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[PMID]:28455169
[Au] Autor:Lee BY; Wedlock PT; Haidari LA; Elder K; Potet J; Manring R; Connor DL; Spiker ML; Bonner K; Rangarajan A; Hunyh D; Brown ST
[Ad] Endereço:HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, United States; Global Obesity Prevention Center (GOPC) at Johns Hopkins University, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: brucelee@jhu.edu.
[Ti] Título:Economic impact of thermostable vaccines.
[So] Source:Vaccine;35(23):3135-3142, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: While our previous work has shown that replacing existing vaccines with thermostable vaccines can relieve bottlenecks in vaccine supply chains and thus increase vaccine availability, the question remains whether this benefit would outweigh the additional cost of thermostable formulations. METHODS: Using HERMES simulation models of the vaccine supply chains for the Republic of Benin, the state of Bihar (India), and Niger, we simulated replacing different existing vaccines with thermostable formulations and determined the resulting clinical and economic impact. Costs measured included the costs of vaccines, logistics, and disease outcomes averted. RESULTS: Replacing a particular vaccine with a thermostable version yielded cost savings in many cases even when charging a price premium (two or three times the current vaccine price). For example, replacing the current pentavalent vaccine with a thermostable version without increasing the vaccine price saved from $366 to $10,945 per 100 members of the vaccine's target population. Doubling the vaccine price still resulted in cost savings that ranged from $300 to $10,706, and tripling the vaccine price resulted in cost savings from $234 to $10,468. As another example, a thermostable rotavirus vaccine (RV) at its current (year) price saved between $131 and $1065. Doubling and tripling the thermostable rotavirus price resulted in cost savings ranging from $102 to $936 and $73 to $808, respectively. Switching to thermostable formulations was highly cost-effective or cost-effective in most scenarios explored. CONCLUSION: Medical cost and productivity savings could outweigh even significant price premiums charged for thermostable formulations of vaccines, providing support for their use.
[Mh] Termos MeSH primário: Vacinas contra Rotavirus/economia
Vacinas contra Rotavirus/provisão & distribuição
Potência de Vacina
[Mh] Termos MeSH secundário: Benin/epidemiologia
Simulação por Computador
Análise Custo-Benefício
Seres Humanos
Índia/epidemiologia
Lactente
Níger/epidemiologia
Infecções por Rotavirus/epidemiologia
Infecções por Rotavirus/prevenção & controle
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Rotavirus Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:27776521
[Au] Autor:Denoeud-Ndam L; Dicko A; Baudin E; Guindo O; Grandesso F; Diawara H; Sissoko S; Sanogo K; Traoré S; Keita S; Barry A; de Smet M; Lasry E; Smit M; Wiesner L; Barnes KI; Djimde AA; Guerin PJ; Grais RF; Doumbo OK; Etard JF
[Ad] Endereço:Epicentre, Paris, France. lise.denoeud@epicentre.msf.org.
[Ti] Título:Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger.
[So] Source:BMC Med;14(1):167, 2016 10 24.
[Is] ISSN:1741-7015
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties of antimalarial drugs in this vulnerable population. We assessed artemether-lumefantrine (AL) clinical efficacy in children with SAM compared to those without. METHODS: Children under 5 years of age with uncomplicated P. falciparum malaria were enrolled between November 2013 and January 2015 in Mali and Niger, one third with uncomplicated SAM and two thirds without. AL was administered under direct observation with a fat intake consisting of ready-to-use therapeutic food (RUTF - Plumpy'Nut®) in SAM children, twice daily during 3 days. Children were followed for 42 days, with PCR-corrected adequate clinical and parasitological response (ACPR) at day 28 as the primary outcome. Lumefantrine concentrations were assessed in a subset of participants at different time points, including systematic measurements on day 7. RESULTS: A total of 399 children (360 in Mali and 39 in Niger) were enrolled. Children with SAM were younger than their non-SAM counterparts (mean 17 vs. 28 months, P < 0.0001). PCR-corrected ACPR was 100 % (95 % CI, 96.8-100 %) in SAM at both day 28 and 42, versus 98.8 % (96.4-99.7 %) at day 28 and 98.3 % (95.6-99.4 %) at day 42 in non-SAM (P = 0.236 and 0.168, respectively). Compared to younger children, children older than 21 months experienced more reinfections and SAM was associated with a greater risk of reinfection until day 28 (adjusted hazard ratio = 2.10 (1.04-4.22), P = 0.038). Day 7 lumefantrine concentrations were significantly lower in SAM than non-SAM (median 251 vs. 365 ng/mL, P = 0.049). CONCLUSIONS: This study shows comparable therapeutic efficacy of AL in children without SAM and in those with SAM when given in combination with RUTF, but a higher risk of reinfection in older children suffering from SAM. This could be associated with poorer exposure to the antimalarials as documented by a lower lumefantrine concentration on day 7. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01958905 , registration date: October 7, 2013.
[Mh] Termos MeSH primário: Antimaláricos/farmacocinética
Artemisininas/farmacocinética
Etanolaminas/farmacocinética
Fluorenos/farmacocinética
Malária Falciparum/tratamento farmacológico
Desnutrição Aguda Grave/metabolismo
[Mh] Termos MeSH secundário: Antimaláricos/administração & dosagem
Artemisininas/administração & dosagem
Pré-Escolar
Combinação de Medicamentos
Etanolaminas/administração & dosagem
Feminino
Fluorenos/administração & dosagem
Seres Humanos
Lactente
Malária Falciparum/metabolismo
Masculino
Mali
Níger
Desnutrição Aguda Grave/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 0 (Drug Combinations); 0 (Ethanolamines); 0 (Fluorenes); 0 (artemether-lumefantrine combination)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180127
[Lr] Data última revisão:
180127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:29028166
[Ti] Título:Continuing risk of meningitis due to Neisseria meningitidis serogroup C in Africa: revised recommendations from a WHO expert consultation.
[Ti] Título:Risque persistant de méningite due à Neisseria meningitidis sérogroupe C en Afrique: recommandations révisées à l'issue d'une consultation d'experts de l'OMS..
[So] Source:Wkly Epidemiol Rec;92(41):612-7, 2017 10 13.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Meningite Meningocócica/epidemiologia
Meningite Meningocócica/microbiologia
Neisseria meningitidis Sorogrupo C
[Mh] Termos MeSH secundário: Comitês Consultivos
África/epidemiologia
Antibacterianos/uso terapêutico
Benin/epidemiologia
Burkina Faso/epidemiologia
Ciprofloxacino/uso terapêutico
Epidemias
Seres Humanos
Mali/epidemiologia
Meningite Meningocócica/tratamento farmacológico
Meningite Meningocócica/prevenção & controle
Níger/epidemiologia
Nigéria/epidemiologia
Vigilância da População
Risco
Vacinação
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:28982133
[Au] Autor:Brindle E; Lillis L; Barney R; Hess SY; Wessells KR; Ouédraogo CT; Stinca S; Kalnoky M; Peck R; Tyler A; Lyman C; Boyle DS
[Ad] Endereço:Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, United States of America.
[Ti] Título:Simultaneous assessment of iodine, iron, vitamin A, malarial antigenemia, and inflammation status biomarkers via a multiplex immunoassay method on a population of pregnant women from Niger.
[So] Source:PLoS One;12(10):e0185868, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deficiencies of vitamin A, iron, and iodine are major public health concerns in many low- and middle-income countries, but information on their status in populations is often lacking due to high costs and logistical challenges associated with assessing micronutrient status. Accurate, user-friendly, and low-cost analytical tools are needed to allow large-scale population surveys on micronutrient status. We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: α-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II. Assay performance was assessed using international reference standards and then verified by comparing the multiplexed and conventional immunoassay results on a training panel of plasma samples collected from US adults. These data were used to assign nominal concentrations to the calibrators of the assay to further improve performance which was then assessed by interrogating plasma samples from a cohort of pregnant women from Niger. The correlation between assays for each biomarker measured from this cohort was typically good, with the exception of thyroglobulin, and the sensitivity ranged from 74% to 93%, and specificity from 81% to 98%. The 7-Plex micronutrient assay has the potential for use as an affordable tool for population surveillance of vitamin A, iron, and iodine deficiencies as well as falciparum malarial parasitemia infectivity and inflammation. The assay is easy-to-use, requires minimal sample volume, and is scalable, rapid, and accurate-needing only a low-cost reader and basic equipment present in most reference laboratory settings and so may be employed by low and middle income countries for micronutrient surveillance to inform on status in key populations. Micronutrient deficiencies including iron, iodine, and vitamin A affect a significant portion of the world's population. Efforts to assess the prevalence of these deficiencies in vulnerable populations are challenging, partly due to measurement tools that are inadequate for assessing multiple micronutrients in large-scale population surveys. We have developed a 7-plex immunoassay for the simultaneous measurement of seven biomarkers relevant to assessing iodine, iron, and vitamin A status, inflammation and Plasmodium falciparum parasitemia by measuring levels of thyroglobulin, ferritin, soluble transferrin receptor, retinol binding protein 4, α-1-acid glycoprotein, C-reactive protein, and histidine-rich protein II. This 7-plex immunoassay technique has potential as a rapid and effective tool for use in large-scale surveys and assessments of nutrition intervention programs in low- and middle-income countries.
[Mh] Termos MeSH primário: Antígenos de Protozoários/sangue
Biomarcadores/sangue
Imunoensaio/métodos
Iodo/sangue
Ferro/sangue
Plasmodium falciparum/imunologia
Vitamina A/sangue
[Mh] Termos MeSH secundário: Estudos de Coortes
Feminino
Seres Humanos
Níger
Gravidez
Curva ROC
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (Biomarkers); 11103-57-4 (Vitamin A); 9679TC07X4 (Iodine); E1UOL152H7 (Iron)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185868


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[PMID]:28722569
[Au] Autor:O'Brien KS; Cotter SY; Amza A; Kadri B; Nassirou B; Stoller NE; Zhou Z; Cotter C; West SK; Bailey RL; Rosenthal PJ; Gaynor BD; Porco TC; Lietman TM
[Ad] Endereço:Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California.
[Ti] Título:Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial.
[So] Source:Am J Trop Med Hyg;97(3):696-701, 2017 Sep.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies designed to determine the effects of mass administration of azithromycin on trachoma have suggested that mass azithromycin distributions may also reduce the prevalence of malaria. These studies have typically examined the impact of a small number of treatments over short durations. In this prespecified substudy of a cluster-randomized trial for trachoma, we compared malaria parasitemia prevalence in 24 communities in Niger randomized to receive either annual or biannual mass azithromycin distributions over 3 years. The 12 communities randomized to annual azithromycin received three treatments during the high-transmission season, and the 12 communities randomized to biannual azithromycin received a total of six treatments: three during the high-transmission season and three during the low-transmission season. Blood samples were taken to assess malariometric indices among children in all study communities at a single time point during the high-transmission season after 3 years of the intervention. No significant differences were identified in malaria parasitemia, parasite density, or hemoglobin concentration between the annual and biannual treatment arms. When compared with annual mass azithromycin alone, additional mass azithromycin distributions given during the low-transmission season did not significantly reduce the subsequent prevalence of malaria parasitemia or parasite density after 3 years, as measured during the high-transmission season.
[Mh] Termos MeSH primário: Azitromicina/administração & dosagem
Azitromicina/uso terapêutico
Malária/prevenção & controle
Parasitemia/tratamento farmacológico
Tracoma/prevenção & controle
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Antibacterianos/uso terapêutico
Feminino
Seres Humanos
Lactente
Malária/sangue
Malária/epidemiologia
Masculino
Níger/epidemiologia
Parasitemia/sangue
Tracoma/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 83905-01-5 (Azithromycin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0487


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[PMID]:28328346
[Au] Autor:Isanaka S; Guindo O; Langendorf C; Matar Seck A; Plikaytis BD; Sayinzoga-Makombe N; McNeal MM; Meyer N; Adehossi E; Djibo A; Jochum B; Grais RF
[Ad] Endereço:From the Department of Research, Epicentre, Paris (S.I., C.L., R.F.G.); the Departments of Nutrition and Global Health and Population, Harvard T.H. Chan School of Public Health, Boston (S.I.); Epicentre (O.G., A.M.S., N.S.-M.), National Hospital (E.A.), and University of Niamey (A.D.), Niamey, Niger
[Ti] Título:Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger.
[So] Source:N Engl J Med;376(12):1121-1130, 2017 03 23.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Each year, rotavirus gastroenteritis is responsible for about 37% of deaths from diarrhea among children younger than 5 years of age worldwide, with a disproportionate effect in sub-Saharan Africa. METHODS: We conducted a randomized, placebo-controlled trial in Niger to evaluate the efficacy of a live, oral bovine rotavirus pentavalent vaccine (BRV-PV, Serum Institute of India) to prevent severe rotavirus gastroenteritis. Healthy infants received three doses of the vaccine or placebo at 6, 10, and 14 weeks of age. Episodes of gastroenteritis were assessed through active and passive surveillance and were graded on the basis of the score on the Vesikari scale (which ranges from 0 to 20, with higher scores indicating more severe disease). The primary end point was the efficacy of three doses of vaccine as compared with placebo against a first episode of laboratory-confirmed severe rotavirus gastroenteritis (Vesikari score, ≥11) beginning 28 days after dose 3. RESULTS: Among the 3508 infants who were included in the per-protocol efficacy analysis, there were 31 cases of severe rotavirus gastroenteritis in the vaccine group and 87 cases in the placebo group (2.14 and 6.44 cases per 100 person-years, respectively), for a vaccine efficacy of 66.7% (95% confidence interval [CI], 49.9 to 77.9). Similar efficacy was seen in the intention-to-treat analyses, which showed a vaccine efficacy of 69.1% (95% CI, 55.0 to 78.7). There was no significant between-group difference in the risk of adverse events, which were reported in 68.7% of the infants in the vaccine group and in 67.2% of those in the placebo group, or in the risk of serious adverse events (in 8.3% in the vaccine group and in 9.1% in the placebo group); there were 27 deaths in the vaccine group and 22 in the placebo group. None of the infants had confirmed intussusception. CONCLUSIONS: Three doses of BRV-PV, an oral rotavirus vaccine, had an efficacy of 66.7% against severe rotavirus gastroenteritis among infants in Niger. (Funded by Médecins sans Frontières Operational Center and the Kavli Foundation; ClinicalTrials.gov number, NCT02145000 .).
[Mh] Termos MeSH primário: Gastroenterite/prevenção & controle
Infecções por Rotavirus/prevenção & controle
Vacinas contra Rotavirus
[Mh] Termos MeSH secundário: Administração Oral
Animais
Bovinos
Fezes/virologia
Feminino
Gastroenterite/epidemiologia
Gastroenterite/virologia
Seres Humanos
Incidência
Lactente
Estimativa de Kaplan-Meier
Masculino
Níger
Rotavirus/isolamento & purificação
Vacinas contra Rotavirus/efeitos adversos
Vacinas contra Rotavirus/economia
Vacinas Atenuadas
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE III; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Rotavirus Vaccines); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170323
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1609462


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[PMID]:28321680
[Au] Autor:Ifelebuegu AO; Ukpebor JE; Ahukannah AU; Nnadi EO; Theophilus SC
[Ad] Endereço:School of Energy, Construction and Environment, Coventry University, Coventry, CV1 5FB, UK. A.Ifelebuegu@coventry.ac.uk.
[Ti] Título:Environmental effects of crude oil spill on the physicochemical and hydrobiological characteristics of the Nun River, Niger Delta.
[So] Source:Environ Monit Assess;189(4):173, 2017 Apr.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Oil spill pollution has remained a source of several international litigations in the Niger Delta region of Nigeria. In this paper, we examined the impacts of small recurrent crude oil spills on the physicochemical, microbial and hydrobiological properties of the Nun River, a primary source of drinking water, food and recreational activities for communities in the region. Samples were collected from six sampling points along the stretch of the lower Nun River over a 3-week period. Temperature, pH salinity, turbidity, total suspended solids, total dissolved solids, dissolved oxygen, phosphate, nitrate, heavy metals, BTEX, PAHs and microbial and plankton contents were assessed to ascertain the quality and level of deterioration of the river. The results obtained were compared with the baseline data from studies, national and international standards. The results of the physicochemical parameters indicated a significant deterioration of the river quality due to oil production activities. Turbidity, TDS, TSS, DO, conductivity and heavy metals (Cd, Cr, Cu, Pb, Ni and Zn) were in breach of the national and international limits for drinking water aquatic health. They were also significantly higher than the initial baseline conditions of the river. Also, there were noticeable changes in the phytoplankton, zooplankton and microbial diversities due to oil pollution across the sampling zones.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Poluição por Petróleo
Petróleo/análise
Rios/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental/métodos
Metais Pesados/análise
Níger
Nigéria
Plâncton
Salinidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Petroleum); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5882-x


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[PMID]:28295033
[Au] Autor:Ousseini IS; Bakasso Y; Kane NA; Couderc M; Zekraoui L; Mariac C; Manicacci D; Rhoné B; Barnaud A; Berthouly-Salazar C; Assoumane A; Moussa D; Moussa T; Vigouroux Y
[Ad] Endereço:Institut de Recherche pour le Développement, Montpellier, France.
[Ti] Título:Myosin XI is associated with fitness and adaptation to aridity in wild pearl millet.
[So] Source:Heredity (Edinb);119(2):88-94, 2017 Aug.
[Is] ISSN:1365-2540
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phenotypic changes in plants can be observed along many environmental gradients and are determined by both environmental and genetic factors. The identification of alleles associated with phenotypic variations is a rapidly developing area of research. We studied the genetic basis of phenotypic variations in 11 populations of wild pearl millet (Pennisetum glaucum) on two North-South aridity gradients, one in Niger and one in Mali. Most of the 11 phenotypic traits assessed in a common garden experiment varied between the populations studied. Moreover, the size of the inflorescence, the number of flowers and aboveground dry mass co-varied positively with a decrease in rainfall. To decipher the genetic basis of these phenotypes, we used an association mapping strategy with a mixed model. We found two SNPs on the same myosin XI contig significantly associated with variations in the average number of flowers. Both the allele frequency of the two SNPs and the average number of flowers co-varied with the rainfall gradient on the two gradients. Interestingly, this gene was also a target of selection during domestication. The Myosin XI gene is thus a good candidate for fitness-related adaptation in wild populations.
[Mh] Termos MeSH primário: Adaptação Fisiológica/genética
Aptidão Genética
Miosinas/genética
Pennisetum/genética
[Mh] Termos MeSH secundário: Alelos
Clima
Frequência do Gene
Estudos de Associação Genética
Genética Populacional
Genótipo
Mali
Níger
Pennisetum/fisiologia
Fenótipo
Proteínas de Plantas/genética
Polimorfismo de Nucleotídeo Único
Chuvas
Água/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 059QF0KO0R (Water); EC 3.6.4.1 (Myosins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1038/hdy.2017.13


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[PMID]:28188551
[Au] Autor:Ejike CE; Eferibe CO; Okonkwo FO
[Ad] Endereço:Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University Ndufu-Alike, Ikwo, PMB 1010, Abakaliki, Ebonyi State, Nigeria. nonsoejikeecc@yahoo.com.
[Ti] Título:Concentrations of some heavy metals in underground water samples from a Nigerian crude oil producing community.
[So] Source:Environ Sci Pollut Res Int;24(9):8436-8442, 2017 Mar.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pollution due to oil exploration activities in the Niger Delta region of Nigeria and government under-investments in potable water infrastructure has led to the dependence of the population on personal boreholes. Yet, there are little quality or surveillance reports on such waters. The concentrations of heavy metals in underground water samples from an oil producing area, Umuebulu, in the Niger Delta were therefore investigated. Water samples were collected from three test points, each approximately 300 m from (1) wellhead area (WHA), (2) flare area (FA) and (3) effluent discharge area (EDA), and one control point located 10 km away from any oil-related activity. The concentrations of lead, arsenic and cadmium were determined in the samples using atomic absorption spectrophotometry. All three heavy metals were present in the test, and control water samples at concentrations significantly (P < 0.05) exceeding the maximum contaminant levels recommended by the World Health Organization. The total hazard index of the water samples showed that their consumption constituted significant health risks in the order EDA > FA > WHA > Control. Appropriate water treatment and surveillance is warranted and therefore recommended for underground water resources of the studied community.
[Mh] Termos MeSH primário: Água Subterrânea/química
Metais Pesados/análise
Indústria de Petróleo e Gás
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Arsênico/análise
Cádmio/análise
Monitoramento Ambiental
Poluição Ambiental
Níger
Nigéria
Espectrofotometria Atômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Water Pollutants, Chemical); 00BH33GNGH (Cadmium); N712M78A8G (Arsenic)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8524-5


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[PMID]:28140615
[Au] Autor:Heller A; Hannig A
[Ad] Endereço:a Department of Anthropology , University of Maryland at College Park , College Park , MD , USA.
[Ti] Título:Unsettling the fistula narrative: cultural pathology, biomedical redemption, and inequities of health access in Niger and Ethiopia.
[So] Source:Anthropol Med;24(1):81-95, 2017 Apr.
[Is] ISSN:1469-2910
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Obstetric fistula, a maternal childbirth injury that results in chronic incontinence, affects an estimated one million women in the global south. In the course of media and donor coverage on this condition, fistula sufferers have been branded as 'child brides' who, following the onset of their incontinence, become social pariahs and eventually find physical and social redemption through surgical repair. This narrative framing pits the violence of 'culture' against the potency of biomedical salvation. Based on over two years of ethnographic research at fistula repair centres in Niger and Ethiopia, this paper challenges this narrative and argues that most women with obstetric fistula remain embedded in social relations, receive continued familial support, and, unexpectedly, experience ambiguous surgical outcomes. This paper interrogates the existing logics of the fistula narrative that have had the unintended effects of obscuring global structural inequalities and diverting attention away from systemic health access reforms.
[Mh] Termos MeSH primário: Acesso aos Serviços de Saúde
Disparidades em Assistência à Saúde
Complicações do Trabalho de Parto/etnologia
Incontinência Urinária/etnologia
Fístula Vaginal/etnologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antropologia Médica
Etiópia
Feminino
Reforma dos Serviços de Saúde
Seres Humanos
Masculino
Níger
Complicações do Trabalho de Parto/psicologia
Complicações do Trabalho de Parto/cirurgia
Gravidez
Autocuidado/psicologia
Apoio Social
Fatores Socioeconômicos
Resultado do Tratamento
Incontinência Urinária/etiologia
Incontinência Urinária/psicologia
Incontinência Urinária/cirurgia
Fístula Vaginal/etiologia
Fístula Vaginal/psicologia
Fístula Vaginal/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1080/13648470.2016.1249252



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