaria during infancy. The IgG3-H435 allele may be under positive selection, given its relatively high frequency in malaria endemic areas.
[Mh] Termos MeSH primário: Antígenos de Histocompatibilidade Classe I/genética
Imunoglobulina G/sangue
Transmissão Vertical de Doença Infecciosa
Malária Falciparum/prevenção & controle
Troca Materno-Fetal
Circulação Placentária
Plasmodium falciparum/imunologia
Polimorfismo Genético
Receptores Fc/genética
[Mh] Termos MeSH secundário: Adulto
Benin
Distribuição de Qui-Quadrado
Feminino
Predisposição Genética para Doença
Meia-Vida
Heterozigoto
Antígenos de Histocompatibilidade Classe I/metabolismo
Homozigoto
Seres Humanos
Lactente
Recém-Nascido
Estimativa de Kaplan-Meier
Modelos Logísticos
Estudos Longitudinais
Malária Falciparum/genética
Malária Falciparum/imunologia
Malária Falciparum/transmissão
Análise Multivariada
Fenótipo
Plasmodium falciparum/patogenicidade
Gravidez
Modelos de Riscos Proporcionais
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Proteólise
Receptores Fc/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fc receptor, neonatal); 0 (Histocompatibility Antigens Class I); 0 (Immunoglobulin G); 0 (Receptors, Fc)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pmed.1002403


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[PMID]:28904687
[Au] Autor:Akpadjan F; Adégbidi H; Attinsounon CA; Koudoukpo C; Dégboé B; Agbessi N; Atadokpèdé F
[Ad] Endereço:Dermatology-Venereology, Faculty of Health, Cotonou, University of Abomey-Calavi, R. Benin.
[Ti] Título:A case of reccuring giant condyloma of vulva in infant without sexual abuse successfully treated with electrocoagulation in Benin.
[So] Source:Pan Afr Med J;27:159, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:We report here a case of giant vulval condyloma in a two-year-old infant infected by her "baby sitter" without sexual abuse. Treated by surgical excision coupled with electrocoagulation, it was noted a rapid recurrence two weeks after treatment requiring a second electrocoagulation session. More than a year later, no lesion was noted, thus demonstrating therapeutic success. The unavailability of imiquimod in our context requires a systematic use of invasive treatment regardless of the age of the patient.
[Mh] Termos MeSH primário: Tumor de Buschke-Lowenstein/diagnóstico
Eletrocoagulação/métodos
Neoplasias Vulvares/diagnóstico
[Mh] Termos MeSH secundário: Benin
Tumor de Buschke-Lowenstein/patologia
Tumor de Buschke-Lowenstein/terapia
Pré-Escolar
Terapia Combinada
Feminino
Seres Humanos
Recidiva
Neoplasias Vulvares/patologia
Neoplasias Vulvares/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.159.11998


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[PMID]:28863143
[Au] Autor:Sanoussi CN; Affolabi D; Rigouts L; Anagonou S; de Jong B
[Ad] Endereço:Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium.
[Ti] Título:Genotypic characterization directly applied to sputum improves the detection of Mycobacterium africanum West African 1, under-represented in positive cultures.
[So] Source:PLoS Negl Trop Dis;11(9):e0005900, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aimed to compare the prevalence of Mycobacterium tuberculosis complex (MTBc) lineages between direct genotyping (on sputum) and indirect genotyping (on culture), to characterize potential culture bias against difficult growers. METHODOLOGY/PRINCIPAL FINDINGS: Smear-positive sputa from consecutive new tuberculosis patients diagnosed in Cotonou, (Benin) were included, before patients had started treatment. An aliquot of decontaminated sputum was used for direct spoligotyping, and another aliquot was cultured on Löwenstein Jensen (LJ) medium (90 days), for indirect spoligotyping. After DNA extraction, spoligotyping was done according to the standard method for all specimens, and patterns obtained from sputa were compared versus those from the derived culture isolates. From 199 patient's sputa, 146 (73.4%) yielded a positive culture. In total, direct spoligotyping yielded a pattern in 98.5% (196/199) of the specimens, versus 73.4% (146/199) for indirect spoligotyping on cultures. There was good agreement between sputum- and isolate derived patterns: 94.4% (135/143) at spoligotype level and 96.5% (138/143) at (sub)lineage level. Two of the 8 pairs with discrepant pattern were suggestive of mixed infection in sputum. Ancestral lineages (Lineage 1, and M. africanum Lineages 5 and 6) were less likely to grow in culture (OR = 0.30, 95%CI (0.14 to 0.64), p = 0.0016); especially Lineage 5 (OR = 0.37 95%CI (0.17 to 0.79), p = 0.010). Among modern lineages, Lineage 4 was over-represented in positive-culture specimens (OR = 3.01, 95%CI (1.4 to 6.51), p = 0.005). CONCLUSIONS/ SIGNIFICANCE: Ancestral lineages, especially M. africanum West African 1 (Lineage 5), are less likely to grow in culture relative to modern lineages, especially M. tuberculosis Euro-American (Lineage 4). Direct spoligotyping on smear positive sputum is effective and efficient compared to indirect spoligotyping of cultures. It allows for a more accurate unbiased determination of the population structure of the M. tuberculosis complex. TRIAL REGISTRATION: ClinicalTrials.gov NCT02744469.
[Mh] Termos MeSH primário: Mycobacterium tuberculosis/genética
Mycobacterium tuberculosis/isolamento & purificação
Escarro/microbiologia
Tuberculose/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Técnicas de Tipagem Bacteriana
Benin/epidemiologia
DNA Bacteriano/genética
Feminino
Genótipo
Seres Humanos
Masculino
Meia-Idade
Mycobacterium tuberculosis/classificação
Reação em Cadeia da Polimerase
Estudos Prospectivos
Tuberculose/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005900



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