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[PMID]:28460130
[Au] Autor:Ochoa A; Kitayama K; Uijtdehaage S; Vermillion M; Eaton M; Carpio F; Serota M; Hochman ME
[Ad] Endereço:UCLA PRIME, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
[Ti] Título:Patient and provider perspectives on the potential value and use of a bilingual online patient portal in a Spanish-speaking safety-net population.
[So] Source:J Am Med Inform Assoc;24(6):1160-1164, 2017 Nov 01.
[Is] ISSN:1527-974X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective: To assess patient and provider perspectives on the potential value and use of a bilingual patient portal in a large safety-net health system serving predominantly Spanish-speaking patients. Materials and Methods: We captured patient and provider perspectives through the administration of surveys to assess Internet access, barriers, and facilitators to patient portal adoption, along with portal preferences. We report on these survey results using descriptive and comparative statistics. Results: Four hundred patients (82% response rate) and 59 providers (80% response rate) participated in the study. Although 73% of providers believed that the patient portal would increase patient satisfaction, just 39% planned to recommend portal use to patients, citing concerns related to time and reimbursement. In contrast, 72% of patients believed the patient portal would strengthen the patient-provider relationship and 77% believed it would improve the quality of care. Latino patients in particular believed the patient portal would strengthen the patient-provider relationship. Seventy-five percent of patients reported interest in a mobile version of the portal. Discussion: Patients from a safety-net health system, most of whom were Spanish-speaking, reported a high level of interest in the patient portal. Providers at the same health system expressed reluctance about the portal due to concerns related to time and reimbursement. Conclusion: Bilingual patient portal implementation has considerable potential to promote health care engagement within Spanish-speaking safety-net populations; however, lack of provider engagement in the process could undermine the effort.
[Mh] Termos MeSH primário: Atitude do Pessoal de Saúde
Atitude Frente à Saúde
Portais do Paciente
Satisfação do Paciente
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
California
Centros Comunitários de Saúde
Registros Eletrônicos de Saúde
Feminino
Seres Humanos
Internet
Masculino
Multilinguismo
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/jamia/ocx040


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[PMID]:29494570
[Au] Autor:Heaton D; Huang S; Shiau R; Casillas S; Straily A; Kong LK; Ng V; Petru V
[Ti] Título:Trichinellosis Outbreak Linked to Consumption of Privately Raised Raw Boar Meat - California, 2017.
[So] Source:MMWR Morb Mortal Wkly Rep;67(8):247-249, 2018 Mar 02.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:On January 15, 2017, a hospital physician notified the Alameda County Public Health Department (ACPHD) in California of a patient with a suspected diagnosis of trichinellosis, a roundworm disease transmitted by the consumption of raw or undercooked meat containing Trichinella spp. larvae (1). A family member of the initial patient reported that at least three other friends and family members had been evaluated at area hospitals for fever, myalgia, abdominal pain, diarrhea, and vomiting. The patients had attended a celebration on December 28, 2016, at which several pork dishes were served, including larb, a traditional Laotian raw pork dish, leading the hospital physician to suspect a diagnosis of trichinellosis. Although the event hosts did not know the exact number of attendees, ACPHD identified 29 persons who attended the event and seven persons who did not attend the event, but consumed pork taken home from the event by attendees. The event hosts reported that the meat had come from a domesticated wild boar raised and slaughtered on their private family farm in northern California. ACPHD conducted a case investigation that included identification of additional cases, testing of leftover raw meat, and a retrospective cohort study to identify risk factors for infection.
[Mh] Termos MeSH primário: Surtos de Doenças
Carne/parasitologia
Alimentos Crus/efeitos adversos
Alimentos Crus/parasitologia
Triquinelose/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
California/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Prática de Saúde Pública
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180302
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6708a3


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[PMID]:29348612
[Au] Autor:Wiemels JL; Walsh KM; de Smith AJ; Metayer C; Gonseth S; Hansen HM; Francis SS; Ojha J; Smirnov I; Barcellos L; Xiao X; Morimoto L; McKean-Cowdin R; Wang R; Yu H; Hoh J; DeWan AT; Ma X
[Ad] Endereço:Department of Epidemiology and Biostatistics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA. joe.wiemels@ucsf.edu.
[Ti] Título:GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.
[So] Source:Nat Commun;9(1):286, 2018 01 18.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Childhood acute lymphoblastic leukemia (ALL) (age 0-14 years) is 20% more common in Latino Americans than non-Latino whites. We conduct a genome-wide association study in a large sample of 3263 Californian children with ALL (including 1949 of Latino heritage) and 3506 controls matched on month and year of birth, sex, and ethnicity, and an additional 12,471 controls from the Kaiser Resource for Genetic Epidemiology Research on Aging Cohort. Replication of the strongest genetic associations is performed in two independent datasets from the Children's Oncology Group and the California Childhood Leukemia Study. Here we identify new risk loci on 17q12 near IKZF3/ZPBP2/GSDMB/ORMDL3, a locus encompassing a transcription factor important for lymphocyte development (IKZF3), and at an 8q24 region known for structural contacts with the MYC oncogene. These new risk loci may impact gene expression via local (four 17q12 genes) or long-range (8q24) interactions, affecting function of well-characterized hematopoietic and growth-regulation pathways.
[Mh] Termos MeSH primário: Cromossomos Humanos Par 17/genética
Cromossomos Humanos Par 8/genética
Predisposição Genética para Doença/genética
Estudo de Associação Genômica Ampla
Leucemia-Linfoma Linfoblástico de Células Precursoras/genética
[Mh] Termos MeSH secundário: Adolescente
California
Pré-Escolar
Feminino
Frequência do Gene
Predisposição Genética para Doença/etnologia
Hispano-Americanos/genética
Seres Humanos
Lactente
Recém-Nascido
Masculino
Polimorfismo de Nucleotídeo Único
Leucemia-Linfoma Linfoblástico de Células Precursoras/etnologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02596-9


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[PMID]:29256431
[Au] Autor:Kamoroff C; Goldberg CS
[Ad] Endereço:School of the Environment, Washington State University, Pullman, WA 99164, USA.
[Ti] Título:Using environmental DNA for early detection of amphibian chytrid fungus Batrachochytrium dendrobatidis prior to a ranid die-off.
[So] Source:Dis Aquat Organ;127(1):75-79, 2017 Dec 19.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Amphibian chytridiomycosis caused by the fungus Batrachochytrium dendrobatidis (Bd) is an emerging infectious disease that has been associated with mass mortality and extinctions of amphibians worldwide. Environmental DNA (eDNA) techniques have been used to detect the presence of Bd in the environment, but not to detect Bd prior to an amphibian die-off. We collected eDNA using filtered water samples from 13 lakes across Sequoia Kings Canyon National Park. Seven of those sites had populations of mountain yellow-legged frogs, an amphibian highly susceptible to chytridiomycosis, and 3 of those populations experienced a Bd related die-off 1 mo post-eDNA sampling. We detected Bd in eDNA samples that were collected 1 mo prior to the observed Bd-caused die-off at all 3 sites affected by Bd, and we did not detect Bd at the other sites where no die-off was observed. Our study indicates the potential to use eDNA techniques for early detection of Bd in the environment.
[Mh] Termos MeSH primário: Quitridiomicetos/genética
DNA Fúngico/isolamento & purificação
Monitoramento Ambiental
Micoses/microbiologia
Ranidae
[Mh] Termos MeSH secundário: Animais
California
Micoses/epidemiologia
Micoses/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.3354/dao03183


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[PMID]:29419997
[Au] Autor:O'Hagan D; Meehan A
[Ti] Título:IG Case Study: Rady Children's Hospital--San Diego. Prioritizing Information Governance Initiatives Already Underway.
[So] Source:J AHIMA;88(5):52-3, 2017 05.
[Is] ISSN:1060-5487
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Gestão da Informação em Saúde/organização & administração
Hospitais Pediátricos
[Mh] Termos MeSH secundário: California
Seres Humanos
Modelos Organizacionais
Estudos de Casos Organizacionais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE


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[PMID]:29412628
[Ti] Título:Health IT Preparing for 'The Big One.'
[So] Source:J AHIMA;88(4):68, 2017 Apr.
[Is] ISSN:1060-5487
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Planejamento em Desastres
Terremotos
Gestão da Informação em Saúde
[Mh] Termos MeSH secundário: California
Troca de Informação em Saúde
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:28460643
[Au] Autor:Clarke CA; Canchola AJ; Moy LM; Neuhausen SL; Chung NT; Lacey JV; Bernstein L
[Ad] Endereço:Cancer Prevention Institute of California, 2201 Walnut Ave. Suite 300, Fremont, CA, 94538, USA.
[Ti] Título:Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study.
[So] Source:Breast Cancer Res;19(1):52, 2017 May 01.
[Is] ISSN:1465-542X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Regular users of aspirin may have reduced risk of breast cancer. Few studies have addressed whether risk reduction pertains to specific breast cancer subtypes defined jointly by hormone receptor (estrogen and progesterone receptor) and human epidermal growth factor receptor 2 (HER2) expression. This study assessed the prospective risk of breast cancer (overall and by subtype) according to use of aspirin and other non-steroidal anti-inflammatory medications (NSAIDs) in a cohort of female public school professionals in California. METHODS: In 1995 - 1996, participants in the California Teachers Study completed a baseline questionnaire on family history of cancer and other conditions, use of NSAIDs, menstrual and reproductive history, self-reported weight and height, living environment, diet, alcohol use, and physical activity. In 2005-2006, 57,164 participants provided some updated information, including use of NSAIDs and 1457 of these participants developed invasive breast cancer before January 2013. Multivariable Cox proportional hazards regression models provided hazard rate ratios (HRR) for the association between NSAID use and risk of invasive breast cancer as well as hormone receptor- and HER2-defined subtypes. RESULTS: Developing breast cancer was associated inversely with taking three or more tablets of low-dose aspirin per week (23% of participants). Among women reporting this exposure, the HRR was 0.84 (95% confidence interval (CI) 0.72-0.98) compared to those not taking NSAIDs and this was particularly evident in women with the hormone receptor-positive/HER2-negative subtype (HRR = 0.80, 95% CI 0.66-0.96). Use of three or more tablets of "other" NSAIDs was marginally associated with lower risk of breast cancer (HRR = 0.79, 95% CI 0.62-1.00). Other associations with NSAIDs were generally null. CONCLUSION: Our observation of reduced risk of breast cancer, among participants who took three or more tablets of low-dose aspirin weekly, is consistent with other reports looking at aspirin without differentiation by dose. This is the first report to suggest that the reduction in risk occurs for low-dose aspirin and not for regular-dose aspirin and only among women with the hormone receptor-positive/HER2-negative subtype. This preliminary study builds on previous knowledge and further supports the need for formal cancer chemoprevention studies of low-dose aspirin.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Aspirina/uso terapêutico
Neoplasias da Mama/tratamento farmacológico
Receptor ErbB-2/genética
[Mh] Termos MeSH secundário: Idoso
Neoplasias da Mama/epidemiologia
Neoplasias da Mama/patologia
California
Relação Dose-Resposta a Droga
Feminino
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Meia-Idade
Modelos de Riscos Proporcionais
Receptores Estrogênicos/genética
Receptores de Progesterona/genética
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Receptors, Estrogen); 0 (Receptors, Progesterone); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, ErbB-2); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s13058-017-0840-7


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[PMID]:29390313
[Au] Autor:Parikh-Patel A; Morris CR; Kizer KW
[Ad] Endereço:California Cancer Reporting and Epidemiologic Surveillance (CalCARES) Program, Institute for Population Health Improvement, University of California Davis Health.
[Ti] Título:Disparities in quality of cancer care: The role of health insurance and population demographics.
[So] Source:Medicine (Baltimore);96(50):e9125, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Escalating costs and concerns about quality of cancer care have increased calls for quality measurement and performance accountability for providers and health plans. The purpose of the present cross-sectional study was to assess variability in the quality of cancer care by health insurance type in California.Persons with breast, ovary, endometrium, cervix, colon, lung, or gastric cancer during the period 2004 to 2014 were identified in the California Cancer Registry. Individuals were stratified into 5 health insurance categories: private insurance, Medicare, Medicaid, dual Medicare and Medicaid eligible, and uninsured. Quality of care was evaluated using Commission on Cancer quality measures. Logistic regression models were generated to assess the independent effect of health insurance type on stage at diagnosis, quality of care and survival after adjusting for age, sex, race/ethnicity, and socioeconomic status (SES).A total of 763,884 cancer cases were evaluated. Individuals with Medicaid or Medicare-Medicaid dual-eligible coverage and the uninsured had significantly lower odds of receiving recommended radiation and/or chemotherapy after diagnosis or surgery for breast, endometrial, and colon cancer, relative to those with private insurance. Dual eligible patients with gastric cancer had 21% lower odds of having the recommended number of lymph nodes removed and examined compared to privately insured patients.After adjusting for known demographic confounders, substantial and consistent disparities in quality of cancer care exist according to type of health insurance in California. Further study is needed to identify particular factors and mechanisms underlying the identified treatment disparities across sources of health insurance.
[Mh] Termos MeSH primário: Demografia
Disparidades em Assistência à Saúde
Cobertura do Seguro
Seguro Saúde
Neoplasias/economia
Neoplasias/terapia
Qualidade da Assistência à Saúde
[Mh] Termos MeSH secundário: California
Estudos Transversais
Feminino
Seres Humanos
Masculino
Sistema de Registros
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009125


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[PMID]:29031188
[Au] Autor:Vermillion Maier ML; Tjeerdema RS
[Ad] Endereço:Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, One Shields Avenue, Davis, CA 95616-8588, USA. Electronic address: mlmaier@ucdavis.edu.
[Ti] Título:Azithromycin sorption and biodegradation in a simulated California river system.
[So] Source:Chemosphere;190:471-480, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Azithromycin (AZ) is a widely-used macrolide antibiotic that is continually deposited into natural waterways by sewage effluent. Though recognized as an emerging contaminant of concern, little is known about its fate and transport in aquatic systems. American River soils and water were used to determine degradation of AZ in microcosms simulating flooded (anaerobic) and non-flooded (aerobic) California watershed conditions. Under aerobic conditions the degradation rate constant (k=0.0084 ± 0.0039 day ) and DT (82.52 ± 56.54 days) were calculated, as AZ disappearance indicated potential degradation. However, based on concurrent product appearance, less than one percent of the parent degraded over 150 days. Throughout the experiment microbial growth was observed by culturing in tryptic soy broth despite antibiotic addition and soil being autoclaved. Sorption likely contributes to AZ recalcitrance, thus the soil-water partition coefficient (log K = 2.18 Lkg ), Freundlich sorption and desorption coefficients (log K = 1.90 ± 0.14 and log K = 2.51 ± 0.30, respectively), and organic-carbon-normalized distribution coefficient (log K = 4.25 Lkg ) were also calculated. Based on these results, AZ degradation in aquatic systems will likely be very limited and transport will fluctuate based on the extent of soil-water saturation or bulk movement of sediment.
[Mh] Termos MeSH primário: Azitromicina/química
Rios/química
Poluentes do Solo/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Adsorção
Antibacterianos/química
Biodegradação Ambiental
California
Simulação por Computador
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 83905-01-5 (Azithromycin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


  10 / 46331 MEDLINE  
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[PMID]:29234797
[Au] Autor:Gomez AM
[Ad] Endereço:Sexual Health and Reproductive Equity Program, School of Social Welfare, University of California, Berkeley.
[Ti] Título:Availability of Pharmacist-Prescribed Contraception in California, 2017.
[So] Source:JAMA;318(22):2253-2254, 2017 Dec 12.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anticoncepcionais Femininos
Prescrições de Medicamentos/estatística & dados numéricos
Farmácias/estatística & dados numéricos
[Mh] Termos MeSH secundário: California
Seres Humanos
Farmacêuticos
Honorários por Prescrição de Medicamentos/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contraceptive Agents, Female)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.15674



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