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[PMID]: 28666142 [Au] Autor: Callies O; Núñez MJ; Perestelo NR; Reyes CP; Torres-Romero D; Jiménez IA; Bazzocchi IL [Ad] Endereço: Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain. [Ti] Título: Distinct sesquiterpene pyridine alkaloids from in Salvadoran and Peruvian Celastraceae species. [So] Source: Phytochemistry;142:21-29, 2017 Oct. [Is] ISSN: 1873-3700 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: As part of a bioprospecting program aimed at the discovery of undescribed natural products from Salvadoran and Peruvian flora, the phytochemical investigations of four Celastraceae species, Celastrus vulcanicola, Maytenus segoviarum, Maytenus jeslkii, and Maytenus cuzcoina, were performed. The current study reports the isolation and structural characterization of five previously undescribed macrolide sesquiterpene pyridine alkaloids, named vulcanicoline-A, cuzcoinine, vulcanicoline-B, jelskiine, and vulcanicoline-C, along with sixteen known alkaloids. The structures of the alkaloids were established by spectrometric and extensive 1D and 2D NMR spectroscopic analysis, including COSY, HSQC, HMBC, and ROESY experiments. The absolute configurations of alkaloids were proposed based on optical rotation sign, and biogenetic considerations. This study represents the first phytochemical analysis of Maytenus segoviarum. [Mh] Termos MeSH primário: Alcaloides/isolamento & purificação Celastraceae/química Piridinas/isolamento & purificação Sesquiterpenos/isolamento & purificação [Mh] Termos MeSH secundário: Alcaloides/química Celastrus El Salvador Maytenus/química Estrutura Molecular Ressonância Magnética Nuclear Biomolecular Peru Piridinas/química Sesquiterpenos/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Alkaloids); 0 (Pyridines); 0 (Sesquiterpenes) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170915 [Lr] Data última revisão: 170915 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170701 [St] Status: MEDLINE

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[PMID]: 28603248 [Au] Autor: Corgosinho PHC; Mercado-Salas NF; Arbizu PM; Silva ENDS; Kihara TC [Ad] Endereço: UNESCO-IHE, Westvest 7, 2611 AX Delft, The Netherlands. user@example.com. [Ti] Título: Revision of the Remaneicaris argentina-group (Copepoda, Harpacticoida, Parastenocarididae): supplementary description of species, and description of the first semi-terrestrial Remaneicaris from the tropical forest of Southeast Mexico. [So] Source: Zootaxa;4238(4):499-530, 2017 Mar 06. [Is] ISSN: 1175-5334 [Cp] País de publicação: New Zealand [La] Idioma: eng [Ab] Resumo: Remaneicaris is a species-rich Neotropical monophyletic group, easily recognized by the synapomorphic position of the outer seta of the third exopodite of leg 4, localized at 2/3 of the outer margin. The genus, comprising 35 species in five monophyletic groups, plus R. ignotus and R. meyerabichi, retains an unusual set of plesiomorphic characters. Herein we supplement the descriptions of the species belonging to the Remaneicaris argentina-group, and describe a new species from the tropical forest of Southeast Mexico. The present study extends the geographic distribution of the genus, with the northernmost record until now being from El Salvador. The genus having hitherto been known from interstitial groundwater habitats, this is its first record in epigean semi-terrestrial habitats. Remaneicaris siankaan sp. nov. was found in phytotelmata (bromeliads), leaf litter, moist soil, permanent ponds (known locally as "aguadas"), and temporal and permanent wetlands (savannahs). The new species can be easily characterized by its finely pitted cuticle, the ε (epsilon)-shaped thumb of the male P3 and the bifid accessory spine with distal hyaline inner tip, which precedes the thumb. A new method for the 3D reconstruction of microcrustaceans is described. [Mh] Termos MeSH primário: Copépodes [Mh] Termos MeSH secundário: Distribuição Animal Estruturas Animais Animais Argentina Tamanho Corporal El Salvador Florestas Masculino México Tamanho do Órgão [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170809 [Lr] Data última revisão: 170809 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170613 [St] Status: MEDLINE [do] DOI: 10.11646/zootaxa.4238.4.2

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[PMID]: 28589548 [Au] Autor: Laskow B; Figueroa R; Alfaro KM; Scarinci IC; Conlisk E; Maza M; Chang JC; Cremer M [Ad] Endereço: Basic Health International, San Salvador, El Salvador. [Ti] Título: A pilot study of community-based self-sampling for HPV testing among non-attenders of cervical cancer screening programs in El Salvador. [So] Source: Int J Gynaecol Obstet;138(2):194-200, 2017 Aug. [Is] ISSN: 1879-3479 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To establish the feasibility and acceptability of home-based HPV self-sampling among women who did not attend screening appointments in rural El Salvador. METHODS: In a cross-sectional study, data were collected from May 2015 to January 2016 among 60 women aged 30-59 years who were not pregnant, provided informed consent, had not been screened in 2 years, had no history of pre-cancer treatment, and did not attend a scheduled HPV screening. Participants completed questionnaires and received educational information before being given an opportunity to self-sample with the Hybrid Capture 2 High Risk HPV DNA Test. RESULTS: Self-sampling was accepted by 41 (68%) participants. Almost all women chose to self-sample because the process was easy (40/41, 98%), could be performed at home (40/41, 98%), and saved time (38/41, 93%), and because they felt less embarrassed (33/41, 80%). The most common reason for declining the test was not wanting to be screened (8/19, 42%). The prevalence of high-risk HPV types among women who accepted self-sampling was 17% (7/41). CONCLUSION: For most women, community-based self-sampling was an acceptable way to participate in a cervical cancer screening program. In low-resource countries, incorporating community-based self-sampling into screening programs might improve coverage of high-risk women. [Mh] Termos MeSH primário: Detecção Precoce de Câncer/métodos Papillomaviridae Infecções por Papillomavirus/diagnóstico Neoplasias do Colo do Útero/diagnóstico [Mh] Termos MeSH secundário: Adulto Serviços de Saúde Comunitária Estudos Transversais El Salvador Estudos de Viabilidade Feminino Conhecimentos, Atitudes e Prática em Saúde Seres Humanos Programas de Rastreamento Meia-Idade Infecções por Papillomavirus/virologia Aceitação pelo Paciente de Cuidados de Saúde Projetos Piloto População Rural Autocuidado Inquéritos e Questionários [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170608 [St] Status: MEDLINE [do] DOI: 10.1002/ijgo.12204

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[PMID]: 28500812 [Au] Autor: Park S; Sanchez DR; Traina MI; Bradfield JS; Hernandez S; Ufion AJA; Dufani J; Bergin P; Wachsner RY; Meymandi SK [Ad] Endereço: Center of Excellence for Chagas Disease, Olive View-UCLA Medical Center, Sylmar, California. [Ti] Título: The Prevalence of Chagas Disease Among Latin American Immigrants with Pacemakers in Los Angeles, California. [So] Source: Am J Trop Med Hyg;96(5):1139-1142, 2017 May. [Is] ISSN: 1476-1645 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: AbstractChagas disease (CD), with associated conduction abnormalities, is a common indication for pacemaker implantation in Latin America. The prevalence of CD in Latin American immigrants with pacemakers residing in the United States has never been studied. This single-center cross-sectional study included pacemaker patients who were aged 18 years or more with a previous residence in Latin America for at least 6 months. Patients with an implantable cardioverter-defibrillator, cardiac resynchronization therapy, or iatrogenic and/or congenital heart block were excluded. Serological testing for was performed at enrollment. A total of 80 patients were enrolled, and CD was diagnosed in six patients (7.5%). Patients with CD were more likely to be from El Salvador ( = 0.001). Other clinical, therapeutic, electrocardiographic, and echocardiographic variables were similar between the CD and non-CD groups. There is a high prevalence of CD among Latin American immigrants with pacemakers in Los Angeles. [Mh] Termos MeSH primário: Anticorpos Antiprotozoários/sangue Cardiomiopatia Chagásica/diagnóstico por imagem Cardiomiopatia Chagásica/etnologia Marca-Passo Artificial Trypanosoma cruzi/isolamento & purificação [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Cardiomiopatia Chagásica/parasitologia Cardiomiopatia Chagásica/cirurgia Estudos Transversais El Salvador/etnologia Eletrocardiografia Emigrantes e Imigrantes Feminino Hispano-Americanos Seres Humanos Los Angeles/epidemiologia Masculino Meia-Idade Prevalência Trypanosoma cruzi/imunologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Protozoan) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170803 [Lr] Data última revisão: 170803 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170514 [St] Status: MEDLINE [do] DOI: 10.4269/ajtmh.16-0826

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[PMID]: 28427363 [Au] Autor: Carcach C [Ad] Endereço: Center for Public Policy, Escuela Superior de Economía y Negocios, Santa Tecla, El Salvador. ccarcach@esen.edu.sv. [Ti] Título: A spatio-temporal analysis of suicide in El Salvador. [So] Source: BMC Public Health;17(1):339, 2017 Apr 20. [Is] ISSN: 1471-2458 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: In 2012, international statistics showed El Salvador's suicide rate as 40th in the world and the highest in Latin America. Over the last 15 years, national statistics show the suicide death rate declining as opposed to an increasing rate of homicide. Though completed suicide is an important social and health issue, little is known about its prevalence, incidence, etiology and spatio-temporal behavior. The primary objective of this study was to examine completed suicide and homicide using the stream analogy to lethal violence within a spatio-temporal framework. METHODS: A Bayesian model was applied to examine the spatio-temporal evolution of the tendency of completed suicide over homicide in El Salvador. Data on numbers of suicides and homicides at the municipal level were obtained from the Instituto de Medicina Legal (IML) and population counts, from the Dirección General de Estadística y Censos (DIGESTYC), for the period of 2002 to 2012. Data on migration were derived from the 2007 Population Census, and inequality data were obtained from a study by Damianovic, Valenzuela and Vera. RESULTS: The data reveal a stable standardized rate of total lethal violence (completed suicide plus homicide) across municipalities over time; a decline in suicide; and a standardized suicide rate decreasing with income inequality but increasing with social isolation. Municipalities clustered in terms of both total lethal violence and suicide standardized rates. CONCLUSIONS: Spatial effects for suicide were stronger among municipalities located in the north-east and center-south sides of the country. New clusters of municipalities with large suicide standardized rates were detected in the north-west, south-west and center-south regions, all of which are part of time-stable clusters of homicide. Prevention efforts to reduce income inequality and mitigate the negative effects of weak relational systems should focus upon municipalities forming time-persistent clusters with a large rate of death by suicide. In municipalities that are part of newly-formed suicide clusters and also are located in areas with a large rate of homicide, interrupting the expansion of spatial concentrations of suicide over time may require the implementation of both public health and public safety interventions. [Mh] Termos MeSH primário: Cidades/estatística & dados numéricos Homicídio/estatística & dados numéricos Suicídio/estatística & dados numéricos [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Teorema de Bayes El Salvador/epidemiologia Feminino Seres Humanos Incidência Masculino Meia-Idade Modelos Teóricos Prevalência Análise Espaço-Temporal Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170911 [Lr] Data última revisão: 170911 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170422 [St] Status: MEDLINE [do] DOI: 10.1186/s12889-017-4251-6

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[PMID]: 28264418 [Au] Autor: Rifkind J [Ad] Endereço: Research Associate, California State Collection of Arthropods, 3294 Meadowview Road, Sacramento, CA 95832 U.S.A.. clerid@aol.com. [Ti] Título: New species of Mutillid Mimicking Enoclerus Gahan (Coleoptera: Cleridae: Clerinae) from Mexico and Central America. [So] Source: Zootaxa;4231(3):zootaxa.4231.3.7, 2017 Feb 12. [Is] ISSN: 1175-5334 [Cp] País de publicação: New Zealand [La] Idioma: eng [Ab] Resumo: Six new species of Enoclerus are described: E. delusus n. sp. from Costa Rica and Panamá, E. incanus n. sp. from México, E. zip n. sp. from México and El Salvador, E. reductesignatus n. sp. from Panamá, and E. citrinifrons n. sp. and E. philogenes n. sp. from Costa Rica. The new species are hypothesized to participate in a Batesian mimicry complex with boldly marked diurnal mutillid wasps as their model. Enoclerus crabronarius var. deletus Wolcott is elevated to species rank as E. deletus Wolcott new status. The identity of E. crabronarius is discussed. [Mh] Termos MeSH primário: Coleópteros [Mh] Termos MeSH secundário: Animais América Central Costa Rica El Salvador México Panamá [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170308 [St] Status: MEDLINE [do] DOI: 10.11646/zootaxa.4231.3.7

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[PMID]: 28126239 [Au] Autor: Wijkström J; González-Quiroz M; Hernandez M; Trujillo Z; Hultenby K; Ring A; Söderberg M; Aragón A; Elinder CG; Wernerson A [Ad] Endereço: Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. [Ti] Título: Renal Morphology, Clinical Findings, and Progression Rate in Mesoamerican Nephropathy. [So] Source: Am J Kidney Dis;69(5):626-636, 2017 May. [Is] ISSN: 1523-6838 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Mesoamerican nephropathy (MeN) is a chronic kidney disease affecting rural inhabitants in Central America. We have previously described the renal morphology in 8 patients from El Salvador. To confirm the renal pathology, we have studied kidney biopsies from patients with MeN in Nicaragua. Follow-up urine and blood samples from both biopsy studies were collected to investigate the natural history. STUDY DESIGN: Case series. SETTINGS & PARTICIPANTS: In the kidney biopsy study, 19 male sugarcane workers in Nicaragua with suspected MeN were investigated with questionnaires, kidney biopsies, and blood and urine analysis. Inclusion criteria were age 20 to 65 years and plasma creatinine level of 1.13 to 2.49mg/dL or estimated glomerular filtration rate (eGFR) of 30 to 80mL/min/1.73m . Exclusion criteria were proteinuria with protein excretion > 3g/24 h, uncontrolled hypertension, diabetes mellitus, or other known kidney disease. In the follow up-study, blood and urine from the kidney biopsy study in Nicaragua (n=18) and our previous biopsy study of MeN cases in El Salvador (n=7) were collected 1 to 1.5 and 2 to 2.5 years after biopsy, respectively. OUTCOMES: Renal morphology, clinical, and biochemical characteristics, change in eGFR per year. MEASUREMENTS: eGFR was calculated using the CKD-EPI creatinine (eGFR ), cystatin C (eGFR ), and creatinine-cystatin C (eGFR ) equations. RESULTS: In the kidney biopsy study, participants had a mean eGFR of 57 (range, 33-96) mL/min/1.73m . 47% had low plasma sodium and 21% had low plasma potassium levels. 16 kidney biopsies were representative and showed glomerulosclerosis (mean, 38%), glomerular hypertrophy, and signs of chronic glomerular ischemia. Mild to moderate tubulointerstitial damage and mostly mild vascular changes were seen. In the follow up-study, median duration of follow-up was 13 (range, 13-27) months. Mean change in eGFR was -4.4±8.4 (range, -27.7 to 10.2) mL/min/1.73m per year. Most patients had stopped working with sugarcane cultivation. LIMITATIONS: 3 biopsy specimens had 4 or fewer glomeruli. CONCLUSIONS: This study confirms the renal morphology of MeN: chronic glomerular and tubulointerstitial damage with glomerulosclerosis and chronic glomerular ischemia. Follow-up data show that eGFRs, on average, deteriorated. [Mh] Termos MeSH primário: Taxa de Filtração Glomerular Glomérulos Renais/patologia Insuficiência Renal Crônica/patologia [Mh] Termos MeSH secundário: Lesão Renal Aguda Adulto América Central/epidemiologia Creatinina/metabolismo Cistatina C/metabolismo Progressão da Doença El Salvador Doenças Endêmicas Fazendeiros Seguimentos Temperatura Alta Seres Humanos Hipertrofia Hipopotassemia/epidemiologia Hipopotassemia/metabolismo Hiponatremia/epidemiologia Hiponatremia/metabolismo Hipovolemia Biópsia Guiada por Imagem Isquemia Rim/metabolismo Rim/patologia Rim/fisiopatologia Glomérulos Renais/irrigação sanguínea Glomérulos Renais/metabolismo Glomérulos Renais/fisiopatologia Masculino Meia-Idade Nicarágua/epidemiologia Exposição Ocupacional Insuficiência Renal Crônica/epidemiologia Insuficiência Renal Crônica/metabolismo Insuficiência Renal Crônica/fisiopatologia População Rural Saccharum Esclerose Ultrassonografia Desequilíbrio Hidroeletrolítico Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cystatin C); AYI8EX34EU (Creatinine) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170731 [Lr] Data última revisão: 170731 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170128 [St] Status: MEDLINE

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[PMID]: 27922905 [Au] Autor: Cremer M; Maza M; Alfaro K; Morales Velado M; Felix J; Castle PE; Kim J; Gage JC [Ad] Endereço: 1Obstetrics, Gynecology & Women's Health Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH; 2Basic Health International, San Salvador, El Salvador; 3National Unit of Control and Prevention of Cancer, Ministry of Health, San Salvador, El Salvador; 4Department of Pathology, University of Southern California, Los Angeles, CA; 5Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD; 6Albert Einstein College of Medicine, Bronx, NY; 7Global Coalition Against Cervical Cancer, Arlington VA; and 8Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA. [Ti] Título: Scale-Up of an Human Papillomavirus Testing Implementation Program in El Salvador. [So] Source: J Low Genit Tract Dis;21(1):26-32, 2017 Jan. [Is] ISSN: 1526-0976 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The Cervical Cancer Prevention in El Salvador is a demonstration project to introduce a lower-cost human papillomavirus (HPV)-DNA test into a public sector project. Started in October 2012, The Cervical Cancer Prevention in El Salvador consists of 3 phases and will ultimately screen 30,000 women. Results of phase 2 of the project are presented. The objective of this project was to compare colposcopy and noncolposcopy-based management for HPV-positive women. MATERIAL AND METHODS: In phase 2, a total of 8,050 women, aged 30 to 49 years, were screened; 6,761 provided both self- and provider-collected specimens and 1,289 provided only provider-testing specimens. HPV results from self-collected specimens were not used in clinical management decisions. Women with provider-collected HPV-positive results were treated based on the strategy assigned to their community; the strategy was colposcopy management (CM) or screen-and-treat (ST) management if they were cryotherapy eligible or colposcopy if not eligible. Outcomes were assessed 6 months after screening. RESULTS: Overall, 489 (12.3%) of 3,963 women receiving CM and 465 (11.4%) of 4,087 women receiving ST tested HPV positive. In the CM cohort, 216 (44.2%) of 489 completed their intervention (203 treated, 11 diagnosed negative, 2 pregnant). In the ST cohort, 411 (88.4%) of 465 completed their intervention (407 treated, 2 diagnosed negative, 1 pregnant). Overall agreement between HPV test results from self-collected and provider-collected specimens was 93.7%, with a κ value of 0.70 (95% CI = 0.68-0.73). CONCLUSIONS: Human papillomavirus testing with ST management resulted in an approximately twice completion rate compared with CM management. Agreement between self- and provider-based sampling was good and might be used to extend screening to women in areas that are more difficult to reach. [Mh] Termos MeSH primário: Detecção Precoce de Câncer/métodos Administração de Serviços de Saúde Infecções por Papillomavirus/diagnóstico Neoplasias do Colo do Útero/prevenção & controle [Mh] Termos MeSH secundário: Adulto Estudos de Coortes El Salvador Feminino Seres Humanos Meia-Idade [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161207 [St] Status: MEDLINE [do] DOI: 10.1097/LGT.0000000000000280

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[PMID]: 27796975 [Au] Autor: Quinteros E; Ribó A; Mejía R; López A; Belteton W; Comandari A; Orantes CM; Pleites EB; Hernández CE; López DL [Ad] Endereço: Ministry of Health El Salvador, Calle Gabriela Mistral Avenida del Prado, National Institute of Health, N° J-234, Col. Buenos Aires I, San Salvador, El Salvador. edgarquinteros.m@gmail.com. [Ti] Título: Heavy metals and pesticide exposure from agricultural activities and former agrochemical factory in a Salvadoran rural community. [So] Source: Environ Sci Pollut Res Int;24(2):1662-1676, 2017 Jan. [Is] ISSN: 1614-7499 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Pesticide handling in farming activities involves substantial hazards for the rural population and for the environment. In Latin America, it is estimated that the population at risk of being affected by heavy metals is over 4 million. This research describes the different types of exposure to pesticides and heavy metals in a rural population (Loma del Gallo), considering both environmental and occupational exposure. This study consists of an inspection in a former pesticide factory (QUIMAGRO), analysis of heavy metals in samples from surface and ground water in the community close to the factory, and a survey to the local population about their perceptions of pesticide exposures. Containers with 34.6 tons of chemicals improperly stored were identified in the former factory and removed by the government. Arsenic and cadmium were found in groundwater, and the highest values were 0.012 and 0.004 mg/l, respectively. These contaminants were also detected in most surface water samples, with maximum values of 0.026 and 0.0001 mg/l, respectively. Results of the survey show that of the 44 participants 42 % were farmers. Farmers used 19 different pesticide products containing 11 active ingredients. The most used active ingredients were paraquat (65 %), methamidophos (35 %), and atrazina (29 %). Eighty-two percent of the farmers did not use personal protective equipment. In addition to the pesticides used in the agriculture of the area, pesticide containers were removed from the QUIMAGRO area, but the pollution was still present at time of sampling and it is evident by the odor of the site. Surface water had the major concentration of heavy metals than the groundwater. Loma del Gallo population has been exposed to toxic pesticide from QUIMAGRO and agriculture for many years. The farmers carry out mishandling of pesticides and they not use PPE. [Mh] Termos MeSH primário: Metais Pesados/análise Exposição Ocupacional Poluentes Químicos da Água/análise [Mh] Termos MeSH secundário: Agricultura Indústria Química El Salvador Feminino Água Subterrânea/análise Seres Humanos Masculino Praguicidas/análise População Rural Inquéritos e Questionários Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Metals, Heavy); 0 (Pesticides); 0 (Water Pollutants, Chemical) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 171104 [Lr] Data última revisão: 171104 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161101 [St] Status: MEDLINE [do] DOI: 10.1007/s11356-016-7899-z

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[PMID]: 27754693 [Au] Autor: Chaurasiya ND; Gogineni V; Elokely KM; León F; Núñez MJ; Klein ML; Walker LA; Cutler SJ; Tekwani BL [Ti] Título: Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B. [So] Source: J Nat Prod;79(10):2538-2544, 2016 Oct 28. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Calea urticifolia (Asteraceae: Asteroideae) has long been used as a traditional medicine in El Salvador to treat arthritis and fever, among other illnesses. The chloroform extract of the leaves of C. urticifolia showed potent inhibition of recombinant human monoamine oxidases (MAO-A and -B). Further bioassay-guided fractionation led to the isolation of a flavonoid, acacetin, as the most prominent MAO inhibitory constituent, with IC values of 121 and 49 nM for MAO-A and -B, respectively. The potency of MAO inhibition by acacetin was >5-fold higher for MAO-A (0.121 µM vs 0.640 µM) and >22-fold higher for MAO-B (0.049 µM vs 1.12 µM) as compared to apigenin, the closest flavone structural analogue. Interaction and binding characteristics of acacetin with MAO-A and -B were determined by enzyme-kinetic assays, enzyme-inhibitor complex binding, equilibrium-dialysis dissociation analyses, and computation analysis. Follow-up studies showed reversible binding of acacetin with human MAO-A and -B, resulting in competitive inhibition. Acacetin showed more preference toward MAO-B than to MAO-A, suggesting its potential for eliciting selective pharmacological effects that might be useful in the treatment of neurological and psychiatric disorders. In addition, the binding modes of acacetin at the enzymatic site of MAO-A and -B were predicted through molecular modeling algorithms, illustrating the high importance of ligand interaction with negative and positive free energy regions of the enzyme active site. [Mh] Termos MeSH primário: Asteraceae/química Flavonas/isolamento & purificação Flavonas/farmacologia Inibidores da Monoaminoxidase/isolamento & purificação Inibidores da Monoaminoxidase/farmacologia [Mh] Termos MeSH secundário: Domínio Catalítico Relação Dose-Resposta a Droga El Salvador Flavonas/química Seres Humanos Concentração Inibidora 50 Modelos Moleculares Estrutura Molecular Inibidores da Monoaminoxidase/química Relação Estrutura-Atividade Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flavones); 0 (Monoamine Oxidase Inhibitors); KWI7J0A2CC (acacetin) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170616 [Lr] Data última revisão: 170616 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161030 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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