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[PMID]:29406663
[Au] Autor:Eby AZ
[Ti] Título:Impacting Parental Vaccine Decision-Making.
[So] Source:Pediatr Nurs;43(1):22-9, 34, 2017 Jan-Feb.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An increase in vaccine hesitancy is contributing to an increase of vaccine refusal and the use of an alternative vaccine schedule (AVS) in the United States. Increasing vaccine knowledge and correcting vaccine misinformation has the potential of shifting parental attitudes, decreasing vaccine hesitancy, and increasing parental intent to vaccinate. The aim was to examine the impact of a voice-over PowerPoint™ presentation on vaccine education and decision-making by vaccine-hesitant parents in a pediatric primary care clinic. A quasi-experimental study using the Parent Attitude about Childhood Vaccine (PACV) Survey was conducted in a suburban pediatric clinic to explore the impact of vaccine education on decision-making by vaccine-hesitant parents. PACV Survey scores were collected over three months. Surveyed parents reported they trust their healthcare provider. Unfortunately, although parents trust the information their medical providers give them on vaccine safety, they continue to be concerned about vaccine side effects. Mothers tended to provide more vaccine-hesitant scores than fathers related to safety and efficacy concerns. The utilization of the PACV Survey and voice-over PowerPoint presentation on vaccine education is an intervention that may be used in pediatric clinics to assist in vaccine education and identify vaccine-hesitant parents. The study contributes to the addition of evidence- based vaccine education.
[Mh] Termos MeSH primário: Tomada de Decisões
Educação em Saúde/organização & administração
Pais/psicologia
Vacinação/psicologia
[Mh] Termos MeSH secundário: Adulto
Arizona
Criança
Feminino
Seres Humanos
Masculino
Desenvolvimento de Programas
Avaliação de Programas e Projetos de Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:27775387
[Au] Autor:Murillo AL; Safan M; Castillo-Chavez C; Phillips ED; Wadhera D
[Ad] Endereço:Simon A Levin Mathematical, Computational and Modeling Sciences Center, Arizona State University, Tempe, AZ, United States. email: Anarina.Murillo@asu.edu.
[Ti] Título:Modeling eating behaviors: The role of environment and positive food association learning via a Ratatouille effect.
[So] Source:Math Biosci Eng;13(4):841-855, 2016 08 01.
[Is] ISSN:1551-0018
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eating behaviors among a large population of children are studied as a dynamic process driven by nonlinear interactions in the sociocultural school environment. The impact of food association learning on diet dynamics, inspired by a pilot study conducted among Arizona children in Pre-Kindergarten to 8th grades, is used to build simple population-level learning models. Qualitatively, mathematical studies are used to highlight the possible ramifications of instruction, learning in nutrition, and health at the community level. Model results suggest that nutrition education programs at the population-level have minimal impact on improving eating behaviors, findings that agree with prior field studies. Hence, the incorporation of food association learning may be a better strategy for creating resilient communities of healthy and non-healthy eaters. A Ratatouille effect can be observed when food association learners become food preference learners, a potential sustainable behavioral change, which in turn, may impact the overall distribution of healthy eaters. In short, this work evaluates the effectiveness of population-level intervention strategies and the importance of institutionalizing nutrition programs that factor in economical, social, cultural, and environmental elements that mesh well with the norms and values in the community.
[Mh] Termos MeSH primário: Aprendizagem por Associação
Meio Ambiente
Comportamento Alimentar/fisiologia
Modelos Teóricos
[Mh] Termos MeSH secundário: Arizona
Dieta/estatística & dados numéricos
Seres Humanos
Projetos Piloto
Instituições Acadêmicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.3934/mbe.2016020


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[PMID]:29258861
[Au] Autor:Carcamo-Noriega EN; Olamendi-Portugal T; Restano-Cassulini R; Rowe A; Uribe-Romero SJ; Becerril B; Possani LD
[Ad] Endereço:Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, UNAM, Av. Universidad 2001, Apartado Postal 510-3, Cuernavaca, Morelos 62210, Mexico. Electronic address: edsoncar@ibt.unam.mx.
[Ti] Título:Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
[So] Source:Arch Biochem Biophys;638:52-57, 2018 01 15.
[Is] ISSN:1096-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated geographic variability in the venom of Centruroides sculpturatus scorpions from different biotopes. Venom from scorpions collected from two different regions in Arizona; Santa Rita Foothills (SR) and Yarnell (Yar) were analyzed. We found differences between venoms, mainly in the two most abundant peptides; SR (CsEv2e and CsEv1f) and Yar (CsEv2 and CsEv1c) identified as natural variants of CsEv1 and CsEv2. Sequence analyses of these peptides revealed conservative amino acid changes between variants, which may underlie biological activity against arthropods. A third peptide (CsEv6) was highly abundant in the Yar venom compared to the SR venom. CsEv6 is a 67 amino acid peptide with 8 cysteines. CsEv6 did not exhibit toxicity to the three animal models tested. However, both venoms shared similarities in peptides that are predicted to deter predators. For example, both venoms expressed CsEI (lethal to chick) in similar abundance, while CsEd and CsEM1a (toxic to mammals) displayed only moderate variation in their abundance. Electrophysiological evaluation of CsEd and CsEM1a showed that both toxins act on the human sodium-channel subtype 1.6 (hNav 1.6). Complete sequencing revealed that both toxins are structurally similar to beta-toxins isolated from different Centruroides species that also target hNav 1.6.
[Mh] Termos MeSH primário: Proteínas de Artrópodes
Variação Genética
Venenos de Escorpião
Escorpiões
[Mh] Termos MeSH secundário: Animais
Arizona
Proteínas de Artrópodes/química
Proteínas de Artrópodes/genética
Proteínas de Artrópodes/toxicidade
Células CHO
Galinhas
Cricetulus
Gryllidae
Células HEK293
Seres Humanos
Camundongos
Canal de Sódio Disparado por Voltagem NAV1.6/genética
Canal de Sódio Disparado por Voltagem NAV1.6/metabolismo
Venenos de Escorpião/química
Venenos de Escorpião/genética
Venenos de Escorpião/toxicidade
Escorpiões/química
Escorpiões/genética
Análise de Sequência de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Arthropod Proteins); 0 (Centruroides toxin); 0 (NAV1.6 Voltage-Gated Sodium Channel); 0 (SCN8A protein, human); 0 (Scorpion Venoms); 141322-33-0 (toxin 2, Centruroides noxius)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


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[PMID]:29176868
[Au] Autor:Robles MD; Turner DS; Haney JA
[Ad] Endereço:The Nature Conservancy, Center for Science and Public Policy, Tucson, Arizona, United States of America.
[Ti] Título:A century of changing flows: Forest management changed flow magnitudes and warming advanced the timing of flow in a southwestern US river.
[So] Source:PLoS One;12(11):e0187875, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The continued provision of water from rivers in the southwestern United States to downstream cities, natural communities and species is at risk due to higher temperatures and drought conditions in recent decades. Snowpack and snowfall levels have declined, snowmelt and peak spring flows are arriving earlier, and summer flows have declined. Concurrent to climate change and variation, a century of fire suppression has resulted in dramatic changes to forest conditions, and yet, few studies have focused on determining the degree to which changing forests have altered flows. In this study, we evaluated changes in flow, climate, and forest conditions in the Salt River in central Arizona from 1914-2012 to compare and evaluate the effects of changing forest conditions and temperatures on flows. After using linear regression models to remove the influence of precipitation and temperature, we estimated that annual flows declined by 8-29% from 1914-1963, coincident with a 2-fold increase in basal area, a 2-3-fold increase in canopy cover, and at least a 10-fold increase in forest density within ponderosa pine forests. Streamflow volumes declined by 37-56% in summer and fall months during this period. Declines in climate-adjusted flows reversed at mid-century when spring and annual flows increased by 10-31% from 1964-2012, perhaps due to more winter rainfall. Additionally, peak spring flows occurred about 12 days earlier in this period than in the previous period, coincident with winter and spring temperatures that increased by 1-2°C. While uncertainties remain, this study adds to the knowledge gained in other regions that forest change has had effects on flow that were on par with climate variability and, in the case of mid-century declines, well before the influence of anthropogenic warming. Current large-scale forest restoration projects hold some promise of recovering seasonal flows.
[Mh] Termos MeSH primário: Mudança Climática
Florestas
Rios
Movimentos da Água
[Mh] Termos MeSH secundário: Arizona
Geografia
Seres Humanos
Modelos Teóricos
Chuvas
Análise de Regressão
Estações do Ano
Neve
Temperatura Ambiente
Fatores de Tempo
Abastecimento de Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187875


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[PMID]:29210228
[Au] Autor:Vaughn NR; Asner GP; Giardina CP
[Ti] Título:Centennial impacts of fragmentation on the canopy structure of tropical montane forest.
[So] Source:Ecol Appl;24(7):1638-50, 2014.
[Is] ISSN:1051-0761
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fragmentation poses one of the greatest threats to tropical forests with short-term changes to the structure of forest canopies affecting microclimate, tree mortality, and growth. Yet the long-term effects of fragmentation are poorly understood because (1) most effects require many decades to materialize, but long-term studies are very rare, (2) the effects of edges on forest canopy structure as a function of fragment size are unknown, and (3) edge effects are often confounded by fragment shape. We quantified the long-term (centennial) effects of fragmentation on forest canopy structure using airborne light detection and ranging (LiDAR) of 1060 Hawaiian rain forest fragments ranging in size from 0.02 to 1000 ha, created more than 130 years ago by flowing lava. Along with distance from edge, we developed a metric, minimum span, to gain additional insight into edge effects on three measures of canopy structure: canopy height, height variation, and gap fraction. Fragment size was a strong determinant of the three structural variables. Larger fragments had greater average height, larger variation in height, and smaller gap fraction. Minimum span had a large effect on the depth and magnitude of edge effects for the three structural variables. Locations associated with high span values (those surrounded by more forest habitat) showed little effect of distance to fragment edge. In contrast, locations with low span values (those more exposed to edges) were severely limited in canopy height, showed lower height variation, and were associated with greater gap fraction values. The minimum span attribute allows for a more accurate characterization of edge as well as fragment-level effects, and when combined with high resolution imagery, can improve planning of protected areas for long-term ecological sustainability and biodiversity protection.
[Mh] Termos MeSH primário: Florestas
Clima Tropical
[Mh] Termos MeSH secundário: Arizona
Biodiversidade
Mudança Climática
Simulação por Computador
Conservação dos Recursos Naturais
Monitoramento Ambiental
Modelos Biológicos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28743548
[Au] Autor:Johnson K; Petti J; Olson A; Custer T
[Ad] Endereço:Honor Health Thompson Peak Medical Center, 7400 E. Thompson Peak Parkway, Scottsdale, AZ, 85255, United States. Electronic address: Kari.Johnson@honorhealth.com.
[Ti] Título:Identifying barriers to early mobilisation among mechanically ventilated patients in a trauma intensive care unit.
[So] Source:Intensive Crit Care Nurs;42:51-54, 2017 Oct.
[Is] ISSN:1532-4036
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mechanically ventilated patients can be at risk for functional decline (Cameron et al., 2015). Early mobilisation of mechanically ventilated patients can improve outcomes after critical illness to prevent this decline. Although registered nurses understand the importance of early mobilisation there are nurses who are unwilling to mobilise patients. AIM: The aim of this study is to examine whether nurses' attitudes and beliefs are barriers for early mobilisation and evaluate whether an education intervention can improve early mobilisation. METHOD: Pre-test, post-test intervention with registered nurses and charge nurses in a 22 bed trauma intensive care setting. PROCEDURE: Pre-test, post-test survey assessed perceived barriers in knowledge, attitudes, and behaviours followed by targeted education. RESULTS: Dependent Sample T-test revealed a statistically significant increase in post-test responses for the subscales knowledge, attitudes, and behaviours with early mobilisation. This over-all increase in post-test results support that understanding barriers can improve patient outcomes. CONCLUSION: Use of structured surveys to identify barriers for early mobilisation among nursing can assist in providing targeted education that address nurse's perception. The education intervention appeared to have a positive impact on attitudes but it is unknown if the difference was sustained over time or affected participants practice or patient outcomes.
[Mh] Termos MeSH primário: Deambulação Precoce/enfermagem
Enfermeiras e Enfermeiros/psicologia
Percepção
Respiração Artificial/enfermagem
[Mh] Termos MeSH secundário: Adulto
Arizona
Atitude do Pessoal de Saúde
Enfermagem de Cuidados Críticos/recursos humanos
Enfermagem de Cuidados Críticos/normas
Feminino
Seres Humanos
Unidades de Terapia Intensiva/organização & administração
Unidades de Terapia Intensiva/tendências
Masculino
Meia-Idade
Enfermeiras e Enfermeiros/normas
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:29016511
[Au] Autor:Clark NM; Schembri M; Jacoby VL
[Ad] Endereço:University of California, San Francisco School of Medicine, and the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California.
[Ti] Título:Change in Surgical Practice for Women With Leiomyomas After the U.S. Food and Drug Administration Morcellator Safety Communication.
[So] Source:Obstet Gynecol;130(5):1057-1063, 2017 Nov.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the association between the U.S. Food and Drug Administration (FDA) communication discouraging use of power morcellators on changes in surgical practice for women with uterine leiomyomas. METHODS: This is a cross-sectional study using data from 2013 to 2014 in the Healthcare Cost and Utilization Project State Inpatient and State Ambulatory Surgical Databases from Arizona, Florida, Kentucky, and New Jersey. Women with a diagnosis of leiomyomas who underwent hysterectomy or myomectomy were included in the analysis. Multivariable models were used to assess changes in the proportion of hysterectomies performed laparoscopically, vaginally, or by laparotomy in the 15 months before the FDA safety communication in April 2013 (January 2013 to March 2014) to the 9 months after the FDA communication (April to December 2014). Changes in the proportion of women who underwent myomectomy compared with hysterectomy were also evaluated during this time period. RESULTS: There were 77,637 hysterectomy and myomectomy cases analyzed from states with both inpatient and ambulatory surgery data; 59% of patients were outpatients. Overall, there was a 4% (95% CI 3.2-4.8%) decrease in the use of laparoscopic hysterectomy for treatment of uterine leiomyomas from 62% of all hysterectomies before the FDA communication on morcellation to 58% afterward. Changes in surgical practice were more pronounced in the inpatient compared with outpatient setting; inpatient laparoscopic hysterectomy decreased by 7% (95% CI 6.1-7.9%) from 24% to 17% of all hysterectomies with an accompanying increase in abdominal hysterectomy of 8% (95% CI 6.7-8.6%) from 71% to 79%. There were no significant changes in the proportion of women with leiomyomas who underwent myomectomy compared with hysterectomy. CONCLUSION: The FDA communication discouraging the use of power morcellators was associated with a decline in laparoscopy to perform hysterectomy, particularly in the inpatient setting. There was no change in the selection of myomectomy compared with hysterectomy for leiomyoma treatment after the FDA communication.
[Mh] Termos MeSH primário: Histerectomia/tendências
Laparoscopia/tendências
Leiomioma/cirurgia
Morcelação/instrumentação
Retirada de Dispositivo Médico Baseada em Segurança
Miomectomia Uterina/tendências
Neoplasias Uterinas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Arizona
Estudos Transversais
Bases de Dados Factuais
Feminino
Florida
Seres Humanos
Histerectomia/instrumentação
Histerectomia/métodos
Kentucky
Laparoscopia/métodos
Meia-Idade
Análise Multivariada
New Jersey
Estados Unidos
United States Food and Drug Administration
Miomectomia Uterina/instrumentação
Miomectomia Uterina/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002309


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[PMID]:28925238
[Au] Autor:Goldberg RF; Goldberg KD; Caruso D
[Ti] Título:The art of the deposition: Teaching residents about medical liability.
[So] Source:Bull Am Coll Surg;102(2):39-42, 2017 02.
[Is] ISSN:0002-8045
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Medicina Defensiva/educação
Educação de Pós-Graduação em Medicina
Internato e Residência
Responsabilidade Legal
[Mh] Termos MeSH secundário: Arizona
Currículo
Seres Humanos
Ensino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:28919326
[Au] Autor:Huynh TP; Jancovich JK; Tripuraneni L; Heck MC; Langland JO; Jacobs BL
[Ad] Endereço:School of Life Sciences, and The Biodesign Institute, Center for Infectious Diseases and Vaccinology Arizona State University, Tempe, AZ 85287-5001, USA.
[Ti] Título:Characterization of a PKR inhibitor from the pathogenic ranavirus, Ambystoma tigrinum virus, using a heterologous vaccinia virus system.
[So] Source:Virology;511:290-299, 2017 Nov.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ambystoma tigrinum virus (ATV) (family Iridoviridae, genus Ranavirus) was isolated from diseased tiger salamanders (Ambystoma tigrinum stebbinsi) from the San Rafael Valley in southern Arizona, USA in 1996. Genomic sequencing of ATV, as well as other members of the genus, identified an open reading frame that has homology to the eukaryotic translation initiation factor, eIF2α (ATV eIF2α homologue, vIF2αH). Therefore, we asked if the ATV vIF2αH could also inhibit PKR. To test this hypothesis, the ATV vIF2αH was cloned into vaccinia virus (VACV) in place of the well-characterized VACV PKR inhibitor, E3L. Recombinant VACV expressing ATV vIF2αH partially rescued deletion of the VACV E3L gene. Rescue coincided with rapid degradation of PKR in infected cells. These data suggest that the salamander virus, ATV, contains a novel gene that may counteract host defenses, and this gene product may be involved in the presentation of disease caused by this environmentally important pathogen.
[Mh] Termos MeSH primário: Inibidores de Proteínas Quinases/metabolismo
Ranavirus/patogenicidade
Proteínas Recombinantes/metabolismo
Proteínas Virais/metabolismo
Fatores de Virulência/metabolismo
eIF-2 Quinase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Ambystoma/virologia
Animais
Arizona
Expressão Gênica
Vetores Genéticos
Interações Hospedeiro-Patógeno
Evasão da Resposta Imune
Ranavirus/genética
Proteínas Recombinantes/genética
Vírus Vaccinia/genética
Proteínas Virais/genética
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 0 (Recombinant Proteins); 0 (Viral Proteins); 0 (Virulence Factors); EC 2.7.11.1 (eIF-2 Kinase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28870655
[Au] Autor:Pfau JC; Buck B; Metcalf RV; Kaupish Z; Stair C; Rodriguez M; Keil DE
[Ad] Endereço:Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA. Electronic address: jean.pfau@montana.edu.
[Ti] Título:Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona.
[So] Source:Toxicol Appl Pharmacol;334:24-34, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been discovered in southern Nevada and northwestern Arizona, where the material exists in extensive recreational areas and is present in yards, roads, parking lots and school yards. The objective was to compare the health outcomes in mice exposed to either LAA or the fibrous amphiboles collected in Arizona at the Lake Mead National Recreational Area at very low doses to represent environmental exposures. In this study, the fibrous amphibole asbestos sample from Arizona (AzA) is composed of winchite (69%), actinolite (22%), and non-amphibole minerals (9%) and has a mean aspect ratio of 16.7±0.9. Fibrous amphibole asbestos from Libby (LAA) is composed of winchite (70%), richterite (9%), tremolite (5%), and non-amphibole minerals (16%) with a mean aspect ratio of 8.4±0.7. C57BL/6 mice were exposed by oropharyngeal aspiration to fiber suspensions at a very low dose of 3µg/mouse. After seven months, both LAA- and AzA-exposed mice had indices of chronic immune dysfunction related to a T 17 cytokine profile, with B cell activation, autoantibody production and proteinuria, suggesting kidney involvement. In addition, both exposures led to significant lung and pleural fibrosis. These data suggest that there is risk of pulmonary disease and autoimmune outcomes with environmental exposure to amphibole asbestos, and that this is not limited to Libby, Montana.
[Mh] Termos MeSH primário: Amiantos Anfibólicos/toxicidade
Peso Corporal/efeitos dos fármacos
Baço/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração por Inalação
Albuminúria
Animais
Anticorpos Antinucleares
Arizona
Amiantos Anfibólicos/administração & dosagem
Autoanticorpos
Citocinas/genética
Citocinas/metabolismo
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Subpopulações de Linfócitos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Nevada
Tamanho do Órgão
Proteinúria
Baço/citologia
Baço/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (Asbestos, Amphibole); 0 (Autoantibodies); 0 (Cytokines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde