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[PMID]:28747198
[Au] Autor:Harding-Esch EM; Kadimpeul J; Sarr B; Sane A; Badji S; Laye M; Sillah A; Burr SE; MacLeod D; Last AR; Holland MJ; Mabey DC; Bailey RL
[Ad] Endereço:Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK. eharding@sgul.ac.uk.
[Ti] Título:Population-based prevalence survey of follicular trachoma and trachomatous trichiasis in the Casamance region of Senegal.
[So] Source:BMC Public Health;18(1):62, 2017 07 26.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Trachoma, caused by ocular infection with Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. We conducted the first population-based trachoma prevalence survey in the Casamance region of Senegal to enable the Senegalese National Eye Care Programme (NECP) to plan its trachoma control activities. The World Health Organization (WHO) guidelines state that any individual with trachomatous trichiasis (TT) should be offered surgery, but that surgery should be prioritised where the prevalence is >0.1%, and that districts and communities with a trachomatous inflammation, follicular (TF) prevalence of ≥10% in 1-9 year-olds should receive mass antibiotic treatment annually for a minimum of three years, along with hygiene promotion and environmental improvement, before re-assessing the prevalence to determine whether treatment can be discontinued (when TF prevalence in 1-9 year-olds falls <5%). METHODS: Local healthcare workers conducted a population-based household survey in four districts of the Bignona Department of Casamance region to estimate the prevalence of TF in 1-9 year-olds, and TT in ≥15 year-olds. Children's facial cleanliness (ocular and/or nasal discharge, dirt on the face, flies on the face) was measured at time of examination. Risk factor questionnaires were completed at the household level. RESULTS: Sixty communities participated with a total censused population of 5580 individuals. The cluster-, age- and sex-adjusted estimated prevalence of TF in 1-9 year-olds was 2.5% (95% Confidence Interval (CI) 1.8-3.6) (38/1425) at the regional level and <5% in all districts, although the upper 95%CI exceeded 5% in all but one district. The prevalence of TT in those aged ≥15 years was estimated to be 1.4% (95%CI 1.0-1.9) (40/2744) at the regional level and >1% in all districts. CONCLUSION: With a prevalence <5%, TF does not appear to be a significant public health problem in this region. However, TF monitoring and surveillance at sub-district level will be required to ensure that elimination targets are sustained and that TF does not re-emerge as a public health problem. TT surgery remains the priority for trachoma elimination efforts in the region, with an estimated 1819 TT surgeries to conduct.
[Mh] Termos MeSH primário: Tracoma/epidemiologia
Triquíase/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Antibacterianos/uso terapêutico
Criança
Pré-Escolar
Estudos Transversais
Esquema de Medicação
Feminino
Promoção da Saúde
Seres Humanos
Lactente
Recém-Nascido
Masculino
Prevalência
Saúde Pública
Fatores de Risco
Senegal/epidemiologia
Tracoma/tratamento farmacológico
Triquíase/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180304
[Lr] Data última revisão:
180304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4605-0


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[PMID]:28450175
[Au] Autor:Madamet M; Kounta MB; Wade KA; Lo G; Diawara S; Fall M; Bercion R; Nakoulima A; Fall KB; Benoit N; Gueye MW; Fall B; Diatta B; Pradines B
[Ad] Endereço:Unité de parasitologie et d'entomologie, Département des maladies infectieuses, Institut de recherche biomédicale des armées, Marseille, France; Aix-Marseille Université, Unité de recherche sur les maladies infectieuses et tropicales emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, Marse
[Ti] Título:Absence of association between polymorphisms in the K13 gene and the presence of Plasmodium falciparum parasites at day 3 after treatment with artemisinin derivatives in Senegal.
[So] Source:Int J Antimicrob Agents;49(6):754-756, 2017 Jun.
[Is] ISSN:1872-7913
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy as first-line treatment for uncomplicated malaria. In addition, intravenous (i.v.) injection of artesunate and artemether has gradually replaced quinine for the treatment of severe malaria. Mutations in the propeller domain of the Kelch 13 gene (K13-propeller, PF3D71343700), such as Y493H, R539T, I543T and C580Y, were recently associated with in vivo and in vitro resistance to artemisinin in Southeast Asia. However, these mutations were not identified in Africa. In total, 181 isolates of Plasmodium falciparum from 161 patients from Dakar, Senegal, were collected between August 2015 and January 2016. The K13-propeller gene of the isolates was sequenced. A search for non-synonymous mutations in the propeller region of K13 was performed in the 181 isolates collected from Dakar from 2015 to 2016. Three synonymous mutations were detected (D464D, C469C and R471R). Of 119 patients treated with i.v. artesunate or intramuscular artemether followed by artemether/lumefantrine, 9 patients were still parasitaemic on Day 3. Parasites from these nine patients were wild-type for K13-propeller. None of the polymorphisms known to be involved in artemisinin resistance in Asia were detected. These results suggest that K13 is not the best predictive marker for artemisinin resistance in Africa. More isolates from clinical failure cases or patients with delayed parasite clearance after treatment with artemisinin derivatives are necessary to identify new molecular markers.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Artemisininas/uso terapêutico
Malária Falciparum/tratamento farmacológico
Malária Falciparum/parasitologia
Plasmodium falciparum/efeitos dos fármacos
Polimorfismo Genético
Proteínas de Protozoários/genética
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Mutação de Sentido Incorreto
Plasmodium falciparum/genética
Plasmodium falciparum/isolamento & purificação
Mutação Puntual
Senegal
Análise de Sequência de DNA
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 0 (Protozoan Proteins); 9RMU91N5K2 (artemisinine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29296143
[Au] Autor:Mbengue MAS; Mboup A; Ly ID; Faye A; Camara FBN; Thiam M; Ndiaye BP; Dieye TN; Mboup S
[Ad] Endereço:Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formations (IRESSEF).
[Ti] Título:Vaccination coverage and immunization timeliness among children aged 12-23 months in Senegal: a Kaplan-Meier and Cox regression analysis approach.
[So] Source:Pan Afr Med J;27(Suppl 3):8, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: Expanded programme on immunizations in resource-limited settings currently measure vaccination coverage defined as the proportion of children aged 12-23 months that have completed their vaccination. However, this indicator does not address the important question of when the scheduled vaccines were administered. We assessed the determinants of timely immunization to help the national EPI program manage vaccine-preventable diseases and impact positively on child survival in Senegal. Methods: Vaccination data were obtained from the Demographic and Health Survey (DHS) carried out across the 14 regions in the country. Children were aged between 12-23 months. The assessment of vaccination coverage was done with the health card and/or by the mother's recall of the vaccination act. For each vaccine, an assessment of delay in age-appropriate vaccination was done following WHO recommendations. Additionally, Kaplan-Meier survival function was used to estimate the proportion vaccinated by age and cox-proportional hazards models were used to examine risk factors for delays. Results: A total of 2444 living children between 12-23 months of age were included in the analysis. The country vaccination was below the WHO recommended coverage level and, there was a gap in timeliness of children immunization. While BCG vaccine uptake was over 95%, coverage decreased with increasing number of Pentavalent vaccine doses (Penta 1: 95.6%, Penta 2: 93.5%: Penta 3: 89.2%). Median delay for BCG was 1.7 weeks. For polio at birth, the median delay was 5 days; all other vaccine doses had median delays of 2-4 weeks. For Penta 1 and Penta 3, 23.5% and 15.7% were given late respectively. A quarter of measles vaccines were not administered or were scheduled after the recommended age. Vaccinations that were not administered within the recommended age ranges were associated with mothers' poor education level, multiple siblings, low socio-economic status and living in rural areas. Conclusion: A significant delay in receipt of infant vaccines is found in Senegal while vaccine coverage is suboptimal. The national expanded program on immunization should consider measuring age at immunization or using seroepidemiological data to better monitor its impact.
[Mh] Termos MeSH primário: Esquemas de Imunização
Cobertura Vacinal/estatística & dados numéricos
Vacinação/estatística & dados numéricos
Vacinas/administração & dosagem
[Mh] Termos MeSH secundário: Fatores Etários
Feminino
Seres Humanos
Programas de Imunização
Lactente
Estimativa de Kaplan-Meier
Masculino
Modelos de Riscos Proporcionais
Senegal
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.supp.2017.27.3.11534


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[PMID]:29281634
[Au] Autor:Bassène MD; Seck MT; Pagabeleguem S; Fall AG; Sall B; Vreysen MJB; Gimonneau G; Bouyer J
[Ad] Endereço:Institut Sénégalais de Recherches Agricoles, Laboratoire National d'Elevage et de Recherches Vétérinaires, Dakar-Hann, Sénégal.
[Ti] Título:Competitiveness and survival of two strains of Glossina palpalis gambiensis in an urban area of Senegal.
[So] Source:PLoS Negl Trop Dis;11(12):e0006172, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In the Niayes area, located in the west of Senegal, only one tsetse species, Glossina palpalis gambiensis Vanderplank (Diptera: Glossinidae) was present. The Government of Senegal initiated and implemented an elimination programme in this area that included a sterile insect technique (SIT) component. The G. p. gambiensis strain (BKF) mass-reared at the Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES) in Burkina Faso was used for the SIT component. METHODOLOGY/PRINCIPAL FINDINGS: Studies conducted in 2011 in four localities in the Niayes area (Pout, Sébikotane, Diacksao Peul and the Parc de Hann) showed that the BKF strain demonstrated inferior survival in the ecosystem of the Parc de Hann, a forested area in the city centre of the capital Dakar. Therefore, G. p. gambiensis flies from the Niayes area (SEN strain) were colonized. Here we compared the competitiveness and survival of the two strains (BKF and SEN) in the Parc de Hann. Released sterile males of the SEN colony showed a daily mortality rate of 0.08 (SD 0.08) as compared with 0.14 (SD 0.08) for the BKF flies but the difference was not significant (p-value = 0.14). However, the competitiveness of the SEN males was lower (0.14 (SD 0.10)) as compared with that of the BKF males (0.76 (SD 0.11)) (p-value < 10-3). CONCLUSIONS/SIGNIFICANCE: Based on the results of this study, it can be concluded that the BKF strain will remain the main strain to be used in the elimination programme. Despite the slightly longer survival of the SEN males in the Parc de Hann, the superior competitiveness of the BKF males is deemed more important for the SIT component, as their shorter survival rates can be easily compensated for by more frequent fly releases.
[Mh] Termos MeSH primário: Agentes de Controle Biológico
Infertilidade Masculina/genética
Controle de Insetos/métodos
Moscas Tsé-Tsé/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Feminino
Insetos Vetores/crescimento & desenvolvimento
Insetos Vetores/virologia
Masculino
Senegal
Moscas Tsé-Tsé/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biological Control Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006172


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[PMID]:27776500
[Au] Autor:Deribew A; Ojal J; Karia B; Bauni E; Oteinde M
[Ad] Endereço:KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. amare.deribew@gmail.com.
[Ti] Título:Under-five mortality rate variation between the Health and Demographic Surveillance System (HDSS) and Demographic and Health Survey (DHS) approaches.
[So] Source:BMC Public Health;16(1):1118, 2016 10 24.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several low and middle-income countries (LMIC) use Demographic and Health Surveys (DHS) and/or Health and Demographic Surveillance System (HDSS) to monitor the health of their population. The level and trends of under-five mortality rates could be different in the HDSS sites compared to the DHS reports. In this study, we investigated the change in under-five mortality rates overtime in the HDSS sites and the corresponding DHS reports in eight countries and 13 sites. METHODS: Under-five mortality rates in the HDSS sites were determined using number of under-five deaths (numerator) and live births (denominator). The trends and annualized rate of change (ARC) of under-five mortality rates in the HDSS sites and the DHS reports were compared by fitting exponential function. RESULTS: Under-five mortality rates declined substantially in most of the sites during the last 10-15 years. Ten out of 13 (77 %) HDSS sites have consistently lower under-five mortality rates than the DHS under-five mortality rates. In the Kilifi HDSS in Kenya, under-five mortality rate declined by 65.6 % between 2003 and 2014 with ARC of 12.2 % (95 % CI: 9.4-15.0). In the same period, the DHS under-five mortality rate in the Coastal region of Kenya declined by 50.8 % with ARC of 6 % (95 % CI: 2.0-9.0). The under-five mortality rate reduction in the Mlomp (78.1 %) and Niakhar (80.8 %) HDSS sites in Senegal during 1993-2012 was significantly higher than the mortality decline observed in the DHS report during the same period. On the other hand, the Kisumu HDSS in Kenya had lower under-five mortality reduction (15.8 %) compared to the mortality reduction observed in the DHS report (27.7 %) during 2003-2008. Under-five mortality rate rose by 27 % in the Agincourt HDSS in South Africa between 1998 to 2003 that was contrary to the 18 % under-five mortality reduction in the DHS report during the same period. CONCLUSIONS: The inconsistency between HDSS and DHS approaches could have global implication on the estimation of child mortality and ethical issues on mortality inequalities. Further studies should be conducted to investigate the reasons of child mortality variation between the HDSS and the DHS approaches.
[Mh] Termos MeSH primário: Mortalidade da Criança
Mortalidade Infantil
Vigilância da População/métodos
[Mh] Termos MeSH secundário: Mortalidade da Criança/tendências
Pré-Escolar
Países em Desenvolvimento
Feminino
Programas Governamentais
Inquéritos Epidemiológicos
Seres Humanos
Lactente
Mortalidade Infantil/tendências
Recém-Nascido
Quênia/epidemiologia
Masculino
Assistência Médica
Senegal/epidemiologia
Fatores Socioeconômicos
África do Sul/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29232377
[Au] Autor:Leslie HH; Sun Z; Kruk ME
[Ad] Endereço:Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
[Ti] Título:Association between infrastructure and observed quality of care in 4 healthcare services: A cross-sectional study of 4,300 facilities in 8 countries.
[So] Source:PLoS Med;14(12):e1002464, 2017 Dec.
[Is] ISSN:1549-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is increasingly apparent that access to healthcare without adequate quality of care is insufficient to improve population health outcomes. We assess whether the most commonly measured attribute of health facilities in low- and middle-income countries (LMICs)-the structural inputs to care-predicts the clinical quality of care provided to patients. METHODS AND FINDINGS: Service Provision Assessments are nationally representative health facility surveys conducted by the Demographic and Health Survey Program with support from the US Agency for International Development. These surveys assess health system capacity in LMICs. We drew data from assessments conducted in 8 countries between 2007 and 2015: Haiti, Kenya, Malawi, Namibia, Rwanda, Senegal, Tanzania, and Uganda. The surveys included an audit of facility infrastructure and direct observation of family planning, antenatal care (ANC), sick-child care, and (in 2 countries) labor and delivery. To measure structural inputs, we constructed indices that measured World Health Organization-recommended amenities, equipment, and medications in each service. For clinical quality, we used data from direct observations of care to calculate providers' adherence to evidence-based care guidelines. We assessed the correlation between these metrics and used spline models to test for the presence of a minimum input threshold associated with good clinical quality. Inclusion criteria were met by 32,531 observations of care in 4,354 facilities. Facilities demonstrated moderate levels of infrastructure, ranging from 0.63 of 1 in sick-child care to 0.75 of 1 for family planning on average. Adherence to evidence-based guidelines was low, with an average of 37% adherence in sick-child care, 46% in family planning, 60% in labor and delivery, and 61% in ANC. Correlation between infrastructure and evidence-based care was low (median 0.20, range from -0.03 for family planning in Senegal to 0.40 for ANC in Tanzania). Facilities with similar infrastructure scores delivered care of widely varying quality in each service. We did not detect a minimum level of infrastructure that was reliably associated with higher quality of care delivered in any service. These findings rely on cross-sectional data, preventing assessment of relationships between structural inputs and clinical quality over time; measurement error may attenuate the estimated associations. CONCLUSION: Inputs to care are poorly correlated with provision of evidence-based care in these 4 clinical services. Healthcare workers in well-equipped facilities often provided poor care and vice versa. While it is important to have strong infrastructure, it should not be used as a measure of quality. Insight into health system quality requires measurement of processes and outcomes of care.
[Mh] Termos MeSH primário: Serviços de Saúde da Criança/normas
Países em Desenvolvimento
Equipamentos e Provisões/provisão & distribuição
Instalações de Saúde
Pessoal de Saúde/educação
Admissão e Escalonamento de Pessoal/normas
Preparações Farmacêuticas/provisão & distribuição
Qualidade da Assistência à Saúde
Serviços de Saúde Reprodutiva/normas
[Mh] Termos MeSH secundário: Adulto
Criança
Estudos Transversais
Serviços de Planejamento Familiar/normas
Feminino
Fidelidade a Diretrizes
Haiti
Seres Humanos
Recém-Nascido
Quênia
Malaui
Serviços de Saúde Materna/normas
Namíbia
Guias de Prática Clínica como Assunto
Gravidez
Ruanda
Senegal
Tanzânia
Uganda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pmed.1002464


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[PMID]:29255566
[Au] Autor:Diedhiou M; Manyacka P; Dieng M; Tendeng JN; Diao ML; Thiam O; Tall H; Thiam I; Konaté I
[Ad] Endereço:Service d'Anesthésie-Réanimation, Centre Hospitalier Régional de Saint Louis, Sénégal.
[Ti] Título:[Feasibility and relevance of safety checklist in the central operating block at the Regional Medical Center, Saint Louis, Senegal].
[Ti] Título:Faisabilité et pertinence de la check-list de sécurité au bloc opératoire central du Centre Hospitalier Régional de Saint Louis du Sénégal..
[So] Source:Pan Afr Med J;28:96, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Introduction: Safety checklist (CL) in the operating block is a quality tool which allows to reduce perioperative morbidity and mortality. That is one of the French National Health Authority requirements for the certification procedure of healthcare institutions. This study aimed to conduct a quantitative and qualitative evaluation of the use of this tool in the central operating block at the Regional Medical Center in Saint Louis. Methods: A prospective evaluation of the indicators for monitoring the practical use of the checklist and the contribution to the improvement of surgical practices in the operating block at the Regional Medical Center in Saint Louis was initiated since the launch of this study in March 2016. Results: CL utilization rate was 75%, compliance rate was 60%; information rate was 99% for the pre-induction items, 93% for the pre-incision items and 88% for the postoperative items. Only 73% of analyzed CL were filled with an effective oral communication according to the three items. CL helped to detect hardware failures and/or adverse events in 15% of cases. No patient's identification or operated side error were objectified in our study. Conclusion: CL contributes in the development of the culture of patient's safety in the operating block and has led to the establishment of a risk mapping in the operating block. Nevertheless, while important, it shouldn't be considered a magic tool to avoid errors but integrated into the improvement in health care quality with other programs such as the reporting of adverse events and the the review of morbidity and mortality.
[Mh] Termos MeSH primário: Lista de Checagem
Erros Médicos/prevenção & controle
Salas Cirúrgicas/normas
Complicações Pós-Operatórias/prevenção & controle
[Mh] Termos MeSH secundário: Comunicação
Falha de Equipamento
Estudos de Viabilidade
Seres Humanos
Segurança do Paciente
Estudos Prospectivos
Senegal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.96.11428


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[PMID]:29230260
[Au] Autor:Bodian M; Thiaw A; Sarr SA; Babaka K; Aw F; Ngaïde AA; Ndiaye MB; Kane A; Jobe M; Mbaye A; Diao M; Sarr M; Ba SA
[Ad] Endereço:Service de Cardiologie, Centre Hospitalier Universitaire Aristide Le Dantec, Dakar, Sénégal.
[Ti] Título:[Epidemiological features of cardiorenal syndrome: a study of 36 cases in the Cardiology Department in Dakar].
[Ti] Título:Syndrome cardio-rénal: aspects épidémiologiques, à propos de 36 cas dans un service de cardiologie de Dakar..
[So] Source:Pan Afr Med J;28:58, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Introduction: Cardiorenal syndrome (CRS) is a pathophysiologic disorder of the heart and the kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. In Africa, particularly in Senegal, the incidence of cardiorenal syndrome is not accurately known. This study aimed to assess the prevalence of CRS in the Cardiology Department. Methods: We conducted a retrospective study including all patients with heart failure associated with alteration of renal function, hospitalized in the Cardiology Department between April 2010 and April 2011. Data were analyzed with the statistical software Epi-Info 3.5.3. Results: 36 patients were included in the study. The prevalence rate was 3.7% with male predominance (sex-ratio 1.77) and an average age of 56.9 years [30-92]. Patients' medical history was dominated by high blood pressure (52.77%) and diabetes (19.4%). The main etiologies were hypertensive cardiomyopathy (39%) and coronary heart disease (19.44%). The symptomatology was dominated by dyspnoea (69.4%) and edema (50%). 17 patients had anemia. The mean measured clearance (MDRD) was 46 ml/min. Doppler echocardiography showed mainly kinetic disorders (89.3%) and left ventricular systolic dysfunction (71%). The three renal ultrasound examinations were normal. Six deaths (16.7%) were recorded. Conclusion: Cardiorenal syndrome is a reality and marks a turning point in the evolution of heart and kidney diseases. In Senegal, its prevalence in the Cardiology Department is low. Prospective multicentric studies should be conducted in order to better evaluate this syndrome in Senegal.
[Mh] Termos MeSH primário: Síndrome Cardiorrenal/epidemiologia
Insuficiência Cardíaca/epidemiologia
Nefropatias/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Anemia/epidemiologia
Síndrome Cardiorrenal/fisiopatologia
Diabetes Mellitus/epidemiologia
Feminino
Insuficiência Cardíaca/fisiopatologia
Seres Humanos
Hipertensão/epidemiologia
Masculino
Meia-Idade
Prevalência
Estudos Retrospectivos
Senegal/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.58.10257


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[PMID]:29187941
[Au] Autor:Mohamed AS; Sagna A; Fall M; Ndoye NA; Mbaye PA; Fall AL; Diaby A; Ndour O; Ngom G
[Ad] Endereço:Centre de Santé des HLM de Dakar, Sénégal.
[Ti] Título:[Accidents of the everyday life (AcVC) in children in Dakar: about 201 cases].
[Ti] Título:Les accidents de la vie courante chez l'enfant à Dakar: à propos de 201 cas..
[So] Source:Pan Afr Med J;27:272, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Accidents of everyday life (AcVC) are common in children and can led to disabling injuries and death. This study aimed to analyze the epidemiological aspects of AcVC and the related injury mechanisms in Dakar. We conducted a descriptive, cross-sectional study conducted from 1 January 2013 to 30 June 2013. All the children victims of domestic accidents, sport and leisure accidents or school accidents were included. We studied some general parameters and some parameters related to each type of AcVC. Two hundred and one children were included, accounting for 27% of emergency consultations. There were 148 boys and 53 girls. Children less than 5 years of age were most affected (37.8%). Football and wrestling game were the main causes of AcVC. AcVC occur mainly at home (58.2%) and in the areas of sport and recreation (31.8%). The fractures predominated in the different types of AcVC: 54.9% of domestic accidents, 68.8% of sport and recreation accidents and 40% of school accidents. From an epidemiological perspective, our results are superimposable to literature. Fractures predominated contrary to literature where bruises were preponderant. Wrestling game is the main cause of these fractures, after football. The acquisition of knowledge about the epidemiological aspects of AcVC and the related injury mechanisms will allow for prevention campaigns in Dakar.
[Mh] Termos MeSH primário: Acidentes por Quedas/estatística & dados numéricos
Acidentes Domésticos/estatística & dados numéricos
Traumatismos em Atletas/epidemiologia
Fraturas Ósseas/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Criança
Pré-Escolar
Estudos Transversais
Serviço Hospitalar de Emergência/estatística & dados numéricos
Feminino
Fraturas Ósseas/etiologia
Hospitais Universitários
Seres Humanos
Lactente
Recém-Nascido
Masculino
Senegal/epidemiologia
Distribuição por Sexo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.272.6759


  10 / 5006 MEDLINE  
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[PMID]:29187931
[Au] Autor:Fall S; Dieng F; Diouf C; Djiba B; Ndao AC; Ndiaye FSD
[Ad] Endereço:Unité d'Hématologie Clinique de l'Hôpital Aristide Le Dantec, Dakar, Sénégal.
[Ti] Título:[Diagnostic and evolutionary profile of multiple myeloma in Senegal: monocentric study conducted from 2005 to 2016].
[Ti] Título:Profil diagnostique et évolutif du myélome multiple au Sénégal: étude monocentrique de 2005 à 2016..
[So] Source:Pan Afr Med J;27:262, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Introduction: Accessibility to innovative multiple myeloma therapies is limited in sub-Saharan Africa. This study aimed to describe the diagnostic and evolutionary features observed during treatment of our patients with myeloma. Methods: We conducted a retrospective, descriptive, analytical study (2005 - 2016) of patients with myeloma included in the study based on International Myeloma Working Group (IMWG) Criteria (2003,2014) at the Hopital Aristide Le Dantec (Senegal). Results: We collected data from 136 medical records (69 men, 67 women) of patients with an average age of 59 years ± 10.1 years, who were less than 65 years of age in 69.1% of cases. Tell-tale signs included bone pain (96.3%), renal failure (36.8%), infection (23.5%), pathological fracture (17.6%), spinal cord compression (16.9%) and malignant hypercalcaemia (16.2%). Isotopic antiglobulin test showed that anti-IgG could be detected in 61.3% of cases and Kappa in 65% of cases. Patients were classified stage III (59.4%) and I-II (40.6%)of the index staging system. The median survival of patients under conventional traitement (Méphalan-Prédnisone: 67.6%, innovative: 5.9%) was 20 months (1-78 months). Survival rates are better in the absence of neurological and infectious complications and for patients with score I-II of the index Staging System. Conclusion: In our study, multiple myeloma was frequently diagnosed before age 65, at advanced stage of tumor mass. Early detection and access to adequate therapies could improve overall survival.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Acesso aos Serviços de Saúde
Mieloma Múltiplo/terapia
[Mh] Termos MeSH secundário: Idoso
Anticorpos Anti-Idiotípicos/imunologia
Feminino
Seres Humanos
Masculino
Melfalan/administração & dosagem
Meia-Idade
Mieloma Múltiplo/diagnóstico
Mieloma Múltiplo/patologia
Estadiamento de Neoplasias
Prednisona/administração & dosagem
Estudos Retrospectivos
Senegal
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Anti-Idiotypic); 0 (anti-IgG); Q41OR9510P (Melphalan); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.262.13164



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