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  1 / 86722 MEDLINE  
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[PMID]:29381740
[Au] Autor:Khokhar JS; Sareen S; Tyagi BS; Singh G; Wilson L; King IP; Young SD; Broadley MR
[Ad] Endereço:School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom.
[Ti] Título:Variation in grain Zn concentration, and the grain ionome, in field-grown Indian wheat.
[So] Source:PLoS One;13(1):e0192026, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wheat is an important dietary source of zinc (Zn) and other mineral elements in many countries. Dietary Zn deficiency is widespread, especially in developing countries, and breeding (genetic biofortification) through the HarvestPlus programme has recently started to deliver new wheat varieties to help alleviate this problem in South Asia. To better understand the potential of wheat to alleviate dietary Zn deficiency, this study aimed to characterise the baseline effects of genotype (G), site (E), and genotype by site interactions (GxE) on grain Zn concentration under a wide range of soil conditions in India. Field experiments were conducted on a diverse panel of 36 Indian-adapted wheat genotypes, grown on a range of soil types (pH range 4.5-9.5), in 2013-14 (five sites) and 2014-15 (six sites). Grain samples were analysed using inductively coupled plasma-mass spectrometry (ICP-MS). The mean grain Zn concentration of the genotypes ranged from 24.9-34.8 mg kg-1, averaged across site and year. Genotype and site effects were associated with 10% and 6% of the overall variation in grain Zn concentration, respectively. Whilst G x E interaction effects were evident across the panel, some genotypes had consistent rankings between sites and years. Grain Zn concentration correlated positively with grain concentrations of iron (Fe), sulphur (S), and eight other elements, but did not correlate negatively with grain yield, i.e. no yield dilution was observed. Despite a relatively small contribution of genotype to the overall variation in grain Zn concentration, due to experiments being conducted across many contrasting sites and two years, our data are consistent with reports that biofortifying wheat through breeding is likely to be effective at scale given that some genotypes performed consistently across diverse soil types. Notably, all soils in this study were probably Zn deficient and interactions between wheat genotypes and soil Zn availability/management (e.g. the use of Zn-containing fertilisers) need to be better-understood to improve Zn supply in food systems.
[Mh] Termos MeSH primário: Triticum/metabolismo
Zinco/metabolismo
[Mh] Termos MeSH secundário: Índia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0192026


  2 / 86722 MEDLINE  
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[PMID]:29237449
[Au] Autor:Singh A; Roy S
[Ad] Endereço:Genetics and Molecular Biology Division, CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh, 226001, India.
[Ti] Título:High altitude population of Arabidopsis thaliana is more plastic and adaptive under common garden than controlled condition.
[So] Source:BMC Ecol;17(1):39, 2017 Dec 13.
[Is] ISSN:1472-6785
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Population differentiation and their adaptation to a particular environment depend on their ability to respond to a new environment. This, in turn is governed to an extent, by the degree of phenotypic plasticity exhibited by the populations. The populations of same species inhabiting different climatic conditions may differ in their phenotypic plasticity. Himalayan populations of Arabidopsis thaliana originating from a steep altitude are exposed to different climatic conditions ranging from sub-tropical to temperate. Thus they might have experienced different selection pressures during evolution and may respond differently under common environmental condition. RESULTS: Phenotypic plasticity and differentiation of natural populations of A. thaliana grown under common garden and controlled conditions were determined. A total of seventeen morphological traits, their plasticity, association between traits and environment were performed using 45 accessions from three populations. Plants from different altitudes differed in phenotypes, their selection and fitness under two conditions. Under both the conditions lower altitude population was characterized by higher leaf count and larger silique than higher and middle altitude population. Flowering time of high altitude population increased while that of low and medium altitude decreased under controlled condition compared to open field. An increase in seed weight and germination was observed for all the population under open field than controlled. Rosette area was under divergent selection in both the condition. The heritability of lower altitude population was the highest under both the conditions, where as it was the least for higher altitude population further indicating that the high altitude populations are more responsive towards phenotypic changes under new environmental conditions. Ninety-nine percent of variability in traits and their plasticity co-varied with the altitude of their origin. The population of high altitude was more plastic and differentiated as compared to the lower altitude one. CONCLUSIONS: Arabidopsis thaliana population native to different altitudes of the west Himalaya responds differently when grown under common environments. The success of high altitude population is more in common garden than the controlled conditions. The significant variability in phenotype and its association with altitude of origin predicts for non-random genetic differentiation among the populations.
[Mh] Termos MeSH primário: Aclimatação
Altitude
Arabidopsis/fisiologia
Meio Ambiente
Fenótipo
[Mh] Termos MeSH secundário: Arabidopsis/genética
Arabidopsis/crescimento & desenvolvimento
Índia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1186/s12898-017-0149-5


  3 / 86722 MEDLINE  
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[PMID]:29458480
[Au] Autor:Pal M; Kumari M; Kiran S; Salwan R; Mayilraj S; Chhibber S; Gulati A
[Ad] Endereço:1​CSIR-Institute of Himalayan Bioresource Technology, Palampur (HP)-176 061, India.
[Ti] Título:Chryseobacterium glaciei sp. nov., isolated from the surface of a glacier in the Indian trans-Himalayas.
[So] Source:Int J Syst Evol Microbiol;68(3):865-870, 2018 Mar.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel bacterial strain, IHBB 10212 , of the genus Chryseobacterium was isolated from a glacier near the Kunzum Pass located in the Lahaul-Spiti in the North-Western Himalayas of India. The cells were Gram-negative, aerobic, non-sporulating, single rods, lacked flagella, and formed yellow to orange pigmented colonies. The strain utilized maltose, trehalose, sucrose, gentibiose, glucose, mannose, fructose, mannitol, arabitol and salicin for growth. Flexirubin-type pigments were produced by strain IHBB 10212 . The 16S rRNA gene sequence analysis showed relatedness of strain IHBB 10212 to Chryseobacterium polytrichastri DSM 26899 (97.43 %), Chryseobacterium greenlandense CIP 110007 (97.29 %) and Chryseobacterium aquaticum KCTC 12483 (96.80 %). Iso-C15 : 0 and summed feature 3 (C16 : 1ω7c/C16 : 1ω6c) constituted the major cellular fatty acids. The polar lipids present were six unidentified aminolipids, one unidentified phospholipid and three unidentified lipids. MK-6 was identified as the major quinone. The DNA G+C content was 34.08  mol%. Digital DNA-DNA hybridization of strain IHBB 10212 with C. polytrichastri, C. greenlandense and C. aquaticum showed values far below the prescribed thresholds of 95 % for average nucleotide identity and 70 % for the Genome-to-Genome Distance Calculator for species delineation. Based on its differences from validly published Chryseobacterium species, strain IHBB 10212 is identified as a new species, for which the proposed name is Chryseobacterium glaciei sp. nov., with IHBB 10212 as the type strain (=MTCC 12457 =JCM 31156 =KACC 19170 ).
[Mh] Termos MeSH primário: Chryseobacterium/classificação
Camada de Gelo/microbiologia
Filogenia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
Chryseobacterium/genética
Chryseobacterium/isolamento & purificação
DNA Bacteriano/genética
Ácidos Graxos/química
Índia
Hibridização de Ácido Nucleico
Fosfolipídeos/química
Pigmentação
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 71ANL51TLA (menaquinone 6)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002600


  4 / 86722 MEDLINE  
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[PMID]:28457672
[Au] Autor:Díaz Ortega JL; Castaneda D; Arellano Quintanilla DM; Martínez D; Trumbo SP; Fernández de Castro J
[Ad] Endereço:Instituto Nacional de Salud Pública, Mexico. Electronic address: jdiaz@insp.mx.
[Ti] Título:Antibody persistence in children aged 6-7years one year following booster immunization with two MMR vaccines applied by aerosol or by injection.
[So] Source:Vaccine;35(23):3116-3122, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:IMPORTANCE: In a previous study on booster vaccination, we reported that two aerosolized MMR vaccines were as safe and immunogenic as injectable vaccines containing the same antigens. We now present results of antibody persistence one year after immunization. OBJECTIVE: To assess the antibody persistence for measles, mumps, and rubella one year following booster immunization. METHODS: We performed clinical and serological follow-up of participants in a previous study of Mexican children aged 6-7years, in which participants were randomized to four groups receiving, by aerosolized or by injection, the MMR SII vaccine (Serum Institute of India), or the MMR II (Merck Sharp & Dhome). We evaluated the antibody persistence by PRN test for measles and by ELISA for rubella and mumps. The occurrence of clinical events was evaluated via periodic visits of a nurse team to children's schools and homes. RESULTS: Of the 260 initial participants, 241 completed one-year follow-up. There were only statistically significant differences in baseline seropositivity for mumps. One year after immunization, seropositivity in all groups was 100% for measles and rubella. The seropositivity rank for mumps was from 90.3% for the injected vaccine MMR II to 96.6% for vaccine MMR SII applied by aerosol; these differences were not statistically significant. With exception of the aerosolized vaccine MMR SII for the geometric mean titer (GMT) for measles, all study groups presented declination of GMT for the three viruses. The difference between the aerosolized vaccines MMR SII and MMR RII was statistically significant for mumps antibodies. Only mild clinical events were identified. CONCLUSION: Under conditions of no endemic transmission for measles and rubella, and of low circulation of mumps virus, school-aged children remained seropositive to the three viruses one year following booster immunization. The study was registered under CMN 2010-005 number at COFEPRIS (National Regulatory Authority).
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Imunização Secundária/métodos
Vírus do Sarampo/imunologia
Vacina contra Sarampo-Caxumba-Rubéola/imunologia
Vírus da Caxumba/imunologia
[Mh] Termos MeSH secundário: Aerossóis
Criança
Ensaio de Imunoadsorção Enzimática
Feminino
Seguimentos
Seres Humanos
Imunização Secundária/efeitos adversos
Índia/epidemiologia
Injeções
Masculino
Sarampo/epidemiologia
Sarampo/imunologia
Sarampo/prevenção & controle
Vacina contra Sarampo-Caxumba-Rubéola/administração & dosagem
Vacina contra Sarampo-Caxumba-Rubéola/efeitos adversos
Caxumba/epidemiologia
Caxumba/imunologia
Caxumba/prevenção & controle
Rubéola (Sarampo Alemão)/epidemiologia
Rubéola (Sarampo Alemão)/imunologia
Rubéola (Sarampo Alemão)/prevenção & controle
Vírus da Rubéola/imunologia
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aerosols); 0 (Antibodies, Viral); 0 (Measles-Mumps-Rubella Vaccine); 0 (rubella antibodies)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  5 / 86722 MEDLINE  
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[PMID]:28455169
[Au] Autor:Lee BY; Wedlock PT; Haidari LA; Elder K; Potet J; Manring R; Connor DL; Spiker ML; Bonner K; Rangarajan A; Hunyh D; Brown ST
[Ad] Endereço:HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, United States; Global Obesity Prevention Center (GOPC) at Johns Hopkins University, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: brucelee@jhu.edu.
[Ti] Título:Economic impact of thermostable vaccines.
[So] Source:Vaccine;35(23):3135-3142, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: While our previous work has shown that replacing existing vaccines with thermostable vaccines can relieve bottlenecks in vaccine supply chains and thus increase vaccine availability, the question remains whether this benefit would outweigh the additional cost of thermostable formulations. METHODS: Using HERMES simulation models of the vaccine supply chains for the Republic of Benin, the state of Bihar (India), and Niger, we simulated replacing different existing vaccines with thermostable formulations and determined the resulting clinical and economic impact. Costs measured included the costs of vaccines, logistics, and disease outcomes averted. RESULTS: Replacing a particular vaccine with a thermostable version yielded cost savings in many cases even when charging a price premium (two or three times the current vaccine price). For example, replacing the current pentavalent vaccine with a thermostable version without increasing the vaccine price saved from $366 to $10,945 per 100 members of the vaccine's target population. Doubling the vaccine price still resulted in cost savings that ranged from $300 to $10,706, and tripling the vaccine price resulted in cost savings from $234 to $10,468. As another example, a thermostable rotavirus vaccine (RV) at its current (year) price saved between $131 and $1065. Doubling and tripling the thermostable rotavirus price resulted in cost savings ranging from $102 to $936 and $73 to $808, respectively. Switching to thermostable formulations was highly cost-effective or cost-effective in most scenarios explored. CONCLUSION: Medical cost and productivity savings could outweigh even significant price premiums charged for thermostable formulations of vaccines, providing support for their use.
[Mh] Termos MeSH primário: Vacinas contra Rotavirus/economia
Vacinas contra Rotavirus/provisão & distribuição
Potência de Vacina
[Mh] Termos MeSH secundário: Benin/epidemiologia
Simulação por Computador
Análise Custo-Benefício
Seres Humanos
Índia/epidemiologia
Lactente
Níger/epidemiologia
Infecções por Rotavirus/epidemiologia
Infecções por Rotavirus/prevenção & controle
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Rotavirus Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  6 / 86722 MEDLINE  
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[PMID]:28449972
[Au] Autor:Sil A; Ravi MD; Patnaik BN; Dhingra MS; Dupuy M; Gandhi DJ; Dhaded SM; Dubey AP; Kundu R; Lalwani SK; Chhatwal J; Mathew LG; Gupta M; Sharma SD; Bavdekar SB; Rout SP; Jayanth MV; D'Cor NA; Mangarule SA; Ravinuthala S; Reddy E J
[Ad] Endereço:Shantha Biotechnics Private Limited - A Sanofi Company, Hyderabad, India. Electronic address: arijit.sil@sanofi.com.
[Ti] Título:Effect of prophylactic or therapeutic administration of paracetamol on immune response to DTwP-HepB-Hib combination vaccine in Indian infants.
[So] Source:Vaccine;35(22):2999-3006, 2017 05 19.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vaccination is considered as the most cost effective method for preventing infectious diseases. Low grade fever is a known adverse effect of vaccination. In India, it is a common clinical practice to prescribe paracetamol either prophylactically or therapeutically to manage fever. Some studies have shown that paracetamol interferes with antibody responses following immunization. This manuscript reports the outcome of a post hoc analysis of data from a clinical trial of a pentavalent vaccine in Indian infants where paracetamol was not used or was used either as prophylaxis or for treatment of fever. METHODS: Pre and post vaccine antibody levels against Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae type B were assessed in no paracetamol and paracetamol groups. The paracetamol group was further divided into prophylactic and treatment groups. RESULTS: Similar rates of seroprotection/seroresponse for anti-D, anti-T, anti-wP, anti-PT, anti-HBs and anti-PRP were observed in all the groups. There was no clear tendency for difference in percentage seroprotection/seroresponse and geometric mean (GM) titers in any of the groups. CONCLUSION: The study found no evidence that paracetamol usage either as prophylactic or for treatment impact immunological responses to DTwP-HepB-Hib combination vaccine. [Clinical trial registry of India (study registration number CTRI/2012/08/002872)].
[Mh] Termos MeSH primário: Acetaminofen/uso terapêutico
Anticorpos Antibacterianos/sangue
Vacina contra Difteria, Tétano e Coqueluche/administração & dosagem
Vacina contra Difteria, Tétano e Coqueluche/imunologia
Vacinas Anti-Haemophilus/administração & dosagem
Vacinas Anti-Haemophilus/imunologia
Vacinas contra Hepatite B/administração & dosagem
Vacinas contra Hepatite B/imunologia
Imunidade Humoral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetaminofen/administração & dosagem
Acetaminofen/efeitos adversos
Difteria/imunologia
Difteria/prevenção & controle
Vacina contra Difteria, Tétano e Coqueluche/efeitos adversos
Feminino
Febre/tratamento farmacológico
Febre/etiologia
Febre/prevenção & controle
Infecções por Haemophilus/etnologia
Infecções por Haemophilus/imunologia
Infecções por Haemophilus/prevenção & controle
Vacinas Anti-Haemophilus/efeitos adversos
Hepatite B/imunologia
Hepatite B/prevenção & controle
Anticorpos Anti-Hepatite B/sangue
Vacinas contra Hepatite B/efeitos adversos
Seres Humanos
Índia
Lactente
Masculino
Tétano/imunologia
Tétano/prevenção & controle
Vacinação
Vacinas Conjugadas/imunologia
Coqueluche/imunologia
Coqueluche/prevenção & controle
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Diphtheria-Tetanus-Pertussis Vaccine); 0 (DtwP-HepB-Hib vaccine); 0 (Haemophilus Vaccines); 0 (Hepatitis B Antibodies); 0 (Hepatitis B Vaccines); 0 (Vaccines, Conjugate); 362O9ITL9D (Acetaminophen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  7 / 86722 MEDLINE  
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[PMID]:28460016
[Au] Autor:Kathirvel S; Tripathy JP; Tun ZM; Patro BK; Singh T; Bhalla A; Devnani M; Wilkinson E
[Ad] Endereço:Department of Community Medicine, School of Public Health, Post Graduate Institute of Medical Education & Research, Chandigarh, India.
[Ti] Título:Physicians' compliance with the National Drug Policy on Malaria in a tertiary teaching hospital, India, from 2010 to 2015: a mixed method study.
[So] Source:Trans R Soc Trop Med Hyg;111(2):62-70, 2017 02 01.
[Is] ISSN:1878-3503
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: National drug policies are formulated to encourage rational use of drugs and to reduce drug resistance. This study assessed physicians' compliance with the National Drug Policy on Malaria at a tertiary care hospital in north India. Methods: This mixed method study extracted data from adult malaria inpatient records of the hospital from 2010-2015, and assessed drug supply at pharmacies. Physicians' practices and perspectives were explored by in-depth interviews. Compliance was assessed by severity, type of species and pregnancy status. Thematic analysis was done for the qualitative data. Results: A total of 247 case files were reviewed. Vivax malaria (41.0%) was more common than falciparum malaria (37.2%). The majority (90.8%) of cases were severe malaria. Overall compliance for use of schizonticidal drug was 73.0% in severe malaria and was only 9.5% in uncomplicated malaria. Compliance for use of gametocidal drug (primaquine) was 15.3%. Schizonticidal drugs were available in all pharmacies except the public one. Primaquine was available in only one. The main themes emerging in the thematic network analysis were physicians' misconceptions, physician-related factors, and hospital-related and drug access factors. Conclusions: The degree of compliance for severe malaria treatment was reasonably good but low for radical cure. Raising knowledge and awareness among health care providers, by using written treatment protocols and continuing medical education would improve compliance.
[Mh] Termos MeSH primário: Antimaláricos/uso terapêutico
Fidelidade a Diretrizes/estatística & dados numéricos
Malária/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Antimaláricos/provisão & distribuição
Atitude do Pessoal de Saúde
Feminino
Hospitais de Ensino/estatística & dados numéricos
Seres Humanos
Índia
Masculino
Meia-Idade
Farmácias/estatística & dados numéricos
Padrões de Prática Médica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimalarials)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/trstmh/trx020


  8 / 86722 MEDLINE  
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[PMID]:27771623
[Au] Autor:Suri D; Bhattad S; Gupta A; Trehan A; Bansal D; Rajwanshi A; Das A; Rawat A; Singh S
[Ad] Endereço:Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
[Ti] Título:Malignancies in Children with Human Immunodeficiency Virus Infection - Our Experience at Chandigarh, North India.
[So] Source:J Trop Pediatr;63(3):210-216, 2017 06 01.
[Is] ISSN:1465-3664
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: With improved survival in children living with human immunodeficiency virus (HIV) infection (CLHIV), malignancies are being increasingly recognized. Patients and methods: Among the CLHIV registered at our institute from January 1994 to March 2015, children with malignancy were analysed in detail. Results: In total, 734 children affected by HIV were registered. Out of these, 11 children (9 boys, 2 girls) were diagnosed to have malignancy. Malignancy was the presenting feature of HIV infection in 4 children. High-grade non-Hodgkin lymphoma (NHL) was the most common malignancy noted in 9 of 11 (81%) children, whereas the remaining 2 children had Hodgkin's lymphoma. Survival in our cohort was 80% among children in whom chemotherapy was initiated, and overall survival was 36% (4 of 11 children). Conclusion: NHL was the most common malignancy in CLHIV in our cohort. Low-conditioning chemotherapy protocols along with initiation of anti-retroviral therapy resulted in improved outcomes in CLHIV with malignancy.
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Neoplasias/complicações
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Criança
Estudos de Coortes
Feminino
Infecções por HIV/diagnóstico
Infecções por HIV/epidemiologia
Seres Humanos
Índia
Linfoma Relacionado a AIDS/diagnóstico
Linfoma Relacionado a AIDS/epidemiologia
Linfoma Relacionado a AIDS/patologia
Linfoma não Hodgkin
Masculino
Registros Médicos
Neoplasias/mortalidade
Fatores de Risco
Distribuição por Sexo
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1093/tropej/fmw074


  9 / 86722 MEDLINE  
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[PMID]:28742443
[Au] Autor:Smith E; Charantimath US; Wilson SF; Hoffman MK
[Ad] Endereço:a Department of Obstetrics and Gynecology , Christiana Care Health System , Newark , DE, USA.
[Ti] Título:Family planning in Southern India: A survey of women's attitudes.
[So] Source:Health Care Women Int;38(10):1022-1033, 2017 Oct.
[Is] ISSN:1096-4665
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Women were recruited from villages in the Belgaum district of India. Members of the research team obtained consent and led 58 interviews in the local languages. Participants were asked questions covering topics related to postpartum contraceptive counseling, knowledge, and experience; postpartum sexual practice; birth spacing desire and counseling; and interest in long-acting reversible contraceptives (LARCs). Women generally desired 3 years of birth spacing. A majority did not receive counseling regarding postpartum contraception during the prenatal period, although most would have liked to have received such counseling. Those who had made a contraceptive plan during the prenatal period had an odds ratio of 25.2 (95% CI 4.9-128.6, p = 0.00001) for using postpartum contraception. Influences on contraceptive decisions primarily came from friends and family, while information from medical providers was not a major influence. Most women did not believe they could make their own decisions regarding contraception use, but those who did had an adjusted odds ratio of 56 (95% CI 3.4-9161, p = 0.0047) of utilizing postpartum contraception. Women generally liked the idea of LARCs. A large majority of the women surveyed (89.66%) liked the idea of a subdermal contraceptive implant, a method currently unavailable in this region. Ultimately, the women surveyed do have healthy attitudes and goals regarding birth spacing but few utilize effective contraception in order to meet their goals. Further efforts in counseling as well as availability of a wider variety of contraceptive methods, including the subdermal contraceptive implant, may decrease the disparity between desires and practices.
[Mh] Termos MeSH primário: Comportamento Contraceptivo
Anticoncepção/métodos
Serviços de Planejamento Familiar/métodos
Conhecimentos, Atitudes e Prática em Saúde
[Mh] Termos MeSH secundário: Adolescente
Adulto
Intervalo entre Nascimentos
Anticoncepção/utilização
Aconselhamento
Serviços de Planejamento Familiar/recursos humanos
Feminino
Seres Humanos
Índia
Período Pós-Parto
Saúde da População Rural
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1080/07399332.2017.1356306


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[PMID]:28452688
[Au] Autor:Singh P; Hayden KA; Ens T; Khan N; Quan H; Plested D; Sinclair S; King-Shier KM
[Ad] Endereço:Faculty of Nursing, University of Calgary, Calgary, AB,Canada.
[Ti] Título:Ethno-cultural Preferences in Receipt of Heart Health Information.
[So] Source:Am J Health Behav;41(2):114-126, 2017 Mar 01.
[Is] ISSN:1945-7359
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We attempted to understand how people of South Asian and Chinese descent prefer to receive health information. METHODS: To achieve this end we conducted a search of academic and grey literature articles published between 1946 and 2016. To be included, articles had to be focused South Asian and Chinese specific ethno-culturally-based preferences of receiving health information. RESULTS: A total of 3478 abstracts were retrieved, of which, 27 articles met the inclusion criteria. We were able to identify South Asian and Chinese people's preferences for and facilitators of receiving health information. South Asians and Chinese preferred health information and programs that were more culturally relevant and appealing, had translations into South Asian and Chinese languages, and used simple terms as opposed to technical jargon. CONCLUSIONS: There is little direction regarding for how to tai- lor health information South Asian and Chinese ethno-cultural groups. Having evidence-based information about how South Asians and Chinese prefer to receive health information has potential to enhance patients' learning and health literacy, improve clinical outcomes, and reduce health disparities.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde/etnologia
Educação de Pacientes como Assunto
[Mh] Termos MeSH secundário: Bangladesh/etnologia
China/etnologia
Seres Humanos
Índia/etnologia
Paquistão/etnologia
Sri Lanka/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.5993/AJHB.41.2.2



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