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  1 / 2025 MEDLINE  
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[PMID]:28466356
[Au] Autor:Jensen RG; Johansen HK; Bjarnsholt T; Eickhardt-Sørensen SR; Homøe P
[Ad] Endereço:Department of Otolaryngology, Head and Neck Surgery, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark. ramon@dadlnet.dk.
[Ti] Título:Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link?
[So] Source:Eur Arch Otorhinolaryngol;274(7):2741-2747, 2017 Jul.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (CSOM). The objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes of otorrhea in CSOM. In a prospective case series at a primary healthcare clinic in Nuuk, Greenland, patients with more than 14 days of otorrhea were included consecutively. Samples for culturing and biofilm analysis were taken at enrollment and at any subsequent episode with otorrhea. Participants were treated with daily saline irrigation and Ciprofloxacin eardrops for 7-14 days. Biofilm was identified in otorrhea in 81% (17/21) of participants at enrollment. Multispecies infections dominated with Non-typeable Haemophilus Influenzae (NTHI), Staphyloccocus aureus, and anaerobes being the most frequent pathogens. After the initial treatment, 19 (90%) had dry ears. Median observation period was 140 days (range 14-280) where 13 participants had one or more recurrences. Median time to first recurrence was 60 days (range 14-197). Among the 13 with recurrence, three individuals had the same genotype of bacteria at a subsequent episode. Another two had the same phenotype (NTHI). The remaining eight had new multispecies infections. We confirmed a high rate of biofilm in CSOM. However, the clinical implication might be of minor importance when treating with irrigation and antibiotic eardrops, as recurrent episodes of otorrhea were dominated by new pathogens in each episode.
[Mh] Termos MeSH primário: Biofilmes
Orelha Média/microbiologia
Otite Média Supurativa/microbiologia
[Mh] Termos MeSH secundário: Administração Tópica
Adolescente
Adulto
Antibacterianos/uso terapêutico
Criança
Pré-Escolar
Doença Crônica
Ciprofloxacino/uso terapêutico
Terapia Combinada
Feminino
Groenlândia
Seres Humanos
Lactente
Masculino
Otite Média Supurativa/tratamento farmacológico
Otite Média Supurativa/terapia
Estudos Prospectivos
Recidiva
Irrigação Terapêutica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-017-4586-8


  2 / 2025 MEDLINE  
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[PMID]:29331558
[Au] Autor:Bautista AT; Miyake Y; Matsuzaki H; Iizuka Y; Horiuchi K
[Ad] Endereço:Philippine Nuclear Research Institute - Department of Science and Technology (PNRI-DOST), Commonwealth Ave., Diliman, Quezon City 1101, Philippines; Department of Nuclear Engineering and Management, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address: atbautistavii@pnri.dos
[Ti] Título:High-resolution I bomb peak profile in an ice core from SE-Dome site, Greenland.
[So] Source:J Environ Radioact;184-185:14-21, 2018 Apr.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:I in natural archives, such as ice cores, can be used as a proxy for human nuclear activities, age marker, and environmental tracer. Currently, there is only one published record of I in ice core (i.e., from Fiescherhorn Glacier, Swiss Alps) and its limited time resolution (1-2 years) prevents the full use of I for the mentioned applications. Here we show I concentrations in an ice core from SE-Dome, Greenland, covering years 1956-1976 at a time resolution of ∼6 months, the most detailed record to date. Results revealed I bomb peaks in years 1959, 1962, and 1963, associated to tests performed by the former Soviet Union, one year prior, in its Novaya Zemlya test site. All I bomb peaks were observed in winter (1958.9, 1962.1, and 1963.0), while tritium bomb peaks, another prominent radionuclide associated with nuclear bomb testing, were observed in spring or summer (1959.3, and 1963.6; Iizuka et al., 2017). These results indicate that I bomb peaks can be used as annual and seasonal age markers for these years. Furthermore, we found that I recorded nuclear fuel reprocessing signals and that these can be potentially used to correct timing of estimated I releases during years 1964-1976. Comparisons with other published records of I in natural archives showed that I can be used as common age marker and tracer for different types of records. Most notably, the 1963 I bomb peak can be used as common age marker for ice and coral cores, providing the means to reconcile age models and associated trends from the polar and tropical regions, respectively.
[Mh] Termos MeSH primário: Camada de Gelo/química
Radioisótopos do Iodo/análise
Armas Nucleares
Monitoramento de Radiação
Poluentes Radioativos/análise
[Mh] Termos MeSH secundário: Groenlândia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Radioactive Pollutants)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


  3 / 2025 MEDLINE  
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[PMID]:28745556
[Au] Autor:Berntsen S; Karlsen APH; Pedersen ML; Mulvad G
[Ad] Endereço:a Queen Ingrid Health Care Center , Nuuk , Greenland.
[Ti] Título:Gonorrhoea in Greenland, incidence and previous preventive measures: a review to improve future strategies.
[So] Source:Int J Circumpolar Health;76(1):1350092, 2017.
[Is] ISSN:2242-3982
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gonorrhoea continues to be a significant health challenge in Greenland. The aim of this study was to describe the development of gonorrhoea in Greenland through time including incidence rates and previous measures taken to address the challenge. A systematic literature search in PubMed, Embase and The Cochrane Library was conducted. Furthermore, local archives were searched in the Health Clinic in Nuuk for relevant literature. From the 1940s the incidence of gonorrhoea increased steadily with a steep incline around 1970, possibly as a consequence of changes in living conditions and urbanisation. Significant declines in the incidence were seen the late 1970s and again in the late 1980s, most likely in the wake of an outbreak of ulcus molle/chancroid in the 1970s and as a result of focused education in venereology for Greenlandic nurses in the late 1980s combined with the stop-AIDS campaign. Since the early 1990s the incidence of gonorrhoea in Greenland has not risen to previously high levels. However, the incidence remains high and with a gradually increasing trend. Prevention intervention strategies such as peer-to-peer sexual education, storytelling and involvement of parent/guardian in sexual education of the youth could be appropriate approaches to improve sexual health in Greenland.
[Mh] Termos MeSH primário: Serviços de Saúde Comunitária/organização & administração
Gonorreia/epidemiologia
Gonorreia/prevenção & controle
Prevenção Primária/organização & administração
Comportamento Sexual/estatística & dados numéricos
[Mh] Termos MeSH secundário: Busca de Comunicante
Feminino
Gonorreia/diagnóstico
Groenlândia
Seres Humanos
Masculino
Neisseria gonorrhoeae/isolamento & purificação
Prevalência
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1080/22423982.2017.1350092


  4 / 2025 MEDLINE  
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[PMID]:29023598
[Au] Autor:Russo R; Giordano D; Paredi G; Marchesani F; Milazzo L; Altomonte G; Del Canale P; Abbruzzetti S; Ascenzi P; di Prisco G; Viappiani C; Fago A; Bruno S; Smulevich G; Verde C
[Ad] Endereço:Institute of Biosciences and BioResources, CNR, Via Pietro Castellino 111, Naples, Italy.
[Ti] Título:The Greenland shark Somniosus microcephalus-Hemoglobins and ligand-binding properties.
[So] Source:PLoS One;12(10):e0186181, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A large amount of data is currently available on the adaptive mechanisms of polar bony fish hemoglobins, but structural information on those of cartilaginous species is scarce. This study presents the first characterisation of the hemoglobin system of one of the longest-living vertebrate species (392 ± 120 years), the Arctic shark Somniosus microcephalus. Three major hemoglobins are found in its red blood cells and are made of two copies of the same α globin combined with two copies of three very similar ß subunits. The three hemoglobins show very similar oxygenation and carbonylation properties, which are unaffected by urea, a very important compound in marine elasmobranch physiology. They display identical electronic absorption and resonance Raman spectra, indicating that their heme-pocket structures are identical or highly similar. The quaternary transition equilibrium between the relaxed (R) and the tense (T) states is more dependent on physiological allosteric effectors than in human hemoglobin, as also demonstrated in polar teleost hemoglobins. Similar to other cartilaginous fishes, we found no evidence for functional differentiation among the three isoforms. The very similar ligand-binding properties suggest that regulatory control of O2 transport may be at the cellular level and that it may involve changes in the cellular concentrations of allosteric effectors and/or variations of other systemic factors. The hemoglobins of this polar shark have evolved adaptive decreases in O2 affinity in comparison to temperate sharks.
[Mh] Termos MeSH primário: Hemoglobinas/química
Hemoglobinas/metabolismo
Oxigênio/metabolismo
Tubarões/metabolismo
[Mh] Termos MeSH secundário: Animais
Monitoramento Ambiental
Groenlândia
Hemoglobinas/genética
Ligação Proteica
Conformação Proteica
Multimerização Proteica
Análise de Sequência de Proteína
Tubarões/genética
Análise Espectral Raman
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186181


  5 / 2025 MEDLINE  
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[PMID]:28974479
[Au] Autor:Rosenquist AH; Høyer BB; Julvez J; Sunyer J; Pedersen HS; Lenters V; Jönsson BAG; Bonde JP; Toft G
[Ad] Endereço:Department of Clinical Epidemiology, Aarhus University Hospital , Aarhus, Denmark.
[Ti] Título:Prenatal and Postnatal PCB-153 and , '-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine.
[So] Source:Environ Health Perspect;125(10):107002, 2017 Oct 03.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis( -chlorophenyl)-ethylene ( '-DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n=1,018), maternal serum PCB-153 and '-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to '-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre- and postnatal '-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal '-DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to '-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5-9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553.
[Mh] Termos MeSH primário: Diclorodifenil Dicloroetileno/sangue
Exposição Ambiental/estatística & dados numéricos
Poluentes Ambientais/sangue
Bifenilos Policlorados/sangue
[Mh] Termos MeSH secundário: Criança
Comportamento Infantil
Desenvolvimento Infantil
Pré-Escolar
Feminino
Groenlândia
Seres Humanos
Masculino
Ucrânia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene); DFC2HB4I0K (Polychlorinated Biphenyls); ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1289/EHP553


  6 / 2025 MEDLINE  
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[PMID]:28910589
[Au] Autor:Tairova Z; Strand J; Bossi R; Larsen MM; Förlin L; Bignert A; Hedman J; Gercken J; Lang T; Fricke NF; Asmund G; Long M; Bonefeld-Jørgensen EC
[Ad] Endereço:a Department of Bioscience , Aarhus University , Roskilde , Denmark.
[Ti] Título:Persistent organic pollutants and related biological responses measured in coastal fish using chemical and biological screening methods.
[So] Source:J Toxicol Environ Health A;80(16-18):862-880, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the spatial distribution, levels of dioxin-like compounds (DLC), and biological responses in two fish species. The viviparous eelpout (Zoarces viviparus) was collected from various locations in the Baltic Sea and in fjords of Kattegat and Skagerrak, while shorthorn sculpin (Myoxocephalus scorpius) was obtained at the polychlorinated biphenyl (PCB) polluted site in North West Greenland. Significant differences were detected both in contaminant levels and relative contributions from either polychlorinated dibenzodioxins (PCDD) or polychlorinated dibenzofurans (PCDF or furans) and mono-ortho- and non-ortho (coplanar) polychlorinated biphenyls (dl-PCB). Fish from the eastern Baltic Sea generally displayed higher contributions from PCDD/F compared to dl-PCB, whereas dl-PCB were generally predominated in fish from Danish, Swedish, and German sites. Levels of dl-PCB in muscle tissues were above OSPAR environmental assessment criteria (EAC) for PCB118, indicating a potential risk of adverse biological effects in the ecosystem, whereas levels of the total WHO-TEQs were below threshold for sea food suggesting limited risks for humans. No significant relationships between levels of DLC (expressed as WHO-TEQ), and biological responses such as the induction of CYP1A enzymatic activity and fry reproductive disorders were observed in eelpout. No marked relationship between WHO-TEQ and combined biological aryl hydrocarbon receptor-mediated transactivity (expressed as AhR-TEQ) was noted. However, there was a positive correlation between polycyclic aromatic hydrocarbon (PAH) metabolites and induction of CYP1A activity, suggesting that PAH exhibited greater potential than DLC to produce biological effects in eelpout from the Baltic Sea.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Peixes/metabolismo
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
Citocromo P-450 CYP1A1/genética
Citocromo P-450 CYP1A1/metabolismo
Dioxinas/análise
Dioxinas/toxicidade
Contaminação de Alimentos/análise
Alemanha
Groenlândia
Bifenilos Policlorados/análise
Dibenzodioxinas Policloradas/análise
Hidrocarbonetos Aromáticos Policíclicos/análise
Receptores de Hidrocarboneto Arílico/metabolismo
Reprodução/efeitos dos fármacos
Alimentos Marinhos/análise
Água do Mar/química
Suécia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dioxins); 0 (Polychlorinated Dibenzodioxins); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Receptors, Aryl Hydrocarbon); 0 (Water Pollutants, Chemical); DFC2HB4I0K (Polychlorinated Biphenyls); EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1372870


  7 / 2025 MEDLINE  
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[PMID]:28715890
[Au] Autor:Bigot M; Hawker DW; Cropp R; Muir DC; Jensen B; Bossi R; Bengtson Nash SM
[Ad] Endereço:Environmental Futures Research Institute, Griffith University , 170 Kessels Rd, Nathan, QLD 4111, Australia.
[Ti] Título:Spring Melt and the Redistribution of Organochlorine Pesticides in the Sea-Ice Environment: A Comparative Study between Arctic and Antarctic Regions.
[So] Source:Environ Sci Technol;51(16):8944-8952, 2017 Aug 15.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Complementary sampling of air, snow, sea-ice, and seawater for a range of organochlorine pesticides (OCPs) was undertaken through the early stages of respective spring sea-ice melting at coastal sites in northeast Greenland and eastern Antarctica to investigate OCP concentrations and redistribution during this time. Mean concentrations in seawater, sea-ice and snow were generally greater at the Arctic site. For example, α-HCH was found to have the largest concentrations of all analytes in Arctic seawater and sea-ice meltwater samples (224-253 and 34.7-48.2 pg·L respectively compared to 1.0-1.3 and <0.63 pg·L respectively for Antarctic samples). Differences in atmospheric samples were generally not as pronounced however. Findings suggest that sea-ice OCP burdens originate from both snow and seawater. The distribution profile between seawater and sea-ice showed a compound-dependency for Arctic samples not evident with those from the Antarctic, possibly due to full submersion of sea-ice at the former. Seasonal sea-ice melt processes may alter the exchange rates of selected OCPs between air and seawater, but are not expected to reverse their direction, which fugacity modeling indicates is volatilisation in the Arctic and net deposition in the Antarctic. These predictions are consistent with the limited current observations.
[Mh] Termos MeSH primário: Hidrocarbonetos Clorados
Praguicidas
[Mh] Termos MeSH secundário: Regiões Antárticas
Regiões Árticas
Monitoramento Ambiental
Groenlândia
Gelo
Água do Mar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Chlorinated); 0 (Ice); 0 (Pesticides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b02481


  8 / 2025 MEDLINE  
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[PMID]:28610584
[Au] Autor:Wielsøe M; Kern P; Bonefeld-Jørgensen EC
[Ad] Endereço:Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
[Ti] Título:Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study.
[So] Source:Environ Health;16(1):56, 2017 Jun 13.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Environmental Persistent Organic Pollutants (POPs) can alter the hormone homeostasis by mimicking, interfering or blocking the function of hormones; moreover POPs are hypothesized to modify the risk of breast cancer. The association between POPs and breast cancer has been widely studied but the conclusions are inconsistent. The present study examined the associations between serum levels of POPs and breast cancer with focus on the highly exposed Greenlandic Inuit population. METHODS: The study design was a case-control study of Inuit women from Greenland. The participants were asked to complete a questionnaire with information on reproductive history and lifestyle and to provide a blood sample. The sampling was carried out in two time periods (2000-2003 and 2011-2014). The serum levels were determined of 14 polychlorinated biphenyls (PCBs), 11 organochlorine pesticides (OCPs), 16 perfluoroalkyl acids (PFAAs), 1 polybrominated biphenyl (PBB), and 9 polybrominated diphenyl ethers (PBDEs). Independent samples t-test was used to compare differences between cases and controls and odds ratios (OR) adjusted for identified confounders were obtained using logistic regression. RESULTS: The study population included 77 breast cancer cases and 84 controls. The majority of the measured compounds declined significantly from 2000 - 2003 to 2011-2014. However, for the perfluorinated carboxylic acids (PFCAs) an increase was observed. The serum levels were significantly higher in cases compared to controls for the majority of the compounds, and after adjusting for age the difference was maintained for ∑OCP, dichlorodiphenyldichloroethylene (p,p'-DDE), ∑PFAA, ∑perfluorinated sulfonic acids (PFSA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS). For the lipophilic POPs, high serum levels (middel/highest vs. lowest tertile) of ∑PCB, ∑estrgoenicPCB, PCB99, PCB138, PCB153, PCB170, PCB170, and PCB183 was associated with breast cancer risk; for the amphiphilic PFAAs, high serum levels of ∑PFAA, ∑PFCA, ∑PFSA, perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), PFHxS, and PFOS were associated with breast cancer risk. CONCLUSION: Significant, positive associations between breast cancer risk and PCBs and PFAAs were observed. The associations indicate that environmental exposure to POPs can be a factor increasing the risk for breast cancer in Inuit women.
[Mh] Termos MeSH primário: Neoplasias da Mama/sangue
Neoplasias da Mama/epidemiologia
Exposição Ambiental
Poluentes Ambientais/sangue
Inuítes
[Mh] Termos MeSH secundário: Neoplasias da Mama/induzido quimicamente
Estudos de Casos e Controles
Monitoramento Ambiental
Feminino
Groenlândia/epidemiologia
Seres Humanos
Meia-Idade
Compostos Orgânicos/sangue
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Organic Chemicals)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1186/s12940-017-0269-6


  9 / 2025 MEDLINE  
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[PMID]:28609971
[Au] Autor:Knight-Jones P; Darbyshire T; Petersen ME; Tovar-Hernández MA
[Ad] Endereço:School of Biological Sciences, University of Wales, Swansea SA2 8PP, UK.. user@example.com.
[Ti] Título:What is Pseudopotamilla reniformis (Sabellidae)? Comparisons of populations from Britain, Iceland and Canada with comments on Eudistylia and Schizobranchia.
[So] Source:Zootaxa;4254(2):201-220, 2017 Apr 12.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:A neotype of Amphitrite Müller (1771) is established and re-described, using material collected in 2001 from near the type locality on the southwest coast of Iceland. We examined material from Iceland, Nova Scotia and Newfoundland, identified as Pseudopotamilla reniformis, showing scissiparity and commonly found in aggregations within kelp holdfasts or amongst encrusting fauna. By contrast, scissiparity has not been seen in a population recorded as P. reniformis from Wales (broadcast spawning is presumed, Chughtai & Knight-Jones 1988), which bores into limestone and that the present analysis shows to belong to a different species from P. reniformis. Sabella oculata Krøyer (1856, Norway) is a junior synonym of P. reniformis. Sabella aspersa Krøyer (1856, Greenland) and Sabella saxicava (Quatrefages, 1866, France) are re-instated and re-described in Pseudopotamilla. Pseudopotamilla saxicava (= Potamilla ehlersi Gravier, 1906) has a widespread distribution from Britain to the Arabian Gulf, Pseudopotamilla aspersa is found in Greenland and the distribution of P. reniformis is reduced to Iceland, northern Norway, Nova Scotia and Newfoundland. The genera Eudistylia Bush and Schizobranchia Bush are discussed in relation to Pseudopotamilla.
[Mh] Termos MeSH primário: Poliquetos
[Mh] Termos MeSH secundário: Animais
Canadá
França
Groenlândia
Islândia
Noruega
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4254.2.3


  10 / 2025 MEDLINE  
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[PMID]:28570574
[Au] Autor:Michelsen SW; Soborg B; Diaz LJ; Hoff ST; Agger EM; Koch A; Rosenkrands I; Wohlfahrt J; Melbye M
[Ad] Endereço:Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
[Ti] Título:The dynamics of immune responses to Mycobacterium tuberculosis during different stages of natural infection: A longitudinal study among Greenlanders.
[So] Source:PLoS One;12(6):e0177906, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Understanding human immunity to Mycobacterium tuberculosis (Mtb) during different stages of infection is important for development of an effective tuberculosis (TB) vaccine. We aimed to evaluate immunity to Mtb infection by measuring immune responses to selected Mtb antigens expressed during different stages of infection over time and to observe sustainability of immunity. METHODS: In a cohort study comprising East Greenlanders aged 17-22 years (2012 to 2014) who had either; undetectable Mtb infection, ongoing or prior Mtb infection at enrolment, we measured immunity to 15 antigens over a one-year period. Quantiferon-TB Gold testing (QFT) defined Mtb infection status (undetected/detected). The eligible study population of East Greenlanders aged 17-22 years was identified from the entire population using the Civil Registration System. From the source population 65 participants were selected by stratified random sampling according to information on Mtb infection stage. Retrospective and prospective information on notified TB (including treatment) was obtained through the mandatory TB notification system and was used to characterise Mtb infection stage (ongoing/prior). Immunity to 15 antigens including two QFT antigens, PPD and 12 non-QFT antigens (representing early, constitutive and latent Mtb infection) was assessed by measuring immune responses using whole-blood antigen stimulation and interferon gamma measurement. RESULTS: Of 65 participants, 54 were considered Mtb-infected. Immunity to Mtb infection fluctuated with high annual risk of conversion (range: 6-69%) and reversion (range: 5-95%). During follow-up, five (8%) participants were notified with TB; neither conversion nor reversion was associated with an increased risk of progressing to TB. CONCLUSIONS: Our findings suggest that human immunity to natural Mtb infection over time is versatile with fluctuations, resulting in high levels of conversion and reversion of immunity, thus human immunity to Mtb is much more dynamic than anticipated. The study findings suggest future use of longitudinal assessment of immune responses when searching for TB vaccine candidate antigens.
[Mh] Termos MeSH primário: Mycobacterium tuberculosis/imunologia
Tuberculose/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Groenlândia
Seres Humanos
Estudos Longitudinais
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177906



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