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[PMID]: 28919504 [Au] Autor: Starrett J; Hayashi CY; Derkarabetian S; Hedin M [Ad] Endereço: Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA; Department of Biological Sciences, Auburn University, 101 Rouse Life Sciences, Auburn, AL 36849, USA. Electronic address: jamesstarrett10@gmail.com. [Ti] Título: Cryptic elevational zonation in trapdoor spiders (Araneae, Antrodiaetidae, Aliatypus janus complex) from the California southern Sierra Nevada. [So] Source: Mol Phylogenet Evol;118:403-413, 2018 Jan. [Is] ISSN: 1095-9513 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The relative roles of ecological niche conservatism versus niche divergence in promoting montane speciation remains an important topic in biogeography. Here, our aim was to test whether lineage diversification in a species complex of trapdoor spiders corresponds with riverine barriers or with an ecological gradient associated with elevational tiering. Aliatypus janus was sampled from throughout its range, with emphasis on populations in the southern Sierra Nevada Mountains of California. We collected multi-locus genetic data to generate a species tree for A. janus and its close relatives. Coalescent based hypothesis tests were conducted to determine if genetic breaks within A. janus conform to riverine barriers. Ecological niche models (ENM) under current and Last Glacial Maximum (LGM) conditions were generated and hypothesis tests of niche conservatism and divergence were performed. Coalescent analyses reveal deeply divergent genetic lineages within A. janus, likely corresponding to cryptic species. Two primary lineages meet along an elevational gradient on the western slopes of the southern Sierra Nevada Mountains. ENMs under both current and LGM conditions indicate that these groups occupy largely non-overlapping niches. ENM hypothesis testing rejected niche identity between the two groups, and supported a sharp ecological gradient occurring where the groups meet. However, the niche similarity test indicated that the two groups may not inhabit different background niches. The Sierra Nevada Mountains provide a natural laboratory for simultaneously testing ecological niche divergence and conservatism and their role in speciation across a diverse range of taxa. Aliatypus janus represents a species complex with cryptic lineages that may have diverged due to parapatric speciation along an ecological gradient, or been maintained by the evolution of ecological niche differences following allopatric speciation. [Mh] Termos MeSH primário: Aranhas/classificação [Mh] Termos MeSH secundário: Animais California Fenômenos Ecológicos e Ambientais Complexo IV da Cadeia de Transporte de Elétrons/química Complexo IV da Cadeia de Transporte de Elétrons/classificação Complexo IV da Cadeia de Transporte de Elétrons/genética Especiação Genética Nevada Filogenia RNA Ribossômico 28S/química RNA Ribossômico 28S/classificação RNA Ribossômico 28S/genética Aranhas/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (RNA, Ribosomal, 28S); EC 1.9.3.1 (Electron Transport Complex IV) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170919 [St] Status: MEDLINE

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[PMID]: 29190268 [Au] Autor: Tapp L; Ramsey JG; Wen A; Gerona R [Ti] Título: Synthetic Cannabinoid and Mitragynine Exposure of Law Enforcement Agents During the Raid of an Illegal Laboratory - Nevada, 2014. [So] Source: MMWR Morb Mortal Wkly Rep;66(47):1291-1294, 2017 Dec 01. [Is] ISSN: 1545-861X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Synthetic cannabinoids (SCs), commonly known by the street name "Spice," are designer drugs of abuse that mimic the psychoactive effects of marijuana. Intentional SC use has resulted in multiple toxicities (1,2), but little is known about occupational SC exposure. After a federal agency's law enforcement personnel in Nevada reported irritability and feeling "high" after raiding illegal SC laboratories and processing seized SCs, a request for a health hazard evaluation was made by the agency to CDC's National Institute for Occupational Safety and Health (NIOSH) in 2014 to evaluate agents' occupational SC exposures. After making the request for a health hazard evaluation, federal agents conducted a raid of an illegal SC laboratory, with assistance from local law enforcement and Drug Enforcement Administration (DEA) personnel and with NIOSH investigators observing from a distance. After the raid, agents collected and processed material evidence. NIOSH investigators tested agents' urine for SC levels before and after the raid and measured SCs in the air and on surfaces after the raid. DEA determined that AB-PINACA (an SC compound) and mitragynine (a plant material with opium-like effects, also known as "kratom") were present in the illegal laboratory. AB-PINACA, its metabolites, and mitragynine were not detected in agents' urine before the raid; however, one or more of these substances was found in the urine of six of nine agents after the raid and processing of the SC evidence. AB-PINACA was detected in one surface wipe sample from the SC laboratory; none was detected in the air in the laboratory or in the offices of the law enforcement agency where the materials were processed after the raid. No policies were in place regarding work practices and use of personal protective equipment (PPE) during raids and evidence processing. To protect agents from SC exposures, NIOSH recommended that the agency require agents to wear a minimum level of PPE (e.g., protective gloves and disposable clothing) and undergo training in PPE and in handling and storing of contaminated evidence from SC laboratory raids. Showers and locker rooms also need to be provided so that agents can reduce contamination and prevent take-home exposure. [Mh] Termos MeSH primário: Canabinoides/urina Drogas Desenhadas Controle de Medicamentos e Entorpecentes/legislação & jurisprudência Laboratórios/legislação & jurisprudência Aplicação da Lei Exposição Ocupacional/análise Alcaloides de Triptamina e Secologanina/urina [Mh] Termos MeSH secundário: Adulto Seres Humanos Indazóis/urina Masculino Meia-Idade Nevada Equipamento de Proteção Individual/utilização Valina/análogos & derivados Valina/urina [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cannabinoids); 0 (Designer Drugs); 0 (Indazoles); 0 (N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide); 0 (Secologanin Tryptamine Alkaloids); EP479K822J (mitragynine); HG18B9YRS7 (Valine) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 180119 [Lr] Data última revisão: 180119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171201 [St] Status: MEDLINE [do] DOI: 10.15585/mmwr.mm6647a3

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[PMID]: 29261690 [Au] Autor: Shan G; Gerstenberger S [Ad] Endereço: School of Community Health Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, United States of America. [Ti] Título: Fisher's exact approach for post hoc analysis of a chi-squared test. [So] Source: PLoS One;12(12):e0188709, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: This research is motivated by one of our survey studies to assess the potential influence of introducing zebra mussels to the Lake Mead National Recreation Area, Nevada. One research question in this study is to investigate the association between the boating activity type and the awareness of zebra mussels. A chi-squared test is often used for testing independence between two factors with nominal levels. When the null hypothesis of independence between two factors is rejected, we are often left wondering where does the significance come from. Cell residuals, including standardized residuals and adjusted residuals, are traditionally used in testing for cell significance, which is often known as a post hoc test after a statistically significant chi-squared test. In practice, the limiting distributions of these residuals are utilized for statistical inference. However, they may lead to different conclusions based on the calculated p-values, and their p-values could be over- o6r under-estimated due to the unsatisfactory performance of asymptotic approaches with regards to type I error control. In this article, we propose new exact p-values by using Fisher's approach based on three commonly used test statistics to order the sample space. We theoretically prove that the proposed new exact p-values based on these test statistics are the same. Based on our extensive simulation studies, we show that the existing asymptotic approach based on adjusted residual is often more likely to reject the null hypothesis as compared to the exact approach due to the inflated family-wise error rates as observed. We would recommend the proposed exact p-value for use in practice as a valuable post hoc analysis technique for chi-squared analysis. [Mh] Termos MeSH primário: Dreissena Modelos Teóricos [Mh] Termos MeSH secundário: Animais Distribuição de Qui-Quadrado Seres Humanos Nevada Recreação [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171221 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0188709

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[PMID]: 29210235 [Au] Autor: Millar CI; Heckman K; Swanston C; Schmidt K; Westfall RD; Delany DL [Ti] Título: Radiocarbon dating of American pika fecal pellets provides insights into population extirpations and climate refugia. [So] Source: Ecol Appl;24(7):1748-68, 2014. [Is] ISSN: 1051-0761 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The American pika (Ochotona princeps) has become a species of concern for its sensitivity to warm temperatures and potential vulnerability to global warming. We explored the value of radiocarbon dating of fecal pellets to address questions of population persistence and timing of site extirpation. Carbon was extracted from pellets collected at 43 locations in the western Great Basin, USA, including three known occupied sites and 40 sites of uncertain status at range margins or where previous studies indicated the species is vulnerable. We resolved calibrated dates with high precision (within several years), most of which fell in the period of the mid-late 20th century bomb curve. The two-sided nature of the bomb curve renders far- and near-side dates of equal probability, which are separated by one to four decades. We document methods for narrowing resolution to one age range, including stratigraphic analysis of vegetation collected from pika haypiles. No evidence was found for biases in atmospheric 14C levels due to fossil-derived or industrial CO2 contamination. Radiocarbon dating indicated that pellets can persist for >59 years; known occupied sites resolved contemporary dates. Using combined evidence from field observations and radiocarbon dating, and the Bodie Mountains as an example, we propose a historical biogeographic scenario for pikas in minor Great Basin mountain ranges adjacent to major cordillera, wherein historical climate variability led to cycles of extirpation and recolonization during alternating cool and warm centuries. Using this model to inform future dynamics for small ranges in biogeographic settings similar to the Bodie Mountains in California, extirpation of pikas appears highly likely under directional warming trends projected for the next century, even while populations in extensive cordillera (e.g., Sierra Nevada, Rocky Mountains, Cascade Range) are likely to remain viable due to extensive, diverse habitat and high connectivity. [Mh] Termos MeSH primário: Distribuição Animal Clima Lagomorpha/fisiologia Datação Radiométrica/veterinária [Mh] Termos MeSH secundário: Animais California Nevada Oregon Dinâmica Populacional Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180108 [Lr] Data última revisão: 180108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171207 [St] Status: MEDLINE

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[PMID]: 28460538 [Au] Autor: Ganta V; Moonie S; Patel D; Hunt AT; Richardson J; Di John D; Ezeanolue EE [Ad] Endereço: a School of Community Health Sciences , University of Nevada Las Vegas , Las Vegas , NV , USA. [Ti] Título: Timely reminder interventions to improve annual Papanicolaou (Pap) smear rates among HIV-infected women in an outpatient center of southern Nevada: a short report. [So] Source: AIDS Care;29(9):1099-1101, 2017 Sep. [Is] ISSN: 1360-0451 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Current guidelines recommend annual Papanicolaou (Pap) smears for human immunodeficiency virus (HIV)-infected women for cervical cancer screening. Rates for such screening in Nevada are below the national rate. Our cohort includes 485 eligible HIV-infected adult women from an outpatient center in Southern Nevada of which only 12 women had obtained a Pap smear in the past year. An intervention was conducted from June 2015 to September 2015, in which reminders to schedule a Pap smear were sent to the remaining cohort of 473 women via sequential text messaging, followed by phone call attempts. Of all subjects, 94% contacted by text messages and 41% contacted by phone calls were successfully reached. There was an increase in the rate of completed Pap smears from 2.5% (12/485) at baseline to 11.8% (56/473) after interventions (p < 0.0001) in a period of three months. Out of the 68 Pap smear results, 20 (29.4%) were abnormal. Our intervention, utilizing methods of communication such as text messaging and phone calls, markedly increased the rate of completed Pap smear screening in our population. [Mh] Termos MeSH primário: Infecções por HIV Programas de Rastreamento/métodos Pacientes Ambulatoriais/estatística & dados numéricos Sistemas de Alerta Mensagem de Texto Esfregaço Vaginal/estatística & dados numéricos [Mh] Termos MeSH secundário: Adulto Estudos de Coortes Detecção Precoce de Câncer Feminino Seres Humanos Meia-Idade Nevada Ambulatório Hospitalar Teste de Papanicolaou Neoplasias do Colo do Útero/diagnóstico Esfregaço Vaginal/utilização [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171229 [Lr] Data última revisão: 171229 [Sb] Subgrupo de revista: IM; X [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1080/09540121.2017.1322677

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[PMID]: 28463769 [Au] Autor: Tipple BJ; Jameel Y; Chau TH; Mancuso CJ; Bowen GJ; Dufour A; Chesson LA; Ehleringer JR [Ad] Endereço: Department of Biology, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA; IsoForensics, Inc., 421 Wakara Way, Suite 100, Salt Lake City, UT 84108, USA. Electronic address: brett.tipple@utah.edu. [Ti] Título: Stable hydrogen and oxygen isotopes of tap water reveal structure of the San Francisco Bay Area's water system and adjustments during a major drought. [So] Source: Water Res;119:212-224, 2017 08 01. [Is] ISSN: 1879-2448 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Water availability and sustainability in the Western United States is a major flashpoint among expanding communities, growing industries, and productive agricultural lands. This issue came to a head in 2015 in the State of California, when the State mandated a 25% reduction in urban water use following a multi-year drought that significantly depleted water resources. Water demands and challenges in supplying water are only expected to intensify as climate perturbations, such as the 2012-2015 California Drought, become more common. As a consequence, there is an increased need to understand linkages between urban centers, water transport and usage, and the impacts of climate change on water resources. To assess if stable hydrogen and oxygen isotope ratios could increase the understanding of these relationships within a megalopolis in the Western United States, we collected and analyzed 723 tap waters across the San Francisco Bay Area during seven collection campaigns spanning 21 months during 2013-2015. The San Francisco Bay Area was selected as it has well-characterized water management strategies and the 2012-2105 California Drought dramatically affected its water resources. Consistent with known water management strategies and previously collected isotope data, we found large spatiotemporal variations in the δ H and δ O values of tap waters within the Bay Area. This is indicative of complex water transport systems and varying municipality-scale management decisions. We observed δ H and δ O values of tap water consistent with waters originating from snowmelt from the Sierra Nevada Mountains, local precipitation, ground water, and partially evaporated reservoir sources. A cluster analysis of the isotope data collected in this study grouped waters from 43 static sampling sites that were associated with specific water utility providers within the San Francisco Bay Area and known management practices. Various management responses to the drought, such as source switching, bringing in new sources, and water conservation, were observed in the isotope data. Finally, we estimated evaporative loss from one utility's reservoir system during the 2015 water year using a modified Craig-Gordon model to estimate the consequences of the drought on this resource. We estimated that upwards of 6.6% of the water in this reservoir system was lost to evaporation. [Mh] Termos MeSH primário: Secas Hidrogênio Isótopos de Oxigênio Água [Mh] Termos MeSH secundário: Baías Cidades Mudança Climática Monitoramento Ambiental Nevada São Francisco [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Oxygen Isotopes); 059QF0KO0R (Water); 7YNJ3PO35Z (Hydrogen) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171204 [Lr] Data última revisão: 171204 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE

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[PMID]: 28976811 [Au] Autor: Campion EW; Morrissey S; Malina D; Sacks CA; Drazen JM [Ti] Título: After the Mass Shooting in Las Vegas - Finding Common Ground on Gun Control. [So] Source: N Engl J Med;377(17):1679-1680, 2017 10 26. [Is] ISSN: 1533-4406 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Armas de Fogo/legislação & jurisprudência Incidentes com Feridos em Massa/prevenção & controle [Mh] Termos MeSH secundário: Seres Humanos Nevada Política Estados Unidos [Pt] Tipo de publicação: EDITORIAL [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171005 [St] Status: MEDLINE [do] DOI: 10.1056/NEJMe1713203

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[PMID]: 28870655 [Au] Autor: Pfau JC; Buck B; Metcalf RV; Kaupish Z; Stair C; Rodriguez M; Keil DE [Ad] Endereço: Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA. Electronic address: jean.pfau@montana.edu. [Ti] Título: Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona. [So] Source: Toxicol Appl Pharmacol;334:24-34, 2017 Nov 01. [Is] ISSN: 1096-0333 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: This project developed from studies demonstrating that Libby Amphibole Asbestos (LAA) causes a non-typical set of health outcomes not generally reported for asbestos, including systemic autoimmunity and an unusual and devastating lamellar pleural thickening that progresses to severe pulmonary dysfunction and death. Further, mineral fiber mixtures with some similarities to LAA have recently been discovered in southern Nevada and northwestern Arizona, where the material exists in extensive recreational areas and is present in yards, roads, parking lots and school yards. The objective was to compare the health outcomes in mice exposed to either LAA or the fibrous amphiboles collected in Arizona at the Lake Mead National Recreational Area at very low doses to represent environmental exposures. In this study, the fibrous amphibole asbestos sample from Arizona (AzA) is composed of winchite (69%), actinolite (22%), and non-amphibole minerals (9%) and has a mean aspect ratio of 16.7±0.9. Fibrous amphibole asbestos from Libby (LAA) is composed of winchite (70%), richterite (9%), tremolite (5%), and non-amphibole minerals (16%) with a mean aspect ratio of 8.4±0.7. C57BL/6 mice were exposed by oropharyngeal aspiration to fiber suspensions at a very low dose of 3µg/mouse. After seven months, both LAA- and AzA-exposed mice had indices of chronic immune dysfunction related to a T 17 cytokine profile, with B cell activation, autoantibody production and proteinuria, suggesting kidney involvement. In addition, both exposures led to significant lung and pleural fibrosis. These data suggest that there is risk of pulmonary disease and autoimmune outcomes with environmental exposure to amphibole asbestos, and that this is not limited to Libby, Montana. [Mh] Termos MeSH primário: Amiantos Anfibólicos/toxicidade Peso Corporal/efeitos dos fármacos Baço/efeitos dos fármacos [Mh] Termos MeSH secundário: Administração por Inalação Albuminúria Animais Anticorpos Antinucleares Arizona Amiantos Anfibólicos/administração & dosagem Autoanticorpos Citocinas/genética Citocinas/metabolismo Feminino Regulação da Expressão Gênica/efeitos dos fármacos Subpopulações de Linfócitos Masculino Camundongos Camundongos Endogâmicos C57BL Nevada Tamanho do Órgão Proteinúria Baço/citologia Baço/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Antinuclear); 0 (Asbestos, Amphibole); 0 (Autoantibodies); 0 (Cytokines) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171017 [Lr] Data última revisão: 171017 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170906 [St] Status: MEDLINE

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[PMID]: 28644276 [Au] Autor: Potera C [Ad] Endereço: Carol Potera. [Ti] Título: An Innovative Syringe Exchange Program. [So] Source: Am J Nurs;117(7):17, 2017 Jul. [Is] ISSN: 1538-7488 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Nevada's pilot vending machine program encourages users to enter treatment programs. [Mh] Termos MeSH primário: Automação/instrumentação Infecções por HIV/prevenção & controle Programas de Troca de Agulhas/organização & administração Abuso de Substâncias por Via Intravenosa/tratamento farmacológico Seringas/provisão & distribuição [Mh] Termos MeSH secundário: Seres Humanos Nevada Projetos Piloto Avaliação de Programas e Projetos de Saúde [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: AIM; IM; N [Da] Data de entrada para processamento: 170624 [St] Status: MEDLINE [do] DOI: 10.1097/01.NAJ.0000520934.96160.36

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[PMID]: 28419978 [Au] Autor: Null SE; Mouzon NR; Elmore LR [Ad] Endereço: Department of Watershed Sciences, Utah State University, Logan, UT., 84322, USA. Electronic address: sarah.null@usu.edu. [Ti] Título: Dissolved oxygen, stream temperature, and fish habitat response to environmental water purchases. [So] Source: J Environ Manage;197:559-570, 2017 Jul 15. [Is] ISSN: 1095-8630 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Environmental water purchases are increasingly used for ecological protection. In Nevada's Walker Basin (western USA), environmental water purchases augment streamflow in the Walker River and increase lake elevation of terminal Walker Lake. However, water quality impairments like elevated stream temperatures and low dissolved oxygen concentrations also limit ecosystems and species, including federally-threatened Lahontan cutthroat trout. In this paper, we prioritize water volumes and locations that most enhance water quality for riverine habitat from potential environmental water rights purchases. We monitored and modeled streamflows, stream temperatures, and dissolved oxygen concentrations using River Modeling System, an hourly, physically-based hydrodynamic and water quality model. Modeled environmental water purchases ranged from average daily increases of 0.11-1.41 cubic meters per second (m /s) during 2014 and 2015, two critically dry years. Results suggest that water purchases consistently cooled maximum daily stream temperatures and warmed nightly minimum temperatures. This prevented extremely low dissolved oxygen concentrations below 5.0 mg/L, but increased the duration of moderate conditions between 5.5 and 6.0 mg/L. Small water purchases less than approximately 0.71 m /s per day had little benefit for Walker River habitat. Dissolved oxygen concentrations were affected by upstream environmental conditions, where suitable upstream water quality improved downstream conditions and vice versa. Overall, this study showed that critically dry water years degrade environmental water quality and habitat, but environmental water purchases of at least 0.71 m /s were promising for river restoration. [Mh] Termos MeSH primário: Ecossistema Abastecimento de Água [Mh] Termos MeSH secundário: Animais Monitoramento Ambiental Peixes Nevada Oxigênio Rios Temperatura Ambiente Água [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 059QF0KO0R (Water); S88TT14065 (Oxygen) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170419 [St] Status: MEDLINE

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