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  1 / 1156 MEDLINE  
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[PMID]:29462152
[Au] Autor:Treacy L; Bolkan HA; Sagbakken M
[Ad] Endereço:Department of Community Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway.
[Ti] Título:Distance, accessibility and costs. Decision-making during childbirth in rural Sierra Leone: A qualitative study.
[So] Source:PLoS One;13(2):e0188280, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sierra Leone has one of the highest maternal mortality ratios in the world. Efforts to reduce maternal mortality have included initiatives to encourage more women to deliver at health facilities. Despite the introduction of the free health care initiative for pregnant women, many women still continue to deliver at home, with few having access to a skilled birth attendant. In addition, inequalities between rural and urban areas in accessing and utilising health facilities persist. Further insight into how and why women make decisions around childbirth will help guide future plans and initiatives in improving maternal health in Sierra Leone. The objective of this study was to explore the perceptions and decision-making processes of women and their communities during childbirth in rural Sierra Leone. METHODS AND FINDINGS: Data were collected through seven focus group discussions and 22 in-depth interviews with recently pregnant women and their community members in two rural villages. Data were analysed using systematic text condensation. Findings revealed that decision-making processes during childbirth are dynamic, intricate and need to be understood within the broader social context that they take place. Factors such as distance and lack of transport, perceived negative behaviour of hospital staff, direct and indirect financial obstacles, as well as the position of women in society all interact and influence how and what decisions are made. CONCLUSIONS: Pregnant women face multiple interacting vulnerabilities that influence their healthcare-seeking decisions during pregnancy and childbirth. Future initiatives to improve access and utilisation of safe healthcare services for pregnant women need to be based on adequate knowledge of structural constraints and health inequities that affect women in rural Sierra Leone.
[Mh] Termos MeSH primário: Tomada de Decisões
Custos de Cuidados de Saúde
Acesso aos Serviços de Saúde
População Rural
[Mh] Termos MeSH secundário: Feminino
Grupos Focais
Seres Humanos
Masculino
Gravidez
Pesquisa Qualitativa
Serra Leoa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188280


  2 / 1156 MEDLINE  
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[PMID]:29298314
[Au] Autor:Nic Lochlainn LM; Gayton I; Theocharopoulos G; Edwards R; Danis K; Kremer R; Kleijer K; Tejan SM; Sankoh M; Jimissa A; Greig J; Caleo G
[Ad] Endereço:European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden.
[Ti] Título:Improving mapping for Ebola response through mobilising a local community with self-owned smartphones: Tonkolili District, Sierra Leone, January 2015.
[So] Source:PLoS One;13(1):e0189959, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: During the 2014-16 Ebola virus disease (EVD) outbreak, the Magburaka Ebola Management Centre (EMC) operated by Médecins Sans Frontières (MSF) in Tonkolili District, Sierra Leone, identified that available district maps lacked up-to-date village information to facilitate timely implementation of EVD control strategies. In January 2015, we undertook a survey in chiefdoms within the MSF EMC catchment area to collect mapping and village data. We explore the feasibility and cost to mobilise a local community for this survey, describe validation against existing mapping sources and use of the data to prioritise areas for interventions, and lessons learned. METHODS: We recruited local people with self-owned Android smartphones installed with open-source survey software (OpenDataKit (ODK)) and open-source navigation software (OpenStreetMap Automated Navigation Directions (OsmAnd)). Surveyors were paired with local motorbike drivers to travel to eligible villages. The collected mapping data were validated by checking for duplication and comparing the village names against a pre-existing village name and location list using a geographic distance and text string-matching algorithm. RESULTS: The survey teams gained sufficient familiarity with the ODK and OsmAnd software within 1-2 hours. Nine chiefdoms in Tonkolili District and three in Bombali District were surveyed within two weeks. Following de-duplication, the surveyors collected data from 891 villages with an estimated 127,021 households. The overall survey cost was €3,395; €3.80 per village surveyed. The MSF GIS team (MSF-OCG) created improved maps for the MSF Magburaka EMC team which were used to support surveillance, investigation of suspect EVD cases, hygiene-kit distribution and EVD survivor support. We shared the mapping data with OpenStreetMap, the local Ministry of Health and Sanitation and Sierra Leone District and National Ebola Response Centres. CONCLUSIONS: Involving local community and using accessible technology allowed rapid implementation, at moderate cost, of a survey to collect geographic and essential village information, and creation of updated maps. These methods could be used for future emergencies to facilitate response.
[Mh] Termos MeSH primário: Surtos de Doenças
Doença pelo Vírus Ebola/epidemiologia
Smartphone
[Mh] Termos MeSH secundário: Doença pelo Vírus Ebola/prevenção & controle
Seres Humanos
Propriedade
Serra Leoa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189959


  3 / 1156 MEDLINE  
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[PMID]:29049274
[Au] Autor:Wilkinson AL; Kaiser R; Jalloh MF; Kamara M; Blau DM; Raghunathan PL; Kamara A; Kamara U; Houston-Suluku N; Clarke K; Jambai A; Redd JT; Hersey S; Osaio-Kamara B
[Ti] Título:Reporting Deaths Among Children Aged <5 Years After the Ebola Virus Disease Epidemic - Bombali District, Sierra Leone, 2015-2016.
[So] Source:MMWR Morb Mortal Wkly Rep;66(41):1116-1118, 2017 Oct 20.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mortality surveillance and vital registration are limited in Sierra Leone, a country with one of the highest mortality rates among children aged <5 years worldwide, approximately 120 deaths per 1,000 live births (1,2). To inform efforts to strengthen surveillance, stillbirths and deaths in children aged <5 years from multiple surveillance streams in Bombali Sebora chiefdom were retrospectively reviewed. In total, during January 2015-November 2016, 930 deaths in children aged <5 years were identified, representing 73.3% of the 1,269 deaths that were expected based on modeled estimates. The "117" telephone alert system established during the Ebola virus disease (Ebola) epidemic captured 683 (73.4%) of all reported deaths in children aged <5 years, and was the predominant reporting source for stillbirths (n = 172). In the absence of complete vital events registration, 117 call alerts markedly improved the completeness of reporting of stillbirths and deaths in children aged <5 years.
[Mh] Termos MeSH primário: Mortalidade da Criança
Epidemias
Doença pelo Vírus Ebola/epidemiologia
Mortalidade Infantil
Vigilância da População
[Mh] Termos MeSH secundário: Pré-Escolar
Seres Humanos
Lactente
Recém-Nascido
Notificação Compulsória
Serra Leoa/epidemiologia
Natimorto/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6641a5


  4 / 1156 MEDLINE  
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[PMID]:29031286
[Au] Autor:Dariano DF; Taitt CR; Jacobsen KH; Bangura U; Bockarie AS; Bockarie MJ; Lahai J; Lamin JM; Leski TA; Yasuda C; Stenger DA; Ansumana R
[Ad] Endereço:College of Science, George Mason University, Fairfax, Virginia.
[Ti] Título:Surveillance of Vector-Borne Infections (Chikungunya, Dengue, and Malaria) in Bo, Sierra Leone, 2012-2013.
[So] Source:Am J Trop Med Hyg;97(4):1151-1154, 2017 Oct.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malaria remains a significant cause of morbidity and mortality in West Africa, but the contribution of other vector-borne infections (VBIs) to the burden of disease has been understudied. We used rapid diagnostic tests (RDTs) for three VBIs to test blood samples from 1,795 febrile residents of Bo City, Sierra Leone, over a 1-year period in 2012-2013. In total, 24% of the tests were positive for malaria, fewer than 5% were positive for markers of dengue virus infection, and 39% were positive for IgM directed against chikungunya virus (CHIKV) or a related alphavirus. In total, more than half (55%) of these febrile individuals tested positive for at least one of the three VBIs, which highlights the very high burden of vector-borne diseases in this population. The prevalence of positives on the Chikungunya IgM and dengue tests did not vary significantly with age ( > 0.36), but higher rates of malaria were observed in children < 15 years of age ( < 0.001). Positive results on the Chikungunya IgM RDTs were moderately correlated with rainfall ( = 0.599). Based on the high prevalence of positive results on the Chikungunya IgM RDTs from individuals Bo and its environs, there is a need to examine whether an ecological shift toward a greater burden from CHIKV or related alphaviruses is occurring in other parts of Sierra Leone or the West African region.
[Mh] Termos MeSH primário: Febre de Chikungunya/epidemiologia
Dengue/epidemiologia
Malária/epidemiologia
Vigilância da População
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Febre de Chikungunya/transmissão
Criança
Culicidae
Dengue/transmissão
Feminino
Seres Humanos
Insetos Vetores
Malária/transmissão
Masculino
Meia-Idade
Serra Leoa/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0798


  5 / 1156 MEDLINE  
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[PMID]:28979647
[Au] Autor:Kaiser R; Johnson N; Jalloh MF; Dafae F; Redd JT; Hersey S; Jambai A
[Ad] Endereço:Centers for Disease Control and Prevention (CDC) Country Office, Freetown, Sierra Leone.
[Ti] Título:The WHO global reference list of 100 core health indicators: the example of Sierra Leone.
[So] Source:Pan Afr Med J;27:246, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:The global reference list of 100 core health indicators is a standard set of indicators published by the World Health Organization in 2015. We reviewed core health indicators in the public domain and in-country for Sierra Leone, the African continent and globally. Review objectives included assessing available sources, accessibility and feasibility of obtaining data and informing efforts to monitor program progress. Our search strategy was guided by feasibility considerations targeting mainly national household surveys in Sierra Leone and topic-specific and health statistics reports published annually by WHO. We also included national, regional and worldwide health indicator estimates published with open access in the literature and compared them with cumulative annual indicators from the weekly national epidemiological bulletin distributed by the Sierra Leone Ministry of Health and Sanitation. We obtained 70 indicators for Sierra Leone from Internet sources and 2 (maternal mortality and malaria incidence) from the national bulletin. Of the 70 indicators, 14 (20%) were modified versions of WHO indicators and provided uncertainty intervals. Maternal mortality showed considerable differences between 2 international sources for 2015 and the most recent national bulletin. We were able to obtain the majority of core indicators for Sierra Leone. Some indicators were similar but not identical, uncertainty intervals were limited and estimates differed for the same year between sources. Current efforts to improve health and mortality surveillance in Sierra Leone will improve availability and quality of reporting in the future. A centralized core indicator reporting website should be considered.
[Mh] Termos MeSH primário: Malária/epidemiologia
Mortalidade Materna
Indicadores de Qualidade em Assistência à Saúde
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Incidência
Vigilância da População/métodos
Serra Leoa/epidemiologia
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.246.11647


  6 / 1156 MEDLINE  
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[PMID]:28922385
[Au] Autor:Gale TV; Horton TM; Grant DS; Garry RF
[Ad] Endereço:Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, United States of America.
[Ti] Título:Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers.
[So] Source:PLoS Negl Trop Dis;11(9):e0005943, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lassa fever afflicts tens of thousands of people in West Africa annually. The rapid progression of patients from febrile illness to fulminant syndrome and death provides incentive for development of clinical prognostic markers that can guide case management. The small molecule profile of serum from febrile patients triaged to the Viral Hemorrhagic Fever Ward at Kenema Government Hospital in Sierra Leone was assessed using untargeted Ultra High Performance Liquid Chromatography Mass Spectrometry. Physiological dysregulation resulting from Lassa virus (LASV) infection occurs at the small molecule level. Effects of LASV infection on pathways mediating blood coagulation, and lipid, amino acid, nucleic acid metabolism are manifest in changes in the levels of numerous metabolites in the circulation. Several compounds, including platelet activating factor (PAF), PAF-like molecules and products of heme breakdown emerged as candidates that may prove useful in diagnostic assays to inform better care of Lassa fever patients.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Heme/metabolismo
Febre Lassa/diagnóstico
Metabolômica/métodos
Fator de Ativação de Plaquetas/análise
[Mh] Termos MeSH secundário: Adolescente
Adulto
África Ocidental/epidemiologia
Anticorpos Antivirais/sangue
Antígenos Virais/sangue
Feminino
Heme/química
Seres Humanos
Imunoglobulina M/sangue
Febre Lassa/epidemiologia
Febre Lassa/imunologia
Febre Lassa/metabolismo
Vírus Lassa/imunologia
Vírus Lassa/isolamento & purificação
Vírus Lassa/fisiologia
Masculino
Espectrometria de Massas
Fator de Ativação de Plaquetas/metabolismo
RNA Viral/sangue
Serra Leoa/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (Biomarkers); 0 (Immunoglobulin M); 0 (Platelet Activating Factor); 0 (RNA, Viral); 42VZT0U6YR (Heme)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005943


  7 / 1156 MEDLINE  
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[PMID]:28892501
[Au] Autor:Deen GF; McDonald SLR; Marrinan JE; Sesay FR; Ervin E; Thorson AE; Xu W; Ströher U; Ongpin P; Abad N; Ariyarajah A; Malik T; Liu H; Ross C; Durski KN; Gaillard P; Morgan O; Formenty P; Knust B; Broutet N; Sahr F; Sierra Leone Ebola Virus Persistence Study Group
[Ad] Endereço:Clinical Studies, Internal Medicine, Connaught Hospital, Ministry of Health and Sanitation, Freetown, Sierra Leone.
[Ti] Título:Implementation of a study to examine the persistence of Ebola virus in the body fluids of Ebola virus disease survivors in Sierra Leone: Methodology and lessons learned.
[So] Source:PLoS Negl Trop Dis;11(9):e0005723, 2017 09.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The 2013-2016 West African Ebola virus disease epidemic was unprecedented in terms of the number of cases and survivors. Prior to this epidemic there was limited data available on the persistence of Ebola virus in survivors' body fluids and the potential risk of transmission, including sexual transmission. METHODOLOGY/PRINCIPAL FINDINGS: Given the urgent need to determine the persistence of Ebola virus in survivors' body fluids, an observational cohort study was designed and implemented during the epidemic response operation in Sierra Leone. This publication describes study implementation methodology and the key lessons learned. Challenges encountered during implementation included unforeseen duration of follow-up, complexity of interpreting and communicating laboratory results to survivors, and the urgency of translating research findings into public health practice. Strong community engagement helped rapidly implement the study during the epidemic. The study was conducted in two phases. The first phase was initiated within five months of initial protocol discussions and assessed persistence of Ebola virus in semen of 100 adult men. The second phase assessed the persistence of virus in multiple body fluids (semen or vaginal fluid, menstrual blood, breast milk, and urine, rectal fluid, sweat, saliva, tears), of 120 men and 120 women. CONCLUSION/SIGNIFICANCE: Data from this study informed national and global guidelines in real time and demonstrated the need to implement semen testing programs among Ebola virus disease survivors. The lessons learned and study tools developed accelerated the implementation of such programs in Ebola virus disease affected countries, and also informed studies examining persistence of Zika virus. Research is a vital component of the public health response to an epidemic of a poorly characterized disease. Adequate resources should be rapidly made available to answer critical research questions, in order to better inform response efforts.
[Mh] Termos MeSH primário: Líquidos Corporais/virologia
Ebolavirus/isolamento & purificação
Doença pelo Vírus Ebola/virologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Serra Leoa
Sobreviventes
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005723


  8 / 1156 MEDLINE  
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[PMID]:28892490
[Au] Autor:Abad N; Malik T; Ariyarajah A; Ongpin P; Hogben M; McDonald SLR; Marrinan J; Massaquoi T; Thorson A; Ervin E; Bernstein K; Ross C; Liu WJ; Kroeger K; Durski KN; Broutet N; Knust B; Deen GF; Sierra Leone Ebola Virus Persistence Study Group
[Ad] Endereço:Social & Behavioral Research and Evaluation Branch, Division of Sexually Transmitted Disease Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, & TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
[Ti] Título:Development of risk reduction behavioral counseling for Ebola virus disease survivors enrolled in the Sierra Leone Ebola Virus Persistence Study, 2015-2016.
[So] Source:PLoS Negl Trop Dis;11(9):e0005827, 2017 09.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: During the 2014-2016 West Africa Ebola Virus Disease (EVD) epidemic, the public health community had concerns that sexual transmission of the Ebola virus (EBOV) from EVD survivors was a risk, due to EBOV persistence in body fluids of EVD survivors, particularly semen. The Sierra Leone Ebola Virus Persistence Study was initiated to investigate this risk by assessing EBOV persistence in numerous body fluids of EVD survivors and providing risk reduction counseling based on test results for semen, vaginal fluid, menstrual blood, urine, rectal fluid, sweat, tears, saliva, and breast milk. This publication describes implementation of the counseling protocol and the key lessons learned. METHODOLOGY/PRINCIPAL FINDINGS: The Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol was developed from a framework used to prevent transmission of HIV and other sexually transmitted infections. The framework helped to identify barriers to risk reduction and facilitated the development of a personalized risk-reduction plan, particularly around condom use and abstinence. Pre-test and post-test counseling sessions included risk reduction guidance, and post-test counseling was based on the participants' individual test results. The behavioral counseling protocol enabled study staff to translate the study's body fluid test results into individualized information for study participants. CONCLUSIONS/SIGNIFICANCE: The Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol provided guidance to mitigate the risk of EBOV transmission from EVD survivors. It has since been shared with and adapted by other EVD survivor body fluid testing programs and studies in Ebola-affected countries.
[Mh] Termos MeSH primário: Terapia Comportamental
Aconselhamento
Transmissão de Doença Infecciosa/prevenção & controle
Doença pelo Vírus Ebola/epidemiologia
Doença pelo Vírus Ebola/prevenção & controle
Assunção de Riscos
Comportamento Sexual
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Serra Leoa/epidemiologia
Sobreviventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005827


  9 / 1156 MEDLINE  
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[PMID]:28834940
[Au] Autor:Cunningham T
[Ad] Endereço:Tim Cunningham is an emergency nurse. He's also the director of the Compassionate Care Initiative at the University of Virginia School of Nursing in Charlottesville, Va., where he holds a joint appointment as an assistant professor of nursing and theater. He returned to Sierra Leone in 2017 to reconnect with Ebola survivors and learn more about the effects of the NGO presence during the Ebola outbreak.
[Ti] Título:International public health emergencies: Lessons learned in West Africa.
[So] Source:Nursing;47(9):1-4, 2017 09.
[Is] ISSN:1538-8689
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Surtos de Doenças/prevenção & controle
Doença pelo Vírus Ebola/epidemiologia
Doença pelo Vírus Ebola/enfermagem
Cooperação Internacional
[Mh] Termos MeSH secundário: Educação em Enfermagem
Emergências
Pessoal Profissional Estrangeiro/psicologia
Seres Humanos
Liderança
Enfermagem Militar
Enfermeiras e Enfermeiros/psicologia
Saúde Pública
Serra Leoa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1097/01.NURSE.0000522010.36514.dc


  10 / 1156 MEDLINE  
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[PMID]:28826426
[Au] Autor:Gleason BL; Foster S; Wilt GE; Miles B; Lewis B; Cauthen K; King M; Bayor F; Conteh S; Sesay T; Kamara SI; Lambert G; Finley P; Beyeler W; Moore T; Gaudioso J; Kilmarx PH; Redd JT
[Ad] Endereço:Center for Global Health, Centers for Disease Control and Prevention (CDC),Atlanta, Georgia,USA.
[Ti] Título:Geospatial analysis of household spread of Ebola virus in a quarantined village - Sierra Leone, 2014.
[So] Source:Epidemiol Infect;145(14):2921-2929, 2017 10.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We performed a spatial-temporal analysis to assess household risk factors for Ebola virus disease (Ebola) in a remote, severely-affected village. We defined a household as a family's shared living space and a case-household as a household with at least one resident who became a suspect, probable, or confirmed Ebola case from 1 August 2014 to 10 October 2014. We used Geographic Information System (GIS) software to calculate inter-household distances, performed space-time cluster analyses, and developed Generalized Estimating Equations (GEE). Village X consisted of 64 households; 42% of households became case-households over the observation period. Two significant space-time clusters occurred among households in the village; temporal effects outweighed spatial effects. GEE demonstrated that the odds of becoming a case-household increased by 4·0% for each additional person per household (P < 0·02) and 2·6% per day (P < 0·07). An increasing number of persons per household, and to a lesser extent, the passage of time after onset of the outbreak were risk factors for household Ebola acquisition, emphasizing the importance of prompt public health interventions that prioritize the most populated households. Using GIS with GEE can reveal complex spatial-temporal risk factors, which can inform prioritization of response activities in future outbreaks.
[Mh] Termos MeSH primário: Surtos de Doenças
Ebolavirus/fisiologia
Características da Família
Doença pelo Vírus Ebola/epidemiologia
Quarentena
[Mh] Termos MeSH secundário: Mapeamento Geográfico
Doença pelo Vírus Ebola/virologia
Seres Humanos
Fatores de Risco
Serra Leoa/epidemiologia
Análise Espacial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001856



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde