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[PMID]:29385172
[Au] Autor:Henriques M; Granadeiro JP; Monteiro H; Nuno A; Lecoq M; Cardoso P; Regalla A; Catry P
[Ad] Endereço:MARE-Marine and Environmental Sciences Centre, ISPA-Instituto Universitário, Rua Jardim do Tabaco Lisbon, Portugal.
[Ti] Título:Not in wilderness: African vulture strongholds remain in areas with high human density.
[So] Source:PLoS One;13(1):e0190594, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vultures constitute an important functional group in many ecosystems, providing crucial ecosystem services both in natural and humanized environments. These scavengers are facing massive declines worldwide, but in several African countries virtually nothing is known on populations' status and threats, hampering the development of adequate conservation strategies. In Guinea-Bissau, globally important populations of Hooded Necrosyrtes monachus and African white-backed vultures Gyps africanus were recently reported. Using the country as a study area, we aim to characterize human-vulture interactions in West Africa applying a multidisciplinary approach. We assessed the status and distribution of vulture populations using data from 1711 km of roadside transects, examined predictors of their distribution, and produced a nationwide population estimate for the Hooded Vulture, using an innovative method based on the relationship between the size of human population in settlements and vulture numbers. We conducted 47 stakeholder interviews to assess perceived roles played by vultures, and to investigate potential anthropogenic threats. Hooded vultures were strongly associated with high human population densities, whereas no relation was found between African white-backed and Rüppell's vultures and any of the tested predictors, which included cattle density, precipitation and Normalized Difference Vegetation Index, among others. We estimate a national population of 43347 Hooded vultures, the largest population reported in the species range. Respondents were generally aware of the services provided by vultures, especially waste and carcass removal, including in urban areas. Hunting for witchcraft and traditional medicine was the most frequently recognised threat, while poisoning was ranked as having the highest impact. We hypothesise that poisoning-related mortality may be affecting African white-backed and Rüppell's vultures' distribution and explain their scarcity in apparently highly suitable habitats. Our results suggest a mutualistic rather than a commensalistic relationship between vultures and humans, with important implications for designing and implementing conservation strategies.
[Mh] Termos MeSH primário: Falconiformes/fisiologia
[Mh] Termos MeSH secundário: Animais
Conservação dos Recursos Naturais
Ecossistema
Guiné-Bissau
Seres Humanos
Dinâmica Populacional
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190594


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[PMID]:28464403
[Au] Autor:Nielsen BU; Byberg S; Aaby P; Rodrigues A; Benn CS; Fisker AB
[Ad] Endereço:Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau.
[Ti] Título:Seasonal variation in child mortality in rural Guinea-Bissau.
[So] Source:Trop Med Int Health;22(7):846-856, 2017 07.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: In many African countries, child mortality is higher in the rainy season than in the dry season. We investigated the effect of season on child mortality by time periods, sex and age in rural Guinea-Bissau. METHODS: Bandim health project follows children under-five in a health and demographic surveillance system in rural Guinea-Bissau. We compared the mortality in the rainy season (June to November) between 1990 and 2013 with the mortality in the dry season (December to May) in Cox proportional hazards models providing rainy vs. dry season mortality rate ratios (r/d-mrr). Seasonal effects were estimated in strata defined by time periods with different frequency of vaccination campaigns, sex and age (<1 month, 1-11 months, 12-59 months). Verbal autopsies were interpreted using InterVa-4 software. RESULTS: From 1990 to 2013, overall mortality was declined by almost two-thirds among 81 292 children (10 588 deaths). Mortality was 51% (95% ci: 45-58%) higher in the rainy season than in the dry season throughout the study period. The seasonal difference increased significantly with age, the r/d-mrr being 0.94 (0.86-1.03) among neonates, 1.57 (1.46-1.69) in post-neonatal infants and 1.83 (1.72-1.95) in under-five children (P for same effect <0.001). According to the InterVa, malaria deaths were the main reason for the seasonal mortality difference, causing 50% of all deaths in the rainy season, but only if the InterVa included season of death, making the argument self-confirmatory. CONCLUSION: The mortality declined throughout the study, yet rainy season continued to be associated with 51% higher overall mortality.
[Mh] Termos MeSH primário: Mortalidade da Criança
Clima
População Rural/estatística & dados numéricos
Estações do Ano
[Mh] Termos MeSH secundário: Fatores Etários
Pré-Escolar
Feminino
Guiné-Bissau
Seres Humanos
Lactente
Recém-Nascido
Masculino
Modelos de Riscos Proporcionais
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12889


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[PMID]:28873392
[Au] Autor:Le Page Y; Vasconcelos M; Palminha A; Melo IQ; Pereira JMC
[Ad] Endereço:University of Lisbon, Instituto Superior de Agronomia, Centro de Estudos Florestais, Lisboa, Portugal.
[Ti] Título:An operational approach to high resolution agro-ecological zoning in West-Africa.
[So] Source:PLoS One;12(9):e0183737, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this work is to develop a simple methodology for high resolution crop suitability analysis under current and future climate, easily applicable and useful in Least Developed Countries. The approach addresses both regional planning in the context of climate change projections and pre-emptive short-term rural extension interventions based on same-year agricultural season forecasts, while implemented with off-the-shelf resources. The developed tools are applied operationally in a case-study developed in three regions of Guinea-Bissau and the obtained results, as well as the advantages and limitations of methods applied, are discussed. In this paper we show how a simple approach can easily generate information on climate vulnerability and how it can be operationally used in rural extension services.
[Mh] Termos MeSH primário: Agricultura/legislação & jurisprudência
Agricultura/métodos
[Mh] Termos MeSH secundário: Clima
Mudança Climática
Produtos Agrícolas
Ecologia
Geografia
Guiné-Bissau
Modelos Estatísticos
Estações do Ano
Classe Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183737


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[PMID]:28545041
[Au] Autor:Hansen NS; Byberg S; Hervig Jacobsen L; Bjerregaard-Andersen M; Jensen AKG; Martins C; Aaby P; Skov Jensen J; Stabell Benn C; Whittle H
[Ad] Endereço:Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
[Ti] Título:Effect of early measles vaccine on pneumococcal colonization: A randomized trial from Guinea-Bissau.
[So] Source:PLoS One;12(5):e0177547, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Measles vaccine (MV) may have non-specific beneficial effects for child health and particularly seems to prevent respiratory infections. Streptococcus pneumoniae is the leading cause of bacterial pneumonia among children worldwide, and nasopharyngeal colonization precedes infection. OBJECTIVE: We investigated whether providing early MV at 18 weeks of age reduced pneumococcal colonization and/or density up to 9 months of age. METHOD: The study was conducted in 2013-2014 in Guinea-Bissau. Pneumococcal vaccine was not part of the vaccination program. Infants aged 18 weeks were block-randomized 2:1 to early or no early MV; at age 9 months, all children were offered MV as per current policy. Nasopharyngeal swabs were taken at baseline, age 6.5 months, and age 9 months. Pneumococcal density was determined by q-PCR. Prevalence ratios of pneumococcal colonization and recent antibiotic treatment (yes/no) by age 6.5 months (PR6.5) and age 9 months (PR9) were estimated using Poisson regression with robust variance estimates while the pneumococcal geometric mean ratio (GMR6.5 and GMR9) was obtained using OLS regression. RESULTS: Analyses included 512 children; 346 early MV-children and 166 controls. At enrolment, the pneumococcal colonization prevalence was 80% (411/512). Comparing early MV-children with controls, the PR6.5 was 1.02 (95%CI = 0.94-1.10), and the PR9 was 1.04 (0.96-1.12). The GMR6.5 was 1.02 (0.55-1.89), and the GMR9 was 0.69 (0.39-1.21). Early MV-children tended to be less frequently treated with antibiotics prior to follow up (PR6.5 0.60 (0.34-1.05) and PR9 0.87 (0.50-1.53)). Antibiotic treatment was associated with considerably lower colonization rates, PR6.5 0.85 (0.71-1.01) and PR9 0.66 (0.52-0.84), as well as lower pneumococcal density, GMR6.5 0.32 (0.12-0.86) and GMR9 0.52 (0.18-1.52). CONCLUSION: Early MV at age 18 weeks had no measurable effect on pneumococcal colonization prevalence or density. Higher consumption of antibiotics among controls may have blurred an effect of early MV. TRIAL REGISTRATION: clinicaltrials.gov NCT01486355.
[Mh] Termos MeSH primário: Vacina contra Sarampo/imunologia
Infecções Pneumocócicas/prevenção & controle
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
DNA Bacteriano/metabolismo
Feminino
Guiné-Bissau/epidemiologia
Seres Humanos
Lactente
Masculino
Infecções Pneumocócicas/tratamento farmacológico
Infecções Pneumocócicas/epidemiologia
Infecções Pneumocócicas/microbiologia
Distribuição de Poisson
Prevalência
Reação em Cadeia da Polimerase em Tempo Real
Streptococcus pneumoniae/genética
Streptococcus pneumoniae/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Measles Vaccine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177547


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[PMID]:28542646
[Au] Autor:Byberg S; Østergaard MD; Rodrigues A; Martins C; Benn CS; Aaby P; Fisker AB
[Ad] Endereço:Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
[Ti] Título:Analysis of risk factors for infant mortality in the 1992-3 and 2002-3 birth cohorts in rural Guinea-Bissau.
[So] Source:PLoS One;12(5):e0177984, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Though still high, the infant mortality rate in Guinea-Bissau has declined. We aimed to identify risk factors including vaccination coverage, for infant mortality in the rural population of Guinea-Bissau and assess whether these risk factors changed from 1992-3 to 2002-3. METHODS: The Bandim Health Project (BHP) continuously surveys children in rural Guinea-Bissau. We investigated the association between maternal and infant factors (especially DTP and measles coverage) and infant mortality. Hazard ratios (HR) were calculated using Cox regression. We tested for interactions with sex, age groups (defined by current vaccination schedule) and cohort to assess whether the risk factors were the same for boys and girls, in different age groups in 1992-3 and in 2002-3. RESULTS: The infant mortality rate declined from 148/1000 person years (PYRS) in 1992-3 to 124/1000 PYRS in 2002-3 (HR = 0.88;95%CI:0.77-0.99); this decline was significant for girls (0.77;0.64-0.94) but not for boys (0.97;0.82-1.15) (p = 0.10 for interaction). Risk factors did not differ significantly by cohort in either distribution or effect. Mortality decline was most marked among girls aged 9-11 months (0.56;0.37-0.83). There was no significant mortality decline for girls 1.5-8 months of age (0.93;0.68-1.28) (p = 0.05 for interaction). DTP and measles coverage increased from 1992-3 to 2002-3. CONCLUSIONS: Risk factors did not change with the decline in mortality. Due to beneficial non-specific effects for girls, the increased coverage of measles vaccination may have contributed to the disproportional decline in mortality by sex and age group.
[Mh] Termos MeSH primário: Mortalidade Infantil
[Mh] Termos MeSH secundário: Difteria/prevenção & controle
Vacina contra Difteria, Tétano e Coqueluche/imunologia
Feminino
Guiné-Bissau/epidemiologia
Seres Humanos
Lactente
Mortalidade Infantil/tendências
Masculino
Sarampo/prevenção & controle
Vacina contra Sarampo/imunologia
Análise Multivariada
Modelos de Riscos Proporcionais
Fatores de Risco
População Rural/estatística & dados numéricos
Fatores Sexuais
Tétano/prevenção & controle
Vacinação
Coqueluche/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diphtheria-Tetanus-Pertussis Vaccine); 0 (Measles Vaccine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177984


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[PMID]:28506274
[Au] Autor:Gamma AE; Slekiene J; von Medeazza G; Asplund F; Cardoso P; Mosler HJ
[Ad] Endereço:EAWAG, Swiss Federal Institute of Aquatic Science & Technology, Environmental and Health Psychology, Überlandstrasse 133, CH-8600, Dübendorf, Switzerland. anna.gamma@eawag.ch.
[Ti] Título:Contextual and psychosocial factors predicting Ebola prevention behaviours using the RANAS approach to behaviour change in Guinea-Bissau.
[So] Source:BMC Public Health;17(1):446, 2017 May 15.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The outbreak of the Ebola virus disease (EVD) in West Africa in December 2013 was the largest Ebola outbreak in history. This study aimed to measure the underlying contextual and psychosocial factors of intentions to perform Ebola prevention behaviours (not touching people who might be suffering from Ebola, reporting suspected cases to the National Ebola Hotline, NEH) in Guinea-Bissau. Geographical location, cross-border market activities, poor water, sanitation and hygiene (WASH) conditions, and burial practices in some communities pose a serious risk in terms of potential EVD outbreak and seriously hamper its prevention in Guinea-Bissau. METHODS: In July and August 2015, quantitative data from 1369 respondents were gathered by structured face-to-face interviews. The questionnaire was based on the psychosocial factors of the RANAS (risks, attitudes, norms, abilities, and self-regulation) model. Data were analyzed by multiple linear regression analyses. RESULTS: The most important predictors for the intention to call the NEH were believing that calling the Hotline would help the infected person, perceiving that important members from the household approve of calling the Hotline, thinking that calling the Hotline is something they should do, and believing that it is important to call the Hotline to report a suspected case. For the intention not to touch someone who might be suffering from Ebola, the most important predictors were health knowledge, the perception of risk with regard to touching a person who might be suffering from Ebola, and the belief that they were able not to touch a possibly infected person. Age in years was the only significant contextual predictor for one of the two behavioural intentions, the intention to call the Hotline. It seems that younger people are more likely to use a service like the NEH than older people. CONCLUSIONS: Strengths and gaps were identified in the study population in relation to the intention to perform prevention behaviours. These call for innovative ways of aligning existing hygiene programs with relevant psychosocial factors. This research is relevant to further outbreaks of contagious diseases as it sheds light on important aspects of the impact of public health interventions during emergencies and epidemics.
[Mh] Termos MeSH primário: Atitude Frente à Saúde
Conhecimentos, Atitudes e Prática em Saúde
Doença pelo Vírus Ebola/prevenção & controle
Doença pelo Vírus Ebola/psicologia
Intenção
Assunção de Riscos
[Mh] Termos MeSH secundário: Adolescente
Adulto
África Ocidental/epidemiologia
Idoso
Idoso de 80 Anos ou mais
Feminino
Guiné-Bissau/epidemiologia
Doença pelo Vírus Ebola/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Modelos Teóricos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4360-2


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[PMID]:28188123
[Au] Autor:Mogensen SW; Andersen A; Rodrigues A; Benn CS; Aaby P
[Ad] Endereço:Bandim Health Project, Indepth Network, Apartado 861, Bissau, Guinea-Bissau.
[Ti] Título:The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment.
[So] Source:EBioMedicine;17:192-198, 2017 Mar.
[Is] ISSN:2352-3964
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We examined the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s. METHODS: The child population had been followed with 3-monthly nutritional weighing sessions since 1978. From June 1981 DTP and OPV were offered from 3months of age at these sessions. Due to the 3-monthly intervals between sessions, the children were allocated by birthday in a 'natural experiment' to receive vaccinations early or late between 3 and 5months of age. We included children who were <6months of age when vaccinations started and children born until the end of December 1983. We compared mortality between 3 and 5months of age of DTP-vaccinated and not-yet-DTP-vaccinated children in Cox proportional hazard models. RESULTS: Among 3-5-month-old children, having received DTP (±OPV) was associated with a mortality hazard ratio (HR) of 5.00 (95% CI 1.53-16.3) compared with not-yet-DTP-vaccinated children. Differences in background factors did not explain the effect. The negative effect was particularly strong for children who had received DTP-only and no OPV (HR=10.0 (2.61-38.6)). All-cause infant mortality after 3months of age increased after the introduction of these vaccines (HR=2.12 (1.07-4.19)). CONCLUSION: DTP was associated with increased mortality; OPV may modify the effect of DTP.
[Mh] Termos MeSH primário: Vacina contra Difteria, Tétano e Coqueluche/efeitos adversos
Mortalidade Infantil
Vacina Antipólio Oral/efeitos adversos
[Mh] Termos MeSH secundário: Vacina contra Difteria, Tétano e Coqueluche/administração & dosagem
Feminino
Guiné-Bissau
Seres Humanos
Lactente
Masculino
Vacina Antipólio Oral/administração & dosagem
População Urbana/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diphtheria-Tetanus-Pertussis Vaccine); 0 (Poliovirus Vaccine, Oral)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


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[PMID]:28173813
[Au] Autor:Russo G; Pavignani E; Guerreiro CS; Neves C
[Ad] Endereço:International Health and Biostatistics Unit, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 100, Lisbon, Portugal. g.russo@qmul.ac.uk.
[Ti] Título:Can we halt health workforce deterioration in failed states? Insights from Guinea-Bissau on the nature, persistence and evolution of its HRH crisis.
[So] Source:Hum Resour Health;15(1):12, 2017 Feb 07.
[Is] ISSN:1478-4491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Guinea-Bissau is one of the world's poorest and least developed countries. Amid poverty, political turmoil and state withdrawal, its health workforce (HW) has been swamped for the last four decades in a deepening crisis of under-resourcing, poor performance and laissez-faire. METHODS: The present study aimed at analysing the human resources for health (HRH) situation in Guinea-Bissau in light of the recent literature on distressed health systems, with the objective of contributing to understanding the ways health workers react to protracted turmoil, the resulting distortions and the counter-measures that might be considered. Through document analysis, focus group discussions, 14 semi-structured and 5 in-depth interviews, we explored patterns as they became visible on the ground. RESULTS: Since independence, Guinea-Bissau experienced political events that have reflected on the healthcare arena and on the evolution of its health workforce, such as different coup attempts, waves of diaspora and shifting external assistance. The chronic scarcity of funds and a 'stable political instability' have lead to the commercialisation of public health services and to flawed mechanisms for training and deploying health personnel. In absence of any form of governance, health workers have come to own and run the health system. We show that the HRH crisis in Guinea-Bissau can only be understood by looking at its historical evolution and at the wider socio-economic context. There are no quick fixes for the deterioration of HRH in undergoverned states; however, the recognition of the ingrained distortions and an understanding of the forces determining the behaviour of key actors are essential premises for the identification of solutions. CONCLUSIONS: Guinea-Bissau's case study suggests that any policy that does not factor in the limited clout of health authorities over a effectively privatised healthcare arena is doomed from the start. Improving health system governance and quality of training should take precedence over expanding HRH. A bloated and ineffective workforce must be managed through incentives rather than administrative orders, in order to improve skills and productivity against higher remuneration and better working conditions. Donor support might be crucial to trigger positive changes, through realistic and sustained investments.
[Mh] Termos MeSH primário: Distúrbios Civis
Serviços de Saúde Comunitária/recursos humanos
Assistência à Saúde/recursos humanos
Países em Desenvolvimento
Pessoal de Saúde
Administração de Recursos Humanos
Pobreza
[Mh] Termos MeSH secundário: Competência Clínica
Serviços de Saúde Comunitária/normas
Assistência à Saúde/normas
Educação
Organização do Financiamento
Grupos Focais
Governo
Guiné-Bissau
Pessoal de Saúde/educação
Política de Saúde
Acesso aos Serviços de Saúde
Seres Humanos
Cooperação Internacional
Satisfação no Emprego
Política
Privatização
Qualidade da Assistência à Saúde
Remuneração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1186/s12960-017-0189-0


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[PMID]:28081788
[Au] Autor:Dario P; Oliveira AR; Ribeiro T; Porto MJ; Dias D; Corte Real F
[Ad] Endereço:INMLCF - National Institute of Legal Medicine and Forensic Sciences, Largo da Sé Nova, s/n, 3000-213 Coimbra, Portugal; University of Lisbon, Faculty of Sciences, Campo Grande, 1749-016 Lisboa, Portugal; CENCIFOR - Forensic Sciences Centre, Largo da Sé Nova, s/n, 3000-213 Coimbra, Portugal; CESAM -
[Ti] Título:Autosomal SNPs study of a population sample from Southern Portugal and from a sample of immigrants from Guinea-Bissau residing in Portugal.
[So] Source:Leg Med (Tokyo);24:32-35, 2017 Jan.
[Is] ISSN:1873-4162
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In recent years, autosomal single nucleotide polymorphisms (SNPs) have been comprehensively investigated in forensic research due to their usefulness in certain circumstances in complementing short tandem repeats (STRs) analysis, or even for use on their own when analysis of STRs fails. However, as with STRs, in order to properly use SNP markers in forensic casuistic we need to understand the population and forensic parameters in question. As a result of Portugal's colonial history during the time of empire, and the subsequent process of decolonization, some African individuals migrated to Portugal, giving rise to large African and African-descendent communities. One of these groups is the community originating from Guinea-Bissau, that in 2014, was enumerated to consist of more than 17,700 individuals with official residency status, more than the third major city of Guinea-Bissau. In order to study the population and forensic parameters mentioned above for the two populations important to our casuistic, a total of 142 unrelated individuals from the South of Portugal and 90 immigrants from Guinea-Bissau (equally non related and all residing in Portugal) were typed with SNaPshot™ assay for all 52 loci included in the SNPforID 52plex.
[Mh] Termos MeSH primário: Emigrantes e Imigrantes
Genética Populacional
Polimorfismo de Nucleotídeo Único/genética
[Mh] Termos MeSH secundário: Impressões Digitais de DNA
Frequência do Gene
Guiné-Bissau
Seres Humanos
Repetições de Microssatélites
Portugal
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE


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[PMID]:28077730
[Au] Autor:Do VA; Biering-Sørensen S; Fisker AB; Balé C; Rasmussen SM; Christensen LD; Jensen KJ; Martins C; Aaby P; Benn CS
[Ad] Endereço:Research Center for Vitamins & Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark.
[Ti] Título:Effect of an Early Dose of Measles Vaccine on Morbidity Between 18 Weeks and 9 Months of Age: A Randomized, Controlled Trial in Guinea-Bissau.
[So] Source:J Infect Dis;215(8):1188-1196, 2017 Apr 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Children in Guinea-Bissau receive measles vaccine (MV) at 9 months of age, but studies have shown that an additional dose before 9 months of age might have beneficial nonspecific effects. Within a randomized trial designed to examine nonspecific effects of early MV receipt on mortality, we conducted a substudy to investigate the effect of early MV receipt on morbidity. Methods: Children were randomly assigned at a ratio of 2:1 to receive 2 doses of MV at 18 weeks and age 9 months (intervention group) or 1 dose of MV at age 9 months, in accordance with current practice (control group). Children were visited weekly from enrollment to age 9 months; the mother reported morbidity, and the field assistants examined the children. Using Cox and binomial regression models, we compared the 2 randomization groups. Results: Among the 1592 children, early measles vaccination was not associated with a higher risk of the well-known adverse events of fever, rash, and convulsions within the first 14 days. From 15 days after randomization to age 9 months, early measles vaccination was associated with reductions in maternally reported diarrhea (hazard ratio [HR], 0.89; 95% confidence interval [CI], .82-.97), vomiting (HR, 0.86; 95% CI, .75-.98), and fever (HR, 0.93; 95% CI, .87-1.00). Conclusion: Early MV receipt was associated with reduced general morbidity in the following months, supporting that early MV receipt may improve the general health of children.
[Mh] Termos MeSH primário: Diarreia/epidemiologia
Imunidade Heteróloga
Vacina contra Sarampo/administração & dosagem
Sarampo/prevenção & controle
Vômito/epidemiologia
[Mh] Termos MeSH secundário: Feminino
Guiné-Bissau/epidemiologia
Visita Domiciliar/estatística & dados numéricos
Seres Humanos
Esquemas de Imunização
Lactente
Masculino
Morbidade
Modelos de Riscos Proporcionais
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Measles Vaccine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jiw512



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