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[PMID]: 29392424 [Au] Autor: Shahkarami S; Mehrasa R; Younesian S; Yaghmaie M; Chahardouli B; Vaezi M; Rezaei N; Nikbakht M; Alimoghaddam K; Ghavamzadeh A; Tavakkoly-Bazzaz J; Ghaffari SH [Ad] Endereço: Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. [Ti] Título: Minimal residual disease (MRD) detection using rearrangement of immunoglobulin/T cell receptor genes in adult patients with acute lymphoblastic leukemia (ALL). [So] Source: Ann Hematol;97(4):585-595, 2018 Apr. [Is] ISSN: 1432-0584 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: MRD detection with allele-specific oligonucleotide-quantitative polymerase chain reaction (ASO-qPCR) and using clone-specific immunoglobulin/T cell receptor rearrangements is considered as a powerful prognostic factor in acute lymphoblastic leukemia (ALL). In the present study, we evaluated an ASO-qPCR assay for MRD quantification in peripheral blood (PB) samples of adult patients with ALL. DNA was isolated from PB samples of patients with newly diagnosed ALL. They were first investigated by multiplex-PCR assay to identify V/J usage. An ASO-qPCR technique was then applied for 2.5-year monthly MRD quantification for detection of patient-specific Ig/TCR receptor rearrangements as a molecular target. From 98 patients who were diagnosed as ALL, 72 (73.5%) were enrolled in the present study for MRD detection. MRD was successfully quantified in patients with 1-month interval time. MRD level at the end of induction therapy up to day 88 was the only significant prognostic factor. Regarding MRD level, patients were categorized into two groups of low and high-risk. 2.5-year OS in all three time points (days 28, 58 and 88) were significantly lower in high-risk group (P < 0.008). The results of the 2.5-year MRD detection indicate that MRD level at the end of induction up to about 6 months after the first diagnosis was associated with clinical outcome. This study may highlight the usefulness of PB and the definitions of cut-off level for early prediction of relapse and for stratifying ALL patients. Short-interval time points and frequent PB sampling to monitor MRD level is suggested for early clinical relapse prediction and clinical management of the disease. [Mh] Termos MeSH primário: Rearranjo Gênico do Linfócito T/efeitos dos fármacos Quimioterapia de Indução Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico [Mh] Termos MeSH secundário: Adulto Alelos Feminino Seguimentos Hospitais Universitários Seres Humanos Irã (Geográfico) Masculino Reação em Cadeia da Polimerase Multiplex Proteínas de Neoplasias/química Proteínas de Neoplasias/genética Proteínas de Neoplasias/metabolismo Neoplasia Residual/diagnóstico Neoplasia Residual/genética Neoplasia Residual/metabolismo Neoplasia Residual/patologia Oligonucleotídeos/química Oligonucleotídeos/metabolismo Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico Leucemia-Linfoma Linfoblástico de Células Precursoras/genética Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia Prognóstico Estudos Prospectivos Reação em Cadeia da Polimerase em Tempo Real Reação em Cadeia da Polimerase Via Transcriptase Reversa Medição de Risco Análise de Sobrevida Carga Tumoral/efeitos dos fármacos [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Neoplasm Proteins); 0 (Oligonucleotides) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1007/s00277-018-3230-z

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[PMID]: 29320815 [Au] Autor: Matin S; Shahbazi G; Namin ST; Moradpour R; Feizi F; Piri-Dogahe H [Ad] Endereço: Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. [Ti] Título: Comparison of Placenta PCR and Maternal Serology of Aborted Women for Detection of Toxoplasma gondii in Ardabil, Iran. [So] Source: Korean J Parasitol;55(6):607-611, 2017 Dec. [Is] ISSN: 1738-0006 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission of the parasite to the fetus. This study was conducted to test the utility of PCR assay to detect recent infections with Toxoplasma in aborted women at various gestational ages who referred to Obstetrics and Gynecology Department of Alavi Hospital in Ardabil during 2014 and 2016. Two hundred women with a history of single or repeated abortion were investigated in this study. Blood samples were tested for specific anti-Toxoplasma IgM and IgG antibodies by ELISA. According to the results, 53.5% of the women under study were positive for anti-Toxoplasma antibodies: 4.0% of them had IgM, 43.0% had IgG, and 6.5% had both IgM and IgG. Subsequently, Nested-PCR analysis was used to detect T. gondii DNA in the placenta of subjects. In 10.5% of the women, the results were positive for 529 bp element of T. gondii. Among them, 5 (23.8%) cases were IgM positive, 1 (4.8%) case was IgG positive, and 11 (52.4%) were both IgM and IgG positive. In 4 (19.0%) patients, none of the antibodies were found to be positive. In total, 16 patients had positive results in both ELISA and PCR methods, and 174 cases had negative results for new infection. The findings of this study revealed that T. gondii might be one of the significant factors leading to abortion, and that the analysis of placenta can be important in order to achieve increased detection sensitivity. [Mh] Termos MeSH primário: Aborto Habitual/etiologia Aborto Espontâneo/etiologia Anticorpos Antiprotozoários/sangue Reação em Cadeia da Polimerase/métodos Complicações Parasitárias na Gravidez/diagnóstico Testes Sorológicos/métodos Toxoplasma/imunologia Toxoplasmose/diagnóstico Toxoplasmose/parasitologia [Mh] Termos MeSH secundário: Adolescente Adulto Biomarcadores/sangue DNA de Protozoário/sangue Ensaio de Imunoadsorção Enzimática Feminino Seres Humanos Imunoglobulina G/sangue Imunoglobulina M/sangue Irã (Geográfico)/epidemiologia Gravidez Complicações Parasitárias na Gravidez/epidemiologia Complicações Parasitárias na Gravidez/parasitologia Toxoplasma/genética Toxoplasmose/complicações Toxoplasmose/epidemiologia Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Protozoan); 0 (Biomarkers); 0 (DNA, Protozoan); 0 (Immunoglobulin G); 0 (Immunoglobulin M) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180112 [St] Status: MEDLINE [do] DOI: 10.3347/kjp.2017.55.6.607

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[PMID]: 29318368 [Au] Autor: Mirlohi MS; Yaghooti H; Shirali S; Aminasnafi A; Olapour S [Ad] Endereço: Hyperlipidemia Research Center, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. [Ti] Título: Increased levels of advanced glycation end products positively correlate with iron overload and oxidative stress markers in patients with ß-thalassemia major. [So] Source: Ann Hematol;97(4):679-684, 2018 Apr. [Is] ISSN: 1432-0584 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The impaired biosynthesis of the ß-globin chain in ß-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production accelerates in oxidative conditions. This study was conducted on 45 patients with major ß-thalassemia who received frequent blood transfusions and chelation therapy and were compared to 40 healthy subjects. Metabolic parameters including glycemic and iron indices, hepatic and renal functions tests, oxidative stress markers, and AGEs (carboxymethyl-lysine and pentosidine) levels were measured. All parameters were significantly increased in ß-thalassemia compared to the control except for glutathione levels. Blood glucose, iron, serum ferritin, non-transferrin-bound iron (NTBI), MDA, soluble form of low-density lipoprotein receptor, glutathione peroxidase, total reactive oxygen species (ROS), and AGE levels were significantly higher in the ß-thalassemia patients. Iron and ferritin showed a significant positive correlation with pentosidine (P < 0.01) but not with carboxymethyl-lysine. The NTBI was markedly increased in the ß-thalassemia patients, and its levels correlated significantly with both carboxymethyl-lysine and pentosidine (P < 0.05). Our findings confirm the oxidative status generated by the iron overload in ß-thalassemia major patients and highlight the enhanced formation of AGEs, which may play an important role in the pathogenesis of ß-thalassemia major. [Mh] Termos MeSH primário: Transfusão de Sangue Produtos Finais de Glicação Avançada/sangue Sobrecarga de Ferro/etiologia Estresse Oxidativo Reação Transfusional/fisiopatologia Talassemia beta/sangue [Mh] Termos MeSH secundário: Adolescente Adulto Biomarcadores/sangue Terapia por Quelação/efeitos adversos Terapia Combinada/efeitos adversos Estudos Transversais Desferroxamina/uso terapêutico Feminino Seres Humanos Irã (Geográfico) Sobrecarga de Ferro/prevenção & controle Masculino Piridonas/uso terapêutico Receptores Depuradores Classe E/sangue Adulto Jovem Talassemia beta/terapia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Glycation End Products, Advanced); 0 (OLR1 protein, human); 0 (Pyridones); 0 (Scavenger Receptors, Class E); 2BTY8KH53L (deferiprone); J06Y7MXW4D (Deferoxamine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180111 [St] Status: MEDLINE [do] DOI: 10.1007/s00277-017-3223-3

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[PMID]: 29175404 [Au] Autor: Dehbandi R; Moore F; Keshavarzi B [Ad] Endereço: Department of Earth Sciences, College of Sciences, Shiraz University, Shiraz, 71454, Iran. Electronic address: rezadehbandi65@gmail.com. [Ti] Título: Geochemical sources, hydrogeochemical behavior, and health risk assessment of fluoride in an endemic fluorosis area, central Iran. [So] Source: Chemosphere;193:763-776, 2018 Feb. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The present study is the first attempt to put forward the possible source(s) and health risk assessment of fluoride in Bahabad, central Iran. Fluoride concentrations ranged from 0.22 to 2.35 mg/L and 292-355 mg/kg in the groundwater and soil samples, respectively. Geochemical provenance techniques using major and rare earth elements in soils revealed that local shale is the most probable source rock of fluoride in the area. A two-step chemical fractionation method applied on soil samples demonstrated that residual and water-soluble fractions were the most probable modes of fluoride in soil, whereas exchangeable fraction had a minor role. The coefficient of aqueous migration showed that fluoride in the studied soils behaved as a mobile element. Moreover, the relative mobility indicated that soils played a more important role than rocks in releasing fluoride into groundwater. In groundwater medium, chemical weathering, evaporation, and ion exchange acted as the main geochemical controlling factors of fluoride enrichment. Findings of this study signify that the role of NaCl and NaSO -type waters should be considered more to recognize susceptible areas to fluoride contamination in groundwater. People in the study area are exposed to high levels of fluoride intake through drinking water, thus making dental fluorosis a major public health concern in the area. Scanning electron microscopy of the dentin's enamel showed morphological modifications (e.g., cracks and fissures) in residents' enamel structures. The results of this study may lead to suitable management strategies to mitigate the endemic fluorosis problem. [Mh] Termos MeSH primário: Monitoramento Ambiental/métodos Poluição Ambiental Fluoretos/efeitos adversos Medição de Risco [Mh] Termos MeSH secundário: Fluoretos/análise Fluorose Dentária/epidemiologia Fluorose Dentária/etiologia Água Subterrânea/química Seres Humanos Troca Iônica Irã (Geográfico) Solo/química Erosão Dentária/diagnóstico por imagem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Soil); Q80VPU408O (Fluorides) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [St] Status: MEDLINE

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[PMID]: 29458458 [Au] Autor: Mohr KI; Moradi A; Glaeser SP; Kämpfer P; Gemperlein K; Nübel U; Schumann P; Müller R; Wink J [Ad] Endereço: 1​Microbial Drugs, Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany. [Ti] Título: Nannocystis konarekensis sp. nov., a novel myxobacterium from an Iranian desert. [So] Source: Int J Syst Evol Microbiol;68(3):721-729, 2018 Mar. [Is] ISSN: 1466-5034 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: An orange-coloured myxobacterium, MNa11734 , was isolated from desert in Iran. MNa11734 had rod-shaped vegetative cells, moved by gliding and was bacteriolytic. No real fruiting body formation could be observed, but sporangioles were produced on water agar. The strain was mesophilic, strictly aerobic and chemoheterotrophic. 16S rRNA gene analyses revealed that MNa11734 belonged to the family Nannocystaceae, genus Nannocystis and was closely related to Nannocystis pusilla Na p29 (DSM 14622 ) and Nannocystis exedens Na e1 (DSM 71 ), with 97.8 and 97.6 % 16S rRNA gene sequence similarity, respectively. Laboratory-measured DNA-DNA hybridization showed only 9.5/15.7 % (reciprocal) similarity between the novel strain and N. pusilla Na p29 , and 14.1/20.4 % between the strain and N. exedens Na e1 , whereas DNA-DNA hybridization estimates derived from draft genome sequences were 21.8-23.0 % and 22.2-23.7 %, respectively, depending on the calculation method. The G+C content of DNA from Nannocystis konarekensis MNa11734 was 73.3 mol%, for N. pusilla Nap29 it was 71.8 mol% and for N. exedens Nae1 it was 72.2 mol%. The major fatty acids of the new strain were C16 : 1 (56.2 %), iso-C17 : 0 (14.4 %), C14 : 0 (8.2 %), C16 : 0 (6.6 %) and iso-C15 : 0 (5.9 %). Strain MNa11734 exhibited phylogenetic and physiological similarities to the two other species of Nannocystis, i.e. N. pusilla and N. exedens, but the differences were sufficient enough to represent a novel species, for which the name Nannocystiskonarekensis sp. nov. is proposed. The type strain is MNa11734 (=DSM 104509 =NCCB 100618 ). [Mh] Termos MeSH primário: Clima Desértico Myxococcales/classificação Filogenia Microbiologia do Solo [Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana Composição de Bases DNA Bacteriano/genética Ácidos Graxos/química Irã (Geográfico) Myxococcales/genética Myxococcales/isolamento & purificação Hibridização de Ácido Nucleico RNA Ribossômico 16S/genética Análise de Sequência de DNA [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180221 [St] Status: MEDLINE [do] DOI: 10.1099/ijsem.0.002569

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[PMID]: 29267669 [Au] Autor: Pourhajibagher M; Ghorbanzadeh R; Bahador A [Ad] Endereço: Tehran University of Medical Sciences, Department of Microbiology, School of Medicine, Tehran, Iran. [Ti] Título: Culture-dependent approaches to explore the prevalence of root canal pathogens from endodontic infections. [So] Source: Braz Oral Res;31:e108, 2017 Dec 18. [Is] ISSN: 1807-3107 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Endodontic infections are considered to be caused by the presence of various microorganisms within the root canal system. Recognition of this microbiota contributes to the successful treatment of infected root canals. This study investigated the microorganisms associated with primary and secondary endodontic infections via culture methods, biochemical tests, and molecular approaches in an Iranian population. Microbial specimens were collected from 36 patients with primary endodontic infection and 14 patients with a history of root canal therapy. Advanced microbiological culture techniques were used to isolate microbiota; subsequently, biochemical tests and 16S ribosomal RNA gene sequencing were performed to identify the microorganisms. Within the total 218 cultivable isolates, Veillonella parvula (20.6%) was found to occur with the highest frequency in primary endodontic infection, followed by Porphyromonas gingivalis (14.1%), and Aggregatibacter actinomycetemcomitans (9.2%). Enterococcus faecalis (36.6%) was the most predominant microorganism in secondary endodontic infections, followed by Candida albicans, Propionibacterium acnes, and V. parvula with frequencies of 20%, 2%, and 2%, respectively. It was concluded that V. parvula and E. faecalis was most frequently found in primary and secondary endodontic infections, respectively. [Mh] Termos MeSH primário: Bactérias Anaeróbias/isolamento & purificação Cavidade Pulpar/microbiologia Doenças da Polpa Dentária/microbiologia [Mh] Termos MeSH secundário: Adulto Bactérias Anaeróbias/genética Infecções Bacterianas/epidemiologia Infecções Bacterianas/microbiologia Contagem de Colônia Microbiana Doenças da Polpa Dentária/epidemiologia Feminino Seres Humanos Irã (Geográfico)/epidemiologia Masculino Meia-Idade Técnicas de Amplificação de Ácido Nucleico Reação em Cadeia da Polimerase Prevalência Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 171222 [St] Status: MEDLINE

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[PMID]: 28457512 [Au] Autor: Soltani S; Aghakhani K; Fallah F [Ad] Endereço: Department of Forensic Medicine and Toxicology, Iran University of Medical Sciences, Tehran, Iran. [Ti] Título: Sex prediction potential of hyoid metric measurements in Iranian adults. [So] Source: Leg Med (Tokyo);25:6-10, 2017 Mar. [Is] ISSN: 1873-4162 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: OBJECTIVES: Human hyoid is sexually dimorphic and is useful for sexing unknown skeletal remains. We aimed to find sex prediction potential of three linear dimensions of hyoid bones obtained from a series of cadavers with Persian ethnicity. METHODS: This cross-sectional study was carried out in 2015 at Forensic Pathology Organization of Tehran, Iran. We directly measured three linear dimensions of a series of hyoid samples obtained from cadavers during their neck autopsy in a convenience method. These dimensions were width, length and distance between lesser horns of hyoid. Height and weight of cadavers were also documented. Cadavers were of Persian ethnicity and at least 25-year-old. Data were analyzed by SPSS16. Logistic Regression Model was applied to find independent sex predictor(s) of hyoid. Statistically significant level was considered <0.05. RESULTS: Hyoids of 349 adult cadavers (176 females and 173 males) with mean±SD age of 39.91±8.13years were investigated. Male cadavers had significantly higher BMI values (p-value<0.001). Mean±SD for width, length and distance between lesser horns of hyoids were 34.45±4.70, 34.61±4.67 and 22.71±2.80mm, respectively. All measured dimensions had greater mean values in males (all with p-values<0.001). After adjusting for BMI, length and distance between lesser horns of hyoid were independent predictors of sex with odd's ratio of 4.67 and 1.97, respectively. Combining these two measurements provided sex classification accuracy of 97.4%. CONCLUSION: Special metric hyoid indicators can help in accurate sexing of skeletal remnants of adult Iranians. Further studies will find the strongest sex predictors of hyoid bones among Persians. [Mh] Termos MeSH primário: Osso Hioide/anatomia & histologia Determinação do Sexo pelo Esqueleto/métodos [Mh] Termos MeSH secundário: Adulto Índice de Massa Corporal Cadáver Estudos Transversais Feminino Seres Humanos Irã (Geográfico) Masculino Meia-Idade [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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[PMID]: 28453720 [Au] Autor: Chavehpour Y; Rashidian A; Raghfar H; Emamgholipour Sefiddashti S; Maroofi A [Ad] Endereço: Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. [Ti] Título: 'Seeking affluent neighbourhoods?' a time-trend analysis of geographical distribution of hospitals in the Megacity of Tehran. [So] Source: Health Policy Plan;32(5):669-675, 2017 Jun 01. [Is] ISSN: 1460-2237 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Objective: Access to hospitals in megacities in low and middle income countries might be hampered by travel barriers and distance. We assessed the 'inverse care law' hypothesis: whether hospitals tended to be built in the relatively better-off areas through the time. Methods: A longitudinal time-series study (1966 to 2011) in Tehran to measure inequality in the distribution of hospital beds. We assessed correlations between the district socioeconomic status and availability of hospital beds via regression analyses, estimated correlation, Gini and concentration indices, and used GIS models to map hospital distributions through time. Finding: We found a clear relationship between socioeconomic status and number of hospital beds per capita ( P -values <0.05). Gini coefficients were about 0.6 and 0.8 for public and private beds, respectively. A third of the variations in hospital bed distribution was explained by the welfare status of the district. For every extra residential room per capita, 130 to 280 extra beds were observed per ten thousand population at the district level. In 2011, out of 162 hospitals, 110 were located in six districts around the centre and northern part of the city. During the time period only two private hospitals were built in relatively disadvantaged districts. Conclusion: Over a period of about fifty years new hospitals had been established in the relatively affluent areas of the city and the relationship between socioeconomic status of district with total, private and public beds were direct and intensive. Results indicate the problem of inequality may remain over time and be resistant to policy initiatives and major political changes. [Mh] Termos MeSH primário: Acesso aos Serviços de Saúde Número de Leitos em Hospital/estatística & dados numéricos Hospitais Urbanos/estatística & dados numéricos Fatores Socioeconômicos [Mh] Termos MeSH secundário: Geografia Irã (Geográfico) [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: H [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1093/heapol/czw172

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[PMID]: 29292978 [Au] Autor: Palm A; Wilander E; Wallgren S; Hillerdal G [Ad] Endereço: Department of Medical Sciences, Respiratory, Allergy and Sleep Research - Uppsala, Sweden Department of Medical Sciences, Respiratory, Allergy and Sleep Research - Uppsala, Sweden. [Ti] Título: Sotrökslunga är en ny sjukdom i Sverige - Exponering för rök från biomassa är orsaken.. [So] Source: Lakartidningen;114, 2017 Dec 18. [Is] ISSN: 1652-7518 [Cp] País de publicação: Sweden [La] Idioma: swe [Ab] Resumo: Black smoke lung disease - a new disease in Sweden We describe two elderly female patients, immigrants to Sweden from Afghanistan, with intensive longtime exposure to smoke from biomass, and who presented with bronchial stenosis and severe bronchial obstruction. CT and X-ray showed bizarre perihilar infiltrates in the lungs. Bronchoscopy revealed black narrow bronchi with a middle lobe stenosis in one of the patients. These findings indicate the diagnosis bronchial anthracofibrosis (BAF). The here described findings are seen mainly in elderly never-smoking women from developing countries who have spent years cooking food in poorly ventilated kitchens. With increased immigration from these countries such cases will be seen in industrialized countries as well. Active tuberculosis must always be excluded but otherwise no more active investigations such as biopsies are warranted. We suggest that this disease should be termed ¼black smoke disease« to differentiate it from coal workers' pneumoconiosis, silicosis, and other classical occupational diseases which can have similar clinical and radiological pictures. This term is easily understood even by non-medical persons and illustratess both the etiology and the black bronchi. [Mh] Termos MeSH primário: Antracose Fumaça/efeitos adversos [Mh] Termos MeSH secundário: Afeganistão/etnologia Antracose/diagnóstico Antracose/diagnóstico por imagem Antracose/etiologia Antracose/patologia Biomassa Broncoscopia Materiais de Construção/efeitos adversos Feminino Seres Humanos Irã (Geográfico)/etnologia Meia-Idade Exposição Ocupacional/efeitos adversos Radiografia Suécia Tomografia Computadorizada por Raios X [Pt] Tipo de publicação: CASE REPORTS [Nm] Nome de substância: 0 (Smoke) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180103 [St] Status: MEDLINE

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[PMID]: 28452699 [Au] Autor: Khajouei R; Salehi F [Ad] Endereço: Medical Informatics Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. [Ti] Título: Health Literacy among Iranian High School Students. [So] Source: Am J Health Behav;41(2):215-222, 2017 Mar 01. [Is] ISSN: 1945-7359 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: We examined the health lit- eracy status of high school students in Kerman, Iran. METHODS: This descriptive cross-sectional study was conducted at high schools in Kerman. Data concerning 3 dimensions of health literacy (health knowledge, health skills and health be- haviors) were collected from 312 students using an adapted version of a valid and reliable questionnaire developed by the Ministry of Health of China. Data analysis was performed by descriptive statistics and chi-square analysis using SPSS version 22. RESULTS: The average age of the students was 16 ± 3 years and 50% (N = 156) of them were girls. Twenty-nine percent of students gained a health literacy score between 37 and 47 (adequate). A statistically significant relationship was found between health literacy and type of school (p < .004), family income (p < .03), and parents' education level (p < .001). CONCLUSION: A large percentage of adolescents in Iran have inadequate health literacy requiring serious interventions by authorities and policy-makers. Incorporating subjects such as mental health, prevention of addiction, and puberty and sexual health into educational curricula can improve Iranian students' health literacy. [Mh] Termos MeSH primário: Comportamentos Relacionados com a Saúde/etnologia Conhecimentos, Atitudes e Prática em Saúde/etnologia Alfabetização em Saúde/estatística & dados numéricos Estudantes/estatística & dados numéricos [Mh] Termos MeSH secundário: Adolescente Estudos Transversais Feminino Seres Humanos Irã (Geográfico)/etnologia Masculino [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.5993/AJHB.41.2.13

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